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OPENSEQ.org
RECQ - ATP-dependent DNA helicase RecQ
UniProt: P15043 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10833
Length: 609 (592)
Sequences: 1540
Seq/Len: 2.60
RECQ
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
423_I 482_V 5.012 1.00
261_I 289_I 4.998 1.00
215_Y 324_T 3.79 1.00
213_I 336_A 3.155 1.00
544_K 548_D 3.152 1.00
31_E 35_D 3.043 1.00
419_A 473_I 2.959 1.00
281_K 286_D 2.909 1.00
566_M 583_V 2.905 1.00
414_T 417_Q 2.882 1.00
231_V 261_I 2.86 1.00
434_Y 452_H 2.806 1.00
18_Q 24_Q 2.765 1.00
270_L 274_V 2.717 1.00
209_D 382_R 2.663 1.00
217_L 374_F 2.584 1.00
239_G 307_F 2.567 1.00
456_K 460_M 2.538 1.00
566_M 595_F 2.48 1.00
586_R 590_R 2.446 1.00
414_T 418_I 2.421 1.00
79_K 83_D 2.4 1.00
565_E 580_V 2.355 1.00
91_A 117_R 2.335 1.00
69_V 143_L 2.32 1.00
416_A 476_L 2.314 1.00
542_L 595_F 2.279 1.00
278_V 290_V 2.262 1.00
573_T 576_E 2.262 1.00
383_L 396_P 2.254 1.00
207_S 391_E 2.249 1.00
538_K 598_L 2.238 1.00
112_R 137_H 2.211 1.00
501_V 508_L 2.167 1.00
574_A 578_L 2.159 1.00
552_V 556_V 2.146 1.00
593_K 597_A 2.138 1.00
36_T 43_C 2.12 1.00
16_V 59_I 2.108 1.00
565_E 569_Q 2.096 1.00
93_A 107_V 2.064 1.00
537_A 540_R 2.062 1.00
264_A 278_V 2.054 1.00
443_N 448_R 2.046 1.00
13_A 59_I 2.019 1.00
461_G 469_W 1.987 0.99
542_L 546_I 1.983 0.99
19_E 585_M 1.982 0.99
451_G 454_K 1.969 0.99
121_I 131_F 1.93 0.99
111_C 119_L 1.92 0.99
110_G 115_Q 1.917 0.99
535_L 599_I 1.912 0.99
198_L 201_P 1.899 0.99
116_I 119_L 1.896 0.99
264_A 290_V 1.89 0.99
14_K 31_E 1.884 0.99
253_A 263_A 1.884 0.99
381_R 401_D 1.873 0.99
422_T 457_V 1.855 0.99
418_I 463_D 1.849 0.99
566_M 599_I 1.836 0.99
38_L 63_L 1.835 0.99
93_A 116_I 1.835 0.99
553_P 556_V 1.831 0.99
185_D 188_T 1.827 0.99
247_A 251_D 1.818 0.99
495_T 498_A 1.817 0.99
494_L 498_A 1.807 0.99
265_A 278_V 1.804 0.99
309_V 337_M 1.801 0.99
33_I 45_V 1.798 0.99
536_F 540_R 1.793 0.99
442_A 458_Y 1.79 0.99
37_V 178_M 1.778 0.98
15_Q 19_E 1.778 0.98
193_V 203_I 1.777 0.98
277_D 281_K 1.776 0.98
500_P 505_E 1.774 0.98
14_K 25_Q 1.746 0.98
440_R 463_D 1.736 0.98
425_R 457_V 1.72 0.98
500_P 506_S 1.719 0.98
317_I 374_F 1.697 0.98
100_T 103_Q 1.691 0.98
421_S 425_R 1.689 0.98
79_K 280_E 1.678 0.98
224_L 255_R 1.674 0.97
243_C 249_V 1.668 0.97
127_M 161_E 1.658 0.97
382_R 386_L 1.654 0.97
220_K 312_D 1.651 0.97
558_F 583_V 1.646 0.97
262_S 288_Q 1.641 0.97
227_L 309_V 1.614 0.97
36_T 41_R 1.613 0.97
569_Q 580_V 1.588 0.96
231_V 307_F 1.579 0.96
42_D 198_L 1.575 0.96
421_S 457_V 1.556 0.96
264_A 287_L 1.552 0.96
418_I 425_R 1.542 0.95
271_E 274_V 1.541 0.95
535_L 570_M 1.51 0.95
549_E 594_P 1.496 0.94
583_V 588_L 1.494 0.94
65_N 139_N 1.493 0.94
418_I 421_S 1.492 0.94
412_G 472_V 1.483 0.94
316_N 319_S 1.481 0.94
234_Q 237_K 1.478 0.94
542_L 566_M 1.477 0.94
29_G 206_S 1.468 0.93
443_N 453_D 1.465 0.93
562_T 577_M 1.436 0.92
435_V 438_V 1.435 0.92
442_A 445_Q 1.419 0.92
558_F 566_M 1.416 0.92
577_M 595_F 1.414 0.92
67_L 117_R 1.414 0.92
566_M 577_M 1.41 0.92
136_A 171_R 1.41 0.92
16_V 63_L 1.41 0.92
163_A 195_L 1.402 0.91
376_E 474_R 1.396 0.91
445_Q 449_D 1.388 0.91
209_D 399_N 1.379 0.90
546_I 595_F 1.371 0.90
68_T 117_R 1.368 0.90
84_Q 301_N 1.353 0.89
408_K 512_V 1.352 0.89
417_Q 421_S 1.352 0.89
252_T 311_F 1.344 0.89
106_E 110_G 1.339 0.89
577_M 583_V 1.337 0.88
465_S 468_H 1.333 0.88
230_Y 337_M 1.328 0.88
447_I 453_D 1.327 0.88
527_F 531_Y 1.326 0.88
434_Y 446_R 1.314 0.87
254_A 258_S 1.313 0.87
338_L 371_M 1.308 0.87
65_N 117_R 1.303 0.87
345_M 372_G 1.301 0.87
481_L 506_S 1.295 0.86
140_P 143_L 1.291 0.86
382_R 399_N 1.287 0.86
434_Y 450_Y 1.286 0.86
41_R 202_L 1.284 0.86
185_D 367_K 1.283 0.85
145_V 165_L 1.279 0.85
481_L 501_V 1.277 0.85
464_K 468_H 1.275 0.85
574_A 593_K 1.27 0.85
101_R 105_L 1.268 0.85
536_F 567_A 1.268 0.85
425_R 460_M 1.268 0.85
170_Q 197_G 1.267 0.84
585_M 589_E 1.264 0.84
246_R 269_G 1.262 0.84
418_I 460_M 1.261 0.84
253_A 265_A 1.255 0.84
565_E 581_N 1.255 0.84
411_D 507_S 1.251 0.83
71_V 165_L 1.25 0.83
64_L 142_L 1.245 0.83
317_I 385_L 1.239 0.83
33_I 204_Q 1.238 0.83
415_D 418_I 1.235 0.82
577_M 592_G 1.233 0.82
71_V 126_L 1.232 0.82
577_M 596_M 1.231 0.82
437_E 444_N 1.223 0.82
485_N 493_Q 1.22 0.81
578_L 585_M 1.22 0.81
447_I 458_Y 1.218 0.81
324_T 336_A 1.218 0.81
578_L 588_L 1.217 0.81
36_T 202_L 1.216 0.81
546_I 557_V 1.214 0.81
188_T 336_A 1.212 0.81
430_F 450_Y 1.209 0.80
222_K 225_D 1.208 0.80
189_R 205_I 1.206 0.80
481_L 497_A 1.204 0.80
143_L 172_F 1.201 0.80
497_A 506_S 1.201 0.80
34_I 59_I 1.195 0.79
143_L 165_L 1.194 0.79
457_V 460_M 1.191 0.79
426_V 435_V 1.19 0.79
142_L 180_L 1.186 0.79
422_T 460_M 1.185 0.79
67_L 111_C 1.181 0.78
99_Q 107_V 1.18 0.78
255_R 259_K 1.18 0.78
425_R 456_K 1.179 0.78
264_A 281_K 1.176 0.78
20_T 90_V 1.174 0.78
556_V 559_N 1.171 0.77
294_V 348_L 1.17 0.77
377_A 384_V 1.169 0.77
440_R 469_W 1.164 0.77
415_D 464_K 1.162 0.77
42_D 169_R 1.16 0.77
186_D 390_G 1.157 0.76
143_L 168_L 1.152 0.76
142_L 577_M 1.152 0.76
266_Y 275_R 1.15 0.76
186_D 189_R 1.15 0.76
430_F 452_H 1.149 0.76
540_R 560_D 1.145 0.75
163_A 191_D 1.143 0.75
400_C 403_C 1.142 0.75
42_D 201_P 1.141 0.75
227_L 252_T 1.14 0.75
245_S 268_A 1.139 0.75
443_N 458_Y 1.135 0.74
417_Q 425_R 1.135 0.74
35_D 39_S 1.133 0.74
257_Q 263_A 1.133 0.74
278_V 287_L 1.132 0.74
152_S 191_D 1.126 0.73
544_K 554_P 1.125 0.73
426_V 438_V 1.124 0.73
71_V 121_I 1.121 0.73
415_D 472_V 1.116 0.73
29_G 32_E 1.116 0.73
577_M 588_L 1.114 0.72
397_C 400_C 1.112 0.72
424_G 494_L 1.109 0.72
595_F 599_I 1.109 0.72
45_V 180_L 1.108 0.72
414_T 463_D 1.107 0.72
78_M 96_N 1.105 0.71
67_L 119_L 1.099 0.71
108_M 112_R 1.099 0.71
546_I 550_S 1.095 0.71
231_V 289_I 1.095 0.71
133_E 136_A 1.09 0.70
597_A 601_A 1.09 0.70
87_A 550_S 1.087 0.70
542_L 598_L 1.086 0.70
144_A 180_L 1.085 0.70
105_L 109_T 1.085 0.70
125_R 131_F 1.084 0.69
542_L 545_S 1.082 0.69
417_Q 502_L 1.078 0.69
421_S 460_M 1.077 0.69
448_R 458_Y 1.075 0.68
558_F 595_F 1.075 0.68
574_A 588_L 1.072 0.68
249_V 265_A 1.07 0.68
248_K 251_D 1.069 0.68
567_A 580_V 1.067 0.68
83_D 279_Q 1.066 0.68
189_R 193_V 1.063 0.67
542_L 577_M 1.062 0.67
263_A 289_I 1.059 0.67
397_C 403_C 1.058 0.67
439_I 460_M 1.057 0.67
501_V 504_G 1.055 0.66
315_R 348_L 1.052 0.66
87_A 557_V 1.048 0.66
249_V 291_V 1.048 0.66
37_V 180_L 1.045 0.65
546_I 552_V 1.04 0.65
136_A 172_F 1.039 0.65
380_C 403_C 1.037 0.64
583_V 595_F 1.034 0.64
380_C 397_C 1.029 0.64
274_V 278_V 1.028 0.63
61_A 118_L 1.027 0.63
363_I 367_K 1.02 0.63
434_Y 438_V 1.019 0.62
280_E 284_R 1.015 0.62
421_S 456_K 1.012 0.62
249_V 278_V 1.012 0.62
360_L 364_E 1.012 0.62
550_S 590_R 1.011 0.62
419_A 435_V 1.008 0.61
348_L 352_L 1.008 0.61
466_H 470_V 1.006 0.61
274_V 277_D 1.005 0.61
380_C 400_C 1.005 0.61
16_V 20_T 1.005 0.61
353_E 365_R 1.003 0.61
129_D 133_E 1.003 0.61
117_R 141_V 1.002 0.60
224_L 252_T 1.001 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4cdgA20.99011000.368Contact Map0.7
1oywA10.85881000.421Contact Map0.747
2v1xA20.88511000.467Contact Map0.734
4a4zA10.93921000.744Contact Map0.407
4gl2A20.72411000.755Contact Map0.496
2i4iA10.60431000.768Contact Map0.643
1fuuA20.58951000.769Contact Map0.626
3eiqA20.58951000.769Contact Map0.548
2j0sA10.58781000.77Contact Map0.622
1xtiA10.59931000.77Contact Map0.667
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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