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OPENSEQ.org
NADC - Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt: P30011 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11546
Length: 297 (275)
Sequences: 1729
Seq/Len: 6.29
NADC
Paralog alert: 0.12 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_R 140_E 4.255 1.00
66_G 290_L 3.58 1.00
268_R 272_E 3.496 1.00
239_E 242_Q 3.459 1.00
156_L 163_L 3.159 1.00
216_V 222_L 2.782 1.00
262_V 270_F 2.683 1.00
223_D 249_R 2.644 1.00
135_V 172_G 2.585 1.00
56_S 111_S 2.547 1.00
87_T 108_E 2.486 1.00
68_F 92_V 2.376 1.00
92_V 102_Q 2.302 1.00
93_D 96_D 2.298 1.00
78_F 121_A 2.288 1.00
28_A 80_Q 2.288 1.00
114_L 294_M 2.278 1.00
167_V 172_G 2.189 1.00
197_R 224_E 2.172 1.00
217_E 221_E 2.15 1.00
89_I 106_E 2.121 1.00
57_H 108_E 2.105 1.00
243_M 258_V 2.092 1.00
91_H 106_E 2.033 1.00
104_L 292_L 1.996 1.00
68_F 98_I 1.986 1.00
242_Q 245_E 1.959 1.00
150_L 277_F 1.955 1.00
24_P 76_E 1.952 1.00
250_T 256_L 1.935 1.00
142_L 149_L 1.923 1.00
65_N 100_A 1.91 1.00
127_T 156_L 1.887 1.00
245_E 248_K 1.865 1.00
81_L 117_G 1.831 1.00
140_E 143_E 1.803 1.00
197_R 201_E 1.794 1.00
200_V 214_V 1.778 1.00
65_N 99_N 1.748 1.00
36_G 180_S 1.747 1.00
144_G 268_R 1.685 1.00
57_H 106_E 1.682 1.00
60_V 292_L 1.648 1.00
82_A 113_V 1.629 1.00
138_Y 264_D 1.603 1.00
35_L 116_T 1.572 0.99
30_A 124_F 1.562 0.99
243_M 270_F 1.562 0.99
134_K 287_V 1.525 0.99
68_F 104_L 1.501 0.99
141_L 264_D 1.498 0.99
198_Q 201_E 1.472 0.99
75_E 79_I 1.462 0.99
127_T 163_L 1.46 0.99
223_D 227_K 1.452 0.99
258_V 270_F 1.451 0.99
64_E 288_Q 1.44 0.99
142_L 147_T 1.439 0.99
40_D 185_I 1.435 0.99
63_R 293_S 1.432 0.99
222_L 250_T 1.432 0.99
55_R 108_E 1.426 0.99
220_E 223_D 1.421 0.99
135_V 139_V 1.419 0.99
145_T 268_R 1.405 0.98
36_G 178_G 1.405 0.98
25_G 29_Q 1.398 0.98
69_C 169_C 1.395 0.98
149_L 267_L 1.388 0.98
92_V 96_D 1.386 0.98
138_Y 280_V 1.379 0.98
269_E 272_E 1.353 0.98
165_Y 169_C 1.352 0.98
195_S 198_Q 1.347 0.98
126_Q 289_A 1.346 0.98
139_V 172_G 1.33 0.98
68_F 71_K 1.318 0.97
76_E 80_Q 1.316 0.97
232_I 255_L 1.313 0.97
97_V 140_E 1.301 0.97
134_K 264_D 1.3 0.97
219_L 246_A 1.292 0.97
247_V 273_T 1.286 0.97
262_V 266_T 1.279 0.97
53_N 110_P 1.277 0.97
222_L 233_I 1.271 0.97
258_V 273_T 1.257 0.96
72_R 94_D 1.256 0.96
144_G 272_E 1.255 0.96
40_D 184_L 1.245 0.96
145_T 272_E 1.243 0.96
255_L 277_F 1.236 0.96
240_T 270_F 1.228 0.96
163_L 287_V 1.22 0.95
148_Q 173_A 1.207 0.95
81_L 113_V 1.199 0.95
241_E 244_R 1.198 0.95
187_E 295_R 1.197 0.95
99_N 102_Q 1.193 0.95
67_V 136_R 1.192 0.95
141_L 267_L 1.182 0.94
58_A 294_M 1.18 0.94
175_H 213_E 1.176 0.94
137_H 264_D 1.164 0.94
240_T 269_E 1.158 0.93
56_S 192_A 1.152 0.93
138_Y 267_L 1.148 0.93
59_T 106_E 1.142 0.93
183_F 207_H 1.141 0.93
197_R 227_K 1.14 0.93
222_L 226_L 1.14 0.93
84_D 110_P 1.136 0.93
89_I 108_E 1.125 0.92
198_Q 202_K 1.125 0.92
266_T 270_F 1.115 0.92
128_L 166_A 1.106 0.91
150_L 209_D 1.105 0.91
213_E 234_M 1.103 0.91
60_V 74_V 1.092 0.90
76_E 79_I 1.092 0.90
86_V 107_L 1.087 0.90
151_D 167_V 1.087 0.90
77_V 117_G 1.083 0.90
266_T 269_E 1.083 0.90
86_V 109_G 1.081 0.90
86_V 113_V 1.081 0.90
233_I 254_A 1.068 0.89
97_V 136_R 1.066 0.89
191_I 217_E 1.058 0.89
74_V 105_F 1.057 0.88
27_V 124_F 1.042 0.88
281_G 285_K 1.038 0.87
103_S 106_E 1.032 0.87
33_E 160_R 1.025 0.86
26_A 29_Q 1.018 0.86
200_V 225_A 1.018 0.86
190_I 194_G 1.016 0.86
27_V 80_Q 1.013 0.85
128_L 163_L 1.003 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qapA20.98991000.314Contact Map0.817
3pajA20.99331000.314Contact Map0.827
3l0gA40.94951000.319Contact Map0.873
3gnnA20.96631000.35Contact Map0.851
2b7nA30.90241000.35Contact Map0.778
1qpoA60.92931000.354Contact Map0.796
3tqvA20.95961000.361Contact Map0.801
1x1oA30.9361000.373Contact Map0.888
3c2eA10.91251000.379Contact Map0.733
1o4uA20.9361000.38Contact Map0.686
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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