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OPENSEQ.org
PPSA - Phosphoenolpyruvate synthase
UniProt: P23538 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10759
Length: 792 (785)
Sequences: 1365
Seq/Len: 1.74
PPSA
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
374_V 444_M 6.191 1.00
373_P 390_D 4.775 1.00
735_S 739_R 4.421 1.00
223_S 293_S 4.258 1.00
732_A 740_A 4.167 1.00
750_I 765_L 3.749 1.00
579_L 645_I 3.682 1.00
410_A 452_V 3.299 1.00
681_I 708_L 3.022 1.00
118_D 158_V 2.986 1.00
655_K 694_Y 2.96 1.00
500_A 573_K 2.922 1.00
607_F 617_S 2.706 1.00
690_Q 732_A 2.702 1.00
444_M 464_A 2.691 1.00
690_Q 728_D 2.676 1.00
484_L 766_M 2.656 1.00
738_I 748_V 2.64 1.00
689_E 740_A 2.613 1.00
629_V 643_I 2.513 1.00
568_A 635_D 2.5 1.00
200_L 327_T 2.466 1.00
230_M 281_I 2.465 1.00
449_N 466_L 2.446 1.00
124_F 134_D 2.393 1.00
667_K 670_E 2.384 1.00
266_R 282_E 2.378 1.00
301_E 304_K 2.359 1.00
537_L 541_I 2.348 1.00
734_L 768_E 2.339 1.00
683_S 729_A 2.315 1.00
208_S 319_I 2.185 0.99
304_K 308_Q 2.144 0.99
622_F 657_V 2.142 0.99
374_V 464_A 2.13 0.99
686_L 733_L 2.102 0.99
662_A 667_K 2.096 0.99
357_K 464_A 2.085 0.99
570_F 575_V 2.076 0.99
615_S 622_F 2.056 0.99
507_V 570_F 2.055 0.99
391_V 450_V 2.048 0.99
690_Q 693_E 2.046 0.99
379_D 382_E 2.028 0.99
266_R 288_Q 2.003 0.99
689_E 743_K 2.002 0.99
487_M 642_E 1.996 0.99
652_D 655_K 1.99 0.99
382_E 385_R 1.989 0.99
358_I 463_Y 1.971 0.98
735_S 768_E 1.954 0.98
651_V 694_Y 1.95 0.98
322_A 333_V 1.924 0.98
693_E 744_Q 1.907 0.98
83_Q 87_A 1.891 0.98
382_E 446_D 1.889 0.98
412_V 452_V 1.886 0.98
734_L 765_L 1.878 0.98
301_E 329_K 1.876 0.98
642_E 674_K 1.867 0.97
374_V 393_V 1.856 0.97
285_P 288_Q 1.851 0.97
8_P 15_Q 1.834 0.97
373_P 449_N 1.829 0.97
225_W 284_V 1.827 0.97
739_R 743_K 1.816 0.97
298_E 323_K 1.796 0.97
732_A 736_M 1.789 0.97
485_K 505_E 1.779 0.96
381_S 403_P 1.76 0.96
632_V 641_V 1.75 0.96
497_F 501_C 1.741 0.96
360_A 437_C 1.734 0.96
363_R 418_R 1.729 0.96
732_A 735_S 1.721 0.95
566_L 575_V 1.714 0.95
350_Y 451_T 1.712 0.95
735_S 767_E 1.709 0.95
361_E 461_Y 1.706 0.95
442_E 464_A 1.694 0.95
360_A 444_M 1.689 0.95
496_A 570_F 1.687 0.95
496_A 575_V 1.679 0.95
93_Q 97_D 1.67 0.94
206_M 302_L 1.665 0.94
131_T 134_D 1.659 0.94
679_C 737_A 1.654 0.94
177_V 183_H 1.651 0.94
105_E 109_R 1.65 0.94
627_E 663_R 1.63 0.93
486_V 773_L 1.627 0.93
374_V 450_V 1.612 0.93
658_V 694_Y 1.612 0.93
737_A 748_V 1.608 0.93
218_V 306_A 1.588 0.92
696_D 745_G 1.579 0.92
579_L 629_V 1.577 0.92
359_I 444_M 1.577 0.92
69_I 160_V 1.576 0.92
265_I 268_V 1.573 0.92
763_A 767_E 1.57 0.92
22_D 90_Q 1.557 0.91
210_D 217_Q 1.55 0.91
124_F 131_T 1.548 0.91
654_A 694_Y 1.54 0.90
538_Q 542_R 1.536 0.90
90_Q 186_V 1.532 0.90
69_I 157_L 1.529 0.90
58_Q 62_Q 1.521 0.90
354_S 468_E 1.515 0.90
439_D 443_R 1.514 0.89
182_D 185_G 1.502 0.89
405_M 411_I 1.501 0.89
567_G 641_V 1.487 0.88
203_S 231_V 1.485 0.88
550_S 553_E 1.475 0.88
67_Q 71_E 1.473 0.88
327_T 331_F 1.465 0.87
654_A 668_R 1.457 0.87
209_I 216_D 1.455 0.87
709_A 730_V 1.455 0.87
360_A 462_V 1.452 0.87
300_Q 304_K 1.45 0.87
23_R 54_D 1.446 0.86
161_K 165_A 1.439 0.86
687_L 690_Q 1.439 0.86
391_V 410_A 1.439 0.86
659_E 663_R 1.437 0.86
126_V 130_A 1.435 0.86
169_N 173_I 1.434 0.86
563_I 643_I 1.431 0.86
69_I 91_I 1.425 0.85
317_M 335_A 1.42 0.85
507_V 566_L 1.418 0.85
126_V 129_S 1.415 0.85
649_R 681_I 1.413 0.85
364_A 418_R 1.409 0.84
9_L 68_R 1.406 0.84
102_P 105_E 1.404 0.84
576_I 747_Y 1.403 0.84
71_E 75_K 1.403 0.84
500_A 569_A 1.402 0.84
206_M 319_I 1.4 0.84
530_F 542_R 1.398 0.84
555_Y 631_R 1.396 0.84
450_V 462_V 1.396 0.84
64_G 67_Q 1.395 0.84
757_D 760_D 1.393 0.83
130_A 134_D 1.391 0.83
371_A 466_L 1.383 0.83
483_P 766_M 1.374 0.82
317_M 337_P 1.372 0.82
61_D 66_N 1.37 0.82
538_Q 623_A 1.364 0.82
282_E 288_Q 1.362 0.82
218_V 302_L 1.358 0.81
654_A 695_F 1.351 0.81
353_H 470_S 1.343 0.80
249_A 311_K 1.34 0.80
482_L 505_E 1.337 0.80
14_N 47_N 1.333 0.80
651_V 690_Q 1.331 0.79
224_A 231_V 1.33 0.79
50_A 189_S 1.328 0.79
90_Q 182_D 1.327 0.79
557_G 569_A 1.326 0.79
660_E 663_R 1.325 0.79
68_R 71_E 1.319 0.79
395_D 414_N 1.316 0.78
649_R 710_L 1.316 0.78
17_G 36_T 1.312 0.78
386_I 390_D 1.31 0.78
741_A 746_K 1.308 0.78
626_C 630_K 1.306 0.78
742_K 771_D 1.304 0.78
445_K 448_E 1.294 0.77
757_D 762_A 1.292 0.77
66_N 70_Y 1.292 0.77
424_I 428_E 1.287 0.76
248_L 323_K 1.285 0.76
106_N 109_R 1.281 0.76
686_L 732_A 1.28 0.76
576_I 697_G 1.28 0.76
348_E 473_S 1.277 0.75
548_F 551_P 1.275 0.75
288_Q 291_I 1.266 0.75
113_A 153_F 1.263 0.74
174_S 178_H 1.261 0.74
126_V 134_D 1.261 0.74
208_S 306_A 1.26 0.74
47_N 194_R 1.26 0.74
375_K 390_D 1.256 0.74
366_G 424_I 1.245 0.73
740_A 743_K 1.244 0.73
649_R 712_L 1.243 0.73
377_I 386_I 1.24 0.72
286_Q 290_D 1.24 0.72
734_L 737_A 1.235 0.72
41_M 308_Q 1.231 0.72
633_R 666_L 1.231 0.72
96_I 162_H 1.225 0.71
93_Q 98_T 1.223 0.71
375_K 387_E 1.223 0.71
158_V 162_H 1.223 0.71
541_I 623_A 1.222 0.71
193_Q 747_Y 1.221 0.71
651_V 665_G 1.22 0.71
58_Q 61_D 1.216 0.70
241_F 293_S 1.214 0.70
661_L 671_N 1.212 0.70
498_D 501_C 1.207 0.69
338_E 342_S 1.205 0.69
696_D 746_K 1.203 0.69
244_H 247_T 1.201 0.69
645_I 657_V 1.199 0.69
661_L 664_Q 1.197 0.68
63_S 98_T 1.197 0.68
655_K 659_E 1.196 0.68
353_H 462_V 1.192 0.68
682_P 711_G 1.192 0.68
531_D 538_Q 1.192 0.68
29_A 33_E 1.188 0.68
444_M 448_E 1.183 0.67
154_D 158_V 1.182 0.67
656_A 726_R 1.178 0.67
133_E 136_P 1.176 0.67
384_N 403_P 1.174 0.66
648_V 654_A 1.171 0.66
33_E 312_H 1.17 0.66
734_L 750_I 1.168 0.66
9_L 58_Q 1.167 0.66
650_T 687_L 1.164 0.65
91_I 186_V 1.162 0.65
559_L 563_I 1.159 0.65
412_V 434_V 1.156 0.65
540_E 543_E 1.154 0.64
560_T 631_R 1.15 0.64
54_D 58_Q 1.15 0.64
415_R 434_V 1.149 0.64
522_V 554_F 1.145 0.63
610_A 657_V 1.143 0.63
488_M 499_F 1.142 0.63
21_V 319_I 1.141 0.63
639_T 671_N 1.141 0.63
402_E 429_L 1.134 0.62
98_T 115_L 1.129 0.62
658_V 696_D 1.129 0.62
567_G 632_V 1.128 0.62
107_A 110_E 1.127 0.62
651_V 693_E 1.126 0.62
496_A 566_L 1.125 0.61
83_Q 86_K 1.124 0.61
10_V 69_I 1.117 0.61
692_L 746_K 1.116 0.61
577_V 641_V 1.112 0.60
210_D 218_V 1.11 0.60
223_S 241_F 1.108 0.60
65_V 470_S 1.108 0.60
319_I 332_I 1.108 0.60
616_D 619_R 1.108 0.60
302_L 306_A 1.106 0.60
536_Q 539_N 1.106 0.60
651_V 687_L 1.106 0.60
174_S 402_E 1.103 0.59
23_R 52_T 1.1 0.59
358_I 467_L 1.098 0.59
16_L 20_D 1.098 0.59
150_V 159_A 1.095 0.58
18_M 21_V 1.092 0.58
100_F 108_I 1.091 0.58
731_K 764_W 1.091 0.58
44_S 329_K 1.087 0.58
556_V 635_D 1.086 0.57
168_F 173_I 1.084 0.57
57_N 185_G 1.083 0.57
662_A 670_E 1.082 0.57
385_R 446_D 1.08 0.57
309_I 332_I 1.079 0.57
525_R 528_L 1.078 0.57
556_V 568_A 1.078 0.57
764_W 768_E 1.074 0.56
391_V 452_V 1.073 0.56
444_M 450_V 1.07 0.56
448_E 464_A 1.068 0.56
593_G 597_E 1.068 0.56
393_V 444_M 1.066 0.55
44_S 301_E 1.066 0.55
486_V 787_L 1.063 0.55
692_L 747_Y 1.062 0.55
221_I 239_D 1.062 0.55
521_G 554_F 1.061 0.55
679_C 685_A 1.06 0.55
207_F 318_D 1.056 0.54
661_L 666_L 1.053 0.54
507_V 569_A 1.053 0.54
239_D 243_V 1.052 0.54
514_F 517_N 1.047 0.53
135_M 172_A 1.045 0.53
29_A 313_Y 1.045 0.53
651_V 655_K 1.043 0.53
432_P 452_V 1.039 0.52
728_D 732_A 1.038 0.52
736_M 740_A 1.037 0.52
174_S 403_P 1.035 0.52
126_V 131_T 1.033 0.52
359_I 442_E 1.031 0.52
553_E 557_G 1.031 0.52
22_D 57_N 1.029 0.51
633_R 639_T 1.028 0.51
632_V 638_L 1.026 0.51
753_Q 776_N 1.026 0.51
106_N 110_E 1.023 0.51
306_A 319_I 1.022 0.51
536_Q 540_E 1.02 0.50
158_V 161_K 1.019 0.50
241_F 294_L 1.019 0.50
494_D 518_R 1.018 0.50
395_D 415_R 1.018 0.50
216_D 306_A 1.017 0.50
622_F 626_C 1.016 0.50
358_I 461_Y 1.016 0.50
138_A 173_I 1.016 0.50
574_R 674_K 1.016 0.50
709_A 733_L 1.014 0.50
627_E 634_N 1.014 0.50
634_N 671_N 1.014 0.50
225_W 291_I 1.013 0.50
583_K 586_E 1.013 0.50
556_V 632_V 1.011 0.49
648_V 738_I 1.011 0.49
631_R 660_E 1.009 0.49
634_N 666_L 1.008 0.49
448_E 566_L 1.008 0.49
51_T 187_A 1.008 0.49
650_T 710_L 1.006 0.49
681_I 711_G 1.006 0.49
219_V 243_V 1.006 0.49
110_E 114_Q 1.006 0.49
12_W 15_Q 1.005 0.49
57_N 61_D 1.005 0.49
308_Q 311_K 1.005 0.49
155_A 159_A 1.005 0.49
498_D 778_D 1.002 0.48
504_N 573_K 1 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2olsA10.99491000.249Contact Map0.583
1h6zA10.91791000.348Contact Map0.496
1vbgA10.88891000.349Contact Map0.596
1kblA10.88761000.362Contact Map0.617
2hwgA20.61991000.693Contact Map0.666
2wqdA10.61241000.699Contact Map0.561
2xz9A20.36111000.809Contact Map0.666
3t05A40.48861000.897Contact Map0.599
2e28A10.48991000.902Contact Map0.615
3qz6A10.28031000.903Contact Map0.423
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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