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OPENSEQ.org
NRDD - Anaerobic ribonucleoside-triphosphate reductase
UniProt: P28903 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11417
Length: 712 (705)
Sequences: 798
Seq/Len: 1.13
NRDD
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
432_D 523_R 4.21 1.00
435_L 524_L 3.293 1.00
443_M 539_F 3.264 1.00
149_D 440_K 3.258 1.00
436_V 531_W 3.059 1.00
439_R 534_E 2.843 1.00
424_E 519_A 2.581 1.00
5_V 61_I 2.507 0.99
692_N 695_K 2.396 0.99
65_V 81_Y 2.375 0.99
62_Q 66_E 2.369 0.99
557_D 573_Y 2.327 0.99
370_Q 373_K 2.271 0.99
315_I 355_E 2.122 0.98
524_L 541_L 2.115 0.98
21_K 43_A 2.094 0.97
698_E 702_R 2.051 0.97
681_G 698_E 2.045 0.97
436_V 527_A 1.969 0.96
682_Y 698_E 1.96 0.96
516_K 520_I 1.946 0.96
678_R 681_G 1.945 0.96
70_M 75_K 1.943 0.96
78_A 82_I 1.915 0.95
62_Q 82_I 1.91 0.95
160_H 552_R 1.907 0.95
695_K 702_R 1.904 0.95
66_E 82_I 1.862 0.94
158_D 415_R 1.857 0.94
428_W 519_A 1.851 0.94
543_S 601_A 1.844 0.94
695_K 698_E 1.803 0.93
418_L 564_V 1.798 0.93
439_R 535_T 1.792 0.92
62_Q 92_R 1.777 0.92
525_R 529_D 1.774 0.92
236_V 306_I 1.773 0.92
59_N 63_T 1.766 0.92
681_G 692_N 1.749 0.91
415_R 557_D 1.74 0.91
522_E 600_L 1.735 0.91
488_S 542_Y 1.716 0.90
678_R 682_Y 1.711 0.90
152_Q 156_R 1.705 0.90
59_N 62_Q 1.704 0.90
681_G 702_R 1.658 0.88
239_S 266_E 1.658 0.88
677_R 692_N 1.657 0.88
62_Q 88_R 1.639 0.87
439_R 531_W 1.638 0.87
58_I 62_Q 1.631 0.87
79_R 83_E 1.63 0.87
682_Y 692_N 1.627 0.87
431_L 435_L 1.618 0.86
173_F 219_I 1.618 0.86
393_N 397_E 1.61 0.86
586_N 589_D 1.609 0.86
184_L 204_A 1.607 0.86
58_I 66_E 1.58 0.84
45_V 72_G 1.577 0.84
88_R 91_E 1.56 0.83
682_Y 702_R 1.558 0.83
142_R 155_E 1.557 0.83
23_A 92_R 1.555 0.83
646_E 669_D 1.552 0.83
677_R 681_G 1.54 0.82
530_Q 534_E 1.53 0.82
217_S 283_T 1.519 0.81
66_E 88_R 1.51 0.80
43_A 46_V 1.509 0.80
502_F 513_L 1.508 0.80
692_N 698_E 1.505 0.80
428_W 431_L 1.503 0.80
295_F 330_L 1.496 0.80
66_E 84_Y 1.488 0.79
443_M 535_T 1.483 0.79
237_T 241_N 1.473 0.78
8_R 92_R 1.468 0.78
592_D 627_Y 1.464 0.78
206_A 277_E 1.458 0.77
201_I 270_A 1.458 0.77
84_Y 92_R 1.453 0.77
130_D 166_Y 1.449 0.77
430_L 434_R 1.449 0.77
199_K 238_A 1.447 0.76
147_P 444_T 1.444 0.76
691_F 695_K 1.441 0.76
66_E 92_R 1.438 0.76
682_Y 691_F 1.438 0.76
415_R 573_Y 1.434 0.75
246_T 262_R 1.432 0.75
81_Y 84_Y 1.431 0.75
679_V 695_K 1.428 0.75
694_G 702_R 1.428 0.75
23_A 62_Q 1.423 0.75
39_C 77_L 1.413 0.74
552_R 556_L 1.408 0.74
478_E 481_K 1.408 0.74
515_A 519_A 1.406 0.73
204_A 235_F 1.402 0.73
62_Q 84_Y 1.396 0.73
120_K 130_D 1.395 0.73
681_G 691_F 1.392 0.72
268_Y 316_A 1.392 0.72
66_E 85_R 1.389 0.72
606_I 610_E 1.383 0.72
418_L 565_P 1.382 0.72
58_I 92_R 1.377 0.71
564_V 572_Y 1.374 0.71
174_N 220_Y 1.363 0.70
4_H 12_K 1.361 0.70
527_A 530_Q 1.359 0.70
681_G 695_K 1.357 0.70
308_E 352_L 1.355 0.69
88_R 92_R 1.355 0.69
677_R 682_Y 1.35 0.69
682_Y 695_K 1.349 0.69
23_A 88_R 1.344 0.69
420_A 426_T 1.34 0.68
572_Y 701_R 1.336 0.68
185_T 235_F 1.332 0.68
692_N 702_R 1.326 0.67
637_T 640_P 1.324 0.67
206_A 273_S 1.32 0.67
5_V 58_I 1.319 0.66
23_A 66_E 1.312 0.66
33_V 74_Y 1.309 0.66
8_R 62_Q 1.307 0.65
33_V 70_M 1.302 0.65
344_D 347_Y 1.298 0.65
675_V 681_G 1.298 0.65
65_V 92_R 1.289 0.64
62_Q 65_V 1.287 0.64
150_V 441_A 1.286 0.64
23_A 81_Y 1.286 0.64
694_G 698_E 1.283 0.63
432_D 527_A 1.283 0.63
336_D 341_K 1.28 0.63
679_V 691_F 1.28 0.63
691_F 699_V 1.279 0.63
432_D 435_L 1.277 0.63
53_R 60_E 1.274 0.62
42_V 72_G 1.268 0.62
435_L 531_W 1.266 0.62
292_T 331_V 1.262 0.61
679_V 692_N 1.262 0.61
77_L 80_A 1.259 0.61
378_F 381_P 1.256 0.61
208_T 274_L 1.256 0.61
180_L 233_A 1.254 0.61
620_A 651_G 1.253 0.61
28_A 77_L 1.252 0.61
681_G 684_G 1.248 0.60
130_D 217_S 1.245 0.60
150_V 440_K 1.245 0.60
519_A 526_Q 1.244 0.60
502_F 516_K 1.241 0.59
678_R 702_R 1.238 0.59
23_A 58_I 1.237 0.59
678_R 692_N 1.232 0.59
102_I 136_V 1.232 0.59
84_Y 88_R 1.232 0.59
82_I 88_R 1.231 0.59
85_R 92_R 1.231 0.59
438_A 489_L 1.227 0.58
502_F 561_F 1.227 0.58
82_I 85_R 1.227 0.58
540_S 603_G 1.226 0.58
64_A 70_M 1.225 0.58
154_H 552_R 1.222 0.58
558_T 563_V 1.222 0.58
50_M 64_A 1.221 0.58
150_V 444_T 1.221 0.58
678_R 698_E 1.22 0.58
68_Q 71_S 1.219 0.57
226_N 401_D 1.219 0.57
213_A 281_L 1.216 0.57
42_V 68_Q 1.212 0.57
311_L 356_C 1.211 0.57
237_T 302_E 1.211 0.57
127_T 329_K 1.21 0.57
58_I 84_Y 1.209 0.56
488_S 603_G 1.208 0.56
154_H 157_G 1.207 0.56
8_R 27_A 1.202 0.56
176_M 219_I 1.201 0.56
298_G 303_S 1.2 0.56
158_D 434_R 1.198 0.55
610_E 613_N 1.197 0.55
69_L 85_R 1.197 0.55
28_A 33_V 1.196 0.55
39_C 43_A 1.191 0.55
697_E 701_R 1.19 0.55
415_R 434_R 1.189 0.55
446_I 450_E 1.187 0.54
148_R 152_Q 1.176 0.53
542_Y 603_G 1.175 0.53
57_D 60_E 1.175 0.53
66_E 70_M 1.175 0.53
31_A 70_M 1.173 0.53
130_D 283_T 1.173 0.53
677_R 705_H 1.172 0.53
157_G 556_L 1.17 0.53
411_L 431_L 1.17 0.53
158_D 560_E 1.168 0.53
354_L 621_L 1.167 0.53
62_Q 85_R 1.166 0.52
676_T 683_L 1.166 0.52
535_T 539_F 1.166 0.52
17_S 44_A 1.165 0.52
314_R 330_L 1.164 0.52
142_R 164_L 1.164 0.52
28_A 39_C 1.163 0.52
273_S 277_E 1.161 0.52
419_E 561_F 1.161 0.52
677_R 691_F 1.159 0.52
550_C 695_K 1.153 0.51
8_R 23_A 1.149 0.51
5_V 512_Q 1.149 0.51
274_L 293_F 1.147 0.51
205_T 270_A 1.147 0.51
25_L 36_A 1.145 0.50
78_A 81_Y 1.144 0.50
410_S 549_L 1.144 0.50
492_I 550_C 1.144 0.50
661_T 666_G 1.143 0.50
28_A 34_D 1.142 0.50
691_F 698_E 1.142 0.50
550_C 553_F 1.14 0.50
426_T 430_L 1.139 0.50
23_A 65_V 1.139 0.50
634_Y 637_T 1.138 0.50
85_R 88_R 1.135 0.49
498_I 502_F 1.135 0.49
45_V 68_Q 1.135 0.49
83_E 86_H 1.133 0.49
419_E 430_L 1.132 0.49
129_R 217_S 1.129 0.49
81_Y 85_R 1.129 0.49
525_R 602_N 1.127 0.49
264_I 309_S 1.126 0.49
511_E 515_A 1.125 0.48
678_R 695_K 1.122 0.48
70_M 82_I 1.12 0.48
675_V 680_C 1.119 0.48
28_A 74_Y 1.117 0.48
383_G 405_N 1.116 0.48
5_V 56_V 1.114 0.47
23_A 27_A 1.113 0.47
13_V 16_K 1.108 0.47
675_V 694_G 1.108 0.47
702_R 705_H 1.105 0.47
17_S 43_A 1.104 0.46
213_A 285_N 1.103 0.46
435_L 523_R 1.1 0.46
561_F 618_L 1.098 0.46
67_N 75_K 1.097 0.46
213_A 217_S 1.096 0.46
59_N 92_R 1.095 0.46
174_N 542_Y 1.095 0.46
27_A 62_Q 1.095 0.46
638_N 641_I 1.093 0.45
435_L 527_A 1.093 0.45
20_I 23_A 1.092 0.45
23_A 85_R 1.089 0.45
552_R 573_Y 1.087 0.45
521_V 524_L 1.087 0.45
58_I 85_R 1.086 0.45
564_V 567_V 1.083 0.44
13_V 80_A 1.081 0.44
696_Q 699_V 1.081 0.44
66_E 79_R 1.079 0.44
116_E 524_L 1.079 0.44
147_P 150_V 1.077 0.44
217_S 285_N 1.077 0.44
498_I 516_K 1.076 0.44
455_R 473_D 1.072 0.43
413_L 497_T 1.071 0.43
23_A 84_Y 1.066 0.43
71_S 74_Y 1.065 0.43
439_R 443_M 1.064 0.43
376_G 387_F 1.062 0.42
59_N 82_I 1.061 0.42
21_K 42_V 1.059 0.42
21_K 40_A 1.058 0.42
28_A 31_A 1.054 0.42
675_V 684_G 1.054 0.42
134_G 165_D 1.054 0.42
33_V 77_L 1.053 0.42
439_R 539_F 1.052 0.42
517_G 597_Y 1.051 0.41
491_Y 521_V 1.051 0.41
208_T 228_I 1.05 0.41
65_V 78_A 1.05 0.41
118_A 201_I 1.05 0.41
679_V 698_E 1.049 0.41
396_G 401_D 1.049 0.41
175_C 384_C 1.049 0.41
679_V 696_Q 1.047 0.41
157_G 415_R 1.047 0.41
67_N 70_M 1.046 0.41
240_Y 244_R 1.043 0.41
272_Q 313_N 1.043 0.41
675_V 682_Y 1.043 0.41
135_I 139_H 1.04 0.40
49_Q 64_A 1.038 0.40
27_A 92_R 1.037 0.40
74_Y 77_L 1.034 0.40
129_R 285_N 1.034 0.40
304_R 348_D 1.033 0.40
351_Q 619_K 1.033 0.40
58_I 79_R 1.033 0.40
333_A 368_Y 1.032 0.40
264_I 308_E 1.032 0.40
129_R 166_Y 1.032 0.40
435_L 439_R 1.031 0.40
131_L 135_I 1.031 0.40
643_E 650_T 1.03 0.40
33_V 71_S 1.029 0.39
677_R 698_E 1.028 0.39
214_Q 218_H 1.025 0.39
7_K 10_G 1.024 0.39
70_M 86_H 1.024 0.39
494_I 517_G 1.022 0.39
9_D 88_R 1.022 0.39
58_I 63_T 1.022 0.39
205_T 274_L 1.02 0.39
59_N 84_Y 1.02 0.39
498_I 517_G 1.019 0.39
450_E 477_S 1.018 0.38
130_D 285_N 1.017 0.38
679_V 682_Y 1.016 0.38
23_A 82_I 1.016 0.38
389_G 538_G 1.015 0.38
411_L 510_N 1.013 0.38
525_R 541_L 1.013 0.38
175_C 385_R 1.013 0.38
58_I 83_E 1.008 0.38
640_P 651_G 1.008 0.38
6_M 45_V 1.007 0.37
447_A 450_E 1.006 0.37
67_N 71_S 1.006 0.37
679_V 699_V 1.006 0.37
684_G 698_E 1.006 0.37
206_A 209_A 1.005 0.37
135_I 295_F 1.005 0.37
204_A 327_F 1.005 0.37
640_P 677_R 1.005 0.37
425_A 668_H 1.004 0.37
514_R 518_I 1.002 0.37
64_A 76_Q 1.002 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h7bA10.84131000.228Contact Map0.602
3hncA20.83571000.865Contact Map0.476
3k8tA10.86941000.869Contact Map0.481
2xapA30.82581000.873Contact Map0.391
2wghA20.740299.90.902Contact Map0.45
1peqA10.772599.90.907Contact Map0.331
3o0qA20.693899.90.909Contact Map0.451
2f3oA20.785198.80.954Contact Map0.42
1r9dA20.800698.80.955Contact Map0.41
1l1lA40.73698.60.957Contact Map0.284
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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