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OPENSEQ.org
PHNM - Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
UniProt: P16689 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10722
Length: 378 (375)
Sequences: 10412
Seq/Len: 27.77
PHNM
Paralog alert: 0.87 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
371_W 376_R 4.783 1.00
3_I 42_G 4.597 1.00
346_V 351_K 4.515 1.00
45_G 368_D 4.437 1.00
22_Q 27_R 4.143 1.00
369_H 376_R 4.105 1.00
42_G 357_L 3.996 1.00
6_V 42_G 3.719 1.00
48_L 358_A 3.573 1.00
19_L 47_L 3.243 1.00
50_G 90_T 3.202 1.00
348_G 351_K 3.183 1.00
344_R 352_R 3.162 1.00
28_A 349_E 3.129 1.00
323_T 326_Q 3.11 1.00
347_I 355_L 3.08 1.00
47_L 357_L 2.989 1.00
4_N 39_A 2.908 1.00
326_Q 329_K 2.813 1.00
6_V 47_L 2.772 1.00
352_R 373_Q 2.683 1.00
48_L 356_V 2.602 1.00
24_G 352_R 2.602 1.00
2_I 20_E 2.591 1.00
5_N 41_D 2.587 1.00
21_V 355_L 2.555 1.00
4_N 18_S 2.448 1.00
25_E 352_R 2.416 1.00
359_H 368_D 2.352 1.00
329_K 333_K 2.345 1.00
355_L 371_W 2.295 1.00
1_M 371_W 2.292 1.00
8_L 17_G 2.265 1.00
45_G 357_L 2.181 1.00
287_S 291_Q 2.139 1.00
334_N 337_Q 2.132 1.00
47_L 355_L 2.131 1.00
370_V 378_F 2.121 1.00
19_L 347_I 2.103 1.00
8_L 19_L 2.086 1.00
3_I 21_V 2.062 1.00
341_L 344_R 2.046 1.00
356_V 367_I 2.009 1.00
86_A 378_F 1.972 1.00
333_K 337_Q 1.964 1.00
45_G 359_H 1.95 1.00
220_R 243_L 1.902 1.00
30_A 33_Q 1.9 1.00
258_E 292_L 1.893 1.00
278_G 282_G 1.882 1.00
29_F 349_E 1.861 1.00
295_L 337_Q 1.839 1.00
85_V 377_V 1.838 1.00
328_V 332_T 1.836 1.00
24_G 373_Q 1.834 1.00
20_E 28_A 1.785 1.00
42_G 47_L 1.753 1.00
333_K 346_V 1.71 1.00
218_L 221_A 1.709 1.00
357_L 371_W 1.702 1.00
7_K 16_S 1.676 1.00
337_Q 346_V 1.666 1.00
93_L 339_L 1.664 1.00
85_V 129_A 1.662 1.00
9_V 14_V 1.632 1.00
6_V 357_L 1.625 1.00
48_L 51_L 1.606 1.00
217_A 221_A 1.602 1.00
219_C 226_L 1.593 1.00
116_N 120_E 1.564 1.00
52_I 336_A 1.563 1.00
1_M 21_V 1.556 1.00
21_V 371_W 1.556 1.00
297_I 338_A 1.553 1.00
174_N 177_K 1.55 1.00
40_M 371_W 1.549 1.00
52_I 335_P 1.54 1.00
54_L 297_I 1.538 1.00
84_M 92_V 1.537 1.00
343_D 351_K 1.537 1.00
3_I 355_L 1.534 1.00
177_K 180_E 1.533 1.00
313_R 317_D 1.528 1.00
337_Q 342_Q 1.512 1.00
356_V 370_V 1.504 1.00
329_K 334_N 1.5 1.00
14_V 325_P 1.47 1.00
315_A 327_A 1.461 1.00
54_L 268_L 1.43 1.00
288_E 292_L 1.43 1.00
5_N 43_E 1.427 1.00
233_T 236_H 1.427 1.00
7_K 14_V 1.427 1.00
238_A 242_Q 1.416 1.00
115_I 119_E 1.415 1.00
290_A 326_Q 1.415 1.00
285_A 288_E 1.414 1.00
19_L 355_L 1.408 1.00
213_E 217_A 1.403 0.99
48_L 328_V 1.393 0.99
372_R 377_V 1.381 0.99
17_G 29_F 1.38 0.99
268_L 297_I 1.38 0.99
54_L 339_L 1.373 0.99
209_Q 213_E 1.368 0.99
2_I 18_S 1.352 0.99
147_L 150_K 1.341 0.99
176_E 180_E 1.33 0.99
18_S 33_Q 1.325 0.99
5_N 16_S 1.322 0.99
10_L 15_V 1.311 0.99
9_V 328_V 1.306 0.99
26_I 355_L 1.302 0.99
20_E 37_P 1.297 0.99
20_E 27_R 1.292 0.99
175_R 178_Y 1.29 0.99
7_K 46_W 1.287 0.99
258_E 262_K 1.285 0.99
54_L 335_P 1.274 0.99
179_R 183_Q 1.268 0.99
278_G 281_S 1.258 0.99
40_M 369_H 1.248 0.99
252_T 256_A 1.241 0.98
210_P 213_E 1.228 0.98
3_I 47_L 1.22 0.98
5_N 42_G 1.216 0.98
322_F 330_L 1.214 0.98
90_T 354_D 1.206 0.98
253_T 256_A 1.187 0.98
17_G 31_E 1.184 0.98
3_I 371_W 1.183 0.98
289_L 294_L 1.179 0.98
367_I 370_V 1.176 0.98
27_R 349_E 1.175 0.98
130_E 373_Q 1.174 0.98
361_K 365_I 1.163 0.97
5_N 44_G 1.141 0.97
1_M 38_E 1.131 0.97
4_N 41_D 1.13 0.97
357_L 369_H 1.129 0.97
58_N 92_V 1.126 0.97
38_E 376_R 1.125 0.97
179_R 221_A 1.118 0.96
214_S 217_A 1.118 0.96
85_V 370_V 1.117 0.96
336_A 345_G 1.116 0.96
6_V 355_L 1.115 0.96
17_G 30_A 1.113 0.96
297_I 334_N 1.111 0.96
266_N 295_L 1.106 0.96
344_R 354_D 1.104 0.96
288_E 291_Q 1.1 0.96
212_R 236_H 1.096 0.96
85_V 372_R 1.093 0.96
52_I 91_T 1.089 0.96
51_L 331_V 1.088 0.96
358_A 367_I 1.088 0.96
52_I 344_R 1.07 0.95
19_L 29_F 1.064 0.95
40_M 376_R 1.056 0.95
113_K 116_N 1.052 0.95
3_I 357_L 1.051 0.94
26_I 347_I 1.046 0.94
254_F 257_A 1.045 0.94
188_L 229_H 1.043 0.94
326_Q 330_L 1.042 0.94
18_S 32_S 1.04 0.94
234_H 279_S 1.037 0.94
342_Q 351_K 1.037 0.94
90_T 370_V 1.033 0.94
18_S 30_A 1.014 0.93
58_N 81_D 1.012 0.93
91_T 354_D 1.01 0.93
55_H 301_D 1.01 0.93
297_I 335_P 1.005 0.93
359_H 365_I 1.005 0.93
331_V 335_P 1.003 0.93
259_A 262_K 1.002 0.92
333_K 351_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ftyA40.94711000.321Contact Map0.835
2gwnA10.92861000.323Contact Map0.841
3e74A40.93391000.325Contact Map0.852
3hm7A60.93121000.327Contact Map0.866
1nfgA40.93921000.331Contact Map0.796
1gkpA60.93651000.332Contact Map0.852
3dc8A20.93121000.333Contact Map0.833
3ls9A20.91011000.338Contact Map0.788
3sfwA20.93651000.34Contact Map0.835
1gkrA40.93121000.341Contact Map0.802
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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