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OPENSEQ.org
PHNH - Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH
UniProt: P16686 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10717
Length: 194 (192)
Sequences: 252
Seq/Len: 1.31
PHNH
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
25_M 184_A 3.666 1.00
21_L 51_V 2.757 1.00
149_I 183_L 2.502 1.00
25_M 175_I 2.39 0.99
34_L 182_L 2.184 0.99
95_A 121_A 1.988 0.97
157_I 185_I 1.953 0.97
23_K 27_E 1.871 0.96
47_A 179_G 1.857 0.95
21_L 175_I 1.847 0.95
51_V 175_I 1.748 0.93
157_I 161_L 1.708 0.92
63_W 120_G 1.55 0.86
56_A 154_P 1.517 0.84
161_L 164_R 1.505 0.84
85_L 188_T 1.504 0.84
56_A 96_V 1.504 0.84
69_N 74_N 1.502 0.83
175_I 184_A 1.495 0.83
41_W 164_R 1.472 0.82
41_W 119_A 1.451 0.80
22_L 118_E 1.438 0.80
95_A 109_L 1.418 0.78
49_T 76_S 1.406 0.77
124_I 175_I 1.4 0.77
79_F 82_N 1.389 0.76
125_L 174_L 1.378 0.75
126_Q 177_T 1.373 0.75
64_L 95_A 1.356 0.74
116_A 119_A 1.351 0.73
14_A 106_L 1.35 0.73
59_D 63_W 1.345 0.73
52_L 96_V 1.337 0.72
22_L 83_A 1.323 0.71
44_L 59_D 1.322 0.71
109_L 121_A 1.305 0.70
5_T 113_T 1.288 0.68
19_R 22_L 1.287 0.68
24_A 184_A 1.277 0.67
185_I 191_V 1.27 0.67
157_I 184_A 1.27 0.67
27_E 147_R 1.269 0.67
22_L 52_L 1.263 0.66
41_W 76_S 1.245 0.64
86_V 121_A 1.242 0.64
113_T 170_L 1.24 0.64
53_L 64_L 1.223 0.62
76_S 164_R 1.219 0.62
11_V 15_Q 1.209 0.61
61_P 93_T 1.205 0.61
61_P 84_P 1.199 0.60
114_A 170_L 1.196 0.60
139_T 146_E 1.195 0.60
138_L 149_I 1.191 0.59
22_L 81_T 1.178 0.58
53_L 80_H 1.176 0.58
23_K 32_V 1.166 0.57
51_V 124_I 1.147 0.55
86_V 91_Q 1.13 0.53
161_L 185_I 1.112 0.52
83_A 177_T 1.109 0.51
45_N 48_T 1.107 0.51
64_L 120_G 1.107 0.51
118_E 188_T 1.106 0.51
54_T 129_S 1.104 0.51
33_A 180_E 1.099 0.50
40_G 91_Q 1.096 0.50
61_P 130_L 1.092 0.50
27_E 83_A 1.082 0.49
109_L 120_G 1.08 0.48
90_E 128_A 1.074 0.48
110_S 188_T 1.072 0.48
62_V 96_V 1.072 0.48
67_P 87_S 1.07 0.47
61_P 133_G 1.069 0.47
29_G 138_L 1.062 0.47
9_L 12_Q 1.06 0.46
45_N 177_T 1.055 0.46
153_L 177_T 1.046 0.45
34_L 67_P 1.045 0.45
52_L 56_A 1.039 0.44
5_T 56_A 1.036 0.44
130_L 133_G 1.032 0.44
60_T 93_T 1.031 0.43
33_A 182_L 1.03 0.43
124_I 184_A 1.029 0.43
120_G 164_R 1.027 0.43
158_L 161_L 1.023 0.43
53_L 61_P 1.021 0.43
132_G 151_P 1.021 0.43
167_P 170_L 1.016 0.42
24_A 32_V 1.016 0.42
5_T 22_L 1.014 0.42
41_W 115_V 1.013 0.42
3_L 93_T 1.011 0.42
85_L 176_L 1.007 0.41
52_L 189_T 1.004 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2fsuA111000.025Contact Map0.511
1pgjA20.4334.10.968Contact Map0.145
2fhzA10.195940.968Contact Map0
1nm2A10.371130.97Contact Map0.166
1g92A10.08252.60.971Contact Map0.461
2zydA20.42272.30.972Contact Map0.182
2bgwA20.48971.90.973Contact Map0.211
1b9pA10.16491.80.973Contact Map0.216
1ncqD10.11861.80.973Contact Map0.314
1bev410.11861.70.973Contact Map0
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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