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OPENSEQ.org
PANF - Sodium/pantothenate symporter
UniProt: P16256 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10685
Length: 483 (474)
Sequences: 5139
Seq/Len: 10.84
PANF
Paralog alert: 0.72 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ACTP PANF PUTP YIDK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
431_V 462_A 5.393 1.00
431_V 458_L 4.059 1.00
362_N 365_R 3.961 1.00
265_D 268_A 3.901 1.00
357_P 365_R 3.566 1.00
464_L 468_R 3.433 1.00
420_A 463_F 3.345 1.00
427_S 466_G 3.166 1.00
170_A 378_G 3.125 1.00
462_A 466_G 3.021 1.00
18_G 22_Y 2.897 1.00
435_L 458_L 2.871 1.00
424_G 467_N 2.853 1.00
157_P 160_T 2.733 1.00
466_G 470_G 2.712 1.00
212_N 215_Q 2.631 1.00
421_N 470_G 2.61 1.00
428_A 463_F 2.479 1.00
203_V 293_L 2.454 1.00
201_I 205_H 2.431 1.00
368_R 372_V 2.365 1.00
421_N 424_G 2.351 1.00
178_F 262_S 2.276 1.00
423_K 470_G 2.261 1.00
43_M 182_V 2.242 1.00
372_V 376_V 2.238 1.00
166_G 382_L 2.237 1.00
413_L 463_F 2.225 1.00
352_Y 360_M 2.18 1.00
115_F 124_V 2.164 1.00
364_T 368_R 2.157 1.00
35_E 40_S 2.153 1.00
163_L 167_I 2.114 1.00
113_M 414_G 2.079 1.00
427_S 462_A 2.066 1.00
379_A 383_L 2.046 1.00
424_G 428_A 2.027 1.00
38_L 41_R 2.02 1.00
14_V 18_G 2.011 1.00
195_G 327_A 2.005 1.00
264_K 268_A 1.967 1.00
417_W 420_A 1.963 1.00
423_K 427_S 1.958 1.00
461_L 465_V 1.937 1.00
11_A 15_V 1.936 1.00
67_G 305_D 1.931 1.00
434_V 438_V 1.92 1.00
118_Y 420_A 1.919 1.00
419_R 468_R 1.898 1.00
417_W 468_R 1.875 1.00
294_G 307_V 1.83 1.00
347_I 351_L 1.791 1.00
417_W 464_L 1.78 1.00
421_N 467_N 1.778 1.00
322_G 326_A 1.763 1.00
212_N 216_T 1.758 1.00
176_G 180_A 1.749 1.00
268_A 271_R 1.742 1.00
122_L 426_L 1.738 1.00
368_R 371_A 1.725 1.00
349_K 353_L 1.723 1.00
211_S 215_Q 1.72 1.00
347_I 373_I 1.71 1.00
352_Y 356_R 1.707 1.00
352_Y 365_R 1.688 1.00
352_Y 369_M 1.679 1.00
410_P 425_A 1.644 1.00
357_P 360_M 1.619 1.00
352_Y 357_P 1.614 1.00
59_A 145_G 1.612 1.00
39_G 178_F 1.591 1.00
3_L 7_L 1.59 1.00
267_K 270_H 1.589 1.00
413_L 460_L 1.573 1.00
47_V 186_T 1.569 1.00
420_A 424_G 1.568 1.00
465_V 468_R 1.567 1.00
100_I 266_S 1.552 1.00
423_K 469_F 1.547 1.00
169_I 336_I 1.54 1.00
50_M 186_T 1.528 1.00
215_Q 219_T 1.516 1.00
427_S 431_V 1.513 1.00
112_D 350_D 1.498 1.00
55_T 338_A 1.485 1.00
15_V 187_M 1.478 1.00
373_I 376_V 1.477 1.00
107_A 116_A 1.477 1.00
99_A 103_R 1.468 1.00
197_V 201_I 1.467 1.00
267_K 271_R 1.466 1.00
216_T 219_T 1.464 1.00
340_L 378_G 1.462 1.00
185_D 259_R 1.439 1.00
6_I 10_V 1.439 1.00
18_G 21_V 1.427 1.00
457_L 461_L 1.424 1.00
15_V 19_I 1.414 1.00
298_I 314_K 1.373 0.99
16_V 187_M 1.371 0.99
48_L 263_Y 1.371 0.99
254_P 258_V 1.369 0.99
130_S 433_G 1.368 0.99
159_E 163_L 1.365 0.99
19_I 187_M 1.358 0.99
430_I 434_V 1.352 0.99
353_L 366_L 1.347 0.99
421_N 466_G 1.341 0.99
424_G 466_G 1.339 0.99
343_S 377_L 1.333 0.99
7_L 11_A 1.33 0.99
104_R 266_S 1.317 0.99
147_A 162_L 1.31 0.99
188_Q 337_N 1.309 0.99
117_R 417_W 1.303 0.99
215_Q 218_Q 1.301 0.99
115_F 354_N 1.3 0.99
113_M 117_R 1.291 0.99
148_R 303_V 1.288 0.99
45_G 268_A 1.285 0.99
129_L 133_V 1.28 0.99
166_G 378_G 1.279 0.99
365_R 368_R 1.274 0.99
428_A 459_S 1.263 0.99
184_N 337_N 1.262 0.99
460_L 464_L 1.259 0.99
37_F 370_S 1.253 0.99
431_V 435_L 1.253 0.99
365_R 369_M 1.252 0.99
417_W 424_G 1.249 0.99
51_T 338_A 1.249 0.99
184_N 188_Q 1.241 0.98
361_Q 365_R 1.231 0.98
169_I 333_M 1.227 0.98
352_Y 361_Q 1.225 0.98
27_R 35_E 1.225 0.98
424_G 427_S 1.224 0.98
160_T 164_I 1.222 0.98
167_I 171_L 1.221 0.98
417_W 467_N 1.216 0.98
146_G 165_F 1.212 0.98
9_L 329_M 1.211 0.98
348_I 370_S 1.209 0.98
10_V 14_V 1.205 0.98
464_L 467_N 1.202 0.98
458_L 462_A 1.194 0.98
310_T 314_K 1.186 0.98
160_T 163_L 1.181 0.98
426_L 430_I 1.18 0.98
124_V 350_D 1.18 0.98
109_T 345_A 1.178 0.98
156_I 161_G 1.174 0.98
185_D 337_N 1.166 0.97
200_L 286_G 1.161 0.97
312_M 324_F 1.158 0.97
127_A 429_M 1.155 0.97
172_Y 333_M 1.154 0.97
181_S 184_N 1.152 0.97
117_R 414_G 1.152 0.97
118_Y 413_L 1.15 0.97
118_Y 414_G 1.15 0.97
151_E 155_G 1.148 0.97
467_N 470_G 1.146 0.97
118_Y 463_F 1.142 0.97
423_K 466_G 1.136 0.97
21_V 25_R 1.134 0.97
207_A 213_A 1.134 0.97
5_V 319_F 1.13 0.97
162_L 382_L 1.122 0.97
163_L 379_A 1.12 0.96
174_A 375_L 1.116 0.96
55_T 185_D 1.109 0.96
159_E 386_W 1.108 0.96
213_A 296_A 1.105 0.96
58_S 62_F 1.104 0.96
112_D 349_K 1.103 0.96
143_F 166_G 1.103 0.96
341_L 344_S 1.097 0.96
419_R 472_S 1.093 0.96
420_A 467_N 1.081 0.95
123_L 426_L 1.078 0.95
97_K 100_I 1.07 0.95
39_G 43_M 1.064 0.95
39_G 262_S 1.06 0.95
417_W 421_N 1.056 0.95
97_K 416_Y 1.055 0.95
71_K 304_P 1.053 0.95
25_R 28_S 1.051 0.94
208_G 212_N 1.05 0.94
34_N 41_R 1.047 0.94
422_A 426_L 1.047 0.94
185_D 338_A 1.046 0.94
414_G 425_A 1.046 0.94
462_A 465_V 1.045 0.94
410_P 459_S 1.041 0.94
356_R 360_M 1.04 0.94
36_Y 374_T 1.038 0.94
49_A 275_I 1.032 0.94
99_A 102_A 1.03 0.94
51_T 55_T 1.027 0.94
274_I 277_T 1.027 0.94
54_A 259_R 1.027 0.94
380_L 383_L 1.022 0.93
163_L 386_W 1.021 0.93
143_F 162_L 1.019 0.93
12_Y 330_A 1.018 0.93
274_I 278_I 1.018 0.93
356_R 359_Q 1.017 0.93
5_V 8_P 1.017 0.93
347_I 377_L 1.015 0.93
204_V 289_L 1.013 0.93
148_R 151_E 1.013 0.93
51_T 54_A 1.012 0.93
172_Y 337_N 1.009 0.93
396_N 399_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xq2A10.98551000.225Contact Map0.651
3dh4A40.9421000.265Contact Map0.593
3l1lA10.871699.30.861Contact Map0.402
3giaA10.865498.90.885Contact Map0.415
2jlnA10.863498.60.896Contact Map0.414
4djkA20.877897.40.922Contact Map0.349
4ainA30.863495.40.938Contact Map0.461
2wswA10.819994.80.94Contact Map0.361
4c7rA30.888294.10.942Contact Map0.373
3dinD20.13256.30.976Contact Map0.286
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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