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OPENSEQ.org
EPTC - Phosphoethanolamine transferase EptC
UniProt: P0CB39 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11914
Length: 577 (533)
Sequences: 623
Seq/Len: 1.17
EPTC
Paralog alert: 0.61 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EPTA EPTB EPTC YBIP YHBX YJGX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
392_T 432_A 4.19 1.00
253_S 262_T 4.013 1.00
242_V 440_V 3.833 1.00
523_T 542_V 3.809 1.00
255_Y 277_V 3.765 1.00
313_L 524_W 3.579 1.00
373_Q 446_D 2.983 1.00
443_L 456_L 2.972 1.00
445_K 448_K 2.861 1.00
459_F 517_L 2.747 1.00
522_H 539_R 2.526 1.00
317_M 528_A 2.403 0.99
406_K 434_L 2.401 0.99
401_P 435_Y 2.22 0.99
281_V 515_Y 2.159 0.98
239_L 384_L 2.092 0.98
405_G 410_N 2.089 0.98
499_W 523_T 2.071 0.97
264_E 438_H 2.041 0.97
247_T 436_N 2.015 0.97
439_V 443_L 1.966 0.96
247_T 433_N 1.917 0.95
250_G 485_H 1.901 0.95
72_A 137_L 1.874 0.95
215_L 218_E 1.873 0.95
241_L 384_L 1.782 0.93
239_L 455_F 1.76 0.92
252_M 389_L 1.751 0.92
238_T 452_P 1.723 0.91
247_T 460_S 1.713 0.91
268_L 441_A 1.705 0.90
128_A 132_T 1.684 0.90
217_N 220_N 1.674 0.89
247_T 252_M 1.661 0.89
247_T 392_T 1.644 0.88
114_E 390_L 1.633 0.88
525_S 532_Y 1.632 0.87
526_D 540_S 1.612 0.87
320_A 528_A 1.601 0.86
260_E 434_L 1.581 0.85
105_F 205_Y 1.574 0.85
369_L 373_Q 1.564 0.84
440_V 456_L 1.559 0.84
253_S 260_E 1.546 0.83
84_A 124_I 1.537 0.83
197_Q 334_T 1.534 0.83
260_E 266_D 1.524 0.82
373_Q 377_N 1.516 0.82
535_Y 540_S 1.497 0.81
235_E 453_N 1.492 0.80
264_E 441_A 1.49 0.80
479_E 487_Y 1.481 0.80
249_R 488_T 1.468 0.79
168_I 172_T 1.466 0.79
526_D 535_Y 1.463 0.78
404_Q 438_H 1.463 0.78
257_Y 430_D 1.449 0.77
366_T 435_Y 1.447 0.77
239_L 322_Y 1.436 0.77
253_S 266_D 1.432 0.76
100_V 103_V 1.43 0.76
241_L 386_I 1.406 0.74
455_F 499_W 1.4 0.74
343_F 346_Q 1.399 0.74
412_D 428_D 1.397 0.74
205_Y 262_T 1.396 0.74
93_G 433_N 1.391 0.73
261_T 430_D 1.389 0.73
265_L 414_V 1.385 0.73
174_I 177_K 1.381 0.73
249_R 277_V 1.381 0.73
322_Y 528_A 1.373 0.72
240_V 387_V 1.371 0.72
282_V 487_Y 1.361 0.71
405_G 425_S 1.349 0.70
482_P 494_W 1.343 0.69
262_T 266_D 1.341 0.69
72_A 132_T 1.339 0.69
364_Y 456_L 1.336 0.69
410_N 428_D 1.329 0.68
106_E 114_E 1.328 0.68
190_M 439_V 1.321 0.68
251_R 430_D 1.32 0.68
317_M 524_W 1.319 0.67
295_A 520_L 1.318 0.67
241_L 459_F 1.317 0.67
515_Y 541_V 1.311 0.67
295_A 459_F 1.31 0.67
493_L 524_W 1.304 0.66
430_D 494_W 1.3 0.66
106_E 205_Y 1.294 0.65
459_F 520_L 1.29 0.65
238_T 376_L 1.284 0.64
401_P 439_V 1.282 0.64
251_R 426_Y 1.282 0.64
254_L 265_L 1.273 0.63
366_T 401_P 1.268 0.63
240_V 371_P 1.262 0.62
396_Y 464_E 1.255 0.62
268_L 448_K 1.253 0.62
292_L 488_T 1.252 0.62
427_N 482_P 1.251 0.61
217_N 532_Y 1.25 0.61
106_E 331_Q 1.244 0.61
115_Y 389_L 1.24 0.60
421_E 424_E 1.237 0.60
417_G 428_D 1.222 0.59
64_P 68_K 1.22 0.59
213_T 336_R 1.217 0.58
158_A 162_G 1.205 0.57
173_F 176_N 1.205 0.57
369_L 446_D 1.204 0.57
240_V 443_L 1.202 0.57
276_T 511_V 1.199 0.57
389_L 439_V 1.197 0.56
249_R 386_I 1.196 0.56
175_K 178_P 1.195 0.56
177_K 353_M 1.183 0.55
298_F 310_Q 1.183 0.55
239_L 528_A 1.183 0.55
78_L 140_T 1.182 0.55
333_M 343_F 1.181 0.55
401_P 438_H 1.174 0.54
493_L 542_V 1.172 0.54
101_L 262_T 1.17 0.54
222_L 382_K 1.169 0.54
68_K 72_A 1.169 0.54
368_V 439_V 1.167 0.54
114_E 395_K 1.165 0.53
280_N 514_K 1.165 0.53
402_E 405_G 1.161 0.53
248_Q 447_F 1.159 0.53
392_T 433_N 1.157 0.53
102_F 330_Q 1.152 0.52
401_P 404_Q 1.151 0.52
259_R 430_D 1.144 0.51
425_S 428_D 1.142 0.51
342_V 348_D 1.142 0.51
268_L 445_K 1.14 0.51
172_T 330_Q 1.137 0.51
241_L 520_L 1.129 0.50
405_G 408_D 1.124 0.49
124_I 127_I 1.121 0.49
342_V 346_Q 1.116 0.49
323_K 381_P 1.115 0.49
246_S 517_L 1.113 0.48
161_Y 538_T 1.112 0.48
101_L 205_Y 1.111 0.48
101_L 170_M 1.111 0.48
248_Q 291_I 1.11 0.48
434_L 457_V 1.11 0.48
324_T 337_N 1.106 0.48
342_V 345_R 1.106 0.48
252_M 432_A 1.103 0.47
80_A 136_V 1.103 0.47
387_V 443_L 1.102 0.47
178_P 509_Q 1.102 0.47
264_E 389_L 1.098 0.47
242_V 456_L 1.097 0.47
333_M 353_M 1.097 0.47
99_S 527_L 1.095 0.47
257_Y 261_T 1.095 0.47
108_N 331_Q 1.092 0.46
252_M 262_T 1.09 0.46
316_M 319_Q 1.088 0.46
115_Y 264_E 1.087 0.46
397_K 421_E 1.086 0.46
436_N 440_V 1.085 0.46
173_F 353_M 1.083 0.45
254_L 277_V 1.082 0.45
299_A 310_Q 1.081 0.45
379_P 384_L 1.08 0.45
176_N 343_F 1.078 0.45
464_E 486_M 1.075 0.45
364_Y 401_P 1.073 0.44
334_T 337_N 1.073 0.44
279_N 511_V 1.071 0.44
330_Q 440_V 1.07 0.44
88_Y 176_N 1.07 0.44
298_F 534_G 1.069 0.44
304_P 334_T 1.068 0.44
156_S 163_L 1.068 0.44
478_N 485_H 1.066 0.44
174_I 178_P 1.066 0.44
243_I 292_L 1.065 0.44
325_F 383_K 1.061 0.43
316_M 526_D 1.06 0.43
89_Y 335_A 1.059 0.43
170_M 318_K 1.058 0.43
237_R 439_V 1.055 0.43
252_M 392_T 1.054 0.43
248_Q 521_I 1.052 0.42
299_A 312_S 1.052 0.42
87_C 174_I 1.052 0.42
104_M 137_L 1.051 0.42
395_K 428_D 1.051 0.42
157_F 542_V 1.05 0.42
94_Q 481_N 1.048 0.42
439_V 541_V 1.047 0.42
459_F 489_I 1.046 0.42
366_T 370_K 1.043 0.42
219_N 319_Q 1.041 0.41
414_V 419_N 1.041 0.41
107_T 157_F 1.04 0.41
259_R 427_N 1.039 0.41
327_I 371_P 1.037 0.41
247_T 262_T 1.037 0.41
343_F 348_D 1.036 0.41
284_S 294_Q 1.036 0.41
275_L 537_P 1.035 0.41
384_L 528_A 1.033 0.41
160_L 163_L 1.033 0.41
317_M 322_Y 1.031 0.41
327_I 368_V 1.028 0.40
64_P 72_A 1.027 0.40
253_S 265_L 1.027 0.40
327_I 439_V 1.026 0.40
240_V 456_L 1.025 0.40
168_I 330_Q 1.024 0.40
96_F 252_M 1.024 0.40
106_E 453_N 1.02 0.39
113_S 129_L 1.02 0.39
100_V 475_Q 1.018 0.39
176_N 330_Q 1.016 0.39
114_E 331_Q 1.014 0.39
320_A 384_L 1.011 0.39
239_L 362_R 1.01 0.39
239_L 524_W 1.009 0.38
93_G 516_S 1.007 0.38
128_A 432_A 1.007 0.38
328_T 438_H 1.004 0.38
218_E 501_A 1.002 0.38
95_E 252_M 1.002 0.38
495_T 505_R 1.002 0.38
252_M 362_R 1.001 0.38
197_Q 312_S 1.001 0.38
64_P 189_R 1 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kavA10.55631000.735Contact Map0.698
2w8dA20.60311000.809Contact Map0.474
3b5qA20.59271000.812Contact Map0.536
3lxqA20.65681000.813Contact Map0.55
2w5qA10.59971000.814Contact Map0.491
2qzuA10.60491000.815Contact Map0.523
3ed4A40.61871000.821Contact Map0.563
2vqrA10.61531000.824Contact Map0.583
1aukA10.54251000.829Contact Map0.502
1fsuA10.55111000.831Contact Map0.594
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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