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SIRB1 - Protein sirB1
UniProt: P0AGM5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11251
Length: 269 (269)
Sequences: 381
Seq/Len: 1.42

SIRB1
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
221_R 237_D 3.096 1.00
118_P 125_L 3.074 1.00
103_A 179_V 2.193 0.99
251_S 255_R 1.865 0.96
63_I 105_L 1.847 0.96
41_L 65_L 1.779 0.95
45_A 112_L 1.771 0.95
188_K 222_G 1.755 0.94
37_E 40_R 1.753 0.94
75_S 84_A 1.746 0.94
34_V 92_K 1.725 0.93
83_D 89_Q 1.633 0.91
119_V 128_R 1.596 0.89
105_L 116_L 1.584 0.89
238_L 254_I 1.526 0.86
26_R 88_D 1.515 0.86
182_K 186_T 1.483 0.84
121_F 152_L 1.482 0.84
220_D 234_A 1.477 0.84
188_K 217_E 1.462 0.83
188_K 234_A 1.428 0.81
62_L 109_A 1.419 0.80
225_Y 230_C 1.405 0.79
141_P 183_L 1.403 0.79
225_Y 229_D 1.385 0.78
136_I 139_I 1.383 0.78
30_P 39_E 1.369 0.77
80_R 84_A 1.369 0.77
249_P 257_Q 1.363 0.77
217_E 220_D 1.355 0.76
121_F 126_I 1.354 0.76
38_L 111_R 1.352 0.76
166_L 200_A 1.351 0.76
219_R 241_F 1.35 0.76
39_E 111_R 1.347 0.75
219_R 222_G 1.331 0.74
241_F 250_I 1.326 0.74
119_V 138_L 1.326 0.74
75_S 85_L 1.323 0.73
38_L 104_V 1.322 0.73
49_I 56_E 1.311 0.72
188_K 220_D 1.303 0.72
17_G 176_N 1.295 0.71
46_K 139_I 1.294 0.71
79_Y 84_A 1.289 0.71
219_R 234_A 1.286 0.70
78_V 102_G 1.285 0.70
82_S 187_L 1.278 0.70
112_L 258_I 1.269 0.69
85_L 186_T 1.267 0.69
67_Y 141_P 1.264 0.69
99_V 102_G 1.248 0.67
230_C 233_V 1.225 0.65
67_Y 103_A 1.213 0.64
201_L 205_E 1.21 0.64
75_S 80_R 1.209 0.63
75_S 99_V 1.208 0.63
66_F 224_I 1.205 0.63
6_D 267_V 1.203 0.63
222_G 241_F 1.201 0.63
90_V 212_P 1.2 0.63
256_A 262_A 1.197 0.62
65_L 70_W 1.197 0.62
47_E 67_Y 1.194 0.62
201_L 221_R 1.191 0.62
40_R 46_K 1.191 0.62
196_Q 199_L 1.186 0.61
29_F 108_V 1.18 0.61
187_L 235_L 1.179 0.61
245_C 249_P 1.179 0.61
74_A 79_Y 1.177 0.60
18_M 27_R 1.176 0.60
98_A 186_T 1.175 0.60
140_N 155_W 1.157 0.58
115_P 119_V 1.155 0.58
150_H 171_L 1.154 0.58
24_A 221_R 1.14 0.57
219_R 223_L 1.136 0.56
188_K 219_R 1.136 0.56
188_K 223_L 1.135 0.56
78_V 85_L 1.132 0.56
147_L 174_A 1.127 0.55
240_Y 244_Q 1.119 0.55
62_L 171_L 1.118 0.55
39_E 42_V 1.114 0.54
248_D 257_Q 1.11 0.54
19_I 34_V 1.11 0.54
203_T 226_A 1.108 0.54
74_A 142_F 1.108 0.54
75_S 97_S 1.108 0.54
253_M 257_Q 1.1 0.53
93_N 111_R 1.1 0.53
67_Y 213_E 1.099 0.53
56_E 148_S 1.098 0.53
121_F 156_L 1.093 0.52
83_D 119_V 1.089 0.52
249_P 255_R 1.083 0.51
87_L 147_L 1.078 0.50
125_L 179_V 1.076 0.50
97_S 183_L 1.076 0.50
75_S 183_L 1.075 0.50
18_M 97_S 1.075 0.50
117_L 130_E 1.072 0.50
259_N 263_H 1.071 0.50
103_A 107_W 1.071 0.50
118_P 179_V 1.069 0.50
103_A 183_L 1.067 0.49
161_S 200_A 1.067 0.49
241_F 245_C 1.067 0.49
116_L 129_I 1.059 0.49
102_G 107_W 1.055 0.48
141_P 152_L 1.054 0.48
153_D 254_I 1.054 0.48
89_Q 145_E 1.052 0.48
16_E 35_Y 1.05 0.48
34_V 37_E 1.048 0.47
150_H 157_K 1.042 0.47
201_L 228_L 1.036 0.46
179_V 243_E 1.035 0.46
62_L 148_S 1.035 0.46
93_N 161_S 1.033 0.46
83_D 94_R 1.033 0.46
239_S 253_M 1.032 0.46
72_F 91_L 1.031 0.46
64_A 69_D 1.026 0.45
78_V 81_L 1.021 0.45
40_R 72_F 1.018 0.44
39_E 137_W 1.015 0.44
70_W 193_E 1.015 0.44
31_S 92_K 1.013 0.44
228_L 246_P 1.011 0.44
6_D 178_E 1.01 0.44
205_E 208_L 1.009 0.43
49_I 87_L 1.009 0.43
6_D 264_K 1.009 0.43
29_F 88_D 1.008 0.43
217_E 246_P 1.007 0.43
145_E 151_M 1.005 0.43
228_L 237_D 1.004 0.43
200_A 204_S 1.003 0.43
106_L 109_A 1.002 0.43
62_L 114_L 1.001 0.43
60_E 106_L 1 0.43
50_S 61_K 1 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3beeA20.334697.50.899Contact Map0.403
3rkvA10.509397.10.905Contact Map0.456
3ma5A40.353297.10.906Contact Map0.424
1pc2A10.4424970.908Contact Map0.382
3k9iA10.423896.90.909Contact Map0.409
2katA10.397896.80.91Contact Map0.245
4apoA20.516796.80.91Contact Map0.386
2dbaA10.527996.70.911Contact Map0.4
4i2zA10.479696.70.911Contact Map0.411
2l6jA10.34296.60.912Contact Map0.308

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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