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OPENSEQ.org
SDHM - L-serine dehydratase 2
UniProt: P30744 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11623
Length: 455 (453)
Sequences: 877
Seq/Len: 1.94
SDHM
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: SDHL SDHM TDCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
189_S 356_E 3.572 1.00
337_V 341_G 3.572 1.00
373_M 424_V 3.286 1.00
264_I 404_V 3.282 1.00
210_A 313_A 3.041 1.00
355_A 360_A 2.998 1.00
220_I 298_A 2.965 1.00
128_R 142_T 2.896 1.00
197_L 202_K 2.765 1.00
314_R 356_E 2.709 1.00
71_A 86_F 2.62 1.00
182_Q 363_A 2.595 1.00
347_C 372_A 2.574 1.00
325_L 425_I 2.522 1.00
197_L 205_L 2.456 1.00
355_A 407_A 2.443 1.00
265_N 405_N 2.402 1.00
326_Y 345_V 2.385 1.00
44_R 112_C 2.369 1.00
179_K 183_E 2.358 1.00
180_H 184_T 2.306 1.00
201_S 204_E 2.304 1.00
326_Y 348_S 2.292 1.00
95_R 104_E 2.251 1.00
67_I 90_V 2.23 1.00
91_N 109_V 2.183 1.00
177_L 191_L 2.156 0.99
44_R 132_L 2.136 0.99
210_A 309_A 2.051 0.99
300_Y 311_S 2.05 0.99
209_L 316_L 2.043 0.99
426_E 430_E 2.041 0.99
94_G 108_P 2.036 0.99
244_R 248_V 2.024 0.99
194_K 197_L 2.023 0.99
8_F 319_A 2.007 0.99
71_A 90_V 2.003 0.99
180_H 191_L 1.982 0.99
108_P 111_Q 1.968 0.99
322_I 352_A 1.948 0.99
189_S 314_R 1.895 0.98
206_E 313_A 1.869 0.98
32_D 139_Y 1.867 0.98
88_Q 92_T 1.854 0.98
34_I 102_Q 1.854 0.98
89_D 93_H 1.822 0.98
122_L 144_Y 1.783 0.97
43_T 133_A 1.778 0.97
176_D 179_K 1.771 0.97
222_R 274_E 1.768 0.97
331_S 337_V 1.745 0.97
130_T 137_V 1.738 0.97
331_S 341_G 1.737 0.97
10_I 211_N 1.732 0.96
9_K 24_K 1.731 0.96
233_K 387_Q 1.723 0.96
360_A 411_L 1.711 0.96
334_G 397_A 1.71 0.96
46_V 130_T 1.693 0.96
48_D 130_T 1.689 0.96
326_Y 373_M 1.677 0.96
120_L 126_G 1.672 0.95
434_D 439_Y 1.647 0.95
193_M 206_E 1.644 0.95
202_K 206_E 1.605 0.94
4_V 320_S 1.601 0.94
181_C 362_P 1.597 0.94
419_V 451_I 1.592 0.94
39_L 103_H 1.58 0.93
265_N 398_I 1.565 0.93
46_V 132_L 1.557 0.93
201_S 205_L 1.545 0.92
361_S 364_Q 1.544 0.92
169_Y 194_K 1.537 0.92
45_V 98_L 1.523 0.91
49_V 66_I 1.517 0.91
219_G 281_V 1.517 0.91
206_E 309_A 1.506 0.91
256_D 408_R 1.502 0.91
130_T 140_S 1.5 0.91
108_P 112_C 1.493 0.90
48_D 116_H 1.483 0.90
186_L 191_L 1.466 0.89
137_V 140_S 1.459 0.89
356_E 365_V 1.455 0.89
43_T 134_G 1.455 0.89
186_L 194_K 1.451 0.89
292_I 379_L 1.447 0.88
269_L 397_A 1.446 0.88
214_E 218_G 1.445 0.88
366_C 417_P 1.424 0.87
27_K 31_D 1.409 0.87
190_G 194_K 1.403 0.86
67_I 113_M 1.398 0.86
172_S 328_M 1.397 0.86
28_Q 151_I 1.394 0.86
218_G 222_R 1.393 0.86
237_P 416_E 1.392 0.86
390_V 418_R 1.373 0.85
132_L 137_V 1.372 0.85
200_H 204_E 1.371 0.85
63_D 115_F 1.367 0.84
241_A 245_R 1.366 0.84
217_R 298_A 1.351 0.83
367_I 417_P 1.342 0.83
309_A 313_A 1.342 0.83
206_E 210_A 1.338 0.83
229_V 235_R 1.334 0.82
227_E 245_R 1.332 0.82
310_N 314_R 1.318 0.81
9_K 76_D 1.309 0.81
362_P 365_V 1.306 0.80
292_I 400_A 1.303 0.80
200_H 208_H 1.302 0.80
67_I 71_A 1.294 0.80
421_L 425_I 1.292 0.79
81_D 105_V 1.289 0.79
348_S 373_M 1.282 0.79
169_Y 184_T 1.282 0.79
334_G 337_V 1.277 0.78
301_D 312_L 1.266 0.77
398_I 405_N 1.264 0.77
399_A 409_M 1.258 0.77
345_V 399_A 1.247 0.76
88_Q 91_N 1.246 0.76
54_S 117_A 1.243 0.76
74_L 77_T 1.243 0.76
58_K 63_D 1.238 0.75
66_I 127_M 1.235 0.75
318_V 356_E 1.234 0.75
376_N 379_L 1.229 0.74
86_F 90_V 1.228 0.74
26_G 129_I 1.226 0.74
208_H 212_V 1.216 0.73
367_I 413_R 1.207 0.73
203_E 207_Q 1.198 0.72
263_W 303_F 1.194 0.71
213_W 312_L 1.192 0.71
221_E 225_S 1.191 0.71
40_K 103_H 1.19 0.71
170_P 195_N 1.19 0.71
366_C 415_S 1.189 0.71
427_T 447_L 1.181 0.70
94_G 109_V 1.179 0.70
189_S 318_V 1.178 0.70
175_A 179_K 1.174 0.70
193_M 202_K 1.17 0.69
197_L 201_S 1.164 0.69
129_I 142_T 1.159 0.68
39_L 98_L 1.144 0.67
347_C 376_N 1.143 0.67
97_M 104_E 1.142 0.66
413_R 417_P 1.135 0.66
224_I 244_R 1.133 0.66
171_Y 321_A 1.128 0.65
236_V 279_G 1.126 0.65
5_F 208_H 1.125 0.65
146_I 220_I 1.122 0.64
27_K 74_L 1.121 0.64
2_I 328_M 1.118 0.64
71_A 97_M 1.115 0.64
347_C 399_A 1.108 0.63
213_W 217_R 1.106 0.63
331_S 432_G 1.102 0.62
13_G 18_H 1.102 0.62
10_I 215_V 1.097 0.62
172_S 176_D 1.094 0.62
311_S 357_L 1.089 0.61
173_S 176_D 1.087 0.61
372_A 376_N 1.084 0.61
14_P 18_H 1.082 0.60
13_G 17_S 1.081 0.60
345_V 373_M 1.069 0.59
29_F 131_A 1.064 0.58
331_S 334_G 1.062 0.58
41_D 138_V 1.06 0.58
81_D 222_R 1.057 0.58
250_Q 412_R 1.055 0.57
42_V 138_V 1.052 0.57
401_V 405_N 1.05 0.57
46_V 114_N 1.045 0.56
141_Q 155_E 1.045 0.56
310_N 313_A 1.045 0.56
13_G 16_S 1.042 0.56
430_E 433_K 1.042 0.56
229_V 233_K 1.04 0.56
141_Q 153_D 1.04 0.56
256_D 348_S 1.039 0.56
58_K 115_F 1.035 0.55
30_T 98_L 1.033 0.55
120_L 142_T 1.033 0.55
87_I 91_N 1.029 0.55
337_V 432_G 1.028 0.54
119_N 124_E 1.028 0.54
211_N 215_V 1.028 0.54
86_F 89_D 1.027 0.54
215_V 219_G 1.019 0.53
188_L 318_V 1.017 0.53
429_Y 433_K 1.016 0.53
89_D 92_T 1.014 0.53
58_K 437_A 1.013 0.53
73_N 86_F 1.011 0.53
329_N 334_G 1.011 0.53
247_L 263_W 1.01 0.52
15_S 18_H 1 0.51
292_I 334_G 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iafA10.32751000.73Contact Map0.88
1ygyA20.439698.90.939Contact Map0.454
2hp0A10.564833.70.982Contact Map0.377
1szqA20.564822.30.984Contact Map0.438
3tsoC20.15827.70.987Contact Map0.536
1vs1A40.15167.60.987Contact Map0.705
2nptA20.21765.90.987Contact Map0.355
3tmlA40.17365.70.988Contact Map0.409
1wotA10.19785.30.988Contact Map0.285
2xmmA20.12754.20.988Contact Map0.594
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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