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OPENSEQ.org
SERB - Phosphoserine phosphatase
UniProt: P0AGB0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10945
Length: 322 (285)
Sequences: 446
Seq/Len: 1.56
SERB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
194_E 221_T 3.182 1.00
146_R 160_S 3.027 1.00
247_Q 251_K 2.948 1.00
155_T 245_D 2.864 1.00
277_L 295_V 2.618 1.00
145_E 149_R 2.587 1.00
229_E 238_N 2.488 1.00
122_I 126_C 2.303 0.99
166_K 238_N 2.265 0.99
224_V 255_R 2.182 0.99
255_R 259_E 2.155 0.99
173_L 209_F 2.097 0.99
229_E 240_I 2.063 0.99
170_A 230_I 2.02 0.98
121_A 186_L 2 0.98
187_T 217_K 1.965 0.98
152_L 156_A 1.857 0.97
123_Q 183_M 1.833 0.96
159_R 241_G 1.799 0.96
145_E 289_Y 1.77 0.95
183_M 289_Y 1.709 0.94
212_E 223_V 1.709 0.94
156_A 160_S 1.684 0.93
201_A 256_L 1.68 0.93
132_K 137_G 1.655 0.93
194_E 219_R 1.641 0.92
285_L 301_V 1.632 0.92
246_A 278_P 1.607 0.91
130_I 168_A 1.605 0.91
115_M 270_I 1.578 0.90
132_K 179_N 1.547 0.89
190_V 200_V 1.545 0.89
153_D 245_D 1.543 0.89
175_Q 178_E 1.533 0.88
224_V 252_T 1.527 0.88
215_R 223_V 1.522 0.88
257_A 262_I 1.504 0.87
253_L 269_A 1.494 0.87
211_A 223_V 1.469 0.85
177_R 213_Y 1.469 0.85
124_I 181_P 1.453 0.85
295_V 298_K 1.437 0.84
108_R 312_F 1.422 0.83
248_Y 252_T 1.415 0.82
288_A 291_A 1.413 0.82
112_L 267_T 1.396 0.81
182_L 217_K 1.371 0.80
124_I 173_L 1.371 0.80
122_I 127_I 1.37 0.79
124_I 129_E 1.334 0.77
168_A 176_V 1.333 0.77
254_T 282_A 1.328 0.76
126_C 129_E 1.327 0.76
199_K 222_A 1.319 0.76
303_I 306_A 1.317 0.76
246_A 294_K 1.317 0.76
136_T 139_M 1.308 0.75
287_I 311_V 1.281 0.73
136_T 164_T 1.275 0.72
139_M 142_E 1.273 0.72
111_G 303_I 1.27 0.72
167_G 284_G 1.269 0.72
193_L 214_L 1.261 0.71
166_K 174_Q 1.251 0.70
127_I 140_V 1.246 0.70
296_N 304_R 1.231 0.68
112_L 194_E 1.231 0.68
139_M 143_V 1.226 0.68
270_I 295_V 1.201 0.66
114_V 156_A 1.199 0.65
121_A 127_I 1.187 0.64
162_V 228_L 1.178 0.63
129_E 290_H 1.173 0.63
115_M 277_L 1.173 0.63
99_A 301_V 1.165 0.62
65_I 75_Q 1.16 0.62
155_T 243_I 1.159 0.62
126_C 290_H 1.145 0.60
277_L 298_K 1.137 0.59
132_K 175_Q 1.136 0.59
149_R 297_E 1.126 0.58
159_R 243_I 1.119 0.58
142_E 146_R 1.119 0.58
108_R 242_D 1.119 0.58
139_M 164_T 1.119 0.58
146_R 151_E 1.118 0.57
201_A 222_A 1.116 0.57
193_L 198_W 1.109 0.56
221_T 280_I 1.106 0.56
128_D 137_G 1.103 0.56
169_D 234_K 1.093 0.55
216_D 258_Q 1.09 0.55
181_P 202_I 1.088 0.54
168_A 172_I 1.087 0.54
121_A 126_C 1.082 0.54
267_T 285_L 1.08 0.53
170_A 233_G 1.076 0.53
210_F 290_H 1.072 0.53
169_D 175_Q 1.071 0.53
306_A 310_G 1.068 0.52
280_I 286_G 1.057 0.51
229_E 236_T 1.055 0.51
143_V 164_T 1.052 0.51
133_L 179_N 1.052 0.51
166_K 229_E 1.051 0.50
117_M 128_D 1.046 0.50
219_R 243_I 1.042 0.50
153_D 156_A 1.042 0.50
64_V 102_G 1.042 0.50
47_L 69_W 1.041 0.49
229_E 232_D 1.033 0.49
302_T 311_V 1.026 0.48
246_A 251_K 1.026 0.48
169_D 280_I 1.024 0.48
56_Q 87_A 1.018 0.47
126_C 210_F 1.017 0.47
176_V 250_A 1.015 0.47
59_L 90_L 1.008 0.46
159_R 251_K 1.007 0.46
170_A 174_Q 1.005 0.46
170_A 209_F 1.001 0.45
174_Q 209_F 1 0.45
89_R 93_E 1 0.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3p96A111000.667Contact Map0.438
3n28A10.98451000.678Contact Map0.538
3m1yA40.67081000.701Contact Map0.571
1l7mA20.65531000.718Contact Map0.601
4ezeA20.9411000.726Contact Map0.574
1rkuA20.62111000.757Contact Map0.472
3fvvA20.65531000.77Contact Map0.428
4as2A40.72671000.778Contact Map0.362
1y8aA10.70191000.781Contact Map0.382
4ap9A40.621199.90.792Contact Map0.406
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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