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TLDD - Protein TldD
UniProt: P0AGG8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12826
Length: 481 (461)
Sequences: 2137
Seq/Len: 4.64
TLDD
Paralog alert: 0.96 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: PMBA TLDD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
386_I 422_V 4.512 1.00
325_E 330_K 4.047 1.00
383_E 415_N 3.979 1.00
288_L 292_E 3.798 1.00
382_V 413_I 3.669 1.00
322_V 325_E 3.541 1.00
384_Y 414_E 3.521 1.00
379_I 413_I 3.405 1.00
439_S 473_D 3.29 1.00
299_D 320_Y 3.086 1.00
439_S 471_K 3.022 1.00
140_R 224_D 3 1.00
247_T 474_N 2.931 1.00
241_V 420_K 2.923 1.00
284_Q 287_E 2.873 1.00
130_S 133_E 2.799 1.00
414_E 420_K 2.719 1.00
414_E 419_T 2.695 1.00
374_T 377_E 2.602 1.00
384_Y 412_L 2.573 1.00
374_T 443_N 2.504 1.00
151_R 193_E 2.456 1.00
192_E 195_G 2.448 1.00
229_E 232_R 2.436 1.00
412_L 419_T 2.433 1.00
152_V 191_V 2.27 1.00
412_L 420_K 2.254 1.00
178_D 310_A 2.221 1.00
293_L 441_V 2.207 1.00
290_A 435_M 2.201 1.00
77_G 96_A 2.197 1.00
42_S 165_L 2.194 1.00
378_I 469_T 2.188 1.00
136_D 140_R 2.133 1.00
373_S 377_E 2.13 1.00
293_L 326_N 2.118 1.00
288_L 436_Q 2.101 1.00
413_I 419_T 2.099 1.00
444_D 469_T 2.084 1.00
380_E 417_K 2.037 1.00
292_E 326_N 2.022 1.00
248_M 477_V 1.957 1.00
434_T 472_V 1.943 1.00
28_L 36_G 1.865 1.00
378_I 440_M 1.848 1.00
22_F 26_G 1.845 1.00
288_L 328_I 1.823 1.00
191_V 235_L 1.811 1.00
320_Y 367_Y 1.776 1.00
376_Q 417_K 1.77 1.00
295_T 322_V 1.744 1.00
339_A 345_T 1.718 0.99
228_K 232_R 1.696 0.99
148_A 228_K 1.692 0.99
42_S 64_Q 1.688 0.99
375_P 469_T 1.686 0.99
269_L 323_L 1.68 0.99
222_R 225_A 1.671 0.99
23_A 86_L 1.667 0.99
411_Y 418_V 1.665 0.99
251_V 378_I 1.664 0.99
75_K 105_D 1.659 0.99
91_Q 94_Q 1.655 0.99
375_P 378_I 1.626 0.99
193_E 239_S 1.606 0.99
370_P 445_L 1.603 0.99
191_V 234_A 1.595 0.99
334_Q 344_M 1.59 0.99
294_C 441_V 1.574 0.99
36_G 171_T 1.567 0.99
144_V 228_K 1.559 0.99
430_S 433_E 1.558 0.99
70_A 96_A 1.551 0.99
145_A 227_A 1.546 0.99
167_L 175_L 1.546 0.99
139_R 143_K 1.541 0.99
144_V 227_A 1.54 0.99
382_V 471_K 1.532 0.99
402_K 430_S 1.519 0.98
295_T 326_N 1.516 0.98
326_N 330_K 1.513 0.98
251_V 382_V 1.489 0.98
136_D 139_R 1.477 0.98
148_A 231_V 1.465 0.98
381_S 440_M 1.452 0.98
301_T 318_G 1.444 0.98
397_D 402_K 1.441 0.98
17_K 20_D 1.43 0.97
152_V 235_L 1.424 0.97
134_K 159_L 1.422 0.97
28_L 32_R 1.42 0.97
322_V 326_N 1.412 0.97
297_V 320_Y 1.411 0.97
133_E 136_D 1.406 0.97
334_Q 342_M 1.406 0.97
321_N 349_N 1.405 0.97
437_Q 473_D 1.403 0.97
385_G 413_I 1.386 0.97
309_V 318_G 1.385 0.97
251_V 413_I 1.384 0.97
320_Y 369_L 1.38 0.97
297_V 369_L 1.379 0.97
90_E 94_Q 1.371 0.96
441_V 470_L 1.353 0.96
198_E 423_K 1.351 0.96
334_Q 338_N 1.351 0.96
316_T 346_P 1.35 0.96
378_I 442_G 1.341 0.96
21_L 169_A 1.339 0.96
321_N 331_G 1.326 0.95
85_S 88_A 1.323 0.95
387_Y 469_T 1.303 0.95
291_S 441_V 1.298 0.95
83_Q 88_A 1.29 0.94
53_R 142_D 1.286 0.94
375_P 379_I 1.284 0.94
381_S 471_K 1.281 0.94
176_A 311_I 1.271 0.94
280_V 432_I 1.268 0.94
204_G 226_W 1.261 0.94
28_L 70_A 1.261 0.94
48_W 55_I 1.26 0.94
94_Q 98_T 1.258 0.93
27_Q 31_R 1.257 0.93
200_G 230_A 1.254 0.93
397_D 400_S 1.252 0.93
264_A 290_A 1.249 0.93
319_Q 345_T 1.241 0.93
251_V 471_K 1.241 0.93
227_A 231_V 1.241 0.93
309_V 364_T 1.239 0.93
323_L 333_M 1.238 0.93
66_V 81_A 1.235 0.93
290_A 294_C 1.233 0.93
275_R 342_M 1.224 0.92
376_Q 380_E 1.222 0.92
50_L 55_I 1.206 0.91
37_D 69_R 1.202 0.91
145_A 230_A 1.202 0.91
407_T 410_A 1.201 0.91
143_K 147_E 1.2 0.91
27_Q 90_E 1.198 0.91
274_N 332_Y 1.193 0.91
73_G 105_D 1.193 0.91
224_D 228_K 1.189 0.91
367_Y 445_L 1.189 0.91
38_L 66_V 1.189 0.91
208_F 304_D 1.189 0.91
202_S 229_E 1.182 0.90
161_G 210_Y 1.175 0.90
19_Q 22_F 1.174 0.90
191_V 238_L 1.173 0.90
152_V 231_V 1.173 0.90
249_P 471_K 1.165 0.89
339_A 346_P 1.165 0.89
272_D 456_K 1.163 0.89
296_V 324_I 1.162 0.89
387_Y 413_I 1.161 0.89
433_E 436_Q 1.155 0.89
275_R 334_Q 1.154 0.89
249_P 474_N 1.152 0.89
271_G 334_Q 1.147 0.89
295_T 369_L 1.14 0.88
28_L 33_L 1.139 0.88
169_A 175_L 1.138 0.88
138_L 157_A 1.137 0.88
375_P 443_N 1.137 0.88
50_L 139_R 1.136 0.88
308_S 365_N 1.135 0.88
321_N 347_T 1.133 0.88
373_S 440_M 1.133 0.88
442_G 469_T 1.133 0.88
386_I 425_A 1.132 0.88
378_I 382_V 1.129 0.87
165_L 179_V 1.127 0.87
248_M 422_V 1.121 0.87
351_R 362_R 1.12 0.87
322_V 330_K 1.113 0.86
265_V 435_M 1.112 0.86
284_Q 432_I 1.112 0.86
300_G 309_V 1.106 0.86
231_V 235_L 1.099 0.85
88_A 92_S 1.098 0.85
251_V 375_P 1.095 0.85
249_P 473_D 1.091 0.85
65_G 78_F 1.089 0.85
52_D 154_E 1.089 0.85
433_E 437_Q 1.084 0.84
259_V 453_V 1.08 0.84
241_V 412_L 1.078 0.84
170_A 174_T 1.076 0.84
379_I 382_V 1.072 0.83
144_V 224_D 1.072 0.83
261_L 368_M 1.072 0.83
434_T 475_L 1.072 0.83
23_A 26_G 1.07 0.83
144_V 231_V 1.069 0.83
331_G 347_T 1.067 0.83
388_A 427_L 1.066 0.83
243_A 246_G 1.065 0.83
295_T 325_E 1.065 0.83
257_P 470_L 1.064 0.83
39_Y 352_R 1.064 0.83
316_T 348_G 1.063 0.83
252_L 388_A 1.059 0.82
25_L 171_T 1.055 0.82
253_G 387_Y 1.055 0.82
391_F 395_Q 1.054 0.82
79_A 92_S 1.052 0.82
438_I 470_L 1.051 0.82
72_S 101_R 1.049 0.82
225_A 229_E 1.049 0.82
87_L 91_Q 1.041 0.81
297_V 322_V 1.039 0.81
134_K 161_G 1.038 0.81
24_I 89_L 1.037 0.81
277_G 282_S 1.032 0.80
145_A 189_V 1.032 0.80
145_A 231_V 1.031 0.80
191_V 231_V 1.03 0.80
437_Q 474_N 1.03 0.80
375_P 444_D 1.027 0.80
72_S 97_R 1.025 0.80
285_V 332_Y 1.018 0.79
367_Y 466_G 1.017 0.79
149_D 193_E 1.015 0.79
391_F 394_G 1.013 0.78
81_A 92_S 1.012 0.78
141_V 223_A 1.005 0.78
142_D 146_R 1.004 0.78
20_D 24_I 1.001 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qtdA40.92311000.204Contact Map0.766
1vpbA10.9211000.218Contact Map0.66
1vl4A20.91061000.219Contact Map0.766
3tv9A10.91681000.221Contact Map0.741
3zj0A10.15598.60.979Contact Map0.463
1s3cA10.26615.10.981Contact Map0.157
1ufhA20.13934.70.981Contact Map0.549
2pdoA80.15384.60.981Contact Map0.708
2fsrA10.17054.20.982Contact Map0.506
3juwA30.155940.982Contact Map0.604
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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