| UniProt: | P24182 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10276 | ||
| Length: | 449 (443) | ||
| Sequences: | 8631 | ||
| Seq/Len: | 19.48 |
| ACCC
Paralog alert: 0.87 [within 20: 0.13] - ratio of genomes with paralogs Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 150_K | 175_D | 4.24 | 1.00 | |
| 93_E | 111_R | 3.873 | 1.00 | |
| 174_G | 177_E | 3.474 | 1.00 | |
| 68_S | 72_I | 3.375 | 1.00 | |
| 4_K | 27_K | 3.172 | 1.00 | |
| 254_R | 258_E | 3.169 | 1.00 | |
| 141_D | 144_K | 3.026 | 1.00 | |
| 146_R | 179_A | 2.913 | 1.00 | |
| 394_N | 397_V | 2.787 | 1.00 | |
| 392_G | 397_V | 2.779 | 1.00 | |
| 5_I | 103_I | 2.742 | 1.00 | |
| 173_R | 177_E | 2.625 | 1.00 | |
| 125_K | 266_D | 2.604 | 1.00 | |
| 62_N | 65_A | 2.6 | 1.00 | |
| 93_E | 97_R | 2.55 | 1.00 | |
| 71_E | 98_S | 2.52 | 1.00 | |
| 258_E | 262_K | 2.502 | 1.00 | |
| 34_S | 50_C | 2.495 | 1.00 | |
| 250_P | 254_R | 2.491 | 1.00 | |
| 132_P | 202_K | 2.476 | 1.00 | |
| 280_E | 283_E | 2.423 | 1.00 | |
| 173_R | 205_E | 2.412 | 1.00 | |
| 3_D | 76_V | 2.4 | 1.00 | |
| 154_Y | 175_D | 2.38 | 1.00 | |
| 123_M | 263_A | 2.351 | 1.00 | |
| 94_Q | 98_S | 2.307 | 1.00 | |
| 4_K | 29_V | 2.285 | 1.00 | |
| 393_E | 397_V | 2.178 | 1.00 | |
| 179_A | 183_S | 2.104 | 1.00 | |
| 121_A | 125_K | 2.098 | 1.00 | |
| 190_K | 196_D | 2.086 | 1.00 | |
| 249_T | 252_L | 2.061 | 1.00 | |
| 218_G | 270_R | 2.052 | 1.00 | |
| 436_N | 442_K | 2.028 | 1.00 | |
| 27_K | 47_E | 2.006 | 1.00 | |
| 337_C | 402_M | 1.995 | 1.00 | |
| 186_R | 196_D | 1.968 | 1.00 | |
| 255_Y | 283_E | 1.961 | 1.00 | |
| 314_R | 319_Q | 1.915 | 1.00 | |
| 86_S | 114_G | 1.905 | 1.00 | |
| 96_E | 107_A | 1.894 | 1.00 | |
| 293_I | 308_L | 1.892 | 1.00 | |
| 261_A | 265_V | 1.881 | 1.00 | |
| 4_K | 47_E | 1.879 | 1.00 | |
| 212_I | 256_I | 1.856 | 1.00 | |
| 147_A | 151_R | 1.852 | 1.00 | |
| 429_N | 434_G | 1.849 | 1.00 | |
| 49_V | 69_A | 1.832 | 1.00 | |
| 67_I | 98_S | 1.817 | 1.00 | |
| 343_D | 415_K | 1.815 | 1.00 | |
| 118_S | 121_A | 1.794 | 1.00 | |
| 311_E | 322_S | 1.789 | 1.00 | |
| 2_L | 76_V | 1.788 | 1.00 | |
| 2_L | 317_A | 1.776 | 1.00 | |
| 49_V | 73_T | 1.772 | 1.00 | |
| 23_E | 310_K | 1.765 | 1.00 | |
| 2_L | 101_I | 1.765 | 1.00 | |
| 67_I | 71_E | 1.744 | 1.00 | |
| 5_I | 21_C | 1.744 | 1.00 | |
| 106_K | 270_R | 1.723 | 1.00 | |
| 7_I | 18_L | 1.717 | 1.00 | |
| 427_D | 439_Y | 1.714 | 1.00 | |
| 262_K | 265_V | 1.697 | 1.00 | |
| 95_V | 100_F | 1.686 | 1.00 | |
| 259_R | 284_F | 1.683 | 1.00 | |
| 31_V | 51_I | 1.679 | 1.00 | |
| 310_K | 314_R | 1.678 | 1.00 | |
| 222_A | 261_A | 1.674 | 1.00 | |
| 140_D | 144_K | 1.67 | 1.00 | |
| 147_A | 150_K | 1.668 | 1.00 | |
| 205_E | 281_N | 1.654 | 1.00 | |
| 175_D | 179_A | 1.652 | 1.00 | |
| 63_I | 94_Q | 1.64 | 1.00 | |
| 171_V | 203_Y | 1.626 | 1.00 | |
| 340_N | 383_S | 1.624 | 1.00 | |
| 113_M | 289_M | 1.615 | 1.00 | |
| 146_R | 175_D | 1.614 | 1.00 | |
| 111_R | 118_S | 1.58 | 1.00 | |
| 134_S | 151_R | 1.579 | 1.00 | |
| 215_L | 315_I | 1.579 | 1.00 | |
| 5_I | 26_I | 1.577 | 1.00 | |
| 70_A | 78_I | 1.571 | 1.00 | |
| 93_E | 108_E | 1.565 | 1.00 | |
| 21_C | 28_T | 1.558 | 1.00 | |
| 106_K | 109_T | 1.552 | 1.00 | |
| 161_S | 197_M | 1.551 | 1.00 | |
| 78_I | 100_F | 1.55 | 1.00 | |
| 22_K | 46_D | 1.546 | 1.00 | |
| 365_V | 390_C | 1.545 | 1.00 | |
| 142_M | 179_A | 1.54 | 1.00 | |
| 143_D | 147_A | 1.537 | 1.00 | |
| 144_K | 147_A | 1.533 | 1.00 | |
| 202_K | 285_Y | 1.533 | 1.00 | |
| 252_L | 255_Y | 1.531 | 1.00 | |
| 30_A | 41_H | 1.53 | 1.00 | |
| 409_L | 418_V | 1.529 | 1.00 | |
| 148_I | 151_R | 1.526 | 1.00 | |
| 215_L | 311_E | 1.523 | 1.00 | |
| 428_E | 432_H | 1.518 | 1.00 | |
| 403_K | 426_N | 1.501 | 1.00 | |
| 353_K | 376_T | 1.496 | 1.00 | |
| 78_I | 95_V | 1.482 | 1.00 | |
| 95_V | 102_F | 1.477 | 1.00 | |
| 121_A | 124_K | 1.477 | 1.00 | |
| 424_I | 430_F | 1.475 | 1.00 | |
| 216_A | 222_A | 1.472 | 1.00 | |
| 64_P | 94_Q | 1.464 | 1.00 | |
| 336_E | 387_K | 1.457 | 1.00 | |
| 407_Q | 422_I | 1.443 | 1.00 | |
| 117_V | 121_A | 1.435 | 1.00 | |
| 149_A | 154_Y | 1.434 | 1.00 | |
| 68_S | 71_E | 1.434 | 1.00 | |
| 255_Y | 259_R | 1.429 | 1.00 | |
| 427_D | 443_K | 1.424 | 1.00 | |
| 112_L | 122_A | 1.417 | 1.00 | |
| 148_I | 152_I | 1.415 | 1.00 | |
| 154_Y | 174_G | 1.415 | 1.00 | |
| 5_I | 313_L | 1.41 | 1.00 | |
| 142_M | 146_R | 1.409 | 1.00 | |
| 255_Y | 258_E | 1.406 | 0.99 | |
| 120_I | 201_E | 1.405 | 0.99 | |
| 182_I | 198_V | 1.402 | 0.99 | |
| 354_I | 371_I | 1.4 | 0.99 | |
| 305_G | 329_H | 1.379 | 0.99 | |
| 146_R | 150_K | 1.379 | 0.99 | |
| 94_Q | 97_R | 1.375 | 0.99 | |
| 108_E | 112_L | 1.362 | 0.99 | |
| 122_A | 126_A | 1.353 | 0.99 | |
| 96_E | 270_R | 1.349 | 0.99 | |
| 67_I | 94_Q | 1.342 | 0.99 | |
| 420_L | 424_I | 1.339 | 0.99 | |
| 55_P | 58_K | 1.336 | 0.99 | |
| 420_L | 440_L | 1.336 | 0.99 | |
| 65_A | 68_S | 1.334 | 0.99 | |
| 396_D | 400_A | 1.332 | 0.99 | |
| 214_V | 264_C | 1.327 | 0.99 | |
| 69_A | 73_T | 1.324 | 0.99 | |
| 353_K | 375_Y | 1.319 | 0.99 | |
| 329_H | 332_G | 1.316 | 0.99 | |
| 220_G | 265_V | 1.314 | 0.99 | |
| 223_I | 323_I | 1.304 | 0.99 | |
| 158_I | 198_V | 1.297 | 0.99 | |
| 2_L | 77_A | 1.296 | 0.99 | |
| 30_A | 45_A | 1.294 | 0.99 | |
| 20_A | 310_K | 1.289 | 0.99 | |
| 392_G | 401_R | 1.282 | 0.99 | |
| 262_K | 266_D | 1.279 | 0.99 | |
| 438_H | 441_E | 1.267 | 0.99 | |
| 403_K | 431_Q | 1.26 | 0.99 | |
| 18_L | 44_L | 1.25 | 0.99 | |
| 70_A | 100_F | 1.243 | 0.98 | |
| 128_V | 286_F | 1.237 | 0.98 | |
| 404_N | 408_E | 1.235 | 0.98 | |
| 143_D | 146_R | 1.234 | 0.98 | |
| 103_I | 313_L | 1.232 | 0.98 | |
| 243_A | 303_I | 1.23 | 0.98 | |
| 142_M | 182_I | 1.229 | 0.98 | |
| 400_A | 431_Q | 1.22 | 0.98 | |
| 15_L | 44_L | 1.206 | 0.98 | |
| 217_D | 221_N | 1.198 | 0.98 | |
| 252_L | 279_F | 1.194 | 0.98 | |
| 26_I | 317_A | 1.181 | 0.98 | |
| 119_A | 123_M | 1.179 | 0.98 | |
| 144_K | 148_I | 1.177 | 0.98 | |
| 101_I | 317_A | 1.174 | 0.98 | |
| 142_M | 183_S | 1.17 | 0.97 | |
| 215_L | 272_A | 1.169 | 0.97 | |
| 335_V | 398_A | 1.168 | 0.97 | |
| 149_A | 178_L | 1.166 | 0.97 | |
| 251_E | 255_Y | 1.163 | 0.97 | |
| 172_V | 181_S | 1.161 | 0.97 | |
| 137_P | 197_M | 1.16 | 0.97 | |
| 170_R | 188_E | 1.158 | 0.97 | |
| 124_K | 130_C | 1.157 | 0.97 | |
| 223_I | 328_V | 1.155 | 0.97 | |
| 145_N | 178_L | 1.152 | 0.97 | |
| 93_E | 107_A | 1.152 | 0.97 | |
| 154_Y | 178_L | 1.151 | 0.97 | |
| 226_A | 328_V | 1.144 | 0.97 | |
| 149_A | 156_V | 1.142 | 0.97 | |
| 305_G | 327_E | 1.136 | 0.97 | |
| 112_L | 118_S | 1.136 | 0.97 | |
| 212_I | 257_G | 1.132 | 0.97 | |
| 149_A | 182_I | 1.132 | 0.97 | |
| 63_I | 67_I | 1.132 | 0.97 | |
| 138_L | 148_I | 1.124 | 0.97 | |
| 335_V | 399_I | 1.121 | 0.97 | |
| 438_H | 442_K | 1.107 | 0.96 | |
| 219_Q | 265_V | 1.106 | 0.96 | |
| 248_I | 252_L | 1.105 | 0.96 | |
| 27_K | 46_D | 1.103 | 0.96 | |
| 157_I | 203_Y | 1.1 | 0.96 | |
| 372_Y | 375_Y | 1.099 | 0.96 | |
| 251_E | 254_R | 1.098 | 0.96 | |
| 122_A | 125_K | 1.096 | 0.96 | |
| 429_N | 443_K | 1.09 | 0.96 | |
| 402_M | 425_M | 1.089 | 0.96 | |
| 206_N | 436_N | 1.08 | 0.95 | |
| 92_A | 102_F | 1.077 | 0.95 | |
| 145_N | 182_I | 1.071 | 0.95 | |
| 219_Q | 320_P | 1.071 | 0.95 | |
| 254_R | 257_G | 1.068 | 0.95 | |
| 388_L | 409_L | 1.065 | 0.95 | |
| 96_E | 106_K | 1.064 | 0.95 | |
| 67_I | 97_R | 1.06 | 0.95 | |
| 302_M | 391_Y | 1.053 | 0.95 | |
| 123_M | 286_F | 1.046 | 0.94 | |
| 399_I | 425_M | 1.046 | 0.94 | |
| 106_K | 268_G | 1.045 | 0.94 | |
| 157_I | 171_V | 1.043 | 0.94 | |
| 324_K | 327_E | 1.037 | 0.94 | |
| 32_H | 48_T | 1.036 | 0.94 | |
| 124_K | 135_D | 1.033 | 0.94 | |
| 91_F | 95_V | 1.03 | 0.94 | |
| 70_A | 95_V | 1.028 | 0.94 | |
| 152_I | 156_V | 1.023 | 0.93 | |
| 64_P | 68_S | 1.022 | 0.93 | |
| 256_I | 284_F | 1.02 | 0.93 | |
| 140_D | 197_M | 1.019 | 0.93 | |
| 397_V | 401_R | 1.01 | 0.93 | |
| 108_E | 111_R | 1.009 | 0.93 | |
| 224_Y | 257_G | 1.009 | 0.93 | |
| 204_L | 287_I | 1.007 | 0.93 | |
| 212_I | 260_C | 1.007 | 0.93 | |
| 156_V | 200_M | 1.005 | 0.93 | |
| 301_E | 389_I | 1.002 | 0.92 | |
| 260_C | 289_M | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3n6rA | 6 | 0.9621 | 100 | 0.27 | Contact Map | 0.685 |
| 3va7A | 1 | 0.833 | 100 | 0.281 | Contact Map | 0.72 |
| 3u9tA | 1 | 0.9666 | 100 | 0.282 | Contact Map | 0.678 |
| 3hblA | 4 | 0.9933 | 100 | 0.287 | Contact Map | 0.799 |
| 2qf7A | 2 | 0.8953 | 100 | 0.287 | Contact Map | 0.729 |
| 1w96A | 3 | 0.9733 | 100 | 0.289 | Contact Map | 0.711 |
| 1ulzA | 1 | 0.9911 | 100 | 0.296 | Contact Map | 0.778 |
| 2dzdA | 2 | 0.9978 | 100 | 0.304 | Contact Map | 0.786 |
| 3jrxA | 1 | 0.9287 | 100 | 0.309 | Contact Map | 0.714 |
| 2w70A | 2 | 0.9889 | 100 | 0.31 | Contact Map | 0.756 |
Sequence Conservation (Image Generated using WebLogo v3)