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OPENSEQ.org
SYY - Tyrosine--tRNA ligase
UniProt: P0AGJ9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11043
Length: 424 (420)
Sequences: 1840
Seq/Len: 4.38
SYY
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
185_C 189_Q 3.909 1.00
314_E 318_Q 3.802 1.00
309_R 314_E 3.508 1.00
69_V 192_V 3.441 1.00
45_D 250_K 3.424 1.00
124_A 128_D 3.392 1.00
305_E 321_K 3.123 1.00
361_Q 372_R 3.051 1.00
134_N 137_T 2.945 1.00
313_G 316_G 2.868 1.00
85_K 240_E 2.859 1.00
42_P 77_G 2.733 1.00
229_T 270_R 2.721 1.00
102_D 105_R 2.697 1.00
269_Y 287_E 2.672 1.00
288_E 292_N 2.651 1.00
205_I 222_G 2.578 1.00
316_G 319_A 2.498 1.00
385_T 412_R 2.496 1.00
212_T 220_V 2.479 1.00
28_R 193_V 2.415 1.00
11_Q 22_E 2.26 1.00
35_A 67_K 2.238 1.00
59_K 63_Q 2.205 1.00
27_E 31_Q 2.174 1.00
184_A 188_K 2.134 1.00
122_I 190_Y 2.129 1.00
285_A 289_E 2.093 1.00
75_A 130_F 2.068 1.00
98_Q 102_D 1.977 1.00
145_H 214_R 1.975 1.00
184_A 215_L 1.959 1.00
38_C 54_P 1.947 1.00
35_A 192_V 1.944 1.00
380_A 394_P 1.931 1.00
99_E 102_D 1.927 1.00
287_E 291_K 1.886 1.00
130_F 133_M 1.876 1.00
269_Y 273_K 1.858 1.00
385_T 390_K 1.832 1.00
114_F 121_A 1.831 1.00
158_K 162_N 1.829 1.00
93_T 96_T 1.817 1.00
280_I 284_N 1.797 1.00
309_R 317_L 1.786 1.00
92_N 100_W 1.774 1.00
256_F 308_T 1.771 1.00
298_R 301_Y 1.77 1.00
36_L 61_F 1.767 1.00
67_K 122_I 1.756 1.00
35_A 69_V 1.749 0.99
188_K 216_H 1.743 0.99
187_N 218_N 1.738 0.99
370_P 374_Q 1.735 0.99
18_Q 202_W 1.734 0.99
99_E 103_K 1.71 0.99
230_K 234_T 1.698 0.99
180_G 207_S 1.697 0.99
58_L 61_F 1.695 0.99
92_N 96_T 1.691 0.99
374_Q 378_T 1.691 0.99
382_N 390_K 1.69 0.99
36_L 58_L 1.686 0.99
40_F 47_L 1.685 0.99
69_V 124_A 1.676 0.99
40_F 55_L 1.664 0.99
146_F 207_S 1.659 0.99
282_E 285_A 1.659 0.99
369_Q 375_A 1.656 0.99
87_A 90_K 1.65 0.99
301_Y 325_E 1.649 0.99
305_E 317_L 1.649 0.99
302_V 306_Q 1.647 0.99
373_G 377_K 1.646 0.99
94_E 98_Q 1.643 0.99
364_V 372_R 1.642 0.99
284_N 287_E 1.62 0.99
378_T 383_A 1.609 0.99
55_L 108_V 1.585 0.99
78_L 94_E 1.562 0.99
279_S 282_E 1.561 0.99
288_E 291_K 1.548 0.98
105_R 109_A 1.544 0.98
362_A 398_F 1.539 0.98
71_L 186_L 1.522 0.98
363_L 384_I 1.511 0.98
12_E 22_E 1.495 0.98
377_K 381_S 1.472 0.98
273_K 287_E 1.472 0.98
368_L 419_C 1.461 0.98
124_A 186_L 1.457 0.97
34_I 193_V 1.455 0.97
101_V 125_N 1.452 0.97
256_F 307_V 1.443 0.97
187_N 216_H 1.434 0.97
54_P 225_V 1.434 0.97
151_M 173_F 1.428 0.97
40_F 54_P 1.425 0.97
378_T 381_S 1.422 0.97
21_D 24_A 1.415 0.97
38_C 196_I 1.402 0.97
40_F 51_H 1.38 0.96
315_E 318_Q 1.378 0.96
147_S 167_G 1.374 0.96
12_E 280_I 1.369 0.96
281_E 284_N 1.363 0.96
256_F 260_W 1.358 0.96
412_R 418_Y 1.358 0.96
315_E 319_A 1.35 0.96
301_Y 321_K 1.345 0.95
321_K 325_E 1.343 0.95
294_G 297_P 1.337 0.95
369_Q 378_T 1.327 0.95
96_T 99_E 1.317 0.95
8_K 26_A 1.315 0.95
278_M 306_Q 1.298 0.94
210_D 213_R 1.297 0.94
318_Q 322_R 1.295 0.94
264_A 267_D 1.294 0.94
61_F 194_L 1.287 0.94
399_K 402_D 1.284 0.94
278_M 282_E 1.279 0.94
115_D 120_S 1.273 0.93
127_Y 131_G 1.272 0.93
23_E 27_E 1.264 0.93
51_H 54_P 1.26 0.93
150_Q 153_N 1.253 0.93
130_F 178_L 1.253 0.93
278_M 302_V 1.249 0.92
396_Y 402_D 1.244 0.92
9_Q 12_E 1.24 0.92
69_V 186_L 1.23 0.92
106_K 247_D 1.23 0.92
255_K 258_Q 1.228 0.92
364_V 369_Q 1.225 0.91
305_E 318_Q 1.217 0.91
27_E 30_A 1.209 0.91
5_N 8_K 1.207 0.91
301_Y 305_E 1.194 0.90
102_D 106_K 1.193 0.90
317_L 321_K 1.191 0.90
194_L 223_L 1.19 0.90
70_A 108_V 1.183 0.89
18_Q 224_T 1.18 0.89
353_M 421_I 1.178 0.89
374_Q 377_K 1.177 0.89
67_K 118_E 1.168 0.89
28_R 34_I 1.167 0.89
74_G 125_N 1.163 0.88
184_A 212_T 1.16 0.88
267_D 270_R 1.144 0.87
20_T 222_G 1.143 0.87
361_Q 365_D 1.143 0.87
234_T 240_E 1.135 0.87
113_D 120_S 1.133 0.87
398_F 409_T 1.131 0.86
317_L 324_T 1.13 0.86
272_L 303_L 1.123 0.86
384_I 413_R 1.123 0.86
293_S 296_A 1.12 0.86
147_S 169_S 1.118 0.86
359_L 396_Y 1.116 0.85
336_S 339_D 1.115 0.85
230_K 242_G 1.108 0.85
322_R 325_E 1.104 0.85
28_R 32_G 1.103 0.85
289_E 298_R 1.099 0.84
254_Y 323_I 1.093 0.84
269_Y 290_D 1.092 0.84
370_P 417_N 1.085 0.83
386_I 398_F 1.08 0.83
154_K 206_T 1.079 0.83
258_Q 328_F 1.077 0.83
135_V 138_F 1.076 0.83
138_F 177_L 1.074 0.82
360_M 372_R 1.071 0.82
74_G 127_Y 1.066 0.82
369_Q 374_Q 1.066 0.82
403_R 423_W 1.064 0.82
38_C 51_H 1.064 0.82
258_Q 262_N 1.056 0.81
276_T 307_V 1.046 0.80
130_F 181_Y 1.04 0.79
378_T 413_R 1.038 0.79
56_L 277_F 1.037 0.79
184_A 216_H 1.032 0.79
28_R 221_F 1.032 0.79
125_N 128_D 1.031 0.79
155_E 159_Q 1.029 0.78
316_G 320_A 1.027 0.78
148_V 173_F 1.025 0.78
362_A 421_I 1.023 0.78
49_L 259_F 1.022 0.78
287_E 290_D 1.02 0.78
360_M 376_R 1.004 0.76
61_F 282_E 1.001 0.76
36_L 194_L 1 0.76
133_M 142_I 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jilA10.98351000.258Contact Map0.764
2ts1A10.98351000.262Contact Map0.77
2janA40.98821000.263Contact Map0.763
1h3fA20.91751000.363Contact Map0.756
1y42X10.78541000.396Contact Map0.728
2yxnA10.75941000.454Contact Map0.749
2pidA20.79251000.457Contact Map0.77
3p0jA40.93161000.575Contact Map0.524
3hv0A20.75941000.591Contact Map0.493
2cycA20.74761000.603Contact Map0.64
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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