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FLGL - Flagellar hook-associated protein 3
UniProt: P29744 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11545
Length: 317 (316)
Sequences: 2526
Seq/Len: 7.99
FLGL
Paralog alert: 0.61 [within 20: 0.35] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_Q 237_K 4.632 1.00
90_A 114_I 3.256 1.00
83_V 121_L 3.166 1.00
129_D 134_Y 3.166 1.00
116_G 119_D 3.037 1.00
111_A 115_Q 2.925 1.00
19_S 300_S 2.883 1.00
276_S 280_D 2.872 1.00
89_N 113_D 2.77 1.00
35_R 42_D 2.732 1.00
53_S 275_M 2.682 1.00
34_K 279_V 2.56 1.00
29_Q 286_T 2.474 1.00
86_A 121_L 2.443 1.00
36_V 45_A 2.415 1.00
285_A 289_S 2.36 1.00
63_T 265_S 2.344 1.00
103_S 106_D 2.341 1.00
57_A 92_E 2.336 1.00
89_N 93_K 2.299 1.00
281_V 286_T 2.222 1.00
61_Q 64_L 2.204 1.00
60_S 268_A 2.194 1.00
94_I 233_N 2.186 1.00
26_Y 293_Q 2.133 1.00
77_E 247_R 2.081 1.00
45_A 278_L 2.08 1.00
73_V 250_L 2.074 1.00
87_I 236_L 2.071 1.00
53_S 279_V 2.044 1.00
120_Q 123_N 2.003 1.00
28_E 38_N 1.96 1.00
110_L 114_I 1.95 1.00
66_R 261_D 1.927 1.00
275_M 279_V 1.885 1.00
105_D 108_A 1.87 1.00
90_A 117_L 1.835 1.00
86_A 124_L 1.833 1.00
89_N 92_E 1.802 1.00
100_G 107_R 1.763 1.00
25_K 29_Q 1.753 1.00
90_A 236_L 1.732 1.00
93_K 113_D 1.732 1.00
111_A 114_I 1.701 1.00
86_A 117_L 1.674 1.00
83_V 243_V 1.673 1.00
115_Q 212_K 1.648 1.00
61_Q 92_E 1.629 1.00
87_I 240_L 1.628 1.00
97_A 110_L 1.585 1.00
108_A 112_T 1.57 1.00
116_G 253_Q 1.55 1.00
87_I 243_V 1.534 1.00
122_L 126_N 1.512 1.00
112_T 249_E 1.499 1.00
51_V 106_D 1.499 1.00
49_A 279_V 1.497 1.00
104_D 108_A 1.496 1.00
112_T 245_T 1.494 0.99
91_Q 95_V 1.49 0.99
88_Q 91_Q 1.474 0.99
26_Y 286_T 1.472 0.99
34_K 281_V 1.46 0.99
26_Y 281_V 1.455 0.99
84_T 244_L 1.453 0.99
26_Y 289_S 1.438 0.99
70_T 254_L 1.425 0.99
115_Q 119_D 1.399 0.99
237_K 241_N 1.397 0.99
59_N 264_G 1.391 0.99
16_I 301_Y 1.389 0.99
98_S 230_D 1.387 0.99
93_K 110_L 1.387 0.99
246_V 249_E 1.378 0.99
297_L 301_Y 1.357 0.99
56_Q 271_Q 1.328 0.99
291_I 294_Q 1.323 0.98
42_D 45_A 1.313 0.98
96_Y 110_L 1.291 0.98
83_V 124_L 1.288 0.98
52_L 131_N 1.287 0.98
83_V 86_A 1.277 0.98
82_Q 85_T 1.271 0.98
106_D 109_S 1.269 0.98
56_Q 272_T 1.268 0.98
80_L 243_V 1.258 0.98
64_L 68_F 1.254 0.98
36_V 49_A 1.245 0.98
94_I 232_T 1.236 0.97
18_N 22_E 1.236 0.97
62_Y 264_G 1.224 0.97
84_T 240_L 1.224 0.97
94_I 229_L 1.22 0.97
36_V 41_D 1.2 0.97
29_Q 281_V 1.176 0.96
69_A 257_L 1.176 0.96
14_R 18_N 1.174 0.96
50_V 244_L 1.168 0.96
16_I 300_S 1.168 0.96
94_I 98_S 1.162 0.96
88_Q 240_L 1.16 0.96
262_S 265_S 1.148 0.95
9_Y 13_M 1.142 0.95
82_Q 259_S 1.131 0.95
123_N 127_T 1.128 0.95
13_M 288_S 1.125 0.95
268_A 272_T 1.124 0.95
95_V 233_N 1.12 0.95
260_L 264_G 1.119 0.95
229_L 232_T 1.117 0.95
79_V 124_L 1.114 0.94
79_V 128_T 1.11 0.94
107_R 229_L 1.109 0.94
134_Y 137_A 1.104 0.94
74_S 254_L 1.102 0.94
94_I 97_A 1.092 0.94
14_R 269_L 1.09 0.94
67_T 261_D 1.089 0.94
240_L 244_L 1.086 0.93
118_R 205_D 1.074 0.93
99_N 102_L 1.074 0.93
129_D 132_G 1.062 0.92
302_K 306_D 1.055 0.92
134_Y 145_P 1.055 0.92
70_T 261_D 1.05 0.92
86_A 120_Q 1.049 0.92
238_N 242_N 1.049 0.92
120_Q 256_E 1.048 0.92
70_T 258_E 1.048 0.92
113_D 252_T 1.047 0.92
235_G 238_N 1.044 0.92
93_K 96_Y 1.043 0.91
283_W 287_I 1.042 0.91
30_M 286_T 1.041 0.91
103_S 109_S 1.041 0.91
301_Y 304_F 1.033 0.91
84_T 88_Q 1.033 0.91
84_T 247_R 1.033 0.91
111_A 118_R 1.029 0.91
19_S 23_W 1.029 0.91
73_V 253_Q 1.015 0.90
28_E 37_V 1.013 0.90
232_T 236_L 1.011 0.90
105_D 241_N 1.01 0.90
15_G 32_T 1.008 0.90
144_A 147_S 1.007 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ucuA10.99371000.339Contact Map0.55
2d4xA10.78231000.368Contact Map0.629
3pwxA20.74761000.378Contact Map0.645
3k8wA10.81391000.494Contact Map0.715
3v47C20.753999.90.634Contact Map0.729
1io1A10.697299.80.694Contact Map0.753
3k1iC20.552199.20.799Contact Map0.573
1oryB10.167296.70.894Contact Map0.327
3k1hA10.495367.60.938Contact Map0.731
3fhnA40.2655.80.965Contact Map0.851
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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