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RIHC - Non-specific ribonucleoside hydrolase RihC
UniProt: P22564 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11082
Length: 304 (300)
Sequences: 1843
Seq/Len: 6.14
RIHC
Paralog alert: 0.64 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: RIHA RIHB RIHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_I 109_D 3.926 1.00
105_L 135_Q 3.617 1.00
4_P 29_D 2.876 1.00
166_I 267_T 2.735 1.00
121_V 238_I 2.638 1.00
134_S 175_C 2.572 1.00
32_L 106_A 2.57 1.00
22_A 238_I 2.473 1.00
174_A 178_R 2.472 1.00
193_Q 286_D 2.437 1.00
133_L 140_K 2.389 1.00
174_A 255_A 2.344 1.00
108_R 132_L 2.322 1.00
35_T 46_T 2.276 1.00
106_A 110_A 2.256 1.00
122_A 148_I 2.25 1.00
243_R 291_G 2.197 1.00
7_L 123_I 2.196 1.00
11_P 49_A 2.183 1.00
66_A 131_L 2.18 1.00
191_T 233_H 2.167 1.00
248_T 286_D 2.156 1.00
3_L 145_R 2.154 1.00
109_D 113_R 2.115 1.00
132_L 136_C 2.065 1.00
31_Q 118_V 2.056 1.00
108_R 136_C 2.055 1.00
8_D 128_N 2.042 1.00
19_I 33_M 2.01 1.00
23_I 30_L 1.996 1.00
112_M 136_C 1.956 1.00
6_F 34_T 1.934 1.00
122_A 129_I 1.911 1.00
34_T 103_A 1.873 1.00
257_E 263_T 1.866 1.00
25_A 299_V 1.86 1.00
9_T 123_I 1.837 1.00
111_L 118_V 1.834 1.00
4_P 31_Q 1.811 1.00
50_L 97_K 1.808 1.00
108_R 139_C 1.806 1.00
112_M 142_Y 1.803 1.00
112_M 138_E 1.793 1.00
20_A 56_W 1.772 1.00
166_I 173_A 1.772 1.00
126_L 176_V 1.705 1.00
50_L 62_L 1.705 1.00
232_M 235_L 1.696 1.00
53_L 60_I 1.681 1.00
117_P 144_R 1.657 1.00
119_T 147_V 1.655 1.00
171_E 264_S 1.631 1.00
251_P 282_Q 1.631 1.00
246_L 291_G 1.625 1.00
208_N 219_S 1.62 1.00
249_L 284_A 1.617 1.00
63_A 106_A 1.605 1.00
72_R 264_S 1.605 1.00
126_L 148_I 1.592 0.99
5_I 121_V 1.577 0.99
7_L 30_L 1.567 0.99
136_C 139_C 1.543 0.99
290_K 294_Q 1.532 0.99
63_A 99_L 1.526 0.99
111_L 132_L 1.525 0.99
54_H 94_H 1.499 0.99
129_I 146_L 1.482 0.99
288_D 291_G 1.458 0.99
203_T 294_Q 1.457 0.99
161_N 266_T 1.444 0.99
240_W 247_F 1.443 0.99
145_R 184_V 1.43 0.99
148_I 177_F 1.428 0.99
132_L 139_C 1.426 0.99
42_V 64_Q 1.424 0.99
105_L 109_D 1.389 0.98
260_G 263_T 1.384 0.98
3_L 144_R 1.377 0.98
122_A 126_L 1.369 0.98
107_I 132_L 1.368 0.98
166_I 177_F 1.363 0.98
148_I 166_I 1.357 0.98
119_T 145_R 1.321 0.97
239_A 292_F 1.317 0.97
82_G 85_G 1.308 0.97
257_E 262_F 1.302 0.97
107_I 129_I 1.301 0.97
9_T 49_A 1.292 0.97
27_E 299_V 1.287 0.97
150_G 166_I 1.284 0.97
221_Y 225_S 1.267 0.96
236_C 287_L 1.267 0.96
122_A 146_L 1.257 0.96
148_I 185_M 1.25 0.96
35_T 49_A 1.249 0.96
47_R 51_Q 1.247 0.96
257_E 260_G 1.246 0.96
34_T 128_N 1.231 0.95
177_F 185_M 1.227 0.95
30_L 123_I 1.225 0.95
217_L 221_Y 1.222 0.95
255_A 262_F 1.218 0.95
110_A 113_R 1.216 0.95
6_F 32_L 1.211 0.95
55_F 217_L 1.204 0.95
263_T 268_V 1.201 0.95
263_T 266_T 1.198 0.95
133_L 179_S 1.184 0.94
115_P 142_Y 1.181 0.94
104_F 132_L 1.166 0.93
111_L 142_Y 1.159 0.93
236_C 247_F 1.157 0.93
186_C 284_A 1.142 0.92
102_P 105_L 1.139 0.92
256_V 267_T 1.138 0.92
6_F 106_A 1.138 0.92
107_I 139_C 1.131 0.92
159_T 162_A 1.13 0.92
257_E 261_E 1.122 0.92
141_P 144_R 1.117 0.91
133_L 143_I 1.115 0.91
54_H 96_R 1.109 0.91
42_V 46_T 1.108 0.91
81_H 85_G 1.107 0.91
200_Y 293_Q 1.105 0.91
254_V 281_V 1.096 0.90
21_A 295_W 1.093 0.90
184_V 240_W 1.093 0.90
252_C 269_V 1.093 0.90
53_L 62_L 1.083 0.90
216_A 220_H 1.082 0.90
47_R 93_E 1.08 0.89
114_A 117_P 1.062 0.88
104_F 108_R 1.059 0.88
188_L 233_H 1.054 0.88
198_P 202_S 1.044 0.87
12_G 16_A 1.042 0.87
156_G 162_A 1.038 0.87
31_Q 110_A 1.034 0.87
111_L 139_C 1.026 0.86
174_A 258_T 1.025 0.86
63_A 101_I 1.021 0.86
22_A 121_V 1.019 0.85
110_A 118_V 1.017 0.85
210_T 215_H 1.016 0.85
184_V 249_L 1.012 0.85
157_N 162_A 1.007 0.84
53_L 59_E 1.006 0.84
3_L 119_T 1.005 0.84
147_V 240_W 1.002 0.84
13_I 87_A 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q8fA40.99011000.032Contact Map0.833
1yoeA10.99011000.034Contact Map0.82
2masA40.98681000.04Contact Map0.823
4kpoA20.98361000.05Contact Map0.793
4kpnA80.98361000.051Contact Map0.814
3t8jA10.98031000.058Contact Map0.745
3t8iA40.97041000.073Contact Map0.818
3fz0A40.98681000.079Contact Map0.765
3epwA20.97041000.123Contact Map0.741
4i71A10.97041000.124Contact Map0.732
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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