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OPENSEQ.org
MUTS - DNA mismatch repair protein MutS
UniProt: P23909 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10625
Length: 853 (848)
Sequences: 2210
Seq/Len: 2.61
MUTS
Paralog alert: 0.06 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
580_I 583_G 5.442 1.00
582_E 643_Q 5.423 1.00
326_Q 569_C 5.213 1.00
322_L 325_Q 5.105 1.00
562_A 638_S 4.98 1.00
457_R 488_N 4.101 1.00
295_L 633_M 3.89 1.00
328_I 558_L 3.61 1.00
430_N 523_L 3.594 1.00
571_T 646_E 3.466 1.00
579_R 646_E 3.434 1.00
329_G 569_C 3.384 1.00
631_A 650_I 3.363 1.00
96_I 109_K 3.318 1.00
318_T 322_L 3.239 1.00
833_D 836_S 3.135 1.00
50_L 86_Q 3.068 1.00
573_I 646_E 3.061 1.00
482_S 501_Y 2.934 1.00
581_T 644_K 2.925 1.00
24_H 110_V 2.924 1.00
435_E 512_K 2.921 1.00
405_D 409_R 2.87 1.00
558_L 638_S 2.833 1.00
76_V 80_L 2.825 1.00
651_D 685_T 2.775 1.00
428_G 434_D 2.693 1.00
279_I 311_L 2.658 1.00
292_A 296_D 2.638 1.00
572_F 647_I 2.624 1.00
812_Q 816_L 2.576 1.00
845_W 848_R 2.536 1.00
477_I 485_A 2.533 1.00
94_E 111_V 2.496 1.00
50_L 88_E 2.49 1.00
412_I 415_P 2.481 1.00
274_R 279_I 2.439 1.00
329_G 639_Y 2.433 1.00
630_I 640_V 2.399 1.00
581_T 600_P 2.329 1.00
279_I 636_I 2.317 1.00
310_W 555_L 2.313 1.00
325_Q 329_G 2.308 1.00
583_G 630_I 2.263 1.00
828_A 848_R 2.261 1.00
632_L 653_I 2.26 1.00
46_R 88_E 2.194 1.00
571_T 644_K 2.177 1.00
828_A 852_L 2.158 1.00
322_L 569_C 2.155 1.00
297_C 564_T 2.152 1.00
42_D 45_K 2.129 1.00
413_D 426_A 2.127 1.00
601_L 627_T 2.098 1.00
155_F 237_A 2.089 1.00
147_T 173_T 2.066 1.00
609_M 712_A 2.059 1.00
325_Q 572_F 2.052 1.00
325_Q 569_C 2.04 1.00
346_G 371_A 2.022 1.00
679_N 683_N 2.012 0.99
339_Q 556_V 1.997 0.99
681_L 785_V 1.989 0.99
812_Q 815_L 1.978 0.99
320_V 323_E 1.969 0.99
97_G 107_E 1.957 0.99
449_R 453_R 1.954 0.99
338_L 378_L 1.944 0.99
326_Q 329_G 1.933 0.99
318_T 572_F 1.923 0.99
581_T 643_Q 1.92 0.99
158_S 261_E 1.918 0.99
582_E 600_P 1.913 0.99
98_D 102_S 1.907 0.99
690_V 721_A 1.883 0.99
373_Q 408_E 1.876 0.99
579_R 602_N 1.872 0.99
612_I 724_L 1.872 0.99
134_A 170_L 1.871 0.99
280_T 312_H 1.867 0.99
30_F 76_V 1.853 0.99
410_A 429_Y 1.845 0.99
690_V 715_L 1.836 0.99
828_A 845_W 1.832 0.99
534_L 537_P 1.824 0.99
832_L 837_L 1.822 0.99
335_T 563_Y 1.821 0.99
715_L 719_I 1.819 0.99
837_L 845_W 1.814 0.99
431_E 435_E 1.813 0.99
204_F 239_C 1.794 0.99
788_R 791_Q 1.789 0.99
567_Y 633_M 1.781 0.98
479_R 482_S 1.772 0.98
840_R 844_E 1.768 0.98
452_V 456_E 1.757 0.98
504_P 508_E 1.755 0.98
269_M 273_T 1.755 0.98
823_S 826_V 1.75 0.98
144_G 236_A 1.746 0.98
330_A 387_S 1.743 0.98
608_R 741_G 1.741 0.98
445_D 449_R 1.739 0.98
686_E 720_K 1.726 0.98
580_I 630_I 1.726 0.98
631_A 689_L 1.726 0.98
19_R 23_Q 1.72 0.98
411_I 531_L 1.718 0.98
457_R 489_Y 1.705 0.98
739_M 742_V 1.705 0.98
318_T 649_P 1.688 0.98
462_T 480_G 1.683 0.98
707_L 711_C 1.675 0.97
268_I 652_R 1.675 0.97
623_Y 762_V 1.674 0.97
298_T 304_S 1.672 0.97
148_L 244_A 1.668 0.97
453_R 505_E 1.665 0.97
325_Q 328_I 1.663 0.97
369_R 408_E 1.66 0.97
611_I 742_V 1.659 0.97
565_L 590_Q 1.655 0.97
835_D 847_Y 1.646 0.97
406_L 531_L 1.644 0.97
282_N 290_T 1.612 0.97
306_M 550_A 1.609 0.97
406_L 534_L 1.602 0.96
299_V 339_Q 1.601 0.96
317_D 320_V 1.6 0.96
560_E 564_T 1.592 0.96
331_L 338_L 1.584 0.96
24_H 113_I 1.584 0.96
339_Q 560_E 1.582 0.96
558_L 636_I 1.577 0.96
16_Q 31_Y 1.576 0.96
828_A 849_L 1.573 0.96
57_K 65_P 1.57 0.96
134_A 173_T 1.57 0.96
832_L 845_W 1.56 0.96
407_L 411_I 1.557 0.96
827_E 831_N 1.555 0.96
310_W 554_V 1.553 0.96
442_G 445_D 1.546 0.95
323_E 392_A 1.546 0.95
438_A 442_G 1.543 0.95
403_L 535_L 1.543 0.95
677_T 692_M 1.536 0.95
584_R 589_E 1.534 0.95
677_T 711_C 1.525 0.95
345_V 549_L 1.524 0.95
267_I 316_R 1.524 0.95
322_L 571_T 1.518 0.95
579_R 644_K 1.518 0.95
433_L 520_A 1.518 0.95
212_Q 245_K 1.501 0.94
716_A 739_M 1.499 0.94
47_A 53_I 1.491 0.94
369_R 407_L 1.489 0.94
15_Q 19_R 1.488 0.94
318_T 574_D 1.477 0.94
538_H 541_A 1.477 0.94
28_L 39_L 1.475 0.94
39_L 47_A 1.474 0.94
299_V 343_R 1.473 0.94
148_L 255_I 1.469 0.94
46_R 50_L 1.467 0.93
341_V 378_L 1.466 0.93
427_S 438_A 1.463 0.93
128_R 304_S 1.46 0.93
328_I 559_A 1.457 0.93
322_L 326_Q 1.456 0.93
841_Q 844_E 1.44 0.93
159_E 233_G 1.439 0.93
80_L 114_V 1.438 0.93
491_R 499_E 1.436 0.93
48_S 55_L 1.434 0.92
692_M 695_I 1.433 0.92
371_A 549_L 1.429 0.92
748_D 763_Q 1.424 0.92
128_R 296_D 1.422 0.92
444_T 517_K 1.422 0.92
21_K 43_D 1.418 0.92
18_L 41_Y 1.417 0.92
628_A 691_L 1.414 0.92
840_R 847_Y 1.408 0.92
39_L 69_A 1.408 0.92
530_E 534_L 1.404 0.91
716_A 741_G 1.386 0.91
315_V 321_L 1.383 0.91
460_L 477_I 1.382 0.90
30_F 39_L 1.38 0.90
475_I 489_Y 1.38 0.90
295_L 561_R 1.372 0.90
378_L 549_L 1.371 0.90
84_V 114_V 1.37 0.90
813_M 816_L 1.367 0.90
526_Q 530_E 1.363 0.90
265_D 317_D 1.362 0.90
211_Q 215_L 1.358 0.89
60_A 64_E 1.357 0.89
389_P 551_E 1.354 0.89
327_T 555_L 1.354 0.89
713_E 788_R 1.348 0.89
842_A 846_I 1.346 0.89
169_E 172_R 1.344 0.89
835_D 840_R 1.343 0.89
746_H 749_A 1.342 0.89
134_A 147_T 1.34 0.89
133_L 240_L 1.336 0.88
10_H 18_L 1.327 0.88
344_Q 374_Q 1.326 0.88
578_I 631_A 1.323 0.88
366_A 370_H 1.323 0.88
788_R 792_K 1.323 0.88
610_L 745_V 1.322 0.88
745_V 764_D 1.31 0.87
581_T 602_N 1.309 0.87
366_A 369_R 1.309 0.87
635_Y 650_I 1.308 0.87
454_E 457_R 1.302 0.87
848_R 851_S 1.301 0.87
13_M 68_M 1.298 0.86
783_K 787_K 1.295 0.86
774_A 790_R 1.282 0.85
234_L 238_G 1.28 0.85
572_F 575_K 1.279 0.85
327_T 389_P 1.275 0.85
481_Q 484_L 1.272 0.85
502_I 507_K 1.271 0.85
561_R 565_L 1.27 0.85
846_I 849_L 1.267 0.85
410_A 531_L 1.264 0.84
360_A 364_D 1.257 0.84
601_L 623_Y 1.255 0.84
315_V 320_V 1.254 0.84
454_E 489_Y 1.251 0.84
615_P 626_Q 1.248 0.83
134_A 178_L 1.246 0.83
582_E 761_S 1.245 0.83
321_L 572_F 1.243 0.83
835_D 850_K 1.242 0.83
398_G 541_A 1.239 0.83
402_E 541_A 1.235 0.82
32_R 73_Y 1.235 0.82
297_C 561_R 1.231 0.82
662_D 667_R 1.229 0.82
30_F 71_I 1.225 0.82
844_E 847_Y 1.222 0.82
311_L 636_I 1.222 0.82
310_W 315_V 1.221 0.81
706_S 709_W 1.22 0.81
754_D 790_R 1.216 0.81
406_L 410_A 1.216 0.81
746_H 763_Q 1.215 0.81
199_R 203_E 1.212 0.81
572_F 648_G 1.211 0.81
36_F 70_G 1.209 0.81
427_S 437_R 1.206 0.80
71_I 76_V 1.205 0.80
528_Y 532_F 1.203 0.80
362_P 424_V 1.202 0.80
98_D 101_T 1.201 0.80
834_P 844_E 1.198 0.80
366_A 415_P 1.196 0.80
466_G 474_Y 1.193 0.79
57_K 60_A 1.19 0.79
38_E 70_G 1.188 0.79
33_M 54_S 1.181 0.78
100_A 107_E 1.178 0.78
648_G 722_L 1.177 0.78
574_D 687_Y 1.175 0.78
848_R 852_L 1.173 0.78
155_F 217_F 1.171 0.78
266_S 313_M 1.167 0.77
33_M 58_R 1.166 0.77
126_Q 129_Q 1.165 0.77
98_D 106_V 1.164 0.77
274_R 280_T 1.164 0.77
51_L 83_L 1.162 0.77
836_S 841_Q 1.162 0.77
577_G 646_E 1.16 0.77
306_M 554_V 1.159 0.77
677_T 695_I 1.156 0.76
829_L 836_S 1.155 0.76
702_Y 797_E 1.155 0.76
829_L 832_L 1.153 0.76
295_L 636_I 1.15 0.76
302_M 550_A 1.147 0.76
345_V 371_A 1.145 0.75
523_L 526_Q 1.136 0.75
583_G 626_Q 1.135 0.74
61_S 65_P 1.132 0.74
210_R 214_N 1.131 0.74
281_Q 285_G 1.13 0.74
412_I 416_P 1.127 0.74
826_V 830_E 1.124 0.73
328_I 639_Y 1.117 0.73
835_D 843_L 1.115 0.73
146_A 236_A 1.112 0.72
41_Y 66_I 1.112 0.72
91_A 113_I 1.111 0.72
358_R 533_D 1.109 0.72
46_R 49_Q 1.109 0.72
135_A 204_F 1.108 0.72
13_M 33_M 1.103 0.71
845_W 849_L 1.101 0.71
159_E 230_A 1.101 0.71
777_A 786_I 1.097 0.71
582_E 598_A 1.094 0.71
32_R 94_E 1.093 0.70
282_N 286_G 1.09 0.70
325_Q 558_L 1.087 0.70
145_Y 169_E 1.086 0.70
589_E 630_I 1.082 0.69
450_L 453_R 1.079 0.69
28_L 47_A 1.078 0.69
678_A 682_H 1.074 0.68
849_L 852_L 1.072 0.68
634_A 640_V 1.071 0.68
373_Q 404_R 1.07 0.68
782_P 785_V 1.064 0.67
134_A 145_Y 1.064 0.67
99_P 106_V 1.063 0.67
68_M 71_I 1.062 0.67
733_T 766_A 1.061 0.67
786_I 790_R 1.06 0.67
144_G 159_E 1.059 0.67
713_E 717_N 1.059 0.67
31_Y 58_R 1.059 0.67
792_K 796_L 1.057 0.67
453_R 457_R 1.055 0.66
30_F 69_A 1.05 0.66
655_T 691_L 1.05 0.66
834_P 850_K 1.044 0.65
451_E 455_R 1.042 0.65
119_I 125_L 1.041 0.65
657_V 730_F 1.04 0.65
318_T 325_Q 1.038 0.65
612_I 762_V 1.037 0.65
684_A 721_A 1.037 0.65
635_Y 649_P 1.034 0.64
791_Q 795_E 1.033 0.64
834_P 852_L 1.029 0.64
736_P 764_D 1.027 0.63
20_L 110_V 1.026 0.63
835_D 844_E 1.026 0.63
834_P 840_R 1.025 0.63
24_H 27_I 1.024 0.63
607_R 764_D 1.023 0.63
439_L 446_Y 1.022 0.63
75_A 78_N 1.018 0.62
573_I 648_G 1.017 0.62
792_K 795_E 1.014 0.62
525_K 532_F 1.013 0.62
576_P 722_L 1.011 0.62
17_Y 33_M 1.01 0.62
755_T 777_A 1.01 0.62
316_R 649_P 1.009 0.61
734_Q 737_E 1.006 0.61
706_S 746_H 1.001 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wb9A20.93791000.232Contact Map0.776
3thxA10.98591000.275Contact Map0.67
2o8bB10.9661000.279Contact Map0.69
1ewqA20.88511000.288Contact Map0.781
3thxB10.96831000.297Contact Map0.743
2i3bA10.157198.60.96Contact Map0.167
2r8rA20.243898.60.96Contact Map0.201
2px0A80.332998.50.962Contact Map0.165
1ye8A10.146598.50.962Contact Map0.182
2orwA20.185298.40.962Contact Map0.462
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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