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OPENSEQ.org
MANC - Mannose-1-phosphate guanylyltransferase
UniProt: P24174 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10161
Length: 478 (469)
Sequences: 917
Seq/Len: 1.96
MANC
Paralog alert: 0.36 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
325_V 328_L 5.024 1.00
186_N 189_T 4.2 1.00
418_K 445_E 3.841 1.00
265_T 268_A 3.728 1.00
112_L 207_L 3.413 1.00
308_T 311_S 3.352 1.00
191_Q 195_A 3.22 1.00
187_L 191_Q 3.212 1.00
218_K 229_E 3.183 1.00
309_E 326_K 3.085 1.00
178_V 268_A 3.08 1.00
102_A 113_M 3.036 1.00
97_L 244_V 2.955 1.00
422_D 440_A 2.954 1.00
418_K 425_I 2.694 1.00
421_I 424_D 2.637 1.00
308_T 322_T 2.596 1.00
318_G 332_Q 2.547 1.00
96_A 217_L 2.52 1.00
110_D 211_G 2.518 1.00
216_E 265_T 2.484 1.00
344_A 347_D 2.478 1.00
162_R 179_A 2.464 1.00
224_I 255_E 2.422 1.00
100_L 225_L 2.395 1.00
322_T 330_V 2.37 1.00
426_K 434_I 2.305 1.00
347_D 350_K 2.231 1.00
307_K 344_A 2.21 1.00
332_Q 337_V 2.207 1.00
402_M 471_F 2.19 1.00
473_D 477_R 2.145 0.99
42_Q 71_Q 2.116 0.99
302_D 360_R 2.116 0.99
36_G 43_T 2.111 0.99
368_E 377_D 2.097 0.99
400_V 443_C 2.093 0.99
9_V 98_A 2.077 0.99
38_L 46_C 2.07 0.99
162_R 180_Q 2.053 0.99
313_V 322_T 2.052 0.99
313_V 320_V 2.052 0.99
200_Y 270_V 2.025 0.99
97_L 228_C 2.006 0.99
189_T 192_A 1.998 0.99
421_I 434_I 1.974 0.99
402_M 469_V 1.953 0.99
221_R 255_E 1.856 0.98
162_R 199_Y 1.85 0.98
367_R 377_D 1.8 0.97
327_D 341_D 1.777 0.97
219_K 266_A 1.774 0.97
245_D 248_A 1.766 0.97
429_G 432_E 1.737 0.97
163_R 200_Y 1.715 0.96
313_V 330_V 1.703 0.96
378_S 386_Q 1.696 0.96
143_K 267_D 1.683 0.96
11_M 117_A 1.639 0.95
299_C 305_N 1.62 0.94
114_L 207_L 1.617 0.94
280_V 289_I 1.599 0.94
235_V 242_I 1.598 0.94
310_N 327_D 1.577 0.93
154_P 187_L 1.549 0.92
161_I 270_V 1.497 0.91
111_P 211_G 1.494 0.91
330_V 339_I 1.49 0.90
397_G 445_E 1.485 0.90
95_I 115_V 1.483 0.90
414_A 453_D 1.483 0.90
90_N 254_E 1.482 0.90
441_T 471_F 1.451 0.89
69_A 240_N 1.438 0.88
87_A 250_L 1.431 0.88
213_Y 217_L 1.43 0.88
97_L 232_M 1.428 0.88
377_D 380_D 1.426 0.88
315_A 320_V 1.423 0.88
225_L 229_E 1.41 0.87
182_V 193_Y 1.409 0.87
284_S 288_E 1.408 0.87
238_D 241_F 1.408 0.87
428_L 432_E 1.407 0.87
375_K 391_T 1.406 0.87
354_Q 358_D 1.405 0.87
162_R 198_E 1.404 0.87
462_Y 466_D 1.404 0.87
155_E 346_Q 1.402 0.86
45_I 72_L 1.4 0.86
296_G 310_N 1.382 0.85
350_K 353_E 1.379 0.85
388_K 465_E 1.375 0.85
221_R 224_I 1.365 0.84
38_L 43_T 1.363 0.84
305_N 313_V 1.356 0.84
399_S 470_R 1.352 0.84
398_L 444_L 1.346 0.83
143_K 269_V 1.338 0.83
420_T 425_I 1.334 0.83
421_I 426_K 1.333 0.82
96_A 213_Y 1.321 0.82
144_L 212_R 1.314 0.81
399_S 477_R 1.306 0.81
238_D 243_R 1.303 0.80
421_I 440_A 1.294 0.80
218_K 225_L 1.283 0.79
399_S 473_D 1.274 0.78
125_E 129_R 1.273 0.78
95_I 213_Y 1.271 0.78
376_Y 388_K 1.255 0.77
329_V 345_V 1.248 0.76
212_R 267_D 1.242 0.76
324_G 344_A 1.238 0.75
229_E 233_S 1.236 0.75
380_D 387_V 1.229 0.75
304_I 319_L 1.227 0.75
411_V 457_V 1.226 0.74
124_D 127_A 1.217 0.74
216_E 268_A 1.217 0.74
127_A 131_A 1.213 0.73
99_A 113_M 1.213 0.73
284_S 345_V 1.21 0.73
368_E 375_K 1.21 0.73
378_S 381_A 1.208 0.73
341_D 345_V 1.203 0.73
192_A 196_S 1.202 0.72
305_N 308_T 1.199 0.72
216_E 267_D 1.198 0.72
376_Y 477_R 1.195 0.72
420_T 443_C 1.189 0.71
92_A 260_A 1.188 0.71
287_W 292_H 1.185 0.71
458_R 468_V 1.183 0.71
390_I 454_L 1.181 0.71
20_W 336_A 1.181 0.71
411_V 454_L 1.176 0.70
234_A 245_D 1.172 0.70
164_G 176_F 1.166 0.69
158_Y 280_V 1.159 0.68
188_E 191_Q 1.158 0.68
144_L 213_Y 1.153 0.68
65_R 241_F 1.147 0.67
215_E 218_K 1.145 0.67
429_G 438_L 1.14 0.67
376_Y 390_I 1.128 0.65
308_T 313_V 1.127 0.65
60_C 64_H 1.126 0.65
405_H 450_I 1.125 0.65
390_I 398_L 1.124 0.65
308_T 325_V 1.119 0.64
465_E 470_R 1.118 0.64
164_G 269_V 1.118 0.64
322_T 328_L 1.117 0.64
428_L 434_I 1.116 0.64
41_L 58_V 1.115 0.64
431_N 459_S 1.111 0.64
189_T 193_Y 1.106 0.63
232_M 235_V 1.102 0.63
326_K 341_D 1.102 0.63
376_Y 398_L 1.101 0.63
341_D 344_A 1.1 0.63
88_G 155_E 1.097 0.62
430_E 449_K 1.095 0.62
161_I 178_V 1.092 0.62
306_H 354_Q 1.092 0.62
377_D 387_V 1.089 0.61
427_L 439_G 1.086 0.61
223_D 253_P 1.085 0.61
232_M 244_V 1.084 0.61
16_G 21_P 1.08 0.60
404_H 450_I 1.08 0.60
416_T 427_L 1.079 0.60
112_L 136_M 1.079 0.60
196_S 199_Y 1.075 0.60
411_V 471_F 1.068 0.59
7_Y 111_P 1.066 0.59
16_G 19_L 1.066 0.59
6_L 136_M 1.063 0.59
380_D 390_I 1.061 0.58
128_F 132_V 1.061 0.58
320_V 337_V 1.059 0.58
58_V 280_V 1.057 0.58
399_S 458_R 1.055 0.58
443_C 472_A 1.055 0.58
91_T 117_A 1.048 0.57
102_A 111_P 1.048 0.57
316_E 332_Q 1.047 0.57
420_T 445_E 1.045 0.57
118_A 423_G 1.039 0.56
95_I 144_L 1.032 0.55
290_S 298_V 1.027 0.55
473_D 476_G 1.025 0.54
208_F 213_Y 1.019 0.54
108_E 111_P 1.017 0.54
46_C 75_L 1.012 0.53
117_A 205_M 1.01 0.53
418_K 447_P 1.01 0.53
329_V 342_R 1.008 0.53
95_I 208_F 1.008 0.53
65_R 82_I 1.006 0.52
306_H 350_K 1.006 0.52
295_E 307_K 1.006 0.52
376_Y 465_E 1.005 0.52
18_R 21_P 1.005 0.52
388_K 468_V 1 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x65A20.69461000.553Contact Map0.721
2cu2A10.69671000.562Contact Map0.563
2qh5A20.62971000.719Contact Map0.765
2e3dA40.56491000.848Contact Map0.586
3jukA40.53561000.852Contact Map0.526
2ux8A80.55021000.853Contact Map0.557
4ecmA10.51051000.859Contact Map0.541
1lvwA40.60671000.859Contact Map0.458
1yp2A40.80541000.86Contact Map0.497
3pnnA10.56491000.861Contact Map0.303
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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