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OPENSEQ.org
KPYK2 - Pyruvate kinase II
UniProt: P21599 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10803
Length: 480 (473)
Sequences: 2160
Seq/Len: 4.57
KPYK2
Paralog alert: 0.31 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: KPYK1 KPYK2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
222_A 243_S 4.449 1.00
139_L 149_E 4.306 1.00
25_E 60_K 4.182 1.00
237_D 272_R 4.1 1.00
137_K 149_E 3.579 1.00
48_K 52_D 3.477 1.00
236_M 269_L 3.355 1.00
12_T 32_A 3.263 1.00
21_D 56_E 3.235 1.00
32_A 35_V 3.109 1.00
205_N 242_A 3.082 1.00
230_V 265_I 3.023 1.00
204_L 222_A 3.008 1.00
282_T 312_T 2.988 1.00
69_G 185_A 2.976 1.00
23_N 26_K 2.902 1.00
82_K 106_D 2.853 1.00
208_R 220_I 2.731 1.00
28_I 65_V 2.669 1.00
20_R 23_N 2.65 1.00
82_K 104_E 2.606 1.00
93_K 147_F 2.588 1.00
66_A 418_A 2.556 1.00
46_D 50_R 2.542 1.00
94_F 110_V 2.475 1.00
137_K 151_T 2.464 1.00
261_E 340_G 2.364 1.00
140_E 147_F 2.331 1.00
23_N 328_S 2.315 1.00
48_K 188_I 2.25 1.00
204_L 220_I 2.248 1.00
51_A 188_I 2.19 1.00
93_K 149_E 2.184 1.00
89_N 92_D 2.151 1.00
92_D 107_K 2.039 1.00
182_I 193_L 2.025 1.00
292_T 325_Q 2.022 1.00
201_G 238_D 2.008 1.00
93_K 139_L 1.978 1.00
80_T 159_N 1.975 1.00
257_I 265_I 1.962 1.00
96_L 136_L 1.937 1.00
260_P 336_R 1.933 1.00
14_L 24_L 1.926 1.00
202_E 206_Y 1.92 1.00
129_L 156_L 1.905 1.00
380_T 455_D 1.891 1.00
71_L 75_K 1.889 1.00
116_G 119_A 1.888 1.00
25_E 29_A 1.887 1.00
246_V 269_L 1.875 1.00
408_S 414_L 1.875 1.00
55_R 58_A 1.875 1.00
21_D 53_K 1.87 1.00
383_I 457_V 1.868 1.00
45_E 48_K 1.867 1.00
241_L 276_L 1.864 1.00
443_N 447_D 1.859 1.00
94_F 148_T 1.858 1.00
88_L 150_V 1.856 1.00
221_V 245_V 1.843 1.00
267_K 310_D 1.817 1.00
315_V 338_C 1.809 1.00
236_M 240_I 1.802 1.00
33_N 63_R 1.792 1.00
19_D 50_R 1.786 1.00
29_A 61_L 1.78 1.00
186_A 218_A 1.779 1.00
51_A 67_I 1.758 1.00
209_R 213_D 1.756 1.00
57_I 61_L 1.752 1.00
219_K 416_L 1.743 1.00
37_M 51_A 1.737 1.00
126_I 135_Q 1.73 0.99
379_V 458_I 1.73 0.99
179_K 206_Y 1.729 0.99
122_V 125_D 1.724 0.99
202_E 205_N 1.699 0.99
81_F 158_N 1.688 0.99
42_G 47_H 1.683 0.99
26_K 29_A 1.673 0.99
189_G 412_R 1.661 0.99
335_A 339_L 1.64 0.99
414_L 427_H 1.625 0.99
386_T 406_A 1.621 0.99
177_K 181_D 1.592 0.99
270_I 282_T 1.591 0.99
12_T 35_V 1.584 0.99
109_K 145_K 1.576 0.99
85_K 155_P 1.575 0.99
123_P 141_V 1.568 0.99
92_D 150_V 1.561 0.99
120_D 170_S 1.54 0.99
326_Y 329_E 1.533 0.98
11_V 34_V 1.53 0.98
308_V 338_C 1.522 0.98
180_A 183_K 1.52 0.98
95_L 145_K 1.504 0.98
183_K 214_A 1.504 0.98
21_D 60_K 1.502 0.98
201_G 242_A 1.495 0.98
56_E 60_K 1.494 0.98
168_G 228_E 1.491 0.98
417_T 420_Y 1.488 0.98
262_L 302_M 1.468 0.98
21_D 57_I 1.466 0.98
48_K 187_L 1.463 0.98
11_V 281_I 1.457 0.98
259_D 333_A 1.446 0.98
142_Q 145_K 1.441 0.97
176_E 180_A 1.432 0.97
126_I 137_K 1.418 0.97
372_A 474_T 1.418 0.97
129_L 136_L 1.413 0.97
28_I 57_I 1.406 0.97
195_V 207_A 1.399 0.97
95_L 147_F 1.399 0.97
35_V 54_V 1.393 0.97
78_V 134_V 1.386 0.97
288_E 292_T 1.382 0.97
226_R 229_A 1.379 0.96
291_I 319_A 1.378 0.96
99_N 144_M 1.371 0.96
52_D 56_E 1.356 0.96
268_A 272_R 1.355 0.96
8_T 308_V 1.343 0.96
136_L 148_T 1.341 0.96
183_K 213_D 1.341 0.96
87_F 155_P 1.339 0.96
118_P 146_V 1.335 0.96
329_E 332_A 1.321 0.95
221_V 281_I 1.32 0.95
240_I 272_R 1.307 0.95
72_Q 75_K 1.301 0.95
27_V 331_V 1.293 0.94
23_N 27_V 1.29 0.94
141_V 146_V 1.289 0.94
25_E 61_L 1.279 0.94
125_D 167_G 1.272 0.94
67_I 190_V 1.272 0.94
30_A 332_A 1.27 0.94
86_V 107_K 1.269 0.94
376_L 379_V 1.268 0.94
121_V 146_V 1.262 0.93
26_K 328_S 1.262 0.93
179_K 183_K 1.255 0.93
444_L 447_D 1.254 0.93
265_I 269_L 1.239 0.93
14_L 37_M 1.232 0.92
456_L 478_T 1.231 0.92
90_I 153_G 1.227 0.92
406_A 423_V 1.222 0.92
301_V 337_V 1.218 0.92
332_A 336_R 1.218 0.92
49_M 53_K 1.214 0.92
237_D 240_I 1.213 0.92
18_T 27_V 1.21 0.91
37_M 54_V 1.206 0.91
406_A 417_T 1.196 0.91
19_D 53_K 1.193 0.91
384_T 395_T 1.189 0.90
51_A 184_T 1.189 0.90
84_G 158_N 1.186 0.90
34_V 68_L 1.181 0.90
286_M 304_V 1.173 0.90
81_F 94_F 1.172 0.90
185_A 190_V 1.168 0.89
37_M 190_V 1.166 0.89
164_K 167_G 1.165 0.89
98_A 118_P 1.158 0.89
380_T 452_M 1.154 0.89
115_K 118_P 1.15 0.88
75_K 226_R 1.147 0.88
20_R 27_V 1.145 0.88
186_A 211_A 1.14 0.88
227_A 231_C 1.139 0.88
6_R 335_A 1.134 0.87
44_P 184_T 1.129 0.87
68_L 194_A 1.127 0.87
18_T 23_N 1.127 0.87
89_N 153_G 1.116 0.86
22_N 25_E 1.115 0.86
444_L 448_K 1.113 0.86
43_S 46_D 1.111 0.86
8_T 338_C 1.1 0.85
264_G 309_L 1.099 0.85
451_L 479_V 1.096 0.85
44_P 181_D 1.095 0.85
164_K 169_L 1.093 0.85
47_H 50_R 1.092 0.85
130_D 133_R 1.089 0.84
367_M 371_Y 1.083 0.84
20_R 53_K 1.081 0.84
201_G 205_N 1.076 0.83
100_L 115_K 1.075 0.83
381_A 405_F 1.073 0.83
93_K 140_E 1.072 0.83
372_A 476_I 1.069 0.83
34_V 314_A 1.066 0.83
364_A 372_A 1.062 0.82
14_L 50_R 1.061 0.82
187_L 214_A 1.06 0.82
105_G 110_V 1.058 0.82
49_M 52_D 1.057 0.82
99_N 145_K 1.056 0.82
78_V 157_S 1.056 0.82
179_K 210_L 1.056 0.82
446_R 453_S 1.047 0.81
79_S 111_G 1.045 0.81
384_T 391_T 1.042 0.81
396_S 420_Y 1.039 0.80
69_G 75_K 1.036 0.80
99_N 109_K 1.034 0.80
72_Q 177_K 1.033 0.80
37_M 67_I 1.023 0.79
379_V 476_I 1.022 0.79
59_A 411_E 1.021 0.79
89_N 107_K 1.021 0.79
117_L 146_V 1.018 0.79
25_E 57_I 1.016 0.78
69_G 190_V 1.015 0.78
24_L 57_I 1.015 0.78
81_F 157_S 1.012 0.78
190_V 218_A 1.01 0.78
83_E 86_V 1.008 0.78
211_A 218_A 1.007 0.77
461_Q 473_T 1.006 0.77
86_V 156_L 1.005 0.77
80_T 104_E 1.004 0.77
288_E 319_A 1.003 0.77
183_K 187_L 1 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3t05A40.98751000.13Contact Map0.802
2e28A10.98121000.131Contact Map0.708
3gr4A40.98961000.131Contact Map0.796
1a3wA20.98751000.137Contact Map0.744
1e0tA40.97291000.138Contact Map0.79
3gg8A40.98961000.139Contact Map0.845
3khdA40.98961000.14Contact Map0.772
4drsA20.98961000.142Contact Map0.767
3hqnD20.98751000.143Contact Map0.776
3qtgA20.93331000.178Contact Map0.708
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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