| UniProt: | P23894 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10462 | ||
| Length: | 293 (258) | ||
| Sequences: | 1636 | ||
| Seq/Len: | 6.34 |
| HTPX
Paralog alert: 0.18 [within 20: 0.00] - ratio of genomes with paralogs |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 243_Q | 287_R | 4.831 | 1.00 | |
| 100_H | 122_T | 4.311 | 1.00 | |
| 142_S | 228_G | 4.071 | 1.00 | |
| 112_R | 115_A | 3.682 | 1.00 | |
| 84_T | 134_E | 3.657 | 1.00 | |
| 223_F | 281_K | 3.587 | 1.00 | |
| 138_A | 229_S | 3.479 | 1.00 | |
| 120_V | 137_I | 2.964 | 1.00 | |
| 131_D | 235_R | 2.889 | 1.00 | |
| 64_G | 97_A | 2.875 | 1.00 | |
| 230_A | 286_L | 2.811 | 1.00 | |
| 69_Q | 83_A | 2.765 | 1.00 | |
| 229_S | 233_V | 2.609 | 1.00 | |
| 227_A | 231_K | 2.6 | 1.00 | |
| 79_V | 93_M | 2.579 | 1.00 | |
| 281_K | 284_E | 2.455 | 1.00 | |
| 243_Q | 283_I | 2.253 | 1.00 | |
| 83_A | 87_R | 2.082 | 1.00 | |
| 128_M | 245_L | 2.078 | 1.00 | |
| 77_W | 130_P | 2.036 | 1.00 | |
| 132_E | 244_R | 2.03 | 1.00 | |
| 271_E | 281_K | 1.967 | 1.00 | |
| 211_S | 215_M | 1.926 | 1.00 | |
| 233_V | 237_K | 1.915 | 1.00 | |
| 102_P | 126_Q | 1.789 | 1.00 | |
| 246_K | 280_D | 1.732 | 1.00 | |
| 246_K | 279_L | 1.731 | 1.00 | |
| 124_L | 133_A | 1.681 | 1.00 | |
| 66_V | 95_Q | 1.659 | 1.00 | |
| 82_V | 96_V | 1.643 | 1.00 | |
| 78_L | 120_V | 1.643 | 1.00 | |
| 45_G | 49_V | 1.635 | 1.00 | |
| 131_D | 237_K | 1.631 | 1.00 | |
| 236_E | 287_R | 1.622 | 1.00 | |
| 41_L | 45_G | 1.59 | 0.99 | |
| 129_S | 244_R | 1.585 | 0.99 | |
| 239_I | 283_I | 1.566 | 0.99 | |
| 134_E | 235_R | 1.554 | 0.99 | |
| 278_P | 281_K | 1.553 | 0.99 | |
| 127_N | 248_S | 1.532 | 0.99 | |
| 116_S | 144_I | 1.503 | 0.99 | |
| 83_A | 93_M | 1.498 | 0.99 | |
| 66_V | 97_A | 1.486 | 0.99 | |
| 56_W | 60_R | 1.452 | 0.99 | |
| 85_Q | 141_I | 1.439 | 0.99 | |
| 65_E | 100_H | 1.431 | 0.99 | |
| 240_A | 244_R | 1.383 | 0.98 | |
| 91_I | 141_I | 1.375 | 0.98 | |
| 147_G | 150_V | 1.375 | 0.98 | |
| 213_I | 217_F | 1.371 | 0.98 | |
| 129_S | 240_A | 1.37 | 0.98 | |
| 283_I | 287_R | 1.37 | 0.98 | |
| 120_V | 125_L | 1.346 | 0.98 | |
| 80_N | 83_A | 1.342 | 0.98 | |
| 75_E | 98_I | 1.339 | 0.98 | |
| 52_L | 111_A | 1.336 | 0.98 | |
| 39_A | 164_I | 1.322 | 0.97 | |
| 62_V | 261_C | 1.32 | 0.97 | |
| 89_A | 232_L | 1.296 | 0.97 | |
| 236_E | 240_A | 1.289 | 0.97 | |
| 67_I | 78_L | 1.288 | 0.97 | |
| 138_A | 232_L | 1.288 | 0.97 | |
| 40_L | 44_F | 1.276 | 0.97 | |
| 81_T | 134_E | 1.27 | 0.97 | |
| 141_I | 144_I | 1.24 | 0.96 | |
| 167_S | 170_L | 1.198 | 0.95 | |
| 97_A | 117_L | 1.19 | 0.95 | |
| 139_H | 222_E | 1.183 | 0.94 | |
| 85_Q | 232_L | 1.176 | 0.94 | |
| 68_E | 79_V | 1.176 | 0.94 | |
| 69_Q | 80_N | 1.166 | 0.94 | |
| 99_Y | 119_A | 1.157 | 0.93 | |
| 31_S | 34_G | 1.153 | 0.93 | |
| 102_P | 122_T | 1.146 | 0.93 | |
| 125_L | 133_A | 1.123 | 0.92 | |
| 220_H | 224_H | 1.12 | 0.92 | |
| 284_E | 288_T | 1.113 | 0.92 | |
| 81_T | 130_P | 1.11 | 0.91 | |
| 167_S | 199_A | 1.107 | 0.91 | |
| 118_V | 229_S | 1.104 | 0.91 | |
| 124_L | 128_M | 1.101 | 0.91 | |
| 67_I | 98_I | 1.1 | 0.91 | |
| 263_N | 266_S | 1.096 | 0.91 | |
| 80_N | 84_T | 1.095 | 0.91 | |
| 152_M | 155_I | 1.095 | 0.91 | |
| 86_A | 141_I | 1.094 | 0.91 | |
| 202_L | 205_V | 1.084 | 0.90 | |
| 258_M | 265_K | 1.075 | 0.90 | |
| 98_I | 288_T | 1.074 | 0.90 | |
| 227_A | 285_A | 1.073 | 0.90 | |
| 112_R | 116_S | 1.066 | 0.89 | |
| 69_Q | 76_R | 1.057 | 0.89 | |
| 146_N | 228_G | 1.056 | 0.89 | |
| 93_M | 96_V | 1.054 | 0.88 | |
| 142_S | 232_L | 1.041 | 0.88 | |
| 55_K | 95_Q | 1.036 | 0.87 | |
| 139_H | 225_A | 1.035 | 0.87 | |
| 91_I | 145_A | 1.025 | 0.86 | |
| 187_E | 190_G | 1.018 | 0.86 | |
| 78_L | 137_I | 1.014 | 0.86 | |
| 31_S | 35_L | 1.011 | 0.85 | |
| 104_I | 127_N | 1.011 | 0.85 | |
| 80_N | 130_P | 1.007 | 0.85 | |
| 135_A | 237_K | 1.007 | 0.85 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4aw6A | 4 | 0.901 | 100 | 0.401 | Contact Map | 0.533 |
| 4il3A | 2 | 0.9113 | 100 | 0.41 | Contact Map | 0.629 |
| 3c37A | 2 | 0.7235 | 100 | 0.611 | Contact Map | 0.543 |
| 3cqbA | 2 | 0.3652 | 99.9 | 0.696 | Contact Map | 0.675 |
| 4jixA | 2 | 0.3652 | 94.2 | 0.924 | Contact Map | 0.568 |
| 4jiuA | 1 | 0.3311 | 90.9 | 0.932 | Contact Map | 0.666 |
| 4ev6A | 5 | 0.2048 | 29.2 | 0.958 | Contact Map | 0.475 |
| 4i0uA | 10 | 0.2048 | 27.2 | 0.959 | Contact Map | 0.4 |
| 4f42A | 1 | 0.3038 | 15.4 | 0.964 | Contact Map | 0.151 |
| 2of5A | 7 | 0.3515 | 5 | 0.971 | Contact Map | 0.187 |
Sequence Conservation (Image Generated using WebLogo v3)