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OPENSEQ.org
PEPD - Cytosol non-specific dipeptidase
UniProt: P15288 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10695
Length: 485 (483)
Sequences: 1408
Seq/Len: 2.92
PEPD
Paralog alert: 0.31 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
416_Q 422_T 5.247 1.00
103_E 466_E 3.707 1.00
97_Q 108_R 3.429 1.00
90_D 93_K 3.339 1.00
92_T 460_D 3.228 1.00
103_E 464_H 3.115 1.00
133_V 480_K 2.971 1.00
38_G 42_E 2.882 1.00
417_R 477_E 2.881 1.00
30_E 34_E 2.698 1.00
104_W 462_Q 2.506 1.00
19_I 32_L 2.47 1.00
99_Y 108_R 2.439 1.00
72_V 162_A 2.429 1.00
51_Q 156_Q 2.359 1.00
20_C 107_A 2.282 1.00
477_E 480_K 2.275 1.00
36_I 77_L 2.261 1.00
72_V 444_M 2.232 1.00
94_D 97_Q 2.187 1.00
37_V 41_K 2.158 1.00
43_K 124_L 2.121 1.00
38_G 41_K 2.082 1.00
18_K 35_Y 2.081 1.00
75_A 120_M 2.077 1.00
414_T 481_E 2.063 1.00
35_Y 38_G 2.004 1.00
43_K 128_A 1.938 0.99
335_S 343_E 1.932 0.99
341_V 427_I 1.906 0.99
20_C 98_P 1.902 0.99
18_K 21_S 1.869 0.99
144_T 150_D 1.863 0.99
20_C 24_H 1.847 0.99
127_L 139_V 1.837 0.99
164_I 407_V 1.823 0.99
100_I 465_I 1.822 0.99
30_E 49_R 1.814 0.99
45_F 57_I 1.792 0.99
250_N 352_T 1.772 0.99
413_E 481_E 1.76 0.99
122_S 471_Y 1.756 0.99
89_H 95_P 1.737 0.99
417_R 481_E 1.737 0.99
61_A 136_P 1.736 0.99
123_A 139_V 1.734 0.99
77_L 141_L 1.722 0.98
411_V 478_L 1.72 0.98
93_K 101_D 1.698 0.98
34_E 38_G 1.692 0.98
371_G 374_Y 1.69 0.98
231_L 264_A 1.649 0.98
35_Y 39_W 1.644 0.98
453_I 456_P 1.637 0.98
27_Y 144_T 1.626 0.97
353_M 358_V 1.625 0.97
185_D 255_R 1.623 0.97
37_V 47_V 1.618 0.97
15_I 125_A 1.602 0.97
17_A 21_S 1.601 0.97
313_I 316_S 1.598 0.97
22_I 35_Y 1.591 0.97
414_T 477_E 1.58 0.97
24_H 32_L 1.549 0.96
75_A 119_G 1.547 0.96
372_K 395_A 1.531 0.96
197_V 311_A 1.516 0.96
140_L 155_L 1.51 0.96
411_V 447_V 1.506 0.96
205_K 303_D 1.496 0.95
82_Q 96_I 1.49 0.95
274_D 277_K 1.488 0.95
463_V 468_V 1.486 0.95
69_K 163_D 1.481 0.95
84_N 261_E 1.477 0.95
469_G 473_T 1.477 0.95
315_K 319_T 1.474 0.95
412_R 425_I 1.465 0.95
71_V 479_L 1.464 0.95
87_T 109_G 1.443 0.94
154_G 158_N 1.442 0.94
380_D 384_K 1.437 0.94
348_V 360_I 1.435 0.94
404_N 409_H 1.434 0.94
33_A 49_R 1.433 0.94
225_G 230_L 1.431 0.94
281_N 285_E 1.427 0.94
89_H 94_D 1.426 0.94
48_E 159_W 1.426 0.94
233_R 290_E 1.424 0.93
208_L 300_L 1.424 0.93
100_I 103_E 1.417 0.93
234_F 238_H 1.408 0.93
137_L 479_L 1.408 0.93
46_H 58_R 1.407 0.93
274_D 278_S 1.405 0.93
231_L 262_A 1.399 0.93
58_R 161_Q 1.395 0.93
179_G 427_I 1.393 0.92
377_S 381_S 1.391 0.92
40_A 47_V 1.39 0.92
464_H 467_S 1.381 0.92
62_T 129_D 1.375 0.92
75_A 141_L 1.363 0.91
225_G 291_L 1.359 0.91
60_P 136_P 1.349 0.91
149_M 363_L 1.346 0.91
15_I 128_A 1.345 0.91
15_I 43_K 1.339 0.90
73_L 123_A 1.338 0.90
188_S 383_G 1.338 0.90
412_R 423_P 1.334 0.90
414_T 418_L 1.334 0.90
37_V 55_I 1.332 0.90
48_E 58_R 1.326 0.90
374_Y 378_M 1.325 0.90
148_G 180_C 1.32 0.90
40_A 59_K 1.32 0.90
166_I 449_I 1.316 0.89
218_G 221_H 1.308 0.89
335_S 340_G 1.299 0.89
243_D 314_A 1.291 0.88
43_K 47_V 1.29 0.88
20_C 110_T 1.286 0.88
318_D 322_R 1.281 0.88
12_L 121_A 1.274 0.87
37_V 49_R 1.271 0.87
339_K 368_I 1.256 0.86
413_E 417_R 1.251 0.86
170_S 456_P 1.251 0.86
412_R 422_T 1.25 0.86
17_A 98_P 1.249 0.86
247_I 308_D 1.247 0.86
36_I 141_L 1.242 0.85
410_L 414_T 1.241 0.85
67_N 484_A 1.234 0.85
21_S 97_Q 1.231 0.85
23_P 82_Q 1.225 0.84
477_E 481_E 1.225 0.84
68_R 483_P 1.219 0.84
192_L 425_I 1.214 0.84
23_P 96_I 1.214 0.84
268_V 276_L 1.202 0.83
101_D 106_K 1.2 0.83
428_I 431_G 1.199 0.83
416_Q 421_K 1.198 0.82
195_E 427_I 1.193 0.82
293_E 296_K 1.193 0.82
451_P 456_P 1.186 0.82
17_A 100_I 1.181 0.81
99_Y 106_K 1.18 0.81
233_R 370_S 1.168 0.80
82_Q 260_R 1.164 0.80
84_N 87_T 1.16 0.80
230_L 287_L 1.16 0.80
11_P 14_D 1.158 0.79
107_A 110_T 1.157 0.79
71_V 482_I 1.155 0.79
339_K 369_D 1.152 0.79
26_S 144_T 1.152 0.79
184_I 376_V 1.151 0.79
58_R 138_E 1.151 0.79
248_D 265_T 1.15 0.79
69_K 483_P 1.15 0.79
249_F 320_F 1.148 0.79
405_S 445_D 1.14 0.78
275_V 279_L 1.136 0.78
52_V 154_G 1.131 0.77
416_Q 423_P 1.128 0.77
102_G 466_E 1.125 0.77
52_V 143_M 1.123 0.76
129_D 472_W 1.122 0.76
313_I 321_I 1.118 0.76
56_L 159_W 1.115 0.76
418_L 477_E 1.112 0.75
40_A 124_L 1.109 0.75
290_E 370_S 1.106 0.75
377_S 380_D 1.104 0.75
203_T 267_A 1.103 0.75
9_P 469_G 1.099 0.74
132_V 476_T 1.098 0.74
229_K 378_M 1.092 0.74
414_T 474_L 1.089 0.73
190_L 388_A 1.087 0.73
32_L 77_L 1.087 0.73
136_P 160_L 1.086 0.73
412_R 416_Q 1.086 0.73
70_P 136_P 1.084 0.73
344_T 371_G 1.084 0.73
205_K 263_F 1.082 0.73
100_I 105_V 1.077 0.72
27_Y 150_D 1.074 0.72
48_E 56_L 1.073 0.72
341_V 367_L 1.067 0.71
39_W 43_K 1.062 0.71
193_D 313_I 1.06 0.70
73_L 479_L 1.056 0.70
163_D 443_E 1.055 0.70
11_P 128_A 1.053 0.70
418_L 473_T 1.047 0.69
84_N 260_R 1.047 0.69
476_T 480_K 1.046 0.69
329_N 343_E 1.046 0.69
333_R 371_G 1.045 0.69
251_G 262_A 1.043 0.69
26_S 147_A 1.043 0.69
208_L 230_L 1.043 0.69
407_V 482_I 1.043 0.69
293_E 337_V 1.04 0.68
104_W 464_H 1.037 0.68
272_K 321_I 1.037 0.68
69_K 164_I 1.032 0.67
320_F 358_V 1.031 0.67
381_S 385_L 1.028 0.67
25_P 28_H 1.028 0.67
320_F 324_L 1.027 0.67
170_S 173_E 1.026 0.67
62_T 133_V 1.023 0.66
173_E 470_H 1.022 0.66
354_T 357_N 1.019 0.66
82_Q 459_P 1.014 0.65
186_F 364_I 1.013 0.65
272_K 275_V 1.013 0.65
335_S 341_V 1.01 0.65
260_R 459_P 1.009 0.65
118_I 468_V 1.005 0.64
246_L 249_F 1.004 0.64
26_S 150_D 1.002 0.64
244_L 266_I 1.002 0.64
130_E 133_V 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qyvA20.99591000.304Contact Map0.729
3mruA211000.316Contact Map0.705
3khxA20.85771000.553Contact Map0.59
1lfwA10.85151000.562Contact Map0.625
3pfoA20.75671000.563Contact Map0.619
1vgyA20.72991000.571Contact Map0.577
2pokA20.83091000.571Contact Map0.624
3pfeA10.83711000.575Contact Map0.55
3gb0A10.72581000.576Contact Map0.626
3rzaA20.74021000.579Contact Map0.638
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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