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OPENSEQ.org
PAAJ - 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
UniProt: P0C7L2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13744
Length: 401 (398)
Sequences: 7194
Seq/Len: 18.08
PAAJ
Paralog alert: 0.73 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATOB FADA FADI PAAJ YQEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
186_L 232_L 3.502 1.00
187_R 191_R 3.482 1.00
270_M 274_Q 3.31 1.00
180_D 335_R 3.199 1.00
3_E 268_E 3.198 1.00
370_A 382_A 2.995 1.00
194_K 198_S 2.991 1.00
36_E 39_V 2.982 1.00
109_G 112_L 2.949 1.00
97_L 367_A 2.896 1.00
187_R 190_Q 2.882 1.00
268_E 272_A 2.859 1.00
306_V 310_A 2.804 1.00
5_F 271_A 2.79 1.00
270_M 273_A 2.751 1.00
37_L 264_I 2.683 1.00
181_Q 247_V 2.661 1.00
306_V 397_I 2.599 1.00
104_I 265_I 2.566 1.00
34_L 113_I 2.503 1.00
179_E 183_S 2.354 1.00
104_I 267_S 2.346 1.00
172_E 243_R 2.231 1.00
202_A 221_Q 2.227 1.00
284_A 310_A 2.22 1.00
2_R 269_Q 2.216 1.00
374_L 379_G 2.21 1.00
319_V 348_P 2.207 1.00
9_G 368_L 2.203 1.00
197_S 228_P 2.178 1.00
10_I 40_R 2.17 1.00
235_L 251_G 2.132 1.00
45_D 48_C 2.091 1.00
225_H 255_G 2.079 1.00
196_Q 226_L 2.051 1.00
261_A 364_A 2.05 1.00
177_S 180_D 2.044 1.00
312_L 381_Y 2.038 1.00
100_A 112_L 2.008 1.00
284_A 306_V 1.99 1.00
111_L 266_A 1.974 1.00
202_A 222_H 1.96 1.00
266_A 271_A 1.943 1.00
318_D 379_G 1.908 1.00
279_R 375_H 1.906 1.00
7_C 266_A 1.88 1.00
32_I 208_V 1.849 1.00
30_A 71_A 1.841 1.00
280_A 371_S 1.838 1.00
30_A 54_L 1.827 1.00
303_T 385_T 1.813 1.00
196_Q 205_I 1.787 1.00
20_A 220_I 1.765 1.00
170_V 176_I 1.737 1.00
349_N 373_E 1.73 1.00
375_H 400_R 1.727 1.00
193_A 197_S 1.726 1.00
312_L 317_M 1.715 1.00
317_M 381_Y 1.71 1.00
48_C 274_Q 1.709 1.00
187_R 341_D 1.694 1.00
164_P 242_F 1.694 1.00
373_E 377_R 1.693 1.00
100_A 265_I 1.685 1.00
193_A 226_L 1.679 1.00
183_S 187_R 1.677 1.00
304_R 308_E 1.672 1.00
37_L 41_N 1.664 1.00
317_M 320_I 1.658 1.00
281_R 399_E 1.639 1.00
34_L 71_A 1.624 1.00
334_L 341_D 1.616 1.00
36_E 206_V 1.606 1.00
334_L 346_V 1.589 1.00
110_D 267_S 1.587 1.00
234_Q 237_G 1.582 1.00
196_Q 222_H 1.569 1.00
340_P 345_H 1.567 1.00
378_N 400_R 1.56 1.00
314_I 320_I 1.558 1.00
266_A 270_M 1.521 1.00
317_M 397_I 1.521 1.00
54_L 115_G 1.521 1.00
180_D 183_S 1.512 1.00
312_L 397_I 1.507 1.00
319_V 373_E 1.5 1.00
110_D 270_M 1.5 1.00
32_I 206_V 1.5 1.00
84_T 99_F 1.499 1.00
383_L 397_I 1.498 1.00
200_I 373_E 1.473 1.00
373_E 376_R 1.472 1.00
36_E 40_R 1.467 1.00
186_L 190_Q 1.463 1.00
209_V 219_E 1.433 1.00
263_L 364_A 1.433 1.00
8_D 37_L 1.428 1.00
3_E 281_R 1.426 1.00
200_I 349_N 1.424 1.00
119_S 122_R 1.421 1.00
103_A 109_G 1.409 1.00
380_R 399_E 1.404 0.99
33_P 262_A 1.401 0.99
203_E 375_H 1.384 0.99
267_S 270_M 1.377 0.99
91_G 394_I 1.371 0.99
35_R 39_V 1.365 0.99
320_I 383_L 1.356 0.99
302_A 395_A 1.355 0.99
286_A 306_V 1.355 0.99
304_R 336_E 1.345 0.99
371_S 375_H 1.343 0.99
190_Q 229_E 1.337 0.99
52_V 72_T 1.336 0.99
8_D 41_N 1.333 0.99
307_L 314_I 1.326 0.99
79_Q 291_E 1.322 0.99
102_R 108_D 1.312 0.99
5_F 281_R 1.311 0.99
305_R 308_E 1.297 0.99
230_T 235_L 1.294 0.99
301_P 304_R 1.29 0.99
28_D 74_L 1.289 0.99
14_I 361_M 1.282 0.99
4_A 265_I 1.278 0.99
97_L 263_L 1.278 0.99
348_P 377_R 1.275 0.99
56_C 59_Q 1.269 0.99
21_L 220_I 1.266 0.99
173_L 294_L 1.263 0.99
318_D 374_L 1.26 0.99
290_V 297_L 1.26 0.99
14_I 355_L 1.259 0.99
67_V 117_V 1.258 0.99
50_D 110_D 1.258 0.99
113_I 264_I 1.258 0.99
94_L 367_A 1.248 0.99
313_S 316_D 1.248 0.99
54_L 262_A 1.238 0.98
282_I 396_M 1.232 0.98
5_F 268_E 1.23 0.98
50_D 109_G 1.221 0.98
368_L 372_H 1.22 0.98
348_P 373_E 1.215 0.98
111_L 270_M 1.215 0.98
370_A 384_C 1.213 0.98
193_A 229_E 1.211 0.98
367_A 398_L 1.199 0.98
10_I 206_V 1.189 0.98
49_I 111_L 1.187 0.98
98_G 396_M 1.185 0.98
183_S 232_L 1.184 0.98
91_G 388_I 1.182 0.98
100_A 114_A 1.18 0.98
31_A 74_L 1.163 0.97
190_Q 194_K 1.16 0.97
97_L 265_I 1.155 0.97
98_G 285_M 1.153 0.97
286_A 305_R 1.151 0.97
9_G 372_H 1.15 0.97
176_I 181_Q 1.148 0.97
211_K 217_V 1.143 0.97
33_P 260_A 1.14 0.97
318_D 345_H 1.129 0.97
126_V 144_T 1.128 0.97
176_I 331_L 1.121 0.97
212_N 218_T 1.121 0.97
53_I 112_L 1.121 0.97
5_F 266_A 1.12 0.96
317_M 383_L 1.116 0.96
284_A 309_R 1.115 0.96
319_V 377_R 1.112 0.96
8_D 40_R 1.112 0.96
95_D 99_F 1.101 0.96
184_F 330_A 1.093 0.96
24_V 32_I 1.084 0.96
187_R 342_D 1.082 0.96
200_I 376_R 1.081 0.95
12_T 33_P 1.08 0.95
212_N 217_V 1.078 0.95
269_Q 273_A 1.076 0.95
284_A 397_I 1.072 0.95
297_L 300_V 1.065 0.95
303_T 383_L 1.059 0.95
186_L 229_E 1.058 0.95
310_A 397_I 1.057 0.95
38_L 44_L 1.056 0.95
283_V 399_E 1.053 0.95
209_V 216_V 1.048 0.94
294_L 297_L 1.048 0.94
339_L 346_V 1.046 0.94
300_V 304_R 1.045 0.94
186_L 235_L 1.044 0.94
204_E 369_A 1.044 0.94
194_K 197_S 1.041 0.94
13_P 220_I 1.041 0.94
365_R 369_A 1.039 0.94
178_R 249_T 1.034 0.94
322_L 385_T 1.034 0.94
212_N 216_V 1.033 0.94
164_P 241_P 1.032 0.94
232_L 236_R 1.025 0.93
38_L 77_L 1.023 0.93
283_V 381_Y 1.022 0.93
209_V 217_V 1.018 0.93
6_I 398_L 1.016 0.93
203_E 376_R 1.01 0.93
173_L 293_R 1.009 0.93
34_L 77_L 1.008 0.93
190_Q 193_A 1.005 0.93
25_R 28_D 1.005 0.93
165_E 243_R 1.004 0.93
37_L 113_I 1.003 0.93
366_L 384_C 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ulqA80.98251000.2Contact Map0.849
2vu1A40.97261000.202Contact Map0.824
4dd5A10.97261000.205Contact Map0.836
4e1lA40.97511000.213Contact Map0.881
3ss6A20.97261000.214Contact Map0.827
2wu9A20.95511000.219Contact Map0.818
1wdkC20.95761000.227Contact Map0.776
3goaA20.95761000.236Contact Map0.828
2iikA20.95261000.236Contact Map0.814
1wl4A10.97261000.236Contact Map0.837
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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