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OPENSEQ.org
RNT - Ribonuclease T
UniProt: P30014 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11547
Length: 215 (212)
Sequences: 218
Seq/Len: 1.03
RNT
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
158_A 197_I 4.042 1.00
126_H 130_M 2.571 0.99
72_P 76_A 2.459 0.99
34_D 69_N 2.437 0.99
24_V 36_L 2.395 0.99
107_I 115_A 2.392 0.99
30_N 33_T 2.352 0.99
18_Y 106_G 2.205 0.98
161_Q 170_T 2.039 0.96
70_L 75_L 2.011 0.96
61_H 78_N 1.955 0.95
45_K 55_D 1.942 0.95
54_P 192_V 1.83 0.92
30_N 34_D 1.82 0.92
173_M 189_R 1.745 0.90
59_H 184_L 1.742 0.89
104_R 140_R 1.725 0.89
21_V 44_L 1.717 0.89
189_R 192_V 1.712 0.88
74_A 157_L 1.63 0.85
43_T 55_D 1.621 0.84
39_I 99_I 1.615 0.84
149_F 156_G 1.599 0.83
152_A 156_G 1.592 0.83
39_I 129_M 1.585 0.83
147_A 152_A 1.548 0.80
17_F 54_P 1.526 0.79
17_F 187_T 1.525 0.79
41_A 62_V 1.483 0.76
159_L 196_E 1.482 0.76
18_Y 107_I 1.477 0.76
168_C 175_F 1.476 0.76
29_F 77_F 1.428 0.72
58_L 116_I 1.41 0.71
96_L 129_M 1.375 0.68
100_F 133_A 1.369 0.68
46_M 156_G 1.364 0.67
74_A 207_W 1.358 0.67
168_C 205_G 1.343 0.66
117_M 129_M 1.314 0.63
42_I 54_P 1.312 0.63
41_A 104_R 1.274 0.60
41_A 79_G 1.272 0.59
70_L 82_P 1.264 0.59
158_A 201_W 1.244 0.57
90_V 95_A 1.219 0.55
119_A 208_P 1.211 0.54
107_I 110_S 1.206 0.53
11_C 106_G 1.201 0.53
122_A 148_T 1.193 0.52
152_A 202_K 1.174 0.50
47_D 53_M 1.168 0.50
17_F 141_N 1.167 0.50
99_I 165_S 1.166 0.50
27_A 77_F 1.156 0.49
133_A 141_N 1.147 0.48
93_Y 97_H 1.145 0.48
12_D 32_K 1.144 0.48
22_I 133_A 1.144 0.48
43_T 152_A 1.14 0.47
39_I 207_W 1.139 0.47
18_Y 119_A 1.136 0.47
35_A 163_V 1.136 0.47
30_N 101_K 1.125 0.46
18_Y 147_A 1.124 0.46
18_Y 159_L 1.111 0.45
82_P 172_G 1.108 0.44
96_L 115_A 1.099 0.43
10_L 184_L 1.096 0.43
71_Q 168_C 1.094 0.43
119_A 147_A 1.093 0.43
44_L 148_T 1.089 0.43
39_I 62_V 1.089 0.43
114_R 140_R 1.088 0.42
196_E 203_R 1.086 0.42
100_F 152_A 1.084 0.42
91_S 189_R 1.081 0.42
75_L 115_A 1.081 0.42
58_L 99_I 1.076 0.41
76_A 179_Q 1.076 0.41
15_R 20_V 1.074 0.41
42_I 57_T 1.071 0.41
42_I 177_S 1.071 0.41
161_Q 166_K 1.06 0.40
27_A 82_P 1.059 0.40
197_I 201_W 1.058 0.40
123_N 148_T 1.055 0.39
60_F 103_V 1.052 0.39
68_A 101_K 1.048 0.39
168_C 206_G 1.035 0.38
62_V 104_R 1.026 0.37
27_A 36_L 1.024 0.37
76_A 86_D 1.023 0.37
155_A 167_A 1.02 0.36
101_K 200_R 1.016 0.36
140_R 145_P 1.015 0.36
126_H 148_T 1.013 0.36
69_N 140_R 1.013 0.36
99_I 103_V 1.011 0.36
41_A 68_A 1.01 0.36
65_F 68_A 1.009 0.35
165_S 197_I 1.003 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3v9wA411000.713Contact Map0.512
2f96A20.9861000.724Contact Map0.502
1zbuA40.962899.90.793Contact Map0.309
4hxhB20.962899.90.795Contact Map0.304
2qxfA10.89399.90.795Contact Map0.37
3cg7A20.958199.90.797Contact Map0.298
2guiA10.860599.90.798Contact Map0.427
3mxmB20.916399.90.798Contact Map0.334
1w0hA10.90799.90.803Contact Map0.311
2xriA10.888499.90.804Contact Map0.396
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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