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OPENSEQ.org
SYR - Arginine--tRNA ligase
UniProt: P11875 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10071
Length: 577 (575)
Sequences: 2127
Seq/Len: 3.70
SYR
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
523_L 565_G 5.425 1.00
60_E 64_T 5.383 1.00
54_A 57_Q 4.94 1.00
114_T 152_K 4.881 1.00
270_A 274_A 4.386 1.00
74_K 86_F 3.812 1.00
147_E 155_R 3.458 1.00
63_L 83_I 3.335 1.00
271_D 275_K 3.16 1.00
245_R 395_D 3.096 1.00
145_T 568_T 2.968 1.00
53_M 61_Q 2.731 1.00
73_S 88_D 2.716 1.00
273_K 285_T 2.632 1.00
467_V 555_A 2.56 1.00
499_R 529_L 2.536 1.00
270_A 273_K 2.423 1.00
57_Q 60_E 2.42 1.00
104_R 107_V 2.412 1.00
99_A 500_L 2.369 1.00
560_K 564_L 2.291 1.00
56_R 79_G 2.274 1.00
468_L 559_A 2.266 1.00
266_P 270_A 2.227 1.00
242_T 391_A 2.212 1.00
245_R 422_N 2.172 1.00
53_M 57_Q 2.167 1.00
365_E 514_G 2.154 1.00
143_V 155_R 2.141 1.00
402_R 418_E 2.136 1.00
464_Y 468_L 2.108 1.00
464_Y 573_T 2.103 1.00
499_R 502_Q 2.091 1.00
322_K 326_E 2.091 1.00
503_F 564_L 2.079 1.00
107_V 148_F 2.061 1.00
406_A 417_L 2.031 1.00
117_V 142_A 1.999 1.00
148_F 503_F 1.968 1.00
507_L 568_T 1.964 1.00
240_Q 244_D 1.943 1.00
530_F 555_A 1.94 1.00
278_A 285_T 1.938 1.00
464_Y 563_K 1.93 1.00
144_R 567_D 1.923 1.00
539_I 555_A 1.908 1.00
149_L 511_A 1.903 1.00
337_I 345_L 1.897 1.00
117_V 143_V 1.896 1.00
510_V 519_M 1.894 1.00
273_K 305_Q 1.889 1.00
244_D 249_T 1.889 1.00
522_Y 526_L 1.875 1.00
273_K 280_E 1.842 1.00
113_Q 331_D 1.839 1.00
321_A 352_V 1.799 0.99
499_R 525_D 1.782 0.99
267_G 270_A 1.764 0.99
325_Y 333_V 1.739 0.99
304_I 318_I 1.728 0.99
464_Y 559_A 1.718 0.99
140_D 144_R 1.699 0.99
394_L 429_V 1.699 0.99
422_N 572_E 1.698 0.99
431_Y 524_Y 1.695 0.99
271_D 322_K 1.691 0.99
277_L 292_F 1.689 0.99
113_Q 332_R 1.681 0.99
245_R 394_L 1.678 0.99
470_V 539_I 1.669 0.99
288_F 291_E 1.666 0.99
271_D 274_A 1.666 0.99
375_K 447_D 1.663 0.99
141_A 144_R 1.663 0.99
154_I 254_D 1.662 0.99
53_M 58_L 1.656 0.99
490_E 537_C 1.647 0.99
89_P 494_A 1.646 0.99
493_E 551_R 1.643 0.99
470_V 555_A 1.637 0.99
321_A 335_Y 1.635 0.99
402_R 406_A 1.631 0.99
559_A 563_K 1.62 0.98
350_A 353_R 1.617 0.98
538_P 541_S 1.6 0.98
137_I 246_L 1.596 0.98
104_R 148_F 1.58 0.98
56_R 78_A 1.58 0.98
216_K 221_D 1.57 0.98
195_D 199_H 1.561 0.98
273_K 278_A 1.558 0.98
212_N 216_K 1.557 0.98
76_E 86_F 1.548 0.98
117_V 146_L 1.541 0.98
107_V 147_E 1.528 0.98
278_A 304_I 1.526 0.97
472_R 576_R 1.523 0.97
39_Y 87_L 1.522 0.97
468_L 575_E 1.514 0.97
114_T 154_I 1.511 0.97
157_N 239_N 1.505 0.97
502_Q 505_E 1.504 0.97
63_L 77_I 1.502 0.97
306_K 310_G 1.492 0.97
556_Q 559_A 1.461 0.97
375_K 445_D 1.459 0.96
149_L 507_L 1.454 0.96
545_E 548_R 1.453 0.96
215_V 219_S 1.435 0.96
28_V 39_Y 1.426 0.96
332_R 365_E 1.426 0.96
345_L 368_M 1.425 0.96
146_L 511_A 1.422 0.96
431_Y 460_M 1.421 0.96
229_R 233_D 1.418 0.96
494_A 498_A 1.415 0.96
116_V 333_V 1.415 0.96
56_R 77_I 1.412 0.96
375_K 380_F 1.41 0.95
120_S 243_Y 1.406 0.95
9_E 13_Q 1.389 0.95
159_V 236_M 1.382 0.95
533_F 537_C 1.381 0.95
195_D 198_K 1.38 0.95
119_Y 143_V 1.377 0.95
419_K 423_A 1.375 0.95
431_Y 455_N 1.375 0.95
140_D 430_K 1.371 0.94
208_E 212_N 1.365 0.94
487_I 547_V 1.362 0.94
280_E 285_T 1.362 0.94
500_L 558_T 1.356 0.94
264_M 267_G 1.352 0.94
145_T 510_V 1.341 0.94
247_N 572_E 1.338 0.94
400_R 403_R 1.337 0.93
256_M 323_Y 1.337 0.93
56_R 60_E 1.323 0.93
135_S 369_F 1.322 0.93
503_F 565_G 1.321 0.93
142_A 367_H 1.321 0.93
396_E 400_R 1.318 0.93
265_L 316_T 1.312 0.93
148_F 568_T 1.307 0.92
8_S 12_R 1.301 0.92
470_V 530_F 1.298 0.92
198_K 202_E 1.297 0.92
472_R 575_E 1.293 0.92
349_W 364_L 1.293 0.92
148_F 564_L 1.282 0.91
500_L 561_T 1.28 0.91
413_P 416_E 1.28 0.91
44_M 62_V 1.277 0.91
6_L 10_K 1.269 0.91
108_A 111_E 1.269 0.91
13_Q 17_A 1.269 0.91
398_L 402_R 1.267 0.91
343_Q 347_Q 1.262 0.91
267_G 326_E 1.261 0.91
524_Y 528_G 1.261 0.91
75_V 85_I 1.256 0.90
77_I 83_I 1.251 0.90
237_T 241_I 1.249 0.90
519_M 565_G 1.247 0.90
51_L 58_L 1.247 0.90
98_Q 101_A 1.241 0.90
10_K 13_Q 1.236 0.89
335_Y 352_V 1.223 0.89
112_K 151_H 1.221 0.89
73_S 89_P 1.214 0.88
399_E 403_R 1.212 0.88
164_T 167_G 1.212 0.88
120_S 136_T 1.208 0.88
38_D 498_A 1.207 0.88
62_V 83_I 1.207 0.88
116_V 330_A 1.205 0.88
233_D 237_T 1.204 0.88
320_C 324_R 1.203 0.88
398_L 418_E 1.198 0.87
110_P 151_H 1.194 0.87
41_A 44_M 1.189 0.87
306_K 311_Y 1.185 0.87
174_E 223_Y 1.18 0.86
333_V 364_L 1.173 0.86
32_A 36_F 1.172 0.86
464_Y 575_E 1.163 0.85
533_F 558_T 1.162 0.85
414_A 418_E 1.159 0.85
236_M 257_G 1.157 0.85
350_A 354_K 1.155 0.85
427_G 461_Q 1.152 0.84
94_E 97_Q 1.151 0.84
469_S 472_R 1.15 0.84
54_A 58_L 1.15 0.84
100_L 553_K 1.148 0.84
166_F 232_V 1.147 0.84
340_R 371_M 1.141 0.84
509_V 513_E 1.136 0.83
173_L 231_L 1.135 0.83
566_L 571_I 1.134 0.83
490_E 493_E 1.132 0.83
61_Q 64_T 1.132 0.83
238_Q 241_I 1.132 0.83
120_S 157_N 1.126 0.83
526_L 558_T 1.125 0.82
353_R 359_P 1.124 0.82
403_R 406_A 1.117 0.82
358_V 364_L 1.116 0.82
541_S 548_R 1.113 0.82
336_Y 367_H 1.112 0.81
398_L 422_N 1.111 0.81
211_R 215_V 1.11 0.81
45_M 80_P 1.109 0.81
463_A 531_S 1.1 0.80
159_V 257_G 1.099 0.80
235_T 382_T 1.099 0.80
458_P 577_M 1.096 0.80
164_T 168_M 1.084 0.79
419_K 422_N 1.083 0.79
266_P 305_Q 1.081 0.79
337_I 366_H 1.079 0.79
566_L 573_T 1.079 0.79
340_R 379_P 1.078 0.79
66_L 75_V 1.078 0.79
197_K 201_D 1.078 0.79
213_Y 224_F 1.077 0.79
500_L 526_L 1.077 0.79
154_I 330_A 1.073 0.78
256_M 260_L 1.071 0.78
135_S 433_D 1.064 0.77
146_L 514_G 1.059 0.77
156_A 320_C 1.058 0.77
250_L 253_D 1.056 0.77
235_T 239_N 1.055 0.76
33_K 36_F 1.053 0.76
467_V 559_A 1.052 0.76
460_M 520_C 1.051 0.76
175_K 209_R 1.048 0.76
495_Q 529_L 1.047 0.76
406_A 414_A 1.046 0.76
563_K 575_E 1.039 0.75
373_L 441_D 1.034 0.74
279_V 288_F 1.032 0.74
446_W 450_L 1.031 0.74
287_V 351_I 1.031 0.74
325_Y 357_Y 1.031 0.74
58_L 61_Q 1.027 0.74
72_A 85_I 1.026 0.74
63_L 67_D 1.026 0.74
533_F 539_I 1.024 0.73
261_Y 316_T 1.018 0.73
175_K 199_H 1.017 0.73
540_L 548_R 1.016 0.73
245_R 391_A 1.015 0.72
312_L 315_T 1.006 0.72
264_M 323_Y 1.005 0.71
212_N 215_V 1.004 0.71
17_A 65_H 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1f7uA10.9741000.234Contact Map0.696
2zueA10.98091000.256Contact Map0.72
1iq0A10.9481000.29Contact Map0.687
3fnrA10.76951000.52Contact Map0.644
3tqoA10.62741000.739Contact Map0.543
3h99A10.66721000.743Contact Map0.411
3sp1A20.67591000.746Contact Map0.485
3u1fA20.65511000.757Contact Map0.521
4lneA30.68111000.761Contact Map0.5
4dlpA30.68111000.761Contact Map0.494
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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