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OPENSEQ.org
WECB - UDP-N-acetylglucosamine 2-epimerase
UniProt: P27828 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11451
Length: 376 (372)
Sequences: 1939
Seq/Len: 5.21
WECB
Paralog alert: 0.25 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
231_D 329_K 3.115 1.00
360_Q 363_S 3.057 1.00
99_T 138_T 3.04 1.00
210_V 229_L 2.832 1.00
153_R 157_L 2.635 1.00
227_H 329_K 2.599 1.00
22_A 25_K 2.589 1.00
4_L 34_C 2.474 1.00
360_Q 364_R 2.419 1.00
139_G 145_H 2.411 1.00
5_T 31_A 2.391 1.00
2_K 30_E 2.37 1.00
154_Q 158_R 2.354 1.00
167_F 368_A 2.339 1.00
83_A 109_Q 2.262 1.00
253_E 257_R 2.237 1.00
305_L 325_V 2.21 1.00
82_L 111_I 2.163 1.00
223_E 257_R 2.152 1.00
91_L 114_G 2.129 1.00
100_L 137_L 2.127 1.00
150_E 154_Q 2.115 1.00
236_H 341_K 2.094 1.00
26_D 370_K 2.093 1.00
22_A 363_S 2.084 1.00
32_K 85_F 2.075 1.00
89_V 114_G 2.066 1.00
79_K 109_Q 2.046 1.00
335_E 338_R 2.039 1.00
210_V 241_I 1.973 1.00
136_T 140_H 1.967 1.00
252_R 256_N 1.955 1.00
89_V 369_L 1.953 1.00
28_F 370_K 1.948 1.00
316_A 322_V 1.939 1.00
232_I 336_V 1.92 1.00
231_D 333_V 1.907 1.00
21_H 24_A 1.886 1.00
358_D 364_R 1.886 1.00
153_R 168_I 1.845 1.00
181_R 281_N 1.831 1.00
153_R 163_D 1.831 1.00
208_I 241_I 1.801 1.00
44_D 48_K 1.799 1.00
75_L 105_A 1.764 1.00
72_C 76_E 1.723 1.00
125_L 143_M 1.705 1.00
252_R 269_D 1.703 1.00
235_T 337_T 1.698 1.00
77_G 80_P 1.679 1.00
114_G 146_F 1.676 1.00
162_A 165_R 1.667 0.99
90_V 106_A 1.659 0.99
343_E 347_Q 1.657 0.99
287_L 307_M 1.657 0.99
82_L 105_A 1.632 0.99
276_F 293_I 1.631 0.99
240_Q 266_I 1.625 0.99
338_R 342_D 1.615 0.99
206_K 238_D 1.613 0.99
236_H 337_T 1.603 0.99
26_D 366_L 1.599 0.99
280_M 286_I 1.582 0.99
151_T 318_T 1.57 0.99
75_L 104_L 1.568 0.99
69_E 80_P 1.565 0.99
29_F 370_K 1.557 0.99
81_I 85_F 1.552 0.99
73_R 77_G 1.548 0.99
229_L 241_I 1.547 0.99
3_V 89_V 1.54 0.99
36_T 98_T 1.538 0.99
242_V 279_L 1.533 0.99
93_H 99_T 1.524 0.99
56_Y 84_E 1.495 0.99
306_V 322_V 1.486 0.99
169_T 361_A 1.481 0.98
330_Q 334_E 1.48 0.98
226_C 255_V 1.478 0.98
26_D 367_E 1.472 0.98
68_T 109_Q 1.47 0.98
89_V 144_Y 1.464 0.98
62_Q 73_R 1.458 0.98
125_L 133_A 1.452 0.98
328_D 331_R 1.434 0.98
146_F 365_I 1.431 0.98
262_V 265_V 1.425 0.98
112_P 143_M 1.408 0.98
285_L 336_V 1.406 0.98
116_V 365_I 1.402 0.98
212_G 225_I 1.4 0.98
5_T 20_V 1.392 0.97
233_A 264_N 1.387 0.97
51_S 183_Q 1.366 0.97
23_L 29_F 1.362 0.97
2_K 85_F 1.344 0.97
80_P 84_E 1.342 0.97
6_V 102_T 1.34 0.97
175_D 359_G 1.339 0.97
6_V 36_T 1.338 0.97
140_H 161_V 1.336 0.97
37_A 59_N 1.332 0.96
92_V 103_S 1.331 0.96
78_L 102_T 1.33 0.96
24_A 31_A 1.329 0.96
22_A 26_D 1.329 0.96
325_V 335_E 1.327 0.96
56_Y 85_F 1.327 0.96
208_I 287_L 1.324 0.96
19_L 362_C 1.314 0.96
306_V 316_A 1.305 0.96
224_E 329_K 1.304 0.96
206_K 284_W 1.304 0.96
345_E 348_A 1.295 0.96
66_G 79_K 1.291 0.96
4_L 82_L 1.284 0.95
283_A 302_K 1.276 0.95
207_M 282_H 1.273 0.95
218_F 250_N 1.264 0.95
16_M 93_H 1.253 0.95
338_R 345_E 1.251 0.94
20_V 33_V 1.246 0.94
299_S 354_N 1.233 0.94
92_V 113_V 1.231 0.94
114_G 369_L 1.227 0.94
245_V 252_R 1.221 0.94
4_L 32_K 1.204 0.93
47_L 54_P 1.193 0.92
363_S 367_E 1.192 0.92
150_E 153_R 1.188 0.92
9_T 12_E 1.184 0.92
157_L 163_D 1.184 0.92
245_V 267_L 1.184 0.92
139_G 161_V 1.175 0.92
71_T 108_Y 1.17 0.91
287_L 332_I 1.169 0.91
103_S 138_T 1.169 0.91
42_M 247_L 1.161 0.91
73_R 76_E 1.16 0.91
317_V 324_L 1.157 0.91
139_G 142_A 1.156 0.91
69_E 76_E 1.153 0.91
37_A 44_D 1.149 0.90
106_A 113_V 1.149 0.90
56_Y 81_I 1.148 0.90
305_L 339_L 1.142 0.90
212_G 243_Y 1.136 0.90
206_K 239_I 1.132 0.90
171_N 295_E 1.123 0.89
71_T 101_A 1.118 0.89
218_F 248_N 1.109 0.88
21_H 179_W 1.107 0.88
5_T 23_L 1.104 0.88
234_T 262_V 1.102 0.88
6_V 90_V 1.092 0.87
40_R 57_D 1.092 0.87
283_A 286_I 1.09 0.87
16_M 91_L 1.088 0.87
248_N 292_G 1.082 0.87
230_A 234_T 1.081 0.87
68_T 79_K 1.077 0.86
79_K 83_A 1.073 0.86
218_F 222_F 1.068 0.86
225_I 332_I 1.067 0.86
208_I 232_I 1.067 0.86
230_A 262_V 1.066 0.86
23_L 369_L 1.065 0.85
298_P 355_P 1.064 0.85
74_I 102_T 1.058 0.85
331_R 334_E 1.058 0.85
124_D 310_T 1.055 0.85
70_I 74_I 1.048 0.84
82_L 106_A 1.046 0.84
280_M 300_L 1.039 0.83
233_A 265_V 1.036 0.83
272_E 275_P 1.029 0.83
78_L 82_L 1.026 0.82
318_T 324_L 1.023 0.82
26_D 29_F 1.022 0.82
142_A 145_H 1.017 0.82
2_K 88_D 1.015 0.81
331_R 335_E 1.013 0.81
64_G 250_N 1.012 0.81
69_E 73_R 1.012 0.81
116_V 146_F 1.011 0.81
220_R 224_E 1.008 0.81
212_G 221_G 1.006 0.81
68_T 75_L 1.003 0.80
280_M 293_I 1.002 0.80
144_Y 372_N 1.001 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v4vA20.96541000.511Contact Map0.763
1vgvA40.99731000.513Contact Map0.836
3dzcA20.98671000.54Contact Map0.849
4fkzA20.97611000.561Contact Map0.873
4hwgA10.95481000.633Contact Map0.725
3ot5A40.97611000.69Contact Map0.843
3l7iA40.946899.90.799Contact Map0.578
1iirA10.912299.80.822Contact Map0.656
3otgA10.896399.80.831Contact Map0.672
3h4tA10.89199.70.834Contact Map0.667
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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