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OPENSEQ.org
MANB - Phosphomannomutase
UniProt: P24175 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10162
Length: 456 (447)
Sequences: 5386
Seq/Len: 12.05
MANB
Paralog alert: 0.94 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: GLMM MANB PGM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
182_A 248_F 4.357 1.00
317_R 320_K 4.339 1.00
174_V 238_A 3.943 1.00
232_A 236_H 3.93 1.00
231_N 235_K 3.925 1.00
256_E 363_G 3.508 1.00
440_V 444_E 3.281 1.00
172_K 201_E 3.207 1.00
153_D 157_D 3.003 1.00
232_A 235_K 2.917 1.00
188_A 195_A 2.778 1.00
49_L 212_N 2.617 1.00
294_V 306_M 2.571 1.00
62_L 93_I 2.567 1.00
299_A 372_A 2.559 1.00
160_F 195_A 2.393 1.00
282_K 303_T 2.355 1.00
41_I 62_L 2.348 1.00
86_H 154_A 2.336 1.00
244_F 348_W 2.259 1.00
45_G 51_S 2.251 1.00
305_V 317_R 2.247 1.00
55_K 71_D 2.237 1.00
360_K 368_D 2.222 1.00
44_G 80_I 2.218 1.00
43_L 59_A 2.208 1.00
63_Q 146_Y 2.178 1.00
444_E 448_R 2.164 1.00
42_V 89_V 2.16 1.00
230_R 234_I 2.159 1.00
40_T 68_D 2.149 1.00
30_R 65_A 2.119 1.00
174_V 232_A 2.117 1.00
253_L 351_V 2.11 1.00
448_R 452_T 2.109 1.00
29_G 58_L 2.096 1.00
32_Y 91_G 2.091 1.00
125_D 128_R 2.076 1.00
391_N 395_Q 2.069 1.00
272_E 300_A 2.036 1.00
317_R 321_E 2.019 1.00
360_K 364_E 1.989 1.00
227_D 231_N 1.976 1.00
153_D 188_A 1.961 1.00
58_L 93_I 1.959 1.00
156_V 189_I 1.951 1.00
275_L 302_G 1.948 1.00
172_K 203_I 1.939 1.00
22_E 53_T 1.932 1.00
33_G 62_L 1.915 1.00
295_D 298_T 1.909 1.00
439_D 442_L 1.905 1.00
15_K 103_D 1.852 1.00
68_D 147_Q 1.848 1.00
256_E 361_T 1.834 1.00
259_Q 367_R 1.822 1.00
233_V 241_G 1.818 1.00
34_E 129_L 1.795 1.00
442_L 445_A 1.741 1.00
172_K 237_G 1.74 1.00
269_L 354_L 1.731 1.00
391_N 394_E 1.716 1.00
204_K 207_N 1.712 1.00
45_G 55_K 1.711 1.00
203_I 236_H 1.707 1.00
82_F 86_H 1.699 1.00
52_E 56_L 1.681 1.00
231_N 234_I 1.665 1.00
32_Y 109_L 1.643 1.00
445_A 449_T 1.626 1.00
361_T 364_E 1.605 1.00
272_E 368_D 1.605 1.00
297_V 302_G 1.604 1.00
270_L 335_F 1.604 1.00
229_T 254_F 1.602 1.00
15_K 104_Y 1.588 1.00
351_V 362_L 1.587 1.00
34_E 65_A 1.586 1.00
436_S 443_M 1.584 1.00
30_R 34_E 1.574 1.00
452_T 455_N 1.571 1.00
267_V 327_G 1.562 1.00
434_V 447_T 1.56 1.00
441_P 445_A 1.559 1.00
355_V 365_L 1.559 1.00
38_P 129_L 1.552 1.00
276_E 358_K 1.531 1.00
45_G 52_E 1.516 1.00
128_R 132_A 1.512 1.00
240_M 355_V 1.51 1.00
187_D 207_N 1.494 1.00
129_L 132_A 1.484 1.00
68_D 144_G 1.482 1.00
62_L 67_V 1.481 1.00
242_I 348_W 1.476 1.00
294_V 298_T 1.472 1.00
211_G 214_P 1.471 1.00
255_D 259_Q 1.46 1.00
272_E 276_E 1.444 1.00
59_A 71_D 1.44 1.00
173_L 240_M 1.436 1.00
314_I 326_G 1.436 1.00
153_D 195_A 1.431 1.00
159_L 349_L 1.428 1.00
229_T 243_A 1.427 1.00
33_G 65_A 1.412 1.00
82_F 158_H 1.406 0.99
447_T 451_L 1.403 0.99
272_E 365_L 1.398 0.99
277_K 357_L 1.393 0.99
42_V 83_A 1.393 0.99
45_G 71_D 1.391 0.99
25_A 107_M 1.381 0.99
171_L 239_D 1.37 0.99
157_D 161_G 1.369 0.99
20_L 24_I 1.361 0.99
177_S 207_N 1.347 0.99
255_D 363_G 1.345 0.99
12_I 28_I 1.34 0.99
12_I 109_L 1.339 0.99
307_S 317_R 1.332 0.99
128_R 131_E 1.331 0.99
40_T 90_D 1.33 0.99
157_D 195_A 1.33 0.99
206_H 228_D 1.33 0.99
273_A 277_K 1.326 0.99
24_I 28_I 1.316 0.99
172_K 236_H 1.314 0.99
257_K 363_G 1.31 0.99
388_E 392_R 1.306 0.99
352_A 355_V 1.302 0.99
26_W 57_A 1.294 0.99
316_E 320_K 1.288 0.99
8_K 11_D 1.287 0.99
47_V 74_M 1.282 0.99
43_L 58_L 1.282 0.99
159_L 346_I 1.267 0.99
393_V 421_L 1.263 0.99
26_W 60_K 1.256 0.99
289_L 293_T 1.245 0.98
16_L 50_T 1.239 0.98
187_D 194_K 1.228 0.98
162_Y 350_L 1.227 0.98
55_K 59_A 1.225 0.98
240_M 352_A 1.225 0.98
448_R 455_N 1.224 0.98
156_V 185_V 1.224 0.98
196_L 349_L 1.224 0.98
33_G 67_V 1.224 0.98
385_Q 388_E 1.217 0.98
76_G 79_E 1.212 0.98
363_G 367_R 1.21 0.98
182_A 244_F 1.209 0.98
194_K 204_K 1.192 0.98
305_V 321_E 1.191 0.98
233_V 254_F 1.189 0.98
285_H 304_P 1.187 0.98
210_D 216_G 1.184 0.98
62_L 69_V 1.184 0.98
175_I 193_F 1.184 0.98
125_D 129_L 1.181 0.98
75_S 79_E 1.18 0.98
242_I 253_L 1.179 0.98
59_A 146_Y 1.173 0.98
242_I 251_C 1.161 0.97
49_L 211_G 1.159 0.97
26_W 64_D 1.158 0.97
360_K 365_L 1.157 0.97
296_V 300_A 1.156 0.97
84_T 92_G 1.142 0.97
269_L 366_V 1.139 0.97
392_R 396_H 1.138 0.97
325_Y 333_H 1.134 0.97
416_D 437_R 1.134 0.97
318_M 323_A 1.131 0.97
364_E 367_R 1.131 0.97
230_R 260_F 1.129 0.97
57_A 61_G 1.127 0.97
229_T 241_G 1.127 0.97
394_E 406_R 1.127 0.97
124_R 128_R 1.121 0.97
388_E 391_N 1.121 0.97
25_A 54_L 1.121 0.97
285_H 289_L 1.116 0.96
150_N 153_D 1.112 0.96
59_A 63_Q 1.112 0.96
273_A 357_L 1.108 0.96
41_I 91_G 1.108 0.96
234_I 237_G 1.106 0.96
9_A 425_N 1.106 0.96
152_R 188_A 1.106 0.96
387_V 391_N 1.101 0.96
389_A 392_R 1.097 0.96
15_K 18_E 1.096 0.96
265_Y 366_V 1.095 0.96
313_F 316_E 1.093 0.96
38_P 125_D 1.088 0.96
203_I 238_A 1.088 0.96
283_I 297_V 1.087 0.96
193_F 348_W 1.084 0.96
29_G 61_G 1.076 0.95
188_A 194_K 1.075 0.95
205_V 232_A 1.071 0.95
173_L 352_A 1.065 0.95
282_K 305_V 1.06 0.95
179_N 206_H 1.057 0.95
295_D 299_A 1.05 0.94
90_D 112_E 1.05 0.94
86_H 158_H 1.048 0.94
175_I 182_A 1.045 0.94
267_V 293_T 1.044 0.94
40_T 70_L 1.043 0.94
171_L 352_A 1.041 0.94
171_L 355_V 1.04 0.94
183_G 187_D 1.034 0.94
152_R 185_V 1.032 0.94
175_I 244_F 1.027 0.94
29_G 62_L 1.027 0.94
193_F 200_V 1.024 0.93
72_I 75_S 1.022 0.93
282_K 323_A 1.018 0.93
292_N 369_R 1.017 0.93
268_G 296_V 1.016 0.93
32_Y 93_I 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f7lA20.97811000.073Contact Map0.782
1wqaA40.97591000.074Contact Map0.789
1tuoA10.96491000.102Contact Map0.63
3uw2A10.96711000.109Contact Map0.746
1p5dX10.96711000.117Contact Map0.778
3pdkA20.95391000.128Contact Map0.781
3i3wA20.94741000.14Contact Map0.743
3na5A20.97591000.157Contact Map0.65
2z0fA20.97591000.161Contact Map0.653
4hjhA20.94961000.163Contact Map0.632
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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