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OPENSEQ.org
YCAC - Uncharacterized protein YcaC
UniProt: P21367 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11241
Length: 208 (181)
Sequences: 3319
Seq/Len: 18.34
YCAC
Paralog alert: 0.66 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: PNCA RUTB YCAC YECD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_N 125_S 3.171 1.00
110_I 123_A 3.066 1.00
97_V 101_K 3.06 1.00
97_V 131_F 2.995 1.00
155_L 160_A 2.967 1.00
43_L 136_V 2.966 1.00
136_V 168_V 2.764 1.00
12_D 106_K 2.512 1.00
107_Q 132_D 2.49 1.00
47_A 52_L 2.356 1.00
20_H 40_V 2.35 1.00
39_N 165_W 2.192 1.00
14_A 105_K 2.101 1.00
46_L 169_A 2.098 1.00
42_A 166_F 2.07 1.00
108_L 126_A 2.057 1.00
164_T 167_G 2.033 1.00
145_E 149_H 1.984 1.00
58_T 83_A 1.952 1.00
39_N 42_A 1.906 1.00
46_L 50_F 1.783 1.00
40_V 111_A 1.778 1.00
97_V 129_E 1.764 1.00
107_Q 134_F 1.742 1.00
139_A 165_W 1.741 1.00
137_T 162_L 1.731 1.00
115_T 148_R 1.726 1.00
138_D 165_W 1.724 1.00
120_A 124_L 1.689 1.00
153_D 156_S 1.657 1.00
95_D 99_A 1.61 1.00
127_I 160_A 1.594 1.00
90_A 122_P 1.571 1.00
13_A 109_I 1.568 1.00
17_L 44_G 1.54 1.00
48_K 79_T 1.536 1.00
116_E 142_T 1.491 1.00
15_V 47_A 1.479 1.00
91_W 126_A 1.469 1.00
137_T 152_W 1.449 1.00
115_T 140_S 1.446 1.00
47_A 109_I 1.438 1.00
17_L 111_A 1.438 1.00
119_V 135_V 1.426 1.00
18_V 118_C 1.424 1.00
149_H 153_D 1.411 1.00
55_I 99_A 1.396 0.99
17_L 40_V 1.395 0.99
140_S 148_R 1.387 0.99
120_A 151_A 1.373 0.99
9_D 12_D 1.366 0.99
41_L 45_D 1.364 0.99
41_L 71_E 1.351 0.99
45_D 75_Q 1.332 0.99
82_I 99_A 1.328 0.99
39_N 138_D 1.325 0.99
22_A 70_P 1.322 0.99
43_L 168_V 1.314 0.99
109_I 168_V 1.275 0.99
137_T 164_T 1.266 0.99
110_I 122_P 1.262 0.99
135_V 140_S 1.221 0.98
98_K 102_A 1.216 0.98
13_A 107_Q 1.213 0.98
123_A 155_L 1.178 0.98
25_L 69_V 1.178 0.98
121_F 124_L 1.14 0.97
37_K 69_V 1.129 0.97
126_A 133_V 1.127 0.97
87_N 130_G 1.126 0.97
123_A 160_A 1.122 0.97
32_E 35_K 1.118 0.96
95_D 98_K 1.117 0.96
12_D 107_Q 1.097 0.96
135_V 152_W 1.086 0.96
146_I 149_H 1.069 0.95
80_P 99_A 1.067 0.95
44_G 48_K 1.06 0.95
23_G 65_N 1.058 0.95
36_F 40_V 1.047 0.94
48_K 78_D 1.044 0.94
19_D 84_R 1.029 0.94
121_F 159_G 1.027 0.94
20_H 113_V 1.025 0.93
24_L 118_C 1.022 0.93
109_I 136_V 1.022 0.93
99_A 103_T 1.016 0.93
16_L 110_I 1.014 0.93
70_P 74_A 1.011 0.93
58_T 68_L 1.008 0.93
101_K 131_F 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1yacA20.99521000.165Contact Map0.716
2b34A80.93271000.206Contact Map0.808
1x9gA10.8991000.246Contact Map0.689
1yzvA10.90871000.247Contact Map0.739
3mcwA20.84621000.307Contact Map0.757
1j2rA40.81731000.308Contact Map0.835
3txyA10.83171000.309Contact Map0.763
1nbaA40.93271000.312Contact Map0.873
3tg2A10.8991000.315Contact Map0.764
3hb7A80.8751000.32Contact Map0.86
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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