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OPENSEQ.org
METE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
UniProt: P25665 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10584
Length: 753 (752)
Sequences: 767
Seq/Len: 1.02
METE
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
469_I 548_V 6.136 1.00
299_A 304_K 4.921 1.00
331_D 351_Q 4.786 1.00
395_R 583_D 4.254 1.00
74_S 167_W 4.156 1.00
466_K 470_V 3.835 1.00
568_V 573_I 3.824 1.00
130_F 171_G 3.648 1.00
408_N 634_D 3.566 1.00
32_T 35_E 3.453 1.00
70_V 162_L 3.366 1.00
61_V 157_V 3.294 1.00
453_D 456_N 3.288 1.00
501_F 558_I 3.163 1.00
26_Y 94_D 3.105 1.00
598_I 629_A 3.033 1.00
147_V 203_I 3.011 1.00
458_R 535_E 2.931 1.00
162_L 166_T 2.834 1.00
497_H 532_I 2.808 1.00
7_T 321_S 2.693 1.00
734_P 738_A 2.652 1.00
697_N 703_W 2.563 0.99
420_R 594_G 2.553 0.99
142_Q 146_E 2.534 0.99
65_A 72_T 2.453 0.99
446_D 451_N 2.409 0.99
40_G 66_W 2.384 0.99
708_L 722_V 2.384 0.99
574_A 624_A 2.353 0.99
447_F 454_A 2.349 0.99
410_Y 414_A 2.259 0.98
421_F 595_I 2.236 0.98
291_I 299_A 2.212 0.98
44_R 149_E 2.188 0.98
147_V 156_K 2.175 0.98
185_N 227_P 2.174 0.98
466_K 543_L 2.167 0.98
342_V 502_V 2.161 0.98
564_P 573_I 2.14 0.97
148_D 201_R 2.127 0.97
156_K 204_E 2.122 0.97
601_P 657_L 2.115 0.97
476_G 748_Q 2.114 0.97
302_T 375_S 2.113 0.97
362_A 368_T 2.085 0.97
701_V 745_Q 2.085 0.97
195_L 206_V 2.085 0.97
319_V 356_L 2.083 0.97
418_R 685_E 2.076 0.97
120_N 268_H 2.074 0.97
247_V 254_I 2.059 0.96
495_G 503_F 2.053 0.96
501_F 526_I 2.03 0.96
69_H 162_L 2.028 0.96
615_D 619_Q 2.02 0.96
443_L 461_I 2.013 0.96
492_E 518_K 1.987 0.95
144_L 201_R 1.977 0.95
147_V 157_V 1.974 0.95
10_F 350_L 1.971 0.95
114_E 172_K 1.958 0.95
421_F 594_G 1.942 0.95
452_L 456_N 1.934 0.94
389_N 499_D 1.914 0.94
611_R 614_W 1.913 0.94
266_L 288_A 1.903 0.94
33_R 94_D 1.883 0.93
526_I 577_I 1.879 0.93
144_L 197_E 1.861 0.93
290_L 308_I 1.861 0.93
113_A 126_M 1.844 0.92
269_G 272_D 1.842 0.92
43_L 47_H 1.841 0.92
454_A 458_R 1.818 0.92
648_N 676_S 1.812 0.92
144_L 194_V 1.811 0.92
698_V 736_T 1.809 0.91
705_E 749_N 1.799 0.91
345_W 381_R 1.796 0.91
560_C 601_P 1.795 0.91
321_S 356_L 1.791 0.91
58_L 158_K 1.766 0.90
23_Q 514_S 1.755 0.90
337_R 505_Q 1.754 0.90
698_V 738_A 1.743 0.89
468_A 485_A 1.728 0.89
732_G 736_T 1.725 0.89
716_P 719_R 1.687 0.87
581_L 601_P 1.668 0.86
412_V 415_E 1.661 0.86
389_N 527_S 1.66 0.86
339_D 386_R 1.652 0.86
160_V 209_D 1.651 0.86
161_L 194_V 1.646 0.85
539_Y 542_S 1.642 0.85
440_I 485_A 1.636 0.85
614_W 649_D 1.633 0.85
414_A 685_E 1.631 0.85
564_P 569_S 1.614 0.84
204_E 237_K 1.605 0.83
589_E 632_A 1.597 0.83
241_T 263_H 1.594 0.83
471_E 737_R 1.589 0.83
141_T 145_D 1.585 0.82
77_L 190_V 1.58 0.82
62_G 142_Q 1.576 0.82
701_V 749_N 1.559 0.81
400_T 403_D 1.559 0.81
60_P 160_V 1.547 0.80
564_P 568_V 1.545 0.80
470_V 474_R 1.544 0.80
479_V 595_I 1.527 0.79
26_Y 33_R 1.527 0.79
344_S 377_P 1.523 0.79
305_Y 359_L 1.51 0.78
99_I 113_A 1.507 0.78
671_M 707_L 1.506 0.78
216_E 610_R 1.494 0.77
445_L 449_K 1.492 0.77
169_W 221_W 1.489 0.77
471_E 475_L 1.481 0.76
405_Q 626_R 1.479 0.76
390_P 394_K 1.475 0.76
537_A 593_I 1.472 0.75
74_S 113_A 1.467 0.75
288_A 311_I 1.465 0.75
292_N 566_E 1.457 0.74
379_Q 383_H 1.456 0.74
601_P 628_N 1.444 0.73
98_R 103_R 1.439 0.73
575_K 623_E 1.436 0.73
263_H 287_S 1.435 0.73
77_L 187_I 1.434 0.73
570_R 606_G 1.434 0.73
702_E 706_A 1.433 0.73
443_L 452_L 1.432 0.72
701_V 742_N 1.428 0.72
218_P 221_W 1.425 0.72
205_W 239_L 1.423 0.72
291_I 304_K 1.415 0.71
300_D 303_E 1.413 0.71
61_V 147_V 1.406 0.71
298_R 374_W 1.405 0.70
188_L 228_A 1.399 0.70
206_V 236_V 1.394 0.70
586_A 632_A 1.39 0.69
308_I 363_L 1.378 0.68
464_H 467_Q 1.377 0.68
442_T 446_D 1.369 0.68
21_K 25_S 1.365 0.67
558_I 577_I 1.364 0.67
45_A 153_L 1.362 0.67
396_L 399_I 1.361 0.67
192_Q 231_A 1.35 0.66
98_R 697_N 1.349 0.66
603_L 645_C 1.348 0.66
62_G 143_L 1.347 0.66
528_R 587_D 1.346 0.66
50_Q 350_L 1.345 0.66
25_S 31_S 1.342 0.65
333_S 350_L 1.34 0.65
586_A 631_V 1.339 0.65
308_I 359_L 1.337 0.65
162_L 240_L 1.323 0.64
186_D 189_P 1.307 0.62
448_K 492_E 1.302 0.62
166_T 212_A 1.302 0.62
585_V 598_I 1.299 0.62
358_L 368_T 1.297 0.61
183_L 186_D 1.297 0.61
346_F 569_S 1.296 0.61
334_V 506_N 1.293 0.61
501_F 577_I 1.292 0.61
568_V 572_T 1.291 0.61
10_F 50_Q 1.291 0.61
462_A 535_E 1.29 0.61
6_H 158_K 1.29 0.61
174_K 670_D 1.289 0.61
655_A 684_N 1.287 0.61
213_L 240_L 1.283 0.60
277_H 288_A 1.281 0.60
7_T 60_P 1.28 0.60
388_H 393_E 1.279 0.60
268_H 292_N 1.273 0.59
172_K 672_E 1.267 0.59
222_L 253_T 1.265 0.59
158_K 492_E 1.263 0.58
312_V 317_L 1.243 0.57
426_W 747_A 1.238 0.56
60_P 159_P 1.238 0.56
72_T 96_L 1.234 0.56
37_L 66_W 1.231 0.55
305_Y 362_A 1.22 0.54
688_P 720_L 1.219 0.54
531_P 587_D 1.218 0.54
458_R 462_A 1.215 0.54
707_L 711_A 1.214 0.54
116_T 672_E 1.209 0.53
732_G 738_A 1.205 0.53
193_Q 197_E 1.205 0.53
197_E 201_R 1.202 0.53
745_Q 748_Q 1.199 0.52
277_H 311_I 1.196 0.52
465_I 485_A 1.195 0.52
504_T 581_L 1.191 0.52
623_E 627_I 1.183 0.51
646_E 672_E 1.181 0.51
22_A 39_V 1.18 0.51
422_K 748_Q 1.177 0.50
38_A 42_E 1.175 0.50
493_Y 536_W 1.173 0.50
16_R 334_V 1.172 0.50
148_D 151_L 1.171 0.50
226_K 230_D 1.169 0.50
62_G 157_V 1.169 0.50
250_N 263_H 1.166 0.49
698_V 734_P 1.165 0.49
448_K 518_K 1.163 0.49
536_W 674_L 1.163 0.49
79_N 167_W 1.162 0.49
575_K 627_I 1.161 0.49
140_W 144_L 1.161 0.49
671_M 711_A 1.158 0.49
589_E 626_R 1.156 0.48
381_R 566_E 1.155 0.48
476_G 546_K 1.155 0.48
161_L 208_I 1.151 0.48
261_G 285_L 1.151 0.48
173_V 180_R 1.151 0.48
358_L 371_L 1.15 0.48
619_Q 623_E 1.149 0.48
291_I 356_L 1.146 0.48
49_D 53_Q 1.145 0.47
321_S 353_C 1.139 0.47
698_V 732_G 1.13 0.46
530_A 535_E 1.13 0.46
16_R 506_N 1.13 0.46
212_A 225_Y 1.123 0.45
589_E 636_T 1.123 0.45
607_L 618_L 1.12 0.45
556_V 574_A 1.119 0.45
165_V 224_A 1.116 0.45
239_L 261_G 1.114 0.45
426_W 750_L 1.112 0.44
704_I 743_M 1.111 0.44
523_I 564_P 1.109 0.44
213_L 225_Y 1.106 0.44
276_L 311_I 1.105 0.44
75_L 96_L 1.104 0.44
537_A 581_L 1.104 0.44
212_A 215_L 1.103 0.44
80_V 139_T 1.103 0.44
452_L 460_G 1.103 0.44
459_T 462_A 1.094 0.43
190_V 193_Q 1.094 0.43
414_A 719_R 1.094 0.43
745_Q 749_N 1.084 0.42
70_V 166_T 1.083 0.42
534_V 591_A 1.082 0.42
245_E 610_R 1.08 0.41
346_F 523_I 1.079 0.41
346_F 564_P 1.079 0.41
412_V 634_D 1.078 0.41
73_T 77_L 1.078 0.41
140_W 190_V 1.076 0.41
384_S 388_H 1.076 0.41
674_L 688_P 1.075 0.41
62_G 146_E 1.073 0.41
188_L 351_Q 1.069 0.40
72_T 147_V 1.069 0.40
411_E 416_A 1.069 0.40
614_W 685_E 1.068 0.40
356_L 360_R 1.068 0.40
222_L 250_N 1.067 0.40
240_L 254_I 1.067 0.40
358_L 469_I 1.066 0.40
42_E 46_R 1.061 0.40
586_A 589_E 1.06 0.40
172_K 669_S 1.06 0.40
65_A 96_L 1.06 0.40
82_A 133_G 1.06 0.40
56_I 60_P 1.06 0.40
642_M 662_I 1.058 0.39
195_L 208_I 1.058 0.39
116_T 172_K 1.056 0.39
462_A 539_Y 1.056 0.39
308_I 319_V 1.055 0.39
45_A 49_D 1.054 0.39
338_L 504_T 1.054 0.39
309_K 367_D 1.054 0.39
399_I 403_D 1.052 0.39
15_L 46_R 1.051 0.39
73_T 76_L 1.051 0.39
338_L 502_V 1.05 0.39
214_V 242_T 1.049 0.39
185_N 231_A 1.048 0.39
80_V 386_R 1.046 0.38
84_H 98_R 1.045 0.38
504_T 521_I 1.044 0.38
274_A 278_K 1.043 0.38
471_E 733_W 1.043 0.38
147_V 204_E 1.042 0.38
341_E 386_R 1.04 0.38
72_T 142_Q 1.036 0.38
456_N 459_T 1.036 0.38
209_D 326_L 1.035 0.37
560_C 606_G 1.034 0.37
62_G 147_V 1.034 0.37
287_S 320_A 1.033 0.37
7_T 353_C 1.029 0.37
606_G 682_Y 1.028 0.37
74_S 79_N 1.027 0.37
78_G 139_T 1.025 0.37
416_A 635_D 1.024 0.36
250_N 254_I 1.024 0.36
61_V 158_K 1.022 0.36
582_R 631_V 1.021 0.36
192_Q 232_L 1.02 0.36
251_L 280_L 1.019 0.36
711_A 720_L 1.019 0.36
543_L 547_P 1.018 0.36
143_L 157_V 1.018 0.36
165_V 212_A 1.016 0.36
443_L 460_G 1.015 0.36
147_V 201_R 1.014 0.36
136_F 187_I 1.014 0.36
80_V 95_T 1.012 0.35
539_Y 543_L 1.009 0.35
179_D 182_S 1.009 0.35
158_K 518_K 1.007 0.35
8_L 263_H 1.005 0.35
203_I 206_V 1.005 0.35
285_L 318_W 1.004 0.35
103_R 697_N 1.002 0.35
13_V 516_C 1.001 0.35
76_L 143_L 1.001 0.35
13_V 330_I 1 0.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ppgA10.99341000.304Contact Map0.659
1t7lA20.96551000.314Contact Map0.694
1u1jA10.9921000.322Contact Map0.602
2nq5A10.97741000.343Contact Map0.7
3rpdA20.43961000.752Contact Map0.454
1ypxA10.43561000.754Contact Map0.494
2infA40.426399.90.938Contact Map0.361
4ay7A20.398499.90.939Contact Map0.306
1j93A10.426399.90.942Contact Map0.352
2ejaA20.406499.80.944Contact Map0.389
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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