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DACB - D-alanyl-D-alanine carboxypeptidase DacB
UniProt: P24228 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10202
Length: 477 (449)
Sequences: 641
Seq/Len: 1.43
DACB
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
63_T 428_A 4.176 1.00
37_A 367_P 3.903 1.00
304_K 396_D 3.832 1.00
89_K 100_D 3.291 1.00
69_A 302_M 3.181 1.00
69_A 303_L 3.163 1.00
119_M 288_A 3.138 1.00
303_L 389_M 3.13 1.00
42_K 437_Q 2.834 1.00
428_A 442_V 2.643 1.00
37_A 58_A 2.505 1.00
90_G 97_L 2.488 1.00
100_D 133_G 2.382 1.00
63_T 442_V 2.365 0.99
134_N 272_G 2.355 0.99
51_D 54_S 2.332 0.99
58_A 367_P 2.314 0.99
99_G 133_G 2.31 0.99
55_Q 368_A 2.295 0.99
416_A 441_F 2.282 0.99
134_N 275_L 2.263 0.99
315_F 332_G 2.176 0.99
370_M 444_Y 2.122 0.99
43_V 440_A 2.109 0.99
391_P 416_A 2.085 0.98
399_L 416_A 2.025 0.98
399_L 427_L 1.923 0.97
416_A 427_L 1.919 0.97
319_G 332_G 1.896 0.97
39_M 371_M 1.893 0.97
110_T 298_L 1.882 0.96
123_L 126_S 1.87 0.96
69_A 299_L 1.857 0.96
433_T 439_M 1.851 0.96
188_A 204_V 1.777 0.95
120_V 266_A 1.775 0.95
67_I 373_V 1.764 0.94
103_A 255_A 1.758 0.94
392_L 396_D 1.736 0.94
168_I 313_T 1.709 0.93
63_T 370_M 1.704 0.93
98_K 132_D 1.703 0.93
302_M 310_I 1.699 0.93
82_F 317_M 1.696 0.93
106_G 141_I 1.67 0.92
40_V 439_M 1.662 0.92
169_V 258_I 1.656 0.92
120_V 259_L 1.654 0.92
307_D 310_I 1.63 0.91
105_F 167_A 1.628 0.91
150_G 362_H 1.581 0.89
92_V 97_L 1.575 0.89
83_T 291_Q 1.566 0.88
151_W 355_D 1.554 0.88
93_E 98_K 1.549 0.88
371_M 442_V 1.534 0.87
418_T 427_L 1.527 0.87
333_S 353_I 1.525 0.86
148_A 151_W 1.518 0.86
319_G 327_G 1.499 0.85
112_K 115_D 1.496 0.85
35_N 53_H 1.495 0.85
73_L 389_M 1.485 0.84
263_L 268_I 1.484 0.84
414_V 441_F 1.481 0.84
100_D 134_N 1.474 0.84
361_R 421_L 1.469 0.84
90_G 133_G 1.436 0.82
374_L 430_F 1.419 0.81
171_R 307_D 1.407 0.80
309_M 313_T 1.391 0.79
42_K 45_A 1.39 0.79
426_N 444_Y 1.39 0.79
39_M 48_P 1.388 0.78
312_D 357_S 1.354 0.76
123_L 268_I 1.34 0.75
371_M 440_A 1.339 0.75
346_V 373_V 1.335 0.75
66_V 373_V 1.333 0.74
420_S 425_Y 1.329 0.74
88_T 287_V 1.322 0.74
89_K 102_V 1.301 0.72
92_V 95_G 1.293 0.71
207_L 211_S 1.278 0.70
124_K 386_F 1.275 0.70
43_V 366_A 1.27 0.69
83_T 289_S 1.266 0.69
124_K 266_A 1.259 0.68
139_T 165_A 1.247 0.67
180_S 206_T 1.243 0.67
142_F 317_M 1.241 0.67
185_G 206_T 1.24 0.67
463_V 466_E 1.24 0.67
172_N 363_N 1.234 0.66
250_D 253_S 1.233 0.66
66_V 390_L 1.232 0.66
386_F 430_F 1.228 0.65
151_W 155_D 1.225 0.65
49_A 439_M 1.225 0.65
103_A 135_V 1.223 0.65
217_C 442_V 1.217 0.64
102_V 319_G 1.208 0.64
35_N 447_G 1.207 0.64
74_I 339_I 1.206 0.63
43_V 375_Q 1.195 0.62
67_I 370_M 1.187 0.62
460_I 466_E 1.185 0.61
86_L 119_M 1.184 0.61
255_A 288_A 1.183 0.61
85_T 106_G 1.182 0.61
254_Y 258_I 1.18 0.61
456_R 460_I 1.174 0.60
105_F 137_I 1.169 0.60
97_L 101_L 1.168 0.60
115_D 290_K 1.166 0.60
299_L 391_P 1.158 0.59
40_V 131_I 1.158 0.59
414_V 431_I 1.157 0.59
96_V 130_Q 1.154 0.58
141_I 320_H 1.154 0.58
168_I 309_M 1.152 0.58
168_I 172_N 1.147 0.58
319_G 331_A 1.146 0.58
427_L 441_F 1.144 0.57
73_L 78_P 1.142 0.57
59_L 364_L 1.141 0.57
165_A 168_I 1.141 0.57
71_A 318_I 1.139 0.57
70_L 377_I 1.139 0.57
39_M 368_A 1.138 0.57
172_N 251_G 1.13 0.56
41_Q 375_Q 1.128 0.56
86_L 259_L 1.127 0.56
171_R 310_I 1.125 0.55
181_A 206_T 1.124 0.55
142_F 166_A 1.119 0.55
353_I 420_S 1.117 0.55
137_I 256_G 1.117 0.55
101_L 123_L 1.113 0.54
130_Q 271_S 1.112 0.54
370_M 420_S 1.109 0.54
166_A 384_L 1.108 0.54
453_A 456_R 1.102 0.53
23_V 27_I 1.099 0.53
77_G 127_G 1.098 0.53
425_Y 443_Q 1.094 0.52
159_C 173_C 1.088 0.52
374_L 428_A 1.087 0.52
153_W 364_L 1.085 0.51
262_E 447_G 1.085 0.51
394_G 398_S 1.084 0.51
58_A 391_P 1.08 0.51
139_T 252_A 1.079 0.51
103_A 288_A 1.078 0.51
56_Q 367_P 1.078 0.51
102_V 277_Q 1.072 0.50
48_P 51_D 1.069 0.50
176_V 231_L 1.068 0.50
315_F 373_V 1.066 0.49
90_G 99_G 1.064 0.49
312_D 329_W 1.064 0.49
113_R 254_Y 1.063 0.49
367_P 444_Y 1.063 0.49
64_Q 363_N 1.06 0.49
199_T 228_R 1.06 0.49
355_D 363_N 1.056 0.48
51_D 368_A 1.056 0.48
420_S 426_N 1.048 0.48
123_L 198_V 1.047 0.48
340_L 346_V 1.046 0.47
23_V 28_T 1.046 0.47
301_I 305_K 1.046 0.47
303_L 386_F 1.044 0.47
90_G 102_V 1.043 0.47
302_M 311_A 1.041 0.47
376_Y 380_H 1.037 0.47
74_I 380_H 1.037 0.47
460_I 463_V 1.034 0.46
53_H 56_Q 1.032 0.46
319_G 335_A 1.032 0.46
390_L 399_L 1.031 0.46
151_W 423_G 1.031 0.46
462_L 467_S 1.028 0.46
153_W 355_D 1.028 0.46
456_R 459_R 1.028 0.46
312_D 355_D 1.025 0.45
81_R 291_Q 1.022 0.45
340_L 418_T 1.022 0.45
131_I 134_N 1.018 0.45
153_W 360_S 1.017 0.44
176_V 190_I 1.013 0.44
326_P 331_A 1.012 0.44
287_V 375_Q 1.01 0.44
106_G 256_G 1.008 0.44
64_Q 67_I 1.006 0.43
121_A 125_K 1.006 0.43
80_F 317_M 1.004 0.43
23_V 26_Y 1.002 0.43
109_P 359_L 1.001 0.43
357_S 363_N 1.001 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ex2A10.96021000.278Contact Map0.713
3a3dA20.94971000.302Contact Map0.728
1w5dA10.93711000.309Contact Map0.687
1w79A40.94341000.315Contact Map0.665
3v39A10.76731000.473Contact Map0.481
3dw0A20.570299.90.835Contact Map0.663
3p09A20.557799.90.838Contact Map0.67
1w7fA20.563999.90.84Contact Map0.686
1bueA10.513699.90.844Contact Map0.658
2bcfA10.530499.90.846Contact Map0.649
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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