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OPENSEQ.org
DMSB - Anaerobic dimethyl sulfoxide reductase chain B
UniProt: P18776 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10233
Length: 205 (190)
Sequences: 1081
Seq/Len: 5.69
DMSB
Paralog alert: 0.64 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DMSB HYCB HYDN HYFA NRFC YDHX YDHY YGFS YNFG YSAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_V 108_A 2.929 1.00
103_R 116_Y 2.642 1.00
73_P 86_K 2.493 1.00
76_T 84_M 2.432 1.00
27_Y 131_D 2.393 1.00
106_H 123_M 2.331 1.00
116_Y 123_M 2.278 1.00
71_E 180_N 2.151 1.00
84_M 114_P 2.143 1.00
167_A 174_A 2.109 1.00
151_D 161_K 2.054 1.00
91_F 128_G 2.045 1.00
139_P 142_V 1.94 1.00
79_C 99_C 1.931 1.00
6_G 155_I 1.931 1.00
84_M 94_V 1.929 1.00
72_D 77_K 1.882 1.00
15_T 147_L 1.861 1.00
99_C 105_C 1.806 1.00
79_C 105_C 1.778 1.00
138_K 142_V 1.752 1.00
170_P 173_R 1.724 1.00
142_V 150_L 1.715 1.00
23_A 144_S 1.671 1.00
7_F 128_G 1.647 1.00
138_K 143_E 1.643 1.00
78_V 104_Y 1.603 0.99
66_S 150_L 1.584 0.99
95_D 98_V 1.579 0.99
130_Y 134_A 1.537 0.99
117_N 124_T 1.528 0.99
116_Y 121_G 1.512 0.99
64_S 150_L 1.51 0.99
154_P 157_E 1.509 0.99
87_R 134_A 1.476 0.99
132_R 137_K 1.474 0.99
28_K 140_I 1.458 0.99
128_G 181_I 1.439 0.98
11_S 64_S 1.429 0.98
65_I 171_L 1.409 0.98
36_F 124_T 1.389 0.98
38_R 115_Q 1.379 0.98
81_S 100_I 1.374 0.98
85_H 95_D 1.369 0.98
14_C 20_C 1.337 0.97
87_R 91_F 1.334 0.97
87_R 93_V 1.321 0.97
99_C 102_C 1.316 0.97
91_F 133_V 1.309 0.97
27_Y 132_R 1.309 0.97
13_R 149_A 1.295 0.96
160_K 163_G 1.283 0.96
79_C 102_C 1.265 0.96
17_C 20_C 1.255 0.95
133_V 152_F 1.244 0.95
28_K 36_F 1.243 0.95
37_R 64_S 1.24 0.95
14_C 17_C 1.235 0.95
74_A 108_A 1.211 0.94
80_P 99_C 1.208 0.94
80_P 105_C 1.205 0.94
157_E 160_K 1.204 0.94
9_I 64_S 1.198 0.94
100_I 104_Y 1.184 0.93
132_R 143_E 1.163 0.92
9_I 150_L 1.158 0.92
173_R 176_F 1.147 0.92
114_P 123_M 1.128 0.91
93_V 130_Y 1.125 0.91
28_K 127_D 1.12 0.90
159_R 163_G 1.11 0.90
8_F 184_K 1.104 0.90
76_T 85_H 1.104 0.90
117_N 120_K 1.103 0.89
102_C 105_C 1.103 0.89
9_I 66_S 1.1 0.89
155_I 159_R 1.098 0.89
78_V 107_M 1.098 0.89
116_Y 120_K 1.098 0.89
159_R 164_D 1.096 0.89
161_K 164_D 1.093 0.89
81_S 84_M 1.082 0.88
7_F 66_S 1.075 0.88
142_V 148_R 1.075 0.88
160_K 164_D 1.072 0.88
61_Y 148_R 1.066 0.87
16_G 19_T 1.052 0.86
104_Y 108_A 1.05 0.86
38_R 65_I 1.046 0.86
71_E 86_K 1.043 0.86
104_Y 107_M 1.041 0.85
96_E 122_H 1.04 0.85
7_F 64_S 1.04 0.85
86_K 91_F 1.035 0.85
73_P 76_T 1.027 0.84
187_A 190_R 1.022 0.84
76_T 86_K 1.017 0.84
81_S 102_C 1.017 0.84
73_P 114_P 1.011 0.83
159_R 162_H 1.005 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ti6B60.94631000.39Contact Map0.661
2ivfB10.99021000.4Contact Map0.668
2vpzB20.93171000.459Contact Map0.648
1kqfB10.99021000.461Contact Map0.637
1h0hB20.94151000.464Contact Map0.612
1q16B10.99021000.527Contact Map0.642
3mm5B20.965999.80.726Contact Map0.243
3gyxB60.726899.30.804Contact Map0.36
2fgoA10.365999.20.812Contact Map0.241
1rgvA10.370799.20.813Contact Map0.291
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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