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OPENSEQ.org
DBPA - ATP-independent RNA helicase DbpA
UniProt: P21693 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10210
Length: 457 (371)
Sequences: 9577
Seq/Len: 25.81
DBPA
Paralog alert: 0.87 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: DBPA DEAD RHLB RHLE SRMB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_G 91_L 4.973 1.00
61_L 74_A 4.14 1.00
11_P 63_Q 4.112 1.00
128_A 133_L 4.038 1.00
37_I 181_L 3.815 1.00
29_V 45_V 3.752 1.00
78_C 87_V 3.475 1.00
41_K 203_L 3.283 1.00
136_H 141_T 2.954 1.00
20_E 97_F 2.95 1.00
248_C 254_C 2.931 1.00
285_V 289_N 2.828 1.00
286_R 291_S 2.632 1.00
61_L 151_V 2.558 1.00
318_L 343_S 2.518 1.00
251_K 274_D 2.503 1.00
12_P 16_T 2.461 1.00
269_L 292_A 2.399 1.00
23_Y 55_A 2.323 1.00
138_Q 169_D 2.315 1.00
309_S 337_N 2.294 1.00
150_L 171_I 2.279 1.00
90_E 93_R 2.215 1.00
312_L 342_I 2.198 1.00
168_D 197_R 2.195 1.00
88_A 92_R 2.188 1.00
88_A 103_I 2.18 1.00
218_Q 329_I 2.174 1.00
20_E 96_R 2.165 1.00
5_S 19_N 2.148 1.00
266_Q 294_V 2.147 1.00
218_Q 325_H 2.123 1.00
329_I 341_A 2.119 1.00
217_E 340_L 2.062 1.00
113_G 117_D 2.03 1.00
75_L 147_L 2.023 1.00
73_Q 124_H 2.019 1.00
16_T 97_F 2.019 1.00
104_L 123_P 2.008 1.00
17_N 97_F 1.952 1.00
157_R 160_D 1.908 1.00
258_C 268_A 1.899 1.00
77_L 133_L 1.88 1.00
73_Q 148_N 1.87 1.00
301_A 305_L 1.847 1.00
91_L 103_I 1.842 1.00
14_Q 63_Q 1.823 1.00
192_A 204_A 1.801 1.00
21_L 93_R 1.792 1.00
91_L 125_I 1.789 1.00
258_C 270_S 1.781 1.00
215_P 338_S 1.772 1.00
36_A 39_A 1.77 1.00
40_G 179_Q 1.756 1.00
253_D 317_E 1.741 1.00
219_Q 340_L 1.713 1.00
282_Q 286_R 1.703 1.00
61_L 149_T 1.697 1.00
88_A 105_T 1.697 1.00
64_Q 148_N 1.692 1.00
10_L 59_L 1.689 1.00
315_N 343_S 1.685 1.00
134_L 169_D 1.684 1.00
137_L 173_F 1.671 1.00
254_C 272_H 1.667 1.00
36_A 203_L 1.651 1.00
233_Q 264_V 1.635 1.00
254_C 270_S 1.629 1.00
164_S 168_D 1.623 1.00
64_Q 149_T 1.622 1.00
248_C 296_V 1.597 1.00
315_N 329_I 1.593 1.00
76_V 91_L 1.592 1.00
57_F 87_V 1.586 1.00
45_V 183_F 1.578 1.00
18_L 23_Y 1.569 1.00
71_Q 146_A 1.554 1.00
244_C 314_V 1.553 1.00
269_L 283_T 1.528 1.00
255_Q 270_S 1.523 1.00
85_D 281_D 1.521 1.00
261_L 296_V 1.518 1.00
297_A 301_A 1.516 1.00
248_C 257_V 1.515 1.00
269_L 286_R 1.505 1.00
246_V 294_V 1.505 1.00
135_D 139_K 1.497 1.00
267_S 293_R 1.493 1.00
228_K 317_E 1.489 1.00
216_I 333_A 1.486 1.00
16_T 20_E 1.485 1.00
7_L 10_L 1.441 1.00
229_I 260_A 1.434 1.00
235_L 342_I 1.428 1.00
42_D 200_R 1.419 1.00
287_F 295_L 1.415 1.00
104_L 126_I 1.409 1.00
357_S 363_K 1.409 1.00
144_L 147_L 1.402 0.99
319_A 325_H 1.384 0.99
84_A 105_T 1.376 0.99
117_D 121_H 1.376 0.99
91_L 127_V 1.372 0.99
128_A 142_V 1.37 0.99
192_A 196_G 1.365 0.99
224_S 227_G 1.358 0.99
57_F 78_C 1.353 0.99
3_A 6_T 1.352 0.99
18_L 55_A 1.336 0.99
36_A 205_I 1.333 0.99
8_N 15_L 1.309 0.99
217_E 338_S 1.296 0.99
41_K 201_D 1.292 0.99
257_V 296_V 1.289 0.99
77_L 128_A 1.288 0.99
104_L 118_S 1.271 0.99
37_I 43_V 1.271 0.99
275_L 283_T 1.261 0.99
243_S 309_S 1.261 0.99
116_R 141_T 1.242 0.98
318_L 356_I 1.24 0.98
81_R 277_Q 1.232 0.98
123_P 126_I 1.22 0.98
19_N 24_L 1.215 0.98
116_R 136_H 1.206 0.98
217_E 365_N 1.198 0.98
106_L 126_I 1.193 0.98
244_C 294_V 1.192 0.98
134_L 166_A 1.175 0.98
36_A 43_V 1.168 0.97
232_L 246_V 1.165 0.97
286_R 292_A 1.161 0.97
189_E 193_A 1.16 0.97
250_T 253_D 1.16 0.97
234_R 238_L 1.159 0.97
78_C 84_A 1.156 0.97
242_S 311_E 1.143 0.97
112_F 139_K 1.142 0.97
166_A 169_D 1.135 0.97
95_A 103_I 1.112 0.96
16_T 19_N 1.108 0.96
102_K 124_H 1.107 0.96
255_Q 272_H 1.099 0.96
111_P 114_M 1.098 0.96
4_F 26_M 1.098 0.96
241_P 244_C 1.098 0.96
38_L 63_Q 1.095 0.96
40_G 64_Q 1.092 0.96
74_A 149_T 1.083 0.96
258_C 262_N 1.08 0.95
237_S 266_Q 1.072 0.95
42_D 199_Q 1.07 0.95
137_L 144_L 1.06 0.95
5_S 15_L 1.057 0.95
315_N 341_A 1.054 0.95
65_I 101_T 1.045 0.94
62_L 95_A 1.04 0.94
134_L 138_Q 1.037 0.94
117_D 120_Q 1.036 0.94
321_D 324_V 1.034 0.94
283_T 292_A 1.031 0.94
14_Q 59_L 1.029 0.94
249_N 320_W 1.019 0.93
72_T 126_I 1.016 0.93
299_D 328_R 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sqwA10.9651000.358Contact Map0.754
3i5xA10.96721000.37Contact Map0.762
2db3A40.81181000.382Contact Map0.851
3fmpB20.82281000.396Contact Map0.805
3eiqA20.81621000.401Contact Map0.72
4c9bA10.81621000.402Contact Map0.789
2j0sA10.81621000.403Contact Map0.782
2i4iA10.83151000.406Contact Map0.795
3fhtA20.82281000.418Contact Map0.824
1s2mA10.83371000.423Contact Map0.821
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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