| UniProt: | P10371 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10444 | ||
| Length: | 245 (238) | ||
| Sequences: | 2992 | ||
| Seq/Len: | 12.57 |
| HIS4
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs Cluster includes: HIS4 HIS6 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 108_S | 114_G | 3.38 | 1.00 | |
| 88_V | 115_W | 3.328 | 1.00 | |
| 161_L | 197_V | 3.287 | 1.00 | |
| 113_K | 163_V | 2.783 | 1.00 | |
| 36_Q | 40_A | 2.678 | 1.00 | |
| 159_T | 163_V | 2.676 | 1.00 | |
| 128_L | 157_V | 2.459 | 1.00 | |
| 143_S | 147_E | 2.45 | 1.00 | |
| 209_D | 212_A | 2.436 | 1.00 | |
| 139_Q | 148_N | 2.32 | 1.00 | |
| 126_L | 160_Y | 2.262 | 1.00 | |
| 82_V | 91_L | 2.229 | 1.00 | |
| 84_S | 87_D | 2.225 | 1.00 | |
| 36_Q | 71_G | 2.193 | 1.00 | |
| 89_A | 93_E | 2.155 | 1.00 | |
| 179_L | 232_K | 2.053 | 1.00 | |
| 37_D | 41_Q | 1.994 | 1.00 | |
| 207_D | 210_D | 1.961 | 1.00 | |
| 110_D | 114_G | 1.956 | 1.00 | |
| 115_W | 124_L | 1.928 | 1.00 | |
| 161_L | 196_Q | 1.889 | 1.00 | |
| 30_D | 33_P | 1.87 | 1.00 | |
| 139_Q | 150_G | 1.846 | 1.00 | |
| 17_H | 178_T | 1.831 | 1.00 | |
| 107_K | 143_S | 1.825 | 1.00 | |
| 159_T | 162_P | 1.81 | 1.00 | |
| 46_L | 74_V | 1.777 | 1.00 | |
| 62_I | 90_A | 1.762 | 1.00 | |
| 88_V | 124_L | 1.744 | 1.00 | |
| 227_A | 233_F | 1.742 | 1.00 | |
| 39_A | 73_N | 1.737 | 1.00 | |
| 30_D | 67_T | 1.736 | 1.00 | |
| 139_Q | 152_S | 1.73 | 1.00 | |
| 205_I | 214_L | 1.691 | 1.00 | |
| 54_A | 103_S | 1.688 | 1.00 | |
| 234_T | 237_E | 1.672 | 1.00 | |
| 89_A | 118_R | 1.664 | 1.00 | |
| 209_D | 213_A | 1.641 | 1.00 | |
| 98_R | 125_V | 1.641 | 1.00 | |
| 127_A | 169_L | 1.62 | 1.00 | |
| 61_Q | 64_L | 1.612 | 1.00 | |
| 63_P | 66_K | 1.606 | 1.00 | |
| 113_K | 117_E | 1.574 | 1.00 | |
| 67_T | 70_A | 1.57 | 1.00 | |
| 20_D | 23_K | 1.558 | 1.00 | |
| 152_S | 155_Q | 1.555 | 1.00 | |
| 236_K | 240_A | 1.54 | 1.00 | |
| 85_E | 115_W | 1.54 | 1.00 | |
| 106_V | 142_V | 1.528 | 1.00 | |
| 116_F | 121_A | 1.505 | 1.00 | |
| 12_T | 27_Y | 1.494 | 1.00 | |
| 224_V | 227_A | 1.493 | 1.00 | |
| 151_V | 159_T | 1.486 | 1.00 | |
| 170_C | 186_L | 1.483 | 1.00 | |
| 170_C | 190_V | 1.463 | 1.00 | |
| 188_E | 193_R | 1.456 | 1.00 | |
| 132_I | 185_S | 1.455 | 1.00 | |
| 208_I | 233_F | 1.451 | 1.00 | |
| 103_S | 107_K | 1.44 | 1.00 | |
| 233_F | 238_A | 1.432 | 1.00 | |
| 55_K | 146_Q | 1.43 | 1.00 | |
| 10_D | 52_T | 1.409 | 1.00 | |
| 107_K | 142_V | 1.406 | 0.99 | |
| 212_A | 216_G | 1.395 | 0.99 | |
| 45_V | 98_R | 1.393 | 0.99 | |
| 142_V | 147_E | 1.389 | 0.99 | |
| 224_V | 228_L | 1.378 | 0.99 | |
| 3_I | 45_V | 1.375 | 0.99 | |
| 153_L | 190_V | 1.373 | 0.99 | |
| 141_A | 148_N | 1.37 | 0.99 | |
| 211_V | 227_A | 1.364 | 0.99 | |
| 110_D | 113_K | 1.363 | 0.99 | |
| 158_E | 194_Y | 1.357 | 0.99 | |
| 92_L | 123_A | 1.354 | 0.99 | |
| 107_K | 147_E | 1.35 | 0.99 | |
| 158_E | 162_P | 1.307 | 0.99 | |
| 104_T | 111_M | 1.303 | 0.99 | |
| 193_R | 218_G | 1.302 | 0.99 | |
| 37_D | 40_A | 1.29 | 0.99 | |
| 85_E | 114_G | 1.274 | 0.99 | |
| 4_P | 43_A | 1.271 | 0.99 | |
| 214_L | 219_V | 1.267 | 0.99 | |
| 59_K | 90_A | 1.261 | 0.99 | |
| 88_V | 99_V | 1.245 | 0.98 | |
| 101_V | 104_T | 1.234 | 0.98 | |
| 166_K | 198_A | 1.228 | 0.98 | |
| 41_Q | 236_K | 1.226 | 0.98 | |
| 127_A | 171_T | 1.222 | 0.98 | |
| 69_V | 76_V | 1.203 | 0.98 | |
| 63_P | 67_T | 1.198 | 0.98 | |
| 172_D | 183_N | 1.198 | 0.98 | |
| 130_V | 170_C | 1.176 | 0.98 | |
| 184_V | 213_A | 1.172 | 0.98 | |
| 66_K | 70_A | 1.169 | 0.97 | |
| 157_V | 190_V | 1.16 | 0.97 | |
| 65_I | 78_V | 1.131 | 0.97 | |
| 138_K | 189_E | 1.127 | 0.97 | |
| 21_Y | 55_K | 1.119 | 0.96 | |
| 189_E | 194_Y | 1.119 | 0.96 | |
| 86_E | 89_A | 1.117 | 0.96 | |
| 48_L | 68_L | 1.116 | 0.96 | |
| 215_R | 222_V | 1.109 | 0.96 | |
| 155_Q | 159_T | 1.108 | 0.96 | |
| 189_E | 193_R | 1.095 | 0.96 | |
| 188_E | 217_T | 1.091 | 0.96 | |
| 153_L | 157_V | 1.073 | 0.95 | |
| 187_Y | 192_A | 1.068 | 0.95 | |
| 154_E | 194_Y | 1.065 | 0.95 | |
| 106_V | 151_V | 1.06 | 0.95 | |
| 41_Q | 234_T | 1.05 | 0.94 | |
| 85_E | 118_R | 1.05 | 0.94 | |
| 32_L | 64_L | 1.049 | 0.94 | |
| 12_T | 29_N | 1.047 | 0.94 | |
| 182_S | 205_I | 1.044 | 0.94 | |
| 113_K | 159_T | 1.033 | 0.94 | |
| 211_V | 224_V | 1.029 | 0.94 | |
| 210_D | 213_A | 1.025 | 0.93 | |
| 211_V | 238_A | 1.022 | 0.93 | |
| 169_L | 223_I | 1.017 | 0.93 | |
| 101_V | 115_W | 1.014 | 0.93 | |
| 190_V | 199_F | 1.009 | 0.93 | |
| 34_R | 37_D | 1.005 | 0.93 | |
| 17_H | 23_K | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2agkA | 1 | 0.9592 | 100 | 0.215 | Contact Map | 0.624 |
| 1jvnA | 2 | 0.9918 | 100 | 0.259 | Contact Map | 0.755 |
| 1qo2A | 2 | 0.9551 | 100 | 0.404 | Contact Map | 0.638 |
| 4gj1A | 1 | 0.9796 | 100 | 0.459 | Contact Map | 0.694 |
| 2y88A | 1 | 0.9714 | 100 | 0.473 | Contact Map | 0.684 |
| 1thfD | 1 | 0.9796 | 100 | 0.485 | Contact Map | 0.813 |
| 1vzwA | 1 | 0.9592 | 100 | 0.485 | Contact Map | 0.666 |
| 4evzA | 2 | 0.9796 | 100 | 0.49 | Contact Map | 0.725 |
| 4axkA | 2 | 0.9755 | 100 | 0.5 | Contact Map | 0.768 |
| 2w6rA | 1 | 0.9714 | 100 | 0.508 | Contact Map | 0.67 |
Sequence Conservation (Image Generated using WebLogo v3)