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OPENSEQ.org
WECG - Probable UDP-N-acetyl-D-mannosaminuronic acid transferase
UniProt: P27836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11458
Length: 246 (237)
Sequences: 1185
Seq/Len: 5.00
WECG
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_P 162_Q 2.969 1.00
112_F 155_R 2.497 1.00
112_F 138_G 2.47 1.00
92_A 95_D 2.401 1.00
177_M 191_G 2.397 1.00
154_E 158_A 2.284 1.00
118_P 141_D 2.143 1.00
118_P 122_A 2.071 1.00
52_I 62_I 1.976 1.00
55_N 175_I 1.976 1.00
110_P 135_N 1.974 1.00
176_I 180_C 1.974 1.00
140_Q 155_R 1.967 1.00
16_Q 63_N 1.961 1.00
164_V 186_D 1.928 1.00
209_I 213_L 1.859 1.00
208_K 212_T 1.838 1.00
101_M 128_L 1.796 1.00
194_G 198_V 1.785 1.00
157_H 185_P 1.77 1.00
46_A 74_S 1.765 1.00
125_E 129_R 1.762 1.00
97_W 165_T 1.757 1.00
123_Q 202_H 1.746 1.00
48_K 170_S 1.734 1.00
121_L 139_S 1.7 1.00
177_M 189_Y 1.679 0.99
228_I 231_Q 1.631 0.99
9_T 18_I 1.627 0.99
78_S 237_Y 1.595 0.99
166_V 177_M 1.591 0.99
94_A 195_T 1.57 0.99
205_R 216_E 1.56 0.99
22_D 25_H 1.551 0.99
113_L 128_L 1.547 0.99
221_L 231_Q 1.544 0.99
121_L 125_E 1.54 0.99
228_I 232_L 1.538 0.99
60_E 64_A 1.518 0.99
43_A 48_K 1.511 0.99
90_R 211_Q 1.508 0.99
117_K 143_Y 1.454 0.98
47_E 194_G 1.444 0.98
26_A 91_V 1.443 0.98
42_V 65_A 1.43 0.98
110_P 137_V 1.428 0.98
112_F 156_I 1.415 0.98
61_L 175_I 1.412 0.98
48_K 58_V 1.41 0.98
73_I 76_V 1.409 0.98
127_K 130_N 1.401 0.97
99_E 102_A 1.401 0.97
19_G 88_V 1.385 0.97
153_F 157_H 1.378 0.97
111_V 165_T 1.373 0.97
46_A 73_I 1.373 0.97
105_G 134_V 1.359 0.97
94_A 198_V 1.35 0.97
117_K 120_V 1.335 0.96
40_T 177_M 1.334 0.96
150_Q 183_V 1.332 0.96
97_W 195_T 1.332 0.96
164_V 189_Y 1.323 0.96
97_W 199_F 1.315 0.96
9_T 16_Q 1.313 0.96
104_A 163_I 1.309 0.96
154_E 157_H 1.304 0.96
192_V 196_Y 1.297 0.95
127_K 131_Q 1.257 0.94
219_Y 223_S 1.251 0.94
164_V 180_C 1.244 0.94
57_E 175_I 1.232 0.93
92_A 205_R 1.231 0.93
165_T 196_Y 1.222 0.93
210_W 215_L 1.22 0.93
97_W 192_V 1.207 0.93
215_L 218_L 1.201 0.92
26_A 67_F 1.197 0.92
70_A 76_V 1.188 0.92
30_L 188_L 1.185 0.92
234_L 238_L 1.183 0.91
206_A 211_Q 1.177 0.91
105_G 133_N 1.177 0.91
123_Q 126_A 1.177 0.91
101_M 111_V 1.174 0.91
41_L 190_M 1.171 0.91
231_Q 234_L 1.167 0.91
28_D 103_R 1.154 0.90
100_L 163_I 1.153 0.90
150_Q 154_E 1.15 0.90
198_V 206_A 1.146 0.90
69_Y 96_L 1.134 0.89
122_A 126_A 1.132 0.89
56_A 60_E 1.126 0.89
48_K 62_I 1.124 0.88
31_F 109_T 1.109 0.88
229_K 232_L 1.107 0.87
157_H 183_V 1.1 0.87
117_K 121_L 1.092 0.86
23_M 99_E 1.09 0.86
119_E 139_S 1.088 0.86
207_P 219_Y 1.084 0.86
237_Y 241_H 1.076 0.85
44_I 48_K 1.065 0.85
204_K 219_Y 1.062 0.84
167_A 196_Y 1.059 0.84
94_A 194_G 1.055 0.84
117_K 202_H 1.054 0.84
169_G 173_Q 1.045 0.83
12_L 17_L 1.043 0.83
149_R 153_F 1.041 0.83
149_R 176_I 1.039 0.83
113_L 196_Y 1.038 0.82
101_M 165_T 1.036 0.82
206_A 216_E 1.028 0.82
23_M 26_A 1.028 0.82
210_W 213_L 1.023 0.81
134_V 137_V 1.022 0.81
59_R 63_N 1.015 0.80
43_A 69_Y 1.015 0.80
95_D 205_R 1.014 0.80
149_R 179_D 1.012 0.80
162_Q 187_A 1.011 0.80
11_T 16_Q 1.006 0.80
48_K 52_I 1.004 0.79
103_R 107_E 1.003 0.79
125_E 139_S 1.002 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ixlA10.857750.20.95Contact Map0.379
2vpqA20.62643.40.951Contact Map0.256
2q5cA20.788640.30.952Contact Map0.315
3n6rA60.638237.40.953Contact Map0.244
1ulzA10.634131.10.955Contact Map0.24
3nklA20.508130.20.956Contact Map0.545
2pjuA40.837427.10.956Contact Map0.39
2w70A20.642326.80.957Contact Map0.263
1y80A10.7561240.958Contact Map0.474
3hblA40.654520.70.959Contact Map0.363
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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