May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YCEA - UPF0176 protein YceA
UniProt: P24188 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11116
Length: 350 (315)
Sequences: 666
Seq/Len: 2.11
YCEA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_E 245_I 4.77 1.00
137_Q 225_E 3.865 1.00
163_V 256_G 3.347 1.00
69_I 79_F 3.346 1.00
53_N 75_N 2.823 1.00
290_I 323_A 2.703 1.00
49_F 109_L 2.543 1.00
135_Y 223_H 2.491 1.00
165_H 199_Y 2.334 1.00
29_F 67_A 2.167 1.00
37_D 40_A 2.143 1.00
73_A 77_E 2.135 1.00
54_V 79_F 2.108 0.99
73_A 97_I 1.977 0.99
188_M 192_K 1.955 0.99
286_H 305_E 1.921 0.99
326_E 330_K 1.92 0.99
146_D 243_R 1.882 0.98
326_E 329_N 1.837 0.98
319_R 327_N 1.83 0.98
182_P 186_E 1.76 0.97
38_P 113_V 1.741 0.97
212_W 216_N 1.724 0.97
31_K 92_G 1.718 0.97
84_Y 92_G 1.715 0.97
209_A 213_M 1.682 0.96
270_C 295_C 1.659 0.96
77_E 81_A 1.654 0.96
151_L 196_I 1.645 0.96
54_V 69_I 1.628 0.95
311_S 319_R 1.611 0.95
43_D 47_Q 1.598 0.95
52_L 75_N 1.597 0.95
46_Y 50_T 1.585 0.94
324_G 327_N 1.585 0.94
139_A 234_K 1.582 0.94
145_L 197_V 1.58 0.94
267_C 270_C 1.56 0.94
258_R 261_D 1.553 0.93
72_P 75_N 1.551 0.93
94_R 225_E 1.541 0.93
141_V 224_I 1.521 0.93
47_Q 51_A 1.499 0.92
320_R 323_A 1.492 0.92
131_N 214_K 1.477 0.91
267_C 295_C 1.472 0.91
230_E 234_K 1.471 0.91
63_E 208_K 1.45 0.90
48_L 52_L 1.444 0.90
158_H 175_D 1.436 0.89
75_N 79_F 1.424 0.89
292_C 295_C 1.42 0.89
162_E 306_I 1.41 0.88
211_A 214_K 1.409 0.88
117_I 121_G 1.408 0.88
27_I 168_N 1.404 0.88
137_Q 140_E 1.402 0.88
167_E 243_R 1.393 0.87
270_C 292_C 1.392 0.87
288_L 308_C 1.385 0.87
229_I 248_N 1.359 0.86
70_S 105_S 1.334 0.84
37_D 123_D 1.306 0.82
318_Q 321_R 1.27 0.80
136_L 140_E 1.267 0.80
35_I 90_L 1.26 0.79
150_A 195_K 1.257 0.79
185_V 216_N 1.256 0.79
37_D 89_A 1.235 0.77
285_C 335_S 1.221 0.76
249_F 288_L 1.219 0.76
267_C 292_C 1.207 0.75
141_V 197_V 1.207 0.75
210_S 223_H 1.202 0.74
120_D 125_P 1.197 0.74
41_T 82_Q 1.195 0.74
330_K 335_S 1.193 0.74
80_R 97_I 1.184 0.73
278_T 301_G 1.181 0.73
29_F 58_V 1.18 0.73
195_K 220_K 1.18 0.73
187_M 193_D 1.174 0.72
316_E 323_A 1.169 0.72
214_K 219_N 1.156 0.70
317_E 320_R 1.143 0.69
107_W 253_E 1.141 0.69
124_D 215_H 1.141 0.69
318_Q 322_R 1.139 0.69
288_L 305_E 1.137 0.69
247_K 263_I 1.136 0.68
316_E 335_S 1.135 0.68
123_D 131_N 1.128 0.68
140_E 298_K 1.125 0.67
184_A 188_M 1.118 0.67
188_M 213_M 1.114 0.66
253_E 268_H 1.112 0.66
27_I 76_V 1.111 0.66
157_N 205_R 1.109 0.66
90_L 218_F 1.106 0.65
187_M 190_A 1.104 0.65
272_A 310_E 1.102 0.65
46_Y 109_L 1.1 0.65
320_R 324_G 1.096 0.64
197_V 240_L 1.093 0.64
80_R 95_L 1.09 0.64
184_A 218_F 1.087 0.63
54_V 75_N 1.084 0.63
172_I 244_F 1.084 0.63
151_L 188_M 1.084 0.63
22_E 301_G 1.083 0.63
196_I 268_H 1.079 0.63
45_L 54_V 1.078 0.62
147_D 150_A 1.074 0.62
68_Q 116_R 1.07 0.62
50_T 53_N 1.07 0.62
27_I 326_E 1.068 0.61
128_D 131_N 1.062 0.61
69_I 75_N 1.061 0.61
50_T 109_L 1.061 0.61
190_A 193_D 1.058 0.60
280_C 285_C 1.057 0.60
134_E 214_K 1.056 0.60
133_G 221_V 1.055 0.60
311_S 323_A 1.055 0.60
247_K 262_E 1.047 0.59
25_T 100_D 1.045 0.59
323_A 337_G 1.044 0.59
59_Y 68_Q 1.042 0.59
328_G 331_I 1.038 0.58
329_N 334_K 1.038 0.58
163_V 187_M 1.037 0.58
152_F 243_R 1.034 0.58
40_A 143_A 1.031 0.57
45_L 79_F 1.03 0.57
230_E 233_R 1.029 0.57
27_I 67_A 1.027 0.57
311_S 329_N 1.026 0.57
312_A 318_Q 1.024 0.57
247_K 323_A 1.023 0.56
311_S 322_R 1.021 0.56
324_G 328_G 1.019 0.56
115_D 316_E 1.008 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f67A10.75431000.616Contact Map0.738
1gmxA10.308699.60.876Contact Map0.68
1veeA10.354399.60.879Contact Map0.479
2fsxA10.377199.60.879Contact Map0.468
3fojA10.282999.50.884Contact Map0.642
3i2vA10.311499.50.885Contact Map0.646
3g5jA20.399.50.885Contact Map0.807
3emeA10.291499.50.885Contact Map0.652
3flhA30.3499.50.886Contact Map0.642
1qxnA20.3899.50.886Contact Map0.652
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.3161 seconds.