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OPENSEQ.org
RECG - ATP-dependent DNA helicase RecG
UniProt: P24230 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10829
Length: 693 (682)
Sequences: 1611
Seq/Len: 2.36
RECG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
310_A 320_V 5.735 1.00
538_S 543_E 5.445 1.00
226_L 664_L 5.368 1.00
625_K 628_E 4.987 1.00
485_Q 561_N 4.564 1.00
519_N 545_H 4.073 1.00
272_A 449_D 3.89 1.00
357_G 361_L 3.756 1.00
484_R 590_V 3.751 1.00
275_R 449_D 3.56 1.00
271_G 450_E 3.437 1.00
367_I 372_V 3.375 1.00
66_G 85_I 3.185 1.00
489_V 553_I 3.155 1.00
314_I 320_V 3.009 1.00
193_T 196_E 2.971 1.00
277_V 308_L 2.911 1.00
535_V 544_L 2.877 1.00
542_G 545_H 2.863 1.00
367_I 375_I 2.838 1.00
366_A 371_Q 2.823 1.00
314_I 374_M 2.788 1.00
229_L 649_A 2.758 1.00
478_A 482_E 2.743 1.00
349_G 372_V 2.733 1.00
521_G 544_L 2.618 1.00
616_S 621_V 2.566 1.00
479_C 518_L 2.561 1.00
65_E 112_R 2.561 1.00
504_A 522_L 2.56 1.00
320_V 395_I 2.543 1.00
515_L 546_L 2.501 1.00
337_F 376_V 2.499 1.00
355_Q 363_Q 2.468 1.00
368_A 387_Q 2.454 1.00
269_P 304_L 2.431 1.00
339_N 558_D 2.417 1.00
225_I 657_M 2.417 1.00
268_K 274_A 2.355 1.00
284_M 313_A 2.342 1.00
456_T 591_A 2.305 1.00
310_A 395_I 2.291 1.00
272_A 275_R 2.252 1.00
613_L 616_S 2.22 1.00
318_K 390_G 2.21 1.00
534_A 538_S 2.206 1.00
612_V 622_I 2.183 1.00
94_M 115_A 2.179 1.00
85_I 115_A 2.112 1.00
42_L 153_P 2.09 1.00
537_A 541_Q 2.06 0.99
475_V 486_A 2.035 0.99
64_V 92_L 2.034 0.99
468_R 568_E 2.018 0.99
11_L 30_L 2.016 0.99
17_V 166_L 2.014 0.99
460_T 596_L 2.007 0.99
475_V 566_I 1.994 0.99
307_A 337_F 1.968 0.99
349_G 363_Q 1.944 0.99
283_D 292_R 1.909 0.99
360_R 364_Q 1.903 0.99
281_E 312_R 1.895 0.99
487_Y 559_V 1.886 0.99
612_V 625_K 1.878 0.99
26_A 31_H 1.874 0.99
292_R 446_S 1.872 0.99
200_T 209_Q 1.86 0.99
347_E 373_Q 1.853 0.99
336_N 558_D 1.846 0.99
365_E 369_S 1.835 0.99
467_R 470_D 1.827 0.98
519_N 543_E 1.823 0.98
195_P 199_R 1.822 0.98
83_C 96_F 1.805 0.98
509_E 513_L 1.8 0.98
20_A 23_N 1.798 0.98
262_L 274_A 1.788 0.98
492_L 496_S 1.786 0.98
163_L 167_T 1.771 0.98
25_L 166_L 1.763 0.98
321_A 381_I 1.752 0.98
272_A 450_E 1.751 0.98
501_A 569_N 1.741 0.98
634_E 639_R 1.736 0.98
194_L 227_E 1.735 0.98
459_T 591_A 1.721 0.97
309_A 393_L 1.716 0.97
624_Q 628_E 1.701 0.97
56_L 62_A 1.697 0.97
83_C 107_L 1.697 0.97
334_A 338_R 1.694 0.97
667_H 671_R 1.694 0.97
237_L 666_R 1.688 0.97
358_K 361_L 1.688 0.97
621_V 624_Q 1.677 0.97
471_I 566_I 1.675 0.97
462_A 610_L 1.674 0.97
484_R 563_S 1.662 0.97
521_G 535_V 1.66 0.97
484_R 561_N 1.657 0.97
322_L 337_F 1.656 0.97
363_Q 372_V 1.654 0.97
479_C 546_L 1.645 0.96
251_L 422_H 1.633 0.96
255_D 315_A 1.633 0.96
621_V 625_K 1.622 0.96
248_A 422_H 1.616 0.96
251_L 316_H 1.616 0.96
456_T 589_A 1.614 0.96
342_A 345_G 1.61 0.96
478_A 484_R 1.603 0.96
230_L 668_I 1.598 0.96
189_Q 664_L 1.587 0.95
337_F 348_V 1.585 0.95
363_Q 367_I 1.582 0.95
458_V 592_S 1.582 0.95
276_V 446_S 1.578 0.95
40_L 201_L 1.573 0.95
364_Q 386_V 1.549 0.95
251_L 313_A 1.548 0.95
518_L 545_H 1.547 0.95
249_Q 318_K 1.545 0.94
63_T 116_Y 1.539 0.94
66_G 115_A 1.537 0.94
232_H 646_F 1.531 0.94
67_E 112_R 1.522 0.94
611_Q 615_D 1.522 0.94
672_Y 675_Q 1.52 0.94
155_T 158_V 1.519 0.94
355_Q 360_R 1.501 0.93
323_M 381_I 1.497 0.93
375_I 388_F 1.496 0.93
474_R 477_H 1.494 0.93
649_A 658_I 1.491 0.93
521_G 538_S 1.484 0.93
18_G 22_S 1.483 0.93
661_V 665_A 1.474 0.92
356_K 359_A 1.467 0.92
307_A 341_F 1.466 0.92
615_D 621_V 1.465 0.92
476_H 517_E 1.464 0.92
355_Q 359_A 1.455 0.92
311_L 315_A 1.454 0.92
272_A 447_V 1.449 0.92
261_L 311_L 1.445 0.91
249_Q 422_H 1.434 0.91
384_E 409_A 1.428 0.91
361_L 365_E 1.426 0.91
347_E 366_A 1.424 0.91
372_V 375_I 1.423 0.91
262_L 308_L 1.423 0.91
275_R 450_E 1.421 0.91
508_W 512_K 1.419 0.90
200_T 205_P 1.405 0.90
335_N 558_D 1.401 0.90
12_S 22_S 1.397 0.90
496_S 499_L 1.396 0.90
233_N 661_V 1.394 0.89
347_E 371_Q 1.392 0.89
221_Q 225_I 1.392 0.89
28_I 155_T 1.391 0.89
154_T 163_L 1.388 0.89
540_K 558_D 1.387 0.89
533_Q 537_A 1.374 0.88
523_V 549_A 1.373 0.88
181_E 188_S 1.364 0.88
95_R 127_E 1.361 0.88
395_I 558_D 1.355 0.88
276_V 279_E 1.352 0.87
225_I 648_V 1.343 0.87
181_E 223_R 1.338 0.87
258_K 281_E 1.321 0.86
108_A 111_R 1.319 0.86
237_L 669_H 1.311 0.85
275_R 279_E 1.311 0.85
68_V 83_C 1.311 0.85
185_P 188_S 1.308 0.85
27_K 155_T 1.304 0.85
283_D 446_S 1.3 0.84
279_E 446_S 1.299 0.84
331_E 335_N 1.294 0.84
197_A 223_R 1.289 0.84
279_E 283_D 1.287 0.84
364_Q 385_Q 1.284 0.83
489_V 565_M 1.281 0.83
65_E 114_L 1.279 0.83
323_M 382_F 1.275 0.83
197_A 201_L 1.274 0.83
346_I 373_Q 1.259 0.82
632_P 635_L 1.258 0.82
201_L 648_V 1.251 0.81
462_A 614_R 1.249 0.81
294_V 448_I 1.241 0.81
21_L 162_T 1.239 0.80
351_L 386_V 1.237 0.80
87_D 90_G 1.231 0.80
229_L 658_I 1.231 0.80
551_T 581_L 1.23 0.80
366_A 369_S 1.23 0.80
159_K 162_T 1.228 0.80
47_R 132_E 1.227 0.79
257_L 315_A 1.225 0.79
92_L 128_M 1.224 0.79
476_H 518_L 1.224 0.79
70_N 84_Q 1.221 0.79
85_I 92_L 1.22 0.79
38_L 194_L 1.219 0.79
494_E 526_R 1.218 0.79
662_Q 666_R 1.204 0.78
294_V 426_M 1.199 0.77
479_C 520_V 1.199 0.77
366_A 372_V 1.195 0.77
475_V 479_C 1.194 0.77
233_N 662_Q 1.186 0.76
563_S 589_A 1.185 0.76
362_A 366_A 1.182 0.76
538_S 541_Q 1.181 0.76
456_T 563_S 1.178 0.75
369_S 372_V 1.176 0.75
660_E 663_R 1.176 0.75
490_C 507_T 1.175 0.75
52_P 55_E 1.168 0.75
167_T 203_R 1.167 0.75
310_A 374_M 1.163 0.74
183_L 223_R 1.163 0.74
434_T 532_K 1.161 0.74
276_V 294_V 1.159 0.74
271_G 275_R 1.154 0.73
160_Q 164_R 1.153 0.73
251_L 312_R 1.148 0.73
283_D 290_M 1.147 0.73
264_A 343_P 1.144 0.72
561_N 588_G 1.142 0.72
206_P 209_Q 1.139 0.72
36_L 167_T 1.138 0.72
260_K 263_A 1.138 0.72
310_A 322_L 1.134 0.71
227_E 641_T 1.131 0.71
451_L 617_N 1.13 0.71
492_L 504_A 1.126 0.71
650_D 653_R 1.126 0.71
85_I 113_V 1.125 0.71
154_T 160_Q 1.124 0.71
608_I 625_K 1.124 0.71
506_A 509_E 1.119 0.70
349_G 366_A 1.116 0.70
66_G 92_L 1.113 0.69
575_L 622_I 1.113 0.69
487_Y 592_S 1.112 0.69
369_S 373_Q 1.112 0.69
119_A 128_M 1.11 0.69
261_L 304_L 1.101 0.68
370_G 389_N 1.099 0.68
611_Q 614_R 1.099 0.68
45_E 61_Y 1.098 0.68
476_H 514_A 1.097 0.68
530_A 534_A 1.092 0.67
225_I 653_R 1.091 0.67
277_V 305_V 1.09 0.67
465_D 599_K 1.09 0.67
182_L 227_E 1.083 0.66
257_L 311_L 1.08 0.66
277_V 448_I 1.078 0.66
25_L 163_L 1.074 0.65
56_L 157_G 1.071 0.65
223_R 227_E 1.069 0.65
519_N 542_G 1.066 0.65
286_L 422_H 1.062 0.64
318_K 392_A 1.059 0.64
519_N 544_L 1.058 0.64
338_R 342_A 1.058 0.64
256_T 260_K 1.057 0.64
355_Q 372_V 1.054 0.63
568_E 571_E 1.052 0.63
250_P 287_D 1.052 0.63
327_E 354_K 1.052 0.63
276_V 449_D 1.049 0.63
284_M 422_H 1.049 0.63
438_T 652_L 1.048 0.63
453_P 456_T 1.045 0.62
492_L 499_L 1.043 0.62
168_D 203_R 1.041 0.62
362_A 365_E 1.039 0.62
607_Q 611_Q 1.038 0.62
565_M 585_V 1.036 0.61
196_E 200_T 1.032 0.61
568_E 597_L 1.031 0.61
596_L 613_L 1.03 0.61
167_T 376_V 1.026 0.60
84_Q 91_I 1.022 0.60
476_H 481_T 1.02 0.60
312_R 316_H 1.019 0.59
321_A 391_L 1.017 0.59
487_Y 557_V 1.015 0.59
321_A 388_F 1.014 0.59
82_T 93_T 1.013 0.59
471_I 595_V 1.011 0.59
120_K 127_E 1.011 0.59
249_Q 390_G 1.009 0.58
598_Y 610_L 1.009 0.58
461_V 470_D 1.008 0.58
527_M 531_E 1.007 0.58
287_D 422_H 1.003 0.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gm5A10.95821000.383Contact Map0.54
2eyqA20.87881000.651Contact Map0.624
2v6iA10.49061000.787Contact Map0.376
2xgjA20.66671000.797Contact Map0.531
2wv9A10.77061000.807Contact Map0.249
1yksA10.50941000.812Contact Map0.307
2z83A10.54551000.824Contact Map0.39
4dduA10.6451000.836Contact Map0.433
3tbkA10.51951000.837Contact Map0.548
3oiyA20.53681000.838Contact Map0.527
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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