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OPENSEQ.org
MALZ - Maltodextrin glucosidase
UniProt: P21517 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10565
Length: 604 (572)
Sequences: 1842
Seq/Len: 3.22
MALZ
Paralog alert: 0.58 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: AMY2 GLGX MALZ SUCP TREC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
187_P 239_L 4.902 1.00
235_N 238_Q 4.085 1.00
252_S 281_Y 3.94 1.00
182_I 199_L 3.755 1.00
467_V 514_Y 3.663 1.00
225_G 228_A 3.647 1.00
191_K 515_Q 3.416 1.00
309_V 356_G 3.258 1.00
190_K 239_L 3.242 1.00
229_L 233_R 3.184 1.00
180_D 231_R 3.147 1.00
321_R 360_A 3.055 1.00
230_L 326_A 3.046 1.00
180_D 228_A 2.893 1.00
237_Q 331_D 2.886 1.00
50_M 66_A 2.879 1.00
210_K 223_F 2.833 1.00
486_G 510_L 2.811 1.00
122_D 528_R 2.734 1.00
23_T 65_R 2.712 1.00
229_L 232_L 2.664 1.00
186_L 239_L 2.646 1.00
249_F 319_I 2.61 1.00
235_N 239_L 2.555 1.00
445_D 483_D 2.547 1.00
123_Q 196_A 2.418 1.00
460_I 507_D 2.402 1.00
218_H 226_D 2.392 1.00
468_V 599_A 2.379 1.00
360_A 363_E 2.315 1.00
494_F 497_K 2.282 1.00
189_L 194_V 2.255 1.00
472_T 544_F 2.251 1.00
358_T 362_K 2.243 1.00
464_P 513_L 2.212 1.00
361_A 368_A 2.19 1.00
130_P 199_L 2.176 1.00
182_I 232_L 2.167 1.00
24_L 35_I 2.128 1.00
329_N 365_Q 2.122 1.00
199_L 202_V 2.118 1.00
19_Q 67_A 2.102 1.00
128_I 133_F 2.094 1.00
471_F 518_I 2.063 1.00
544_F 555_V 2.021 1.00
443_Q 446_S 2.019 1.00
217_R 319_I 1.995 1.00
324_L 361_A 1.99 1.00
472_T 555_V 1.977 1.00
197_L 236_T 1.954 1.00
519_A 523_K 1.952 1.00
320_V 357_I 1.941 1.00
120_A 369_Y 1.928 1.00
194_V 241_M 1.901 0.99
362_K 388_D 1.882 0.99
310_N 318_S 1.86 0.99
469_W 557_I 1.835 0.99
301_L 308_L 1.833 0.99
186_L 236_T 1.83 0.99
48_V 66_A 1.829 0.99
197_L 241_M 1.809 0.99
229_L 245_L 1.789 0.99
467_V 483_D 1.75 0.99
22_I 81_F 1.75 0.99
21_L 65_R 1.748 0.99
229_L 330_M 1.742 0.99
180_D 184_E 1.722 0.99
373_E 447_H 1.719 0.99
53_Q 65_R 1.709 0.99
321_R 325_K 1.709 0.99
133_F 189_L 1.694 0.99
543_V 556_A 1.684 0.98
244_V 332_G 1.676 0.98
236_T 241_M 1.668 0.98
324_L 368_A 1.656 0.98
231_R 235_N 1.634 0.98
204_K 218_H 1.632 0.98
185_K 188_Y 1.619 0.98
512_A 515_Q 1.611 0.98
464_P 509_A 1.605 0.98
336_D 373_E 1.603 0.98
511_F 515_Q 1.597 0.98
36_M 82_K 1.594 0.98
336_D 447_H 1.593 0.98
322_H 328_W 1.577 0.97
464_P 510_L 1.567 0.97
124_I 518_I 1.557 0.97
545_V 552_R 1.553 0.97
24_L 83_L 1.542 0.97
313_Y 321_R 1.537 0.97
125_F 196_A 1.517 0.97
485_V 499_F 1.512 0.96
324_L 365_Q 1.505 0.96
320_V 361_A 1.501 0.96
122_D 195_T 1.493 0.96
353_H 357_I 1.491 0.96
125_F 441_F 1.489 0.96
356_G 360_A 1.488 0.96
512_A 516_R 1.487 0.96
467_V 517_M 1.472 0.96
188_Y 511_F 1.457 0.95
251_H 336_D 1.447 0.95
488_D 497_K 1.441 0.95
251_H 447_H 1.428 0.95
325_K 364_T 1.417 0.94
322_H 326_A 1.412 0.94
22_I 37_L 1.411 0.94
179_L 228_A 1.403 0.94
392_N 442_N 1.4 0.94
284_S 288_T 1.398 0.94
355_A 386_V 1.394 0.94
404_L 469_W 1.394 0.94
334_R 373_E 1.393 0.94
191_K 511_F 1.385 0.93
124_I 522_K 1.384 0.93
189_L 197_L 1.381 0.93
33_Q 84_L 1.381 0.93
365_Q 368_A 1.377 0.93
180_D 183_S 1.376 0.93
313_Y 360_A 1.368 0.93
34_R 49_P 1.368 0.93
251_H 373_E 1.367 0.93
246_D 447_H 1.359 0.93
301_L 341_L 1.356 0.92
524_S 553_V 1.345 0.92
336_D 448_D 1.336 0.92
320_V 333_W 1.333 0.92
373_E 448_D 1.333 0.92
137_L 140_E 1.329 0.91
236_T 239_L 1.326 0.91
334_R 447_H 1.325 0.91
34_R 84_L 1.318 0.91
228_A 231_R 1.313 0.91
183_S 231_R 1.302 0.90
246_D 336_D 1.291 0.90
513_L 517_M 1.286 0.90
195_T 241_M 1.28 0.89
524_S 551_Q 1.279 0.89
33_Q 86_H 1.278 0.89
133_F 501_W 1.275 0.89
313_Y 357_I 1.268 0.89
244_V 371_V 1.268 0.89
461_A 464_P 1.267 0.89
128_I 481_Y 1.25 0.88
545_V 554_L 1.249 0.88
27_T 62_T 1.248 0.88
477_P 521_R 1.246 0.88
36_M 49_P 1.244 0.87
444_L 470_L 1.241 0.87
198_Y 391_M 1.241 0.87
134_A 185_K 1.232 0.87
236_T 243_L 1.225 0.86
219_V 229_L 1.225 0.86
20_L 71_S 1.225 0.86
130_P 202_V 1.221 0.86
540_N 560_G 1.218 0.86
101_P 104_R 1.217 0.86
472_T 557_I 1.216 0.86
129_F 200_N 1.215 0.86
518_I 522_K 1.211 0.85
452_F 459_D 1.207 0.85
202_V 229_L 1.206 0.85
247_G 335_L 1.205 0.85
540_N 559_R 1.204 0.85
354_V 357_I 1.201 0.85
465_L 559_R 1.19 0.84
217_R 322_H 1.183 0.84
334_R 448_D 1.181 0.83
293_L 340_M 1.176 0.83
246_D 373_E 1.175 0.83
190_K 241_M 1.175 0.83
84_L 89_Q 1.17 0.83
289_A 300_K 1.165 0.82
444_L 466_A 1.16 0.82
535_L 554_L 1.158 0.82
196_A 369_Y 1.157 0.82
352_Q 356_G 1.157 0.82
162_D 498_P 1.157 0.82
246_D 448_D 1.15 0.81
125_F 244_V 1.148 0.81
558_N 598_S 1.136 0.80
230_L 322_H 1.13 0.80
180_D 225_G 1.127 0.79
199_L 229_L 1.122 0.79
487_L 500_P 1.122 0.79
417_D 420_T 1.117 0.78
396_F 400_L 1.115 0.78
198_Y 371_V 1.114 0.78
17_K 20_L 1.114 0.78
467_V 471_F 1.11 0.78
321_R 364_T 1.11 0.78
210_K 222_Q 1.109 0.78
468_V 513_L 1.108 0.78
187_P 190_K 1.107 0.78
404_L 466_A 1.106 0.77
204_K 221_P 1.105 0.77
134_A 160_D 1.104 0.77
592_L 602_W 1.102 0.77
422_M 534_V 1.101 0.77
131_D 223_F 1.097 0.77
135_R 140_E 1.094 0.76
220_D 223_F 1.094 0.76
47_S 82_K 1.091 0.76
381_W 387_E 1.089 0.76
225_G 231_R 1.085 0.76
564_E 593_A 1.084 0.75
37_L 456_L 1.083 0.75
194_V 518_I 1.081 0.75
246_D 334_R 1.08 0.75
252_S 301_L 1.074 0.75
126_Y 484_E 1.074 0.75
188_Y 504_E 1.073 0.74
216_Y 311_E 1.073 0.74
337_V 391_M 1.069 0.74
219_V 226_D 1.068 0.74
259_F 311_E 1.065 0.74
463_L 510_L 1.064 0.74
35_I 83_L 1.064 0.74
179_L 219_V 1.062 0.73
203_F 216_Y 1.059 0.73
586_Q 590_G 1.058 0.73
338_V 374_H 1.057 0.73
127_Q 200_N 1.056 0.73
137_L 141_A 1.051 0.72
452_F 466_A 1.05 0.72
135_R 141_A 1.049 0.72
122_D 529_H 1.047 0.72
217_R 249_F 1.047 0.72
131_D 135_R 1.043 0.71
249_F 312_I 1.041 0.71
453_K 463_L 1.038 0.71
21_L 67_A 1.038 0.71
250_N 447_H 1.037 0.71
16_S 19_Q 1.035 0.71
128_I 199_L 1.035 0.71
483_D 514_Y 1.035 0.71
36_M 84_L 1.034 0.70
245_L 330_M 1.033 0.70
533_Q 545_V 1.031 0.70
135_R 142_E 1.029 0.70
192_L 518_I 1.026 0.70
35_I 64_W 1.025 0.70
177_G 181_G 1.025 0.70
219_V 486_G 1.019 0.69
129_F 132_R 1.014 0.68
159_R 163_E 1.011 0.68
50_M 81_F 1.007 0.68
202_V 245_L 1.005 0.67
587_L 590_G 1.003 0.67
183_S 235_N 1.002 0.67
396_F 473_W 1.001 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ji1A20.98511000.284Contact Map0.725
1j0hA20.91561000.284Contact Map0.824
1ea9C20.91231000.285Contact Map0.812
1wzlA20.91061000.297Contact Map0.805
4aeeA20.88911000.312Contact Map0.759
4aefA20.82451000.334Contact Map0.757
2e8yA20.87581000.379Contact Map0.73
2wanA10.87581000.382Contact Map0.697
2wc7A10.75831000.385Contact Map0.79
2z1kA40.7451000.395Contact Map0.777
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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