OPENSEQ.org - ACPH - ECOLI GREMLIN

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ACPH - Acyl carrier protein phosphodiesterase

UniProt:	P21515	Sequence MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11095
Length:	193 (191)
Sequences:	321
Seq/Len:	1.68

ACPH
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
83_H	170_Y	3.362	1.00
8_H	181_Y	2.632	1.00
64_W	176_R	2.247	0.99
61_A	81_W	2.171	0.99
44_M	48_I	2.109	0.99
84_F	170_Y	2.079	0.99
10_A	16_S	2.069	0.99
131_Q	134_V	1.951	0.98
7_L	21_L	1.856	0.97
88_H	174_E	1.848	0.97
28_G	46_R	1.8	0.96
106_R	131_Q	1.782	0.96
96_F	104_Y	1.77	0.96
57_E	183_R	1.762	0.96
79_V	145_V	1.725	0.95
145_V	148_G	1.598	0.92
7_L	105_A	1.559	0.91
32_E	39_V	1.506	0.89
86_S	98_L	1.46	0.86
144_N	148_G	1.456	0.86
92_L	178_W	1.449	0.86
61_A	176_R	1.446	0.86
61_A	65_F	1.419	0.84
18_S	116_S	1.401	0.83
9_L	180_F	1.382	0.82
31_E	34_F	1.351	0.80
51_L	180_F	1.346	0.80
90_S	99_Q	1.304	0.77
120_F	125_N	1.284	0.75
69_T	161_D	1.278	0.75
60_E	191_K	1.271	0.74
86_S	102_V	1.271	0.74
58_V	81_W	1.263	0.73
7_L	16_S	1.26	0.73
16_S	20_N	1.249	0.72
5_A	53_D	1.238	0.71
83_H	125_N	1.236	0.71
44_M	50_V	1.232	0.71
36_P	39_V	1.222	0.70
41_G	174_E	1.216	0.69
2_N	6_H	1.214	0.69
26_V	120_F	1.214	0.69
54_N	59_R	1.199	0.68
148_G	151_S	1.195	0.67
52_T	180_F	1.173	0.65
1_M	6_H	1.171	0.65
102_V	134_V	1.171	0.65
75_I	155_R	1.159	0.64
104_Y	140_D	1.157	0.64
92_L	141_F	1.152	0.63
38_V	67_S	1.143	0.62
27_R	50_V	1.139	0.62
86_S	127_L	1.136	0.62
10_A	21_L	1.118	0.60
10_A	70_R	1.105	0.58
13_A	16_S	1.097	0.57
186_A	190_R	1.092	0.57
42_I	46_R	1.088	0.57
115_D	183_R	1.086	0.56
80_M	166_L	1.081	0.56
62_R	73_A	1.075	0.55
83_H	137_R	1.074	0.55
42_I	116_S	1.074	0.55
105_A	149_M	1.067	0.54
20_N	41_G	1.067	0.54
58_V	177_F	1.066	0.54
51_L	61_A	1.065	0.54
60_E	168_A	1.06	0.54
4_L	98_L	1.053	0.53
66_R	165_D	1.04	0.51
2_N	5_A	1.035	0.51
124_N	128_W	1.028	0.50
5_A	52_T	1.026	0.50
62_R	93_S	1.023	0.50
76_T	162_S	1.021	0.49
50_V	54_N	1.02	0.49
142_I	148_G	1.019	0.49
178_W	182_P	1.018	0.49
157_D	160_R	1.017	0.49
91_Q	179_Q	1.011	0.48
13_A	37_D	1.008	0.48
25_F	150_A	1.006	0.48
41_G	79_V	1.004	0.48
15_S	148_G	1.001	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2ebfX	1	0.9119	61	0.944	Contact Map	0.14
2bmbA	1	0.3523	8.5	0.964	Contact Map	0.044
2jqtA	1	0.3264	7.1	0.965	Contact Map	0.285
1wa5C	1	0.8653	6.5	0.966	Contact Map	0.138
1u8vA	4	0.7202	5.8	0.967	Contact Map	0.093
3lb2A	2	0.2642	4.7	0.968	Contact Map	0.584
2k7rA	1	0.285	4.7	0.968	Contact Map	0.039
1v54E	2	0.4819	3.5	0.97	Contact Map	0.219
3evoA	2	0.3575	3.2	0.971	Contact Map	0.366
3fkbA	6	0.3575	3.1	0.971	Contact Map	0.526

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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