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OPENSEQ.org

RL18 - 50S ribosomal protein L18
UniProt: P0C018 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10879
Length: 117 (116)
Sequences: 1377
Seq/Len: 11.87

RL18
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
88_K 116_Q 3.793 1.00
73_A 76_K 3.545 1.00
89_D 116_Q 3.39 1.00
76_K 80_E 2.969 1.00
83_L 88_K 2.929 1.00
68_K 105_A 2.787 1.00
80_E 84_E 2.764 1.00
67_N 70_A 2.396 1.00
26_L 37_A 2.378 1.00
11_A 95_S 2.259 1.00
77_A 81_R 2.165 1.00
55_E 81_R 2.139 1.00
79_A 113_A 1.894 1.00
39_V 78_V 1.849 1.00
39_V 82_A 1.829 1.00
72_A 112_E 1.818 1.00
24_T 42_P 1.768 1.00
35_I 106_L 1.744 1.00
41_A 44_G 1.726 1.00
72_A 109_A 1.698 1.00
90_V 117_F 1.577 1.00
109_A 113_A 1.566 1.00
110_A 115_L 1.525 1.00
7_R 97_F 1.497 1.00
80_E 83_L 1.391 0.99
46_E 85_K 1.352 0.99
20_E 24_T 1.336 0.99
6_A 10_R 1.325 0.99
27_V 95_S 1.318 0.99
39_V 87_I 1.29 0.99
30_R 102_R 1.277 0.99
72_A 76_K 1.272 0.99
106_L 109_A 1.262 0.99
8_I 12_T 1.234 0.98
39_V 90_V 1.231 0.98
79_A 109_A 1.205 0.98
53_T 70_A 1.183 0.98
76_K 112_E 1.174 0.98
82_A 115_L 1.164 0.97
69_D 72_A 1.143 0.97
2_D 5_S 1.115 0.96
27_V 40_I 1.11 0.96
37_A 78_V 1.108 0.96
12_T 16_R 1.106 0.96
51_A 77_A 1.1 0.96
34_H 53_T 1.086 0.96
67_N 102_R 1.053 0.95
48_L 87_I 1.05 0.94
104_Q 108_D 1.043 0.94
68_K 72_A 1.031 0.94
81_R 85_K 1.02 0.93
56_K 60_E 1.004 0.93
77_A 80_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bboQ111000.133Contact Map0.475
4kixO111000.15Contact Map0.695
3v2dS10.95731000.165Contact Map0.647
1ovyA10.98291000.179Contact Map0.479
2zjrL10.94021000.189Contact Map0.405
1vq8N10.98291000.272Contact Map0.679
3j3bD111000.273Contact Map0.516
3j39D111000.28Contact Map0.573
3j21O10.98291000.285Contact Map0.695
4a17M111000.288Contact Map0.519

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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