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OPENSEQ.org
CYSI - Sulfite reductase [NADPH] hemoprotein beta-component
UniProt: P17846 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10190
Length: 570 (548)
Sequences: 1178
Seq/Len: 2.15
CYSI
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
356_W 405_E 4.27 1.00
546_E 554_R 3.612 1.00
318_T 321_A 3.525 1.00
248_G 276_Y 3.415 1.00
101_K 105_E 3.234 1.00
317_E 320_K 3.077 1.00
322_E 325_R 2.949 1.00
404_P 407_E 2.934 1.00
269_R 272_S 2.913 1.00
235_M 289_V 2.887 1.00
298_N 304_N 2.846 1.00
97_Q 384_K 2.794 1.00
314_V 318_T 2.666 1.00
237_F 251_L 2.65 1.00
477_T 484_G 2.631 1.00
126_L 129_N 2.572 1.00
237_F 286_A 2.376 1.00
20_R 24_E 2.364 1.00
106_N 132_P 2.357 1.00
281_H 329_I 2.354 1.00
98_A 136_M 2.301 1.00
390_F 398_L 2.299 1.00
242_E 246_L 2.271 1.00
537_R 541_E 2.249 1.00
278_P 281_H 2.2 1.00
84_C 122_F 2.183 1.00
251_L 289_V 2.135 1.00
393_T 399_I 2.128 1.00
198_V 286_A 2.027 0.99
105_E 136_M 2.023 0.99
106_N 136_M 1.97 0.99
503_L 522_I 1.958 0.99
219_T 228_I 1.916 0.99
318_T 322_E 1.904 0.99
93_T 384_K 1.888 0.99
292_T 323_V 1.887 0.99
547_G 550_D 1.883 0.99
97_Q 381_E 1.878 0.98
156_L 394_A 1.852 0.98
360_L 415_A 1.851 0.98
173_W 249_F 1.851 0.98
381_E 384_K 1.846 0.98
531_L 535_I 1.8 0.98
114_L 392_I 1.796 0.98
220_V 237_F 1.792 0.98
379_L 398_L 1.792 0.98
389_D 402_G 1.783 0.98
219_T 233_N 1.741 0.97
355_N 404_P 1.736 0.97
450_F 524_E 1.736 0.97
407_E 410_K 1.734 0.97
104_G 376_K 1.733 0.97
114_L 398_L 1.706 0.97
231_H 252_L 1.696 0.97
425_T 459_D 1.676 0.96
472_I 535_I 1.655 0.96
132_P 136_M 1.644 0.96
304_N 313_R 1.634 0.96
125_I 133_V 1.633 0.96
169_E 245_K 1.632 0.96
414_I 418_S 1.631 0.95
216_F 290_V 1.624 0.95
237_F 249_F 1.618 0.95
288_A 323_V 1.618 0.95
98_A 101_K 1.611 0.95
382_I 414_I 1.605 0.95
102_F 133_V 1.599 0.95
251_L 285_V 1.594 0.95
102_F 142_L 1.589 0.95
93_T 383_A 1.581 0.94
403_V 411_I 1.573 0.94
252_L 273_E 1.57 0.94
406_S 413_K 1.562 0.94
25_S 29_R 1.537 0.93
101_K 104_G 1.535 0.93
288_A 292_T 1.523 0.93
319_F 323_V 1.514 0.93
250_N 273_E 1.504 0.92
58_Y 217_K 1.497 0.92
232_A 488_L 1.488 0.92
541_E 555_A 1.487 0.92
253_V 323_V 1.484 0.92
235_M 286_A 1.481 0.91
104_G 377_T 1.477 0.91
86_L 91_I 1.464 0.91
409_A 413_K 1.461 0.91
135_Q 139_S 1.444 0.90
316_V 320_K 1.428 0.89
311_L 316_V 1.418 0.89
321_A 325_R 1.415 0.89
175_K 179_E 1.413 0.89
281_H 284_A 1.408 0.88
291_T 326_R 1.407 0.88
27_Y 209_Q 1.397 0.88
274_F 320_K 1.394 0.88
155_V 198_V 1.392 0.88
98_A 139_S 1.388 0.88
523_T 526_E 1.381 0.87
274_F 323_V 1.375 0.87
385_I 414_I 1.374 0.87
30_G 34_E 1.372 0.87
18_A 50_L 1.371 0.87
276_Y 279_L 1.37 0.87
350_K 405_E 1.361 0.86
136_M 139_S 1.359 0.86
513_R 553_V 1.358 0.86
315_G 318_T 1.356 0.86
542_R 554_R 1.346 0.85
287_E 291_T 1.345 0.85
322_E 326_R 1.34 0.85
285_V 327_A 1.329 0.84
218_T 235_M 1.324 0.84
263_N 301_D 1.32 0.84
542_R 546_E 1.319 0.84
98_A 140_V 1.316 0.83
349_V 357_H 1.314 0.83
551_F 555_A 1.314 0.83
464_K 532_D 1.312 0.83
350_K 356_W 1.312 0.83
235_M 283_L 1.307 0.83
61_D 66_R 1.302 0.83
324_E 328_G 1.302 0.83
281_H 327_A 1.298 0.82
162_Y 357_H 1.291 0.82
102_F 136_M 1.288 0.82
17_D 20_R 1.286 0.81
253_V 316_V 1.284 0.81
269_R 312_E 1.278 0.81
296_W 314_V 1.277 0.81
289_V 319_F 1.265 0.80
148_A 308_K 1.264 0.80
537_R 555_A 1.264 0.80
177_I 286_A 1.263 0.80
267_Y 312_E 1.261 0.80
253_V 319_F 1.256 0.79
457_N 460_N 1.251 0.79
92_T 95_Q 1.251 0.79
284_A 327_A 1.246 0.79
414_I 417_E 1.24 0.78
149_N 217_K 1.238 0.78
104_G 110_G 1.235 0.78
409_A 412_E 1.228 0.77
522_I 530_S 1.221 0.77
148_A 217_K 1.216 0.76
253_V 311_L 1.215 0.76
456_D 459_D 1.214 0.76
504_H 517_M 1.212 0.76
132_P 135_Q 1.2 0.75
298_N 313_R 1.2 0.75
307_T 319_F 1.197 0.75
219_T 230_L 1.193 0.74
158_T 227_D 1.19 0.74
105_E 132_P 1.185 0.74
314_V 319_F 1.184 0.73
246_L 249_F 1.184 0.73
89_G 154_N 1.184 0.73
100_D 377_T 1.183 0.73
191_I 331_F 1.181 0.73
428_R 459_D 1.181 0.73
68_E 72_Q 1.18 0.73
217_K 256_G 1.18 0.73
371_P 374_P 1.18 0.73
49_F 53_R 1.174 0.73
123_H 217_K 1.169 0.72
355_N 402_G 1.164 0.72
324_E 330_K 1.16 0.71
499_G 524_E 1.159 0.71
532_D 536_G 1.158 0.71
508_N 553_V 1.157 0.71
191_I 249_F 1.157 0.71
457_N 528_L 1.154 0.71
238_V 250_N 1.148 0.70
328_G 331_F 1.144 0.70
400_I 411_I 1.138 0.69
58_Y 148_A 1.136 0.69
455_I 459_D 1.131 0.68
149_N 256_G 1.125 0.68
503_L 527_I 1.124 0.68
406_S 410_K 1.123 0.68
33_A 37_N 1.122 0.68
72_Q 76_P 1.118 0.67
112_I 122_F 1.115 0.67
125_I 130_V 1.115 0.67
461_L 465_H 1.114 0.67
315_G 320_K 1.113 0.67
508_N 512_T 1.109 0.66
94_K 384_K 1.108 0.66
476_V 484_G 1.101 0.65
240_I 276_Y 1.1 0.65
156_L 233_N 1.1 0.65
431_S 451_L 1.1 0.65
161_P 393_T 1.093 0.65
35_D 48_N 1.092 0.65
67_A 71_E 1.086 0.64
392_I 398_L 1.086 0.64
311_L 314_V 1.083 0.64
236_N 258_S 1.082 0.63
439_T 447_A 1.08 0.63
86_L 119_T 1.08 0.63
223_P 227_D 1.078 0.63
148_A 442_L 1.078 0.63
292_T 454_F 1.077 0.63
314_V 322_E 1.073 0.63
139_S 413_K 1.07 0.62
57_M 130_V 1.07 0.62
21_M 47_D 1.069 0.62
116_N 258_S 1.069 0.62
522_I 527_I 1.067 0.62
69_R 72_Q 1.066 0.62
209_Q 264_K 1.062 0.61
94_K 406_S 1.06 0.61
177_I 220_V 1.057 0.61
457_N 529_A 1.057 0.61
475_R 482_G 1.056 0.61
131_K 193_L 1.055 0.61
131_K 194_D 1.054 0.60
272_S 316_V 1.053 0.60
274_F 316_V 1.053 0.60
270_T 514_I 1.053 0.60
400_I 414_I 1.051 0.60
237_F 282_T 1.048 0.60
534_L 538_W 1.048 0.60
295_D 326_R 1.045 0.59
277_L 282_T 1.044 0.59
53_R 60_Q 1.04 0.59
166_L 222_I 1.038 0.59
490_E 549_G 1.033 0.58
493_L 503_L 1.033 0.58
172_E 176_K 1.032 0.58
445_A 501_Y 1.028 0.58
536_G 540_K 1.028 0.58
367_I 379_L 1.026 0.57
482_G 487_M 1.025 0.57
457_N 532_D 1.023 0.57
68_E 73_K 1.022 0.57
235_M 251_L 1.018 0.56
230_L 271_A 1.015 0.56
384_K 388_G 1.013 0.56
242_E 247_V 1.012 0.56
281_H 332_E 1.012 0.56
230_L 238_V 1.012 0.56
59_Q 80_M 1.01 0.56
278_P 332_E 1.01 0.56
150_D 302_R 1.009 0.55
413_K 417_E 1.009 0.55
249_F 279_L 1.007 0.55
411_I 414_I 1.006 0.55
277_L 508_N 1.002 0.55
442_L 481_N 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g38A10.99821000.208Contact Map0.707
1zj8A20.91581000.318Contact Map0.695
3b0gA10.88071000.371Contact Map0.665
2akjA10.87891000.375Contact Map0.642
3or1A20.57021000.763Contact Map0.564
3or1B20.52811000.775Contact Map0.645
3mm5A20.51231000.778Contact Map0.53
3mm5B20.51000.798Contact Map0.589
3noyA40.698.40.948Contact Map0.317
4g9pA10.6211910.972Contact Map0.377
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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