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OPENSEQ.org
MUTL - DNA mismatch repair protein MutL
UniProt: P23367 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11281
Length: 615 (607)
Sequences: 1532
Seq/Len: 2.52
MUTL
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_T 59_N 7.292 1.00
35_L 185_V 6.101 1.00
27_V 54_I 3.407 1.00
44_I 175_I 3.362 1.00
107_R 149_D 3.35 1.00
64_K 67_E 3.348 1.00
38_G 61_C 3.202 1.00
235_T 293_E 3.169 1.00
113_R 141_V 3.137 1.00
68_L 112_S 3.106 1.00
72_L 108_L 2.911 1.00
447_A 577_A 2.651 1.00
114_T 117_Q 2.509 1.00
441_I 460_L 2.46 1.00
563_R 567_S 2.419 1.00
468_R 565_L 2.412 1.00
115_A 141_V 2.372 1.00
63_I 68_L 2.354 1.00
536_Q 540_P 2.281 1.00
272_I 288_F 2.267 1.00
46_I 171_I 2.266 1.00
448_L 455_I 2.256 1.00
45_D 55_R 2.253 1.00
63_I 67_E 2.234 1.00
122_Q 135_K 2.209 1.00
299_V 310_V 2.192 1.00
4_Q 81_A 2.186 1.00
168_F 191_H 2.16 1.00
68_L 121_W 2.15 1.00
445_D 568_E 2.121 1.00
27_V 171_I 2.107 1.00
31_V 175_I 2.096 1.00
127_G 152_Y 2.09 1.00
111_T 137_A 2.09 1.00
28_K 32_E 2.078 1.00
237_R 293_E 2.011 0.99
46_I 168_F 2.007 0.99
107_R 126_E 2.006 0.99
109_T 122_Q 2.004 0.99
461_P 596_P 1.966 0.99
256_C 272_I 1.949 0.99
5_V 73_A 1.93 0.99
41_R 59_N 1.929 0.99
26_V 150_L 1.922 0.99
7_P 10_L 1.918 0.99
216_C 255_Y 1.916 0.99
53_L 148_L 1.898 0.99
53_L 146_E 1.885 0.99
596_P 601_Q 1.884 0.99
68_L 110_L 1.875 0.99
461_P 594_T 1.874 0.99
594_T 601_Q 1.865 0.99
513_D 525_A 1.861 0.99
112_S 121_W 1.842 0.99
111_T 122_Q 1.839 0.99
47_E 53_L 1.836 0.99
437_R 450_E 1.835 0.99
439_L 455_I 1.828 0.99
166_T 170_H 1.826 0.99
236_L 292_L 1.817 0.99
55_R 144_T 1.815 0.99
465_R 596_P 1.803 0.99
227_I 290_L 1.765 0.98
584_V 591_L 1.751 0.98
448_L 457_L 1.747 0.98
579_T 583_D 1.737 0.98
439_L 448_L 1.716 0.98
228_E 235_T 1.705 0.98
254_Q 288_F 1.705 0.98
72_L 125_A 1.701 0.98
443_H 450_E 1.679 0.97
51_A 164_E 1.679 0.97
92_L 260_G 1.67 0.97
241_A 247_T 1.646 0.97
109_T 146_E 1.646 0.97
465_R 594_T 1.645 0.97
186_T 201_A 1.637 0.97
441_I 572_W 1.621 0.97
212_L 239_W 1.619 0.97
111_T 146_E 1.612 0.96
295_D 298_Q 1.611 0.96
270_H 319_H 1.59 0.96
41_R 186_T 1.582 0.96
265_D 315_S 1.581 0.96
461_P 465_R 1.58 0.96
63_I 71_A 1.566 0.96
314_Q 317_L 1.564 0.96
43_D 188_N 1.561 0.95
258_V 312_F 1.561 0.95
573_S 576_Q 1.553 0.95
160_F 312_F 1.546 0.95
461_P 601_Q 1.536 0.95
462_V 465_R 1.528 0.95
45_D 57_R 1.516 0.94
13_Q 104_S 1.5 0.94
470_A 588_C 1.497 0.94
43_D 190_S 1.485 0.94
594_T 597_G 1.485 0.94
111_T 139_H 1.483 0.94
230_Q 235_T 1.483 0.94
560_W 564_N 1.459 0.93
466_W 588_C 1.448 0.92
458_L 581_L 1.446 0.92
459_S 462_V 1.444 0.92
63_I 69_A 1.442 0.92
443_H 454_N 1.441 0.92
48_R 52_K 1.437 0.92
65_K 136_P 1.436 0.92
464_E 565_L 1.431 0.92
20_V 104_S 1.421 0.92
45_D 190_S 1.417 0.91
26_V 147_V 1.408 0.91
493_S 496_E 1.408 0.91
241_A 287_A 1.405 0.91
65_K 121_W 1.403 0.91
63_I 73_A 1.401 0.91
594_T 602_S 1.398 0.91
441_I 577_A 1.396 0.91
114_T 141_V 1.388 0.90
570_A 576_Q 1.387 0.90
481_A 525_A 1.382 0.90
234_L 292_L 1.372 0.90
558_A 563_R 1.371 0.89
471_Q 583_D 1.371 0.89
496_E 547_A 1.367 0.89
2_P 67_E 1.367 0.89
71_A 99_L 1.364 0.89
168_F 196_V 1.358 0.89
123_A 130_M 1.355 0.89
559_Q 563_R 1.35 0.88
596_P 602_S 1.345 0.88
120_A 139_H 1.345 0.88
578_I 582_A 1.345 0.88
560_W 563_R 1.344 0.88
3_I 6_L 1.341 0.88
111_T 120_A 1.336 0.88
105_V 150_L 1.336 0.88
445_D 609_I 1.334 0.88
496_E 540_P 1.329 0.87
505_S 508_A 1.324 0.87
195_I 198_Q 1.313 0.87
51_A 161_L 1.313 0.87
225_L 329_V 1.306 0.86
460_L 572_W 1.304 0.86
72_L 110_L 1.304 0.86
199_Y 211_R 1.301 0.86
31_V 178_I 1.294 0.85
35_L 182_R 1.283 0.85
230_Q 233_D 1.281 0.85
467_L 580_L 1.277 0.84
31_V 187_I 1.275 0.84
175_I 189_L 1.27 0.84
566_M 601_Q 1.268 0.84
438_V 577_A 1.264 0.84
139_H 144_T 1.258 0.83
497_K 521_V 1.25 0.83
555_G 558_A 1.244 0.82
564_N 567_S 1.243 0.82
496_E 544_G 1.242 0.82
207_Q 210_R 1.239 0.82
278_D 593_K 1.237 0.82
572_W 577_A 1.237 0.82
405_Y 408_L 1.236 0.82
555_G 559_Q 1.235 0.82
465_R 601_Q 1.232 0.81
8_P 12_N 1.231 0.81
608_A 611_A 1.23 0.81
465_R 597_G 1.217 0.80
441_I 461_P 1.216 0.80
149_D 152_Y 1.211 0.80
303_V 311_R 1.211 0.80
451_R 454_N 1.205 0.79
523_I 539_I 1.202 0.79
15_A 18_E 1.201 0.79
27_V 175_I 1.199 0.79
489_R 522_T 1.197 0.79
438_V 447_A 1.194 0.79
70_L 73_A 1.192 0.78
292_L 321_F 1.191 0.78
275_A 323_Y 1.181 0.77
515_Q 524_R 1.178 0.77
20_V 101_S 1.171 0.77
112_S 236_L 1.171 0.77
168_F 189_L 1.168 0.76
109_T 148_L 1.168 0.76
13_Q 83_L 1.165 0.76
459_S 596_P 1.162 0.76
461_P 464_E 1.159 0.76
376_Y 379_A 1.158 0.76
447_A 460_L 1.158 0.76
258_V 310_V 1.151 0.75
294_I 331_Q 1.15 0.75
247_T 284_Q 1.15 0.75
163_T 446_C 1.15 0.75
178_I 257_Y 1.146 0.74
454_N 606_H 1.142 0.74
80_I 85_D 1.138 0.74
193_G 280_L 1.136 0.74
461_P 569_H 1.136 0.74
449_L 458_L 1.134 0.73
459_S 594_T 1.132 0.73
504_Q 508_A 1.131 0.73
236_L 321_F 1.123 0.72
446_C 576_Q 1.123 0.72
47_E 52_K 1.121 0.72
441_I 447_A 1.12 0.72
257_Y 291_Y 1.119 0.72
445_D 460_L 1.119 0.72
173_E 176_R 1.118 0.72
504_Q 521_V 1.117 0.72
584_V 588_C 1.111 0.71
534_N 537_I 1.105 0.71
125_A 128_R 1.104 0.70
451_R 606_H 1.102 0.70
465_R 567_S 1.098 0.70
63_I 114_T 1.096 0.70
581_L 585_E 1.094 0.69
15_A 75_H 1.089 0.69
500_L 521_V 1.088 0.69
442_V 448_L 1.086 0.69
212_L 289_V 1.084 0.68
63_I 281_G 1.083 0.68
465_R 602_S 1.081 0.68
102_I 147_V 1.077 0.68
462_V 601_Q 1.075 0.68
444_S 569_H 1.074 0.67
559_Q 564_N 1.073 0.67
228_E 237_R 1.073 0.67
15_A 19_V 1.071 0.67
459_S 465_R 1.066 0.67
566_M 572_W 1.066 0.67
65_K 117_Q 1.065 0.66
444_S 571_Q 1.065 0.66
92_L 182_R 1.062 0.66
20_V 156_A 1.061 0.66
459_S 601_Q 1.06 0.66
57_R 139_H 1.058 0.66
49_G 168_F 1.057 0.66
56_I 145_L 1.055 0.65
108_L 125_A 1.048 0.65
556_N 560_W 1.046 0.64
558_A 561_I 1.046 0.64
584_V 592_V 1.045 0.64
20_V 493_S 1.045 0.64
274_Q 323_Y 1.045 0.64
48_R 164_E 1.044 0.64
464_E 468_R 1.044 0.64
163_T 166_T 1.043 0.64
22_R 156_A 1.042 0.64
179_A 215_I 1.04 0.64
31_V 100_A 1.037 0.63
100_A 103_S 1.036 0.63
501_E 516_S 1.035 0.63
555_G 561_I 1.033 0.63
556_N 559_Q 1.033 0.63
229_W 325_G 1.031 0.63
597_G 602_S 1.029 0.63
126_E 131_N 1.029 0.63
26_V 54_I 1.028 0.62
553_E 556_N 1.027 0.62
188_N 195_I 1.026 0.62
488_L 536_Q 1.023 0.62
242_D 245_H 1.022 0.62
474_P 589_P 1.022 0.62
462_V 603_V 1.021 0.62
460_L 566_M 1.019 0.61
55_R 146_E 1.019 0.61
469_Q 595_P 1.017 0.61
171_I 239_W 1.016 0.61
314_Q 320_D 1.012 0.61
27_V 30_L 1.007 0.60
268_I 272_I 1.006 0.60
561_I 564_N 1.004 0.60
499_A 503_A 1.002 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b63A10.53661000.504Contact Map0.734
3h4lA20.53981000.511Contact Map0.697
3na3A10.55281000.518Contact Map0.718
1h7sA20.53011000.523Contact Map0.741
3cwvA20.51871000.712Contact Map0.566
3kdgA20.29921000.727Contact Map0.665
3ncvA20.33331000.73Contact Map0.631
1kijA20.54471000.743Contact Map0.581
4hy1A20.5481000.743Contact Map0.537
1ei1A20.53981000.746Contact Map0.593
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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