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OPENSEQ.org
ENTE - Enterobactin synthase component E
UniProt: P10378 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10263
Length: 536 (507)
Sequences: 30535
Seq/Len: 60.23
ENTE
Paralog alert: 0.83 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
184_V 201_P 3.972 1.00
383_L 417_I 3.788 1.00
118_Q 189_L 3.665 1.00
364_E 386_R 3.292 1.00
70_I 98_V 3.215 1.00
59_D 95_K 3.048 1.00
397_S 400_H 2.951 1.00
77_L 121_P 2.897 1.00
74_E 122_A 2.879 1.00
418_S 426_T 2.816 1.00
203_T 392_R 2.752 1.00
454_H 492_F 2.748 1.00
436_N 441_K 2.747 1.00
369_D 373_N 2.728 1.00
55_N 95_K 2.604 1.00
459_Y 515_L 2.596 1.00
120_E 396_K 2.571 1.00
366_W 374_P 2.532 1.00
382_R 412_C 2.469 1.00
40_I 48_Q 2.436 1.00
75_T 101_V 2.404 1.00
266_P 270_K 2.377 1.00
368_A 384_M 2.33 1.00
89_T 125_I 2.327 1.00
452_L 460_A 2.264 1.00
451_L 476_A 2.261 1.00
118_Q 397_S 2.21 1.00
43_I 252_T 2.193 1.00
380_V 416_L 2.191 1.00
57_A 88_I 2.173 1.00
224_T 303_K 2.158 1.00
400_H 403_S 2.156 1.00
225_R 252_T 2.137 1.00
93_L 98_V 2.121 1.00
398_P 402_A 2.11 1.00
32_T 55_N 2.105 1.00
384_M 412_C 2.1 1.00
61_L 88_I 2.076 1.00
64_S 68_Q 2.075 1.00
122_A 150_R 2.074 1.00
475_C 508_E 2.069 1.00
55_N 59_D 2.051 1.00
522_D 525_Q 2.017 1.00
354_T 426_T 2.013 1.00
72_P 183_E 2.005 1.00
437_R 442_I 1.965 1.00
224_T 274_N 1.935 1.00
114_A 196_T 1.926 1.00
52_R 56_Q 1.918 1.00
367_V 417_I 1.912 1.00
38_D 52_R 1.903 1.00
399_Q 403_S 1.901 1.00
419_I 425_I 1.897 1.00
366_W 384_M 1.885 1.00
66_R 96_L 1.878 1.00
314_A 318_A 1.875 1.00
420_D 426_T 1.869 1.00
446_E 502_K 1.834 1.00
71_K 74_E 1.832 1.00
254_V 273_V 1.794 1.00
113_N 117_S 1.777 1.00
433_D 523_K 1.768 1.00
420_D 424_Y 1.75 1.00
49_L 88_I 1.747 1.00
485_R 488_Q 1.745 1.00
477_Y 526_L 1.741 1.00
58_A 95_K 1.709 1.00
76_A 93_L 1.704 1.00
417_I 427_V 1.698 1.00
94_L 185_A 1.697 1.00
525_Q 528_Q 1.695 1.00
462_L 476_A 1.683 1.00
44_D 84_A 1.675 1.00
50_S 53_E 1.674 1.00
61_L 92_A 1.67 1.00
119_I 189_L 1.666 1.00
81_G 127_D 1.66 1.00
70_I 76_A 1.646 1.00
452_L 459_Y 1.646 1.00
59_D 63_C 1.642 1.00
272_Q 301_S 1.636 1.00
92_A 96_L 1.633 1.00
203_T 206_D 1.63 1.00
318_A 322_A 1.612 1.00
87_Y 243_S 1.611 1.00
43_I 48_Q 1.602 1.00
380_V 428_Q 1.599 1.00
77_L 103_A 1.595 1.00
418_S 428_Q 1.588 1.00
73_G 183_E 1.585 1.00
76_A 98_V 1.584 1.00
278_L 283_V 1.572 1.00
448_E 462_L 1.572 1.00
377_Q 419_I 1.567 1.00
456_A 488_Q 1.558 1.00
77_L 116_A 1.546 1.00
334_M 411_Y 1.544 1.00
184_V 392_R 1.538 1.00
75_T 395_Y 1.538 1.00
39_S 223_Q 1.535 1.00
479_V 513_L 1.533 1.00
365_V 385_T 1.529 1.00
201_P 393_G 1.524 1.00
221_T 224_T 1.524 1.00
40_I 50_S 1.522 1.00
43_I 271_H 1.522 1.00
41_A 54_L 1.521 1.00
463_V 477_Y 1.515 1.00
187_F 395_Y 1.508 1.00
56_Q 60_N 1.494 1.00
189_L 199_L 1.494 1.00
268_I 301_S 1.492 1.00
351_I 422_E 1.488 1.00
206_D 390_T 1.48 1.00
369_D 375_L 1.477 1.00
118_Q 396_K 1.472 1.00
404_A 411_Y 1.45 1.00
487_V 491_R 1.448 1.00
516_T 522_D 1.445 1.00
376_P 379_E 1.444 1.00
224_T 275_V 1.442 1.00
182_D 205_N 1.44 1.00
383_L 427_V 1.438 1.00
227_L 273_V 1.435 1.00
40_I 43_I 1.433 1.00
263_L 266_P 1.428 1.00
48_Q 271_H 1.425 1.00
246_V 251_G 1.423 1.00
53_E 56_Q 1.42 1.00
37_S 52_R 1.414 1.00
307_V 312_L 1.405 0.99
61_L 125_I 1.403 0.99
435_I 444_A 1.4 0.99
490_R 507_V 1.398 0.99
58_A 92_A 1.394 0.99
73_G 392_R 1.393 0.99
70_I 123_L 1.387 0.99
49_L 84_A 1.384 0.99
54_L 91_F 1.366 0.99
458_I 481_K 1.36 0.99
103_A 112_L 1.347 0.99
480_V 509_C 1.346 0.99
190_S 200_I 1.343 0.99
283_V 305_L 1.342 0.99
99_A 184_V 1.341 0.99
465_M 475_C 1.335 0.99
391_F 405_F 1.334 0.99
406_D 412_C 1.334 0.99
57_A 60_N 1.332 0.99
202_R 206_D 1.332 0.99
40_I 252_T 1.32 0.99
78_V 89_T 1.318 0.99
380_V 418_S 1.318 0.99
180_P 183_E 1.316 0.99
225_R 273_V 1.308 0.99
416_L 431_E 1.298 0.99
116_A 121_P 1.289 0.99
256_A 267_L 1.288 0.99
385_T 413_S 1.276 0.99
206_D 338_L 1.274 0.99
215_V 249_A 1.27 0.99
445_E 449_N 1.268 0.99
70_I 74_E 1.266 0.99
117_S 196_T 1.263 0.99
491_R 495_E 1.26 0.99
382_R 431_E 1.255 0.99
108_Q 111_E 1.255 0.99
281_P 310_A 1.251 0.99
450_L 493_L 1.249 0.99
387_G 390_T 1.249 0.99
260_S 263_L 1.238 0.98
31_L 35_A 1.236 0.98
494_R 503_L 1.23 0.98
114_A 118_Q 1.228 0.98
313_S 316_L 1.228 0.98
370_A 431_E 1.226 0.98
276_T 302_L 1.222 0.98
201_P 395_Y 1.218 0.98
91_F 247_F 1.215 0.98
478_L 507_V 1.214 0.98
267_L 271_H 1.211 0.98
367_V 375_L 1.204 0.98
68_Q 151_V 1.204 0.98
225_R 254_V 1.202 0.98
35_A 55_N 1.201 0.98
312_L 317_A 1.201 0.98
478_L 509_C 1.2 0.98
358_P 365_V 1.199 0.98
467_D 473_K 1.191 0.98
375_L 379_E 1.19 0.98
465_M 506_R 1.187 0.98
433_D 445_E 1.185 0.98
499_A 502_K 1.184 0.98
75_T 99_A 1.182 0.98
49_L 57_A 1.18 0.98
41_A 51_Y 1.174 0.98
118_Q 196_T 1.172 0.98
187_F 199_L 1.171 0.98
435_I 474_S 1.169 0.97
434_Q 443_A 1.166 0.97
383_L 425_I 1.161 0.97
101_V 119_I 1.156 0.97
54_L 88_I 1.155 0.97
114_A 189_L 1.154 0.97
475_C 506_R 1.152 0.97
357_Y 424_Y 1.15 0.97
288_Q 319_R 1.148 0.97
453_R 497_G 1.146 0.97
55_N 58_A 1.14 0.97
477_Y 510_V 1.14 0.97
438_G 470_M 1.139 0.97
113_N 145_E 1.137 0.97
480_V 484_L 1.132 0.97
490_R 494_R 1.13 0.97
513_L 521_V 1.125 0.97
32_T 95_K 1.123 0.97
75_T 187_F 1.123 0.97
365_V 425_I 1.113 0.96
386_R 410_F 1.111 0.96
365_V 383_L 1.11 0.96
451_L 460_A 1.109 0.96
188_Q 335_A 1.107 0.96
111_E 502_K 1.106 0.96
489_V 507_V 1.103 0.96
351_I 424_Y 1.102 0.96
61_L 89_T 1.1 0.96
355_Q 427_V 1.099 0.96
191_G 518_V 1.097 0.96
64_S 67_R 1.097 0.96
181_A 205_N 1.092 0.96
486_A 509_C 1.092 0.96
84_A 88_I 1.092 0.96
54_L 58_A 1.091 0.96
416_L 429_G 1.09 0.96
494_R 500_E 1.09 0.96
57_A 85_E 1.089 0.96
44_D 47_R 1.088 0.96
454_H 489_V 1.085 0.96
205_N 388_P 1.083 0.96
47_R 57_A 1.081 0.95
65_L 125_I 1.076 0.95
49_L 54_L 1.073 0.95
79_Q 112_L 1.067 0.95
493_L 503_L 1.065 0.95
473_K 505_D 1.058 0.95
246_V 253_V 1.057 0.95
319_R 323_E 1.056 0.95
399_Q 402_A 1.055 0.95
440_E 501_F 1.047 0.94
254_V 267_L 1.045 0.94
367_V 425_I 1.043 0.94
369_D 379_E 1.042 0.94
185_A 204_H 1.041 0.94
62_A 95_K 1.04 0.94
201_P 392_R 1.04 0.94
466_E 472_E 1.038 0.94
65_L 93_L 1.036 0.94
39_S 252_T 1.036 0.94
476_A 507_V 1.031 0.94
75_T 120_E 1.028 0.94
488_Q 491_R 1.027 0.94
226_Y 246_V 1.026 0.94
486_A 507_V 1.019 0.93
510_V 513_L 1.017 0.93
74_E 98_V 1.017 0.93
64_S 166_A 1.013 0.93
279_V 282_A 1.01 0.93
151_V 155_L 1.009 0.93
200_I 391_F 1.008 0.93
459_Y 479_V 1.004 0.93
368_A 374_P 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mdbA10.98691000.123Contact Map0.774
4iz6A20.99811000.128Contact Map0.76
3o83A20.99441000.139Contact Map0.757
3tsyA10.97761000.168Contact Map0.778
3r44A10.94781000.174Contact Map0.824
3g7sA20.96831000.178Contact Map0.803
3etcA20.9721000.178Contact Map0.845
4fuqA40.92351000.179Contact Map0.803
3ni2A10.96641000.182Contact Map0.813
2d1sA10.96831000.182Contact Map0.723
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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