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OPENSEQ.org
YBHA - Pyridoxal phosphate phosphatase YbhA
UniProt: P21829 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11239
Length: 272 (271)
Sequences: 5507
Seq/Len: 20.32
YBHA
Paralog alert: 0.75 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: COF MPGP SUPH YBHA YBJI YIDA YIGL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_P 259_T 4.761 1.00
256_G 265_Q 4.281 1.00
220_A 234_A 3.459 1.00
257_D 260_T 3.391 1.00
231_L 237_G 3.254 1.00
24_S 268_Y 3.008 1.00
16_T 20_T 2.946 1.00
4_R 217_N 2.893 1.00
208_V 218_V 2.819 1.00
8_L 39_L 2.743 1.00
24_S 261_D 2.737 1.00
245_D 249_A 2.665 1.00
43_T 50_I 2.657 1.00
22_L 261_D 2.605 1.00
228_I 247_V 2.562 1.00
7_A 204_L 2.347 1.00
199_S 229_S 2.293 1.00
31_R 34_E 2.271 1.00
256_G 260_T 2.261 1.00
247_V 250_R 2.24 1.00
228_I 250_R 2.197 1.00
23_P 27_E 2.163 1.00
215_M 233_A 2.156 1.00
239_A 251_A 2.149 1.00
26_I 56_A 2.124 1.00
214_S 217_N 2.121 1.00
5_V 40_I 2.119 1.00
232_E 250_R 2.074 1.00
205_T 233_A 2.066 1.00
225_F 246_A 2.018 1.00
238_V 266_F 2.003 1.00
245_D 248_K 1.963 1.00
31_R 268_Y 1.848 1.00
237_G 252_N 1.841 1.00
225_F 244_D 1.81 1.00
206_K 209_E 1.799 1.00
29_L 39_L 1.798 1.00
31_R 35_A 1.765 1.00
10_L 15_L 1.724 1.00
220_A 231_L 1.717 1.00
73_D 76_A 1.695 1.00
205_T 209_E 1.687 1.00
202_K 205_T 1.65 1.00
64_I 203_R 1.646 1.00
86_P 89_K 1.644 1.00
7_A 42_V 1.64 1.00
241_G 257_D 1.636 1.00
253_I 270_H 1.629 1.00
8_L 221_F 1.586 1.00
255_I 262_S 1.573 1.00
239_A 243_A 1.556 1.00
6_I 267_I 1.535 1.00
236_T 252_N 1.529 1.00
204_L 230_M 1.528 1.00
216_E 235_G 1.518 1.00
22_L 25_S 1.5 1.00
236_T 253_I 1.484 1.00
32_A 37_Y 1.481 1.00
81_E 206_K 1.467 1.00
73_D 78_T 1.464 1.00
263_I 267_I 1.461 1.00
27_E 31_R 1.461 1.00
234_A 237_G 1.434 1.00
201_G 233_A 1.428 1.00
6_I 32_A 1.425 1.00
208_V 213_W 1.407 0.99
30_A 34_E 1.395 0.99
5_V 208_V 1.392 0.99
221_F 263_I 1.391 0.99
185_W 188_H 1.388 0.99
16_T 259_T 1.375 0.99
208_V 215_M 1.352 0.99
38_Q 211_Q 1.343 0.99
5_V 213_W 1.331 0.99
37_Y 219_V 1.313 0.99
43_T 65_C 1.313 0.99
221_F 266_F 1.307 0.99
219_V 266_F 1.306 0.99
28_A 264_A 1.301 0.99
253_I 266_F 1.298 0.99
231_L 247_V 1.284 0.99
144_S 147_E 1.28 0.99
24_S 28_A 1.279 0.99
246_A 249_A 1.27 0.99
25_S 261_D 1.27 0.99
220_A 230_M 1.256 0.99
238_V 255_I 1.254 0.99
40_I 207_W 1.246 0.98
17_P 258_N 1.243 0.98
206_K 210_A 1.24 0.98
219_V 238_V 1.236 0.98
255_I 266_F 1.235 0.98
228_I 232_E 1.226 0.98
69_T 195_R 1.222 0.98
172_G 176_E 1.22 0.98
215_M 218_V 1.213 0.98
97_L 160_L 1.212 0.98
24_S 265_Q 1.207 0.98
26_I 30_A 1.198 0.98
243_A 248_K 1.188 0.98
256_G 262_S 1.181 0.98
195_R 198_N 1.181 0.98
242_N 258_N 1.178 0.98
33_R 60_D 1.177 0.98
83_D 206_K 1.172 0.98
243_A 247_V 1.162 0.97
248_K 254_V 1.16 0.97
89_K 92_Q 1.154 0.97
239_A 247_V 1.139 0.97
5_V 218_V 1.137 0.97
253_I 269_S 1.131 0.97
237_G 247_V 1.127 0.97
6_I 37_Y 1.126 0.97
7_A 40_I 1.115 0.96
235_G 252_N 1.107 0.96
199_S 202_K 1.091 0.96
224_N 244_D 1.089 0.96
253_I 265_Q 1.071 0.95
83_D 195_R 1.067 0.95
7_A 218_V 1.064 0.95
240_M 255_I 1.06 0.95
50_I 63_A 1.059 0.95
201_G 229_S 1.058 0.95
69_T 198_N 1.056 0.95
219_V 270_H 1.05 0.94
79_V 82_A 1.049 0.94
70_Y 79_V 1.04 0.94
218_V 234_A 1.033 0.94
194_A 199_S 1.032 0.94
98_N 115_E 1.028 0.94
236_T 266_F 1.027 0.94
208_V 233_A 1.027 0.94
266_F 270_H 1.025 0.93
30_A 33_R 1.024 0.93
95_E 99_E 1.02 0.93
218_V 235_G 1.013 0.93
207_W 211_Q 1.003 0.93
46_H 66_C 1.002 0.92
240_M 262_S 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nrwA10.99261000.175Contact Map0.804
3pgvA40.95591000.19Contact Map0.772
1rkqA20.96691000.216Contact Map0.831
3l7yA10.95221000.217Contact Map0.788
2b30A40.95961000.219Contact Map0.743
3daoA20.95221000.232Contact Map0.756
1nf2A30.95221000.235Contact Map0.85
1rlmA40.94851000.235Contact Map0.843
3dnpA10.97431000.241Contact Map0.802
2rbkA10.93751000.242Contact Map0.744
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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