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OPENSEQ.org
PRIA - Primosomal protein N'
UniProt: P17888 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10763
Length: 732 (728)
Sequences: 1695
Seq/Len: 2.33
PRIA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
411_M 421_V 4.679 1.00
246_K 315_G 4.414 1.00
345_A 352_I 4.077 1.00
16_F 36_F 3.85 1.00
204_A 208_G 3.684 1.00
506_P 534_R 3.523 1.00
527_E 532_G 3.514 1.00
407_L 555_A 3.413 1.00
250_V 265_F 3.284 1.00
272_P 298_A 3.214 1.00
414_H 593_E 3.157 1.00
419_N 590_K 3.141 1.00
238_L 248_A 3.125 1.00
643_D 649_A 3.033 1.00
202_E 379_R 2.955 1.00
247_Q 311_F 2.822 1.00
5_H 48_S 2.72 1.00
202_E 378_T 2.697 1.00
31_R 68_D 2.649 1.00
32_V 46_V 2.63 1.00
410_R 593_E 2.623 1.00
531_G 550_D 2.565 1.00
274_E 297_A 2.565 1.00
19_L 62_A 2.516 1.00
220_W 375_L 2.48 1.00
362_E 569_R 2.459 1.00
3_V 60_L 2.459 1.00
508_S 533_A 2.426 1.00
423_L 555_A 2.416 1.00
76_S 348_E 2.38 1.00
248_A 316_V 2.359 1.00
502_F 535_I 2.355 1.00
4_A 20_L 2.318 1.00
613_G 616_A 2.305 1.00
414_H 421_V 2.3 1.00
276_L 309_T 2.298 1.00
360_A 363_T 2.235 1.00
415_L 502_F 2.225 1.00
80_L 340_L 2.223 1.00
342_V 352_I 2.22 1.00
412_R 416_Q 2.199 1.00
21_P 24_M 2.18 1.00
239_E 243_A 2.166 1.00
26_V 46_V 2.165 1.00
392_L 595_V 2.163 1.00
39_Q 42_R 2.128 1.00
419_N 552_T 2.127 1.00
210_I 237_V 2.122 1.00
390_H 593_E 2.106 1.00
410_R 595_V 2.086 1.00
582_A 594_V 2.066 0.99
234_Y 355_G 2.061 0.99
447_R 685_G 2.039 0.99
223_A 364_L 2.033 0.99
411_M 502_F 2.03 0.99
414_H 419_N 2.027 0.99
498_L 507_I 2.007 0.99
446_P 468_S 1.975 0.99
641_A 656_L 1.953 0.99
5_H 17_D 1.949 0.99
505_V 534_R 1.94 0.99
550_D 590_K 1.939 0.99
641_A 649_A 1.919 0.99
137_K 140_Q 1.902 0.99
618_A 622_L 1.887 0.99
200_N 381_A 1.887 0.99
236_S 239_E 1.886 0.99
637_V 705_I 1.884 0.99
368_Q 619_E 1.882 0.99
84_A 340_L 1.881 0.99
81_L 99_A 1.867 0.99
410_R 413_Q 1.845 0.99
311_F 314_L 1.844 0.99
238_L 250_V 1.841 0.99
407_L 423_L 1.836 0.98
160_F 164_A 1.835 0.98
455_H 464_H 1.828 0.98
274_E 288_A 1.824 0.98
456_Q 496_Q 1.818 0.98
365_C 369_Q 1.809 0.98
406_A 410_R 1.783 0.98
342_V 372_Y 1.78 0.98
680_A 683_R 1.778 0.98
3_V 17_D 1.765 0.98
240_N 244_Q 1.76 0.98
40_Q 64_V 1.757 0.98
307_L 341_A 1.755 0.98
269_F 299_I 1.746 0.98
225_V 386_P 1.739 0.98
404_A 407_L 1.726 0.97
366_N 371_K 1.72 0.97
199_L 207_V 1.718 0.97
206_A 375_L 1.718 0.97
637_V 727_V 1.715 0.97
26_V 66_V 1.708 0.97
81_L 92_I 1.702 0.97
307_L 344_R 1.694 0.97
343_Y 346_H 1.664 0.97
415_L 505_V 1.661 0.97
361_L 622_L 1.655 0.97
452_Y 468_S 1.651 0.96
376_R 615_D 1.65 0.96
242_L 298_A 1.644 0.96
526_A 530_R 1.642 0.96
12_L 16_F 1.629 0.96
206_A 353_I 1.628 0.96
90_H 95_V 1.612 0.96
240_N 243_A 1.609 0.96
6_V 44_G 1.586 0.95
641_A 653_L 1.585 0.95
5_H 50_S 1.582 0.95
84_A 95_V 1.573 0.95
414_H 553_L 1.566 0.95
422_I 551_V 1.565 0.95
644_H 686_R 1.561 0.95
505_V 535_I 1.553 0.95
528_V 536_L 1.552 0.95
30_C 66_V 1.543 0.94
635_S 728_D 1.537 0.94
554_V 585_A 1.537 0.94
450_H 465_H 1.528 0.94
283_S 287_S 1.519 0.94
608_T 616_A 1.505 0.93
623_A 626_R 1.505 0.93
390_H 406_A 1.503 0.93
8_L 34_V 1.483 0.93
8_L 42_R 1.479 0.92
292_A 300_V 1.464 0.92
87_Y 728_D 1.464 0.92
17_D 53_S 1.459 0.92
397_Q 405_P 1.456 0.92
428_R 513_D 1.453 0.92
363_T 372_Y 1.451 0.92
292_A 309_T 1.446 0.91
77_V 344_R 1.444 0.91
365_C 633_W 1.436 0.91
284_E 518_K 1.425 0.91
394_L 599_H 1.424 0.90
328_K 726_D 1.423 0.90
638_I 690_Q 1.417 0.90
408_I 501_L 1.416 0.90
438_D 481_S 1.413 0.90
83_W 343_Y 1.407 0.90
415_L 535_I 1.399 0.89
427_R 432_P 1.399 0.89
642_E 686_R 1.396 0.89
7_A 92_I 1.395 0.89
423_L 537_I 1.394 0.89
575_A 613_G 1.385 0.89
515_T 520_A 1.381 0.89
403_L 408_I 1.377 0.88
138_Q 171_K 1.373 0.88
33_R 65_E 1.373 0.88
232_E 268_R 1.37 0.88
552_T 590_K 1.364 0.88
431_A 486_P 1.359 0.88
135_S 138_Q 1.359 0.88
235_L 268_R 1.357 0.87
4_A 63_V 1.355 0.87
9_P 93_G 1.352 0.87
413_Q 417_A 1.347 0.87
19_L 60_L 1.346 0.87
68_D 71_P 1.34 0.87
81_L 96_L 1.336 0.86
515_T 518_K 1.33 0.86
210_I 353_I 1.327 0.86
32_V 44_G 1.326 0.86
4_A 49_V 1.325 0.86
207_V 237_V 1.322 0.86
343_Y 347_S 1.322 0.86
241_V 248_A 1.321 0.85
319_I 336_H 1.321 0.85
37_G 61_K 1.316 0.85
494_L 557_L 1.315 0.85
239_E 268_R 1.314 0.85
166_Q 170_K 1.312 0.85
423_L 498_L 1.307 0.85
366_N 372_Y 1.306 0.85
288_A 297_A 1.305 0.85
412_R 502_F 1.305 0.85
391_V 606_L 1.303 0.84
4_A 21_P 1.3 0.84
145_L 174_C 1.298 0.84
649_A 689_W 1.295 0.84
497_T 501_L 1.295 0.84
556_L 596_L 1.293 0.84
163_A 167_A 1.292 0.84
90_H 333_W 1.285 0.83
415_L 421_V 1.284 0.83
324_D 546_H 1.284 0.83
424_F 581_V 1.283 0.83
443_A 461_L 1.282 0.83
184_S 287_S 1.279 0.83
209_A 375_L 1.276 0.83
342_V 366_N 1.275 0.83
219_A 342_V 1.274 0.83
79_R 347_S 1.272 0.82
219_A 372_Y 1.261 0.82
344_R 348_E 1.256 0.81
367_V 374_L 1.251 0.81
245_G 315_G 1.249 0.81
617_F 621_A 1.249 0.81
281_N 284_E 1.248 0.81
197_L 236_S 1.246 0.81
528_V 533_A 1.238 0.80
141_A 160_F 1.236 0.80
378_T 615_D 1.23 0.79
211_H 240_N 1.224 0.79
510_I 521_L 1.22 0.79
17_D 60_L 1.219 0.79
445_C 448_C 1.219 0.79
119_F 175_D 1.219 0.79
222_L 375_L 1.214 0.78
414_H 417_A 1.214 0.78
84_A 333_W 1.213 0.78
487_V 558_D 1.207 0.78
213_A 220_W 1.205 0.77
219_A 352_I 1.202 0.77
630_L 694_Q 1.201 0.77
607_Q 611_Y 1.2 0.77
362_E 567_D 1.2 0.77
404_A 555_A 1.199 0.77
515_T 519_G 1.195 0.77
364_L 374_L 1.194 0.77
412_R 501_L 1.192 0.76
209_A 373_R 1.19 0.76
448_C 466_C 1.186 0.76
302_G 306_A 1.186 0.76
495_E 509_R 1.185 0.76
307_L 340_L 1.181 0.75
86_D 706_N 1.18 0.75
82_L 92_I 1.179 0.75
556_L 578_Y 1.179 0.75
491_T 511_D 1.176 0.75
446_P 470_R 1.176 0.75
454_L 472_V 1.171 0.75
445_C 466_C 1.169 0.74
33_R 64_V 1.168 0.74
167_A 171_K 1.165 0.74
288_A 291_K 1.161 0.74
388_I 591_Q 1.16 0.74
437_H 487_V 1.159 0.73
657_R 661_L 1.157 0.73
491_T 509_R 1.156 0.73
362_E 568_F 1.152 0.73
339_D 342_V 1.148 0.72
411_M 498_L 1.146 0.72
247_Q 298_A 1.145 0.72
607_Q 610_L 1.14 0.72
141_A 165_L 1.135 0.71
622_L 633_W 1.131 0.71
221_L 367_V 1.131 0.71
569_R 572_E 1.13 0.71
556_L 581_V 1.129 0.71
292_A 311_F 1.127 0.70
650_P 689_W 1.124 0.70
510_I 515_T 1.123 0.70
421_V 502_F 1.122 0.70
495_E 499_A 1.122 0.70
153_D 156_A 1.116 0.69
20_L 63_V 1.111 0.69
249_L 303_T 1.111 0.69
428_R 455_H 1.11 0.69
82_L 86_D 1.107 0.68
223_A 374_L 1.105 0.68
598_T 601_P 1.1 0.68
506_P 532_G 1.099 0.68
28_A 78_W 1.098 0.68
473_P 477_P 1.097 0.67
428_R 464_H 1.095 0.67
249_L 311_F 1.094 0.67
288_A 309_T 1.093 0.67
276_L 288_A 1.091 0.67
300_V 311_F 1.086 0.66
388_I 593_E 1.084 0.66
477_P 480_G 1.083 0.66
32_V 63_V 1.079 0.66
650_P 654_Q 1.077 0.65
246_K 313_N 1.077 0.65
223_A 376_R 1.076 0.65
462_R 469_Q 1.076 0.65
237_V 316_V 1.075 0.65
47_V 78_W 1.073 0.65
319_I 352_I 1.072 0.65
26_V 30_C 1.07 0.65
413_Q 416_Q 1.07 0.65
521_L 525_L 1.069 0.65
319_I 342_V 1.067 0.64
15_T 47_V 1.066 0.64
424_F 537_I 1.065 0.64
441_W 478_S 1.065 0.64
411_M 414_H 1.057 0.63
345_A 350_I 1.057 0.63
522_E 526_A 1.054 0.63
476_C 479_C 1.054 0.63
645_N 648_H 1.051 0.63
33_R 40_Q 1.048 0.62
13_P 16_F 1.047 0.62
528_V 551_V 1.046 0.62
276_L 292_A 1.044 0.62
80_L 259_P 1.041 0.62
367_V 372_Y 1.04 0.61
578_Y 609_L 1.037 0.61
381_A 384_A 1.036 0.61
670_L 693_L 1.035 0.61
412_R 504_G 1.033 0.61
489_L 493_Q 1.032 0.61
252_V 280_L 1.028 0.60
233_V 377_L 1.026 0.60
223_A 614_Y 1.021 0.59
229_G 587_R 1.019 0.59
149_K 179_E 1.015 0.59
28_A 49_V 1.013 0.58
232_E 236_S 1.011 0.58
141_A 168_L 1.011 0.58
465_H 683_R 1.007 0.58
319_I 337_A 1.006 0.58
74_T 348_E 1.006 0.58
414_H 552_T 1.005 0.57
320_D 583_G 1.001 0.57
531_G 534_R 1 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gm5A10.75961000.805Contact Map0.572
2eyqA20.82511000.815Contact Map0.589
4f92B10.73631000.853Contact Map0.468
4dduA10.68991000.855Contact Map0.568
2ocaA10.6681000.859Contact Map0.395
4bgdA10.71451000.861Contact Map0.5
2fwrA40.61481000.864Contact Map0.48
3fhoA20.6681000.867Contact Map0.454
3peyA10.5151000.867Contact Map0.468
3fhtA20.52321000.868Contact Map0.472
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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