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UGPB - sn-glycerol-3-phosphate-binding periplasmic protein UgpB
UniProt: P0AG80 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11047
Length: 438 (408)
Sequences: 7351
Seq/Len: 18.02
UGPB
Paralog alert: 0.82 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: CYSP MALE MODA POTD POTF SUBI THIB UGPB YCJN YDCS YNJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
413_T 416_Q 4.598 1.00
231_V 415_Q 4.405 1.00
153_D 284_N 3.783 1.00
238_E 242_K 3.759 1.00
102_K 321_Y 3.707 1.00
26_T 58_V 3.675 1.00
235_A 239_E 3.644 1.00
52_N 326_K 3.545 1.00
42_D 46_Q 3.241 1.00
152_K 286_G 3.156 1.00
415_Q 419_D 3.094 1.00
48_F 326_K 3.05 1.00
226_N 419_D 3.04 1.00
103_P 135_H 2.895 1.00
49_N 56_K 2.781 1.00
55_Y 323_G 2.762 1.00
173_A 239_E 2.664 1.00
150_Y 286_G 2.606 1.00
419_D 423_E 2.6 1.00
43_S 46_Q 2.593 1.00
47_R 330_F 2.585 1.00
26_T 56_K 2.56 1.00
174_D 178_K 2.517 1.00
177_A 243_K 2.493 1.00
320_T 323_G 2.468 1.00
47_R 50_A 2.466 1.00
155_F 266_M 2.463 1.00
46_Q 50_A 2.421 1.00
333_K 336_N 2.42 1.00
239_E 243_K 2.402 1.00
228_P 232_K 2.391 1.00
412_K 420_T 2.365 1.00
119_Q 352_A 2.34 1.00
422_V 426_N 2.327 1.00
326_K 329_D 2.32 1.00
168_T 171_D 2.312 1.00
235_A 414_P 2.3 1.00
152_K 156_K 2.291 1.00
160_L 175_Y 2.27 1.00
122_P 126_G 2.237 1.00
153_D 157_K 2.212 1.00
24_V 56_K 2.194 1.00
48_F 55_Y 2.19 1.00
28_P 58_V 2.165 1.00
171_D 174_D 2.125 1.00
406_S 412_K 2.082 1.00
129_S 136_L 2.045 1.00
235_A 415_Q 2.042 1.00
318_K 321_Y 2.027 1.00
45_A 49_N 2.014 1.00
231_V 414_P 2.013 1.00
174_D 177_A 1.982 1.00
45_A 327_F 1.978 1.00
83_A 320_T 1.975 1.00
416_Q 420_T 1.975 1.00
426_N 430_R 1.959 1.00
84_I 328_L 1.944 1.00
406_S 411_K 1.927 1.00
370_D 374_R 1.883 1.00
416_Q 419_D 1.837 1.00
47_R 339_E 1.83 1.00
226_N 422_V 1.81 1.00
407_V 417_A 1.808 1.00
107_V 325_A 1.807 1.00
322_T 326_K 1.784 1.00
67_Q 70_S 1.76 1.00
46_Q 49_N 1.753 1.00
177_A 181_A 1.734 1.00
76_F 81_A 1.73 1.00
45_A 59_P 1.711 1.00
105_Y 135_H 1.699 1.00
238_E 407_V 1.691 1.00
338_A 342_Q 1.69 1.00
55_Y 326_K 1.678 1.00
85_L 313_M 1.673 1.00
38_G 42_D 1.672 1.00
30_W 75_A 1.667 1.00
47_R 51_E 1.661 1.00
48_F 330_F 1.652 1.00
166_P 171_D 1.641 1.00
232_K 235_A 1.634 1.00
179_L 265_A 1.614 1.00
167_K 171_D 1.614 1.00
259_F 285_Y 1.608 1.00
28_P 60_T 1.602 1.00
423_E 427_Q 1.592 1.00
339_E 343_K 1.583 1.00
170_Q 173_A 1.58 1.00
403_E 420_T 1.565 1.00
148_L 288_G 1.559 1.00
399_I 424_R 1.554 1.00
150_Y 288_G 1.554 1.00
43_S 47_R 1.531 1.00
152_K 284_N 1.522 1.00
398_V 402_E 1.521 1.00
164_Q 167_K 1.52 1.00
420_T 423_E 1.512 1.00
161_D 164_Q 1.51 1.00
419_D 422_V 1.48 1.00
327_F 331_L 1.479 1.00
407_V 414_P 1.475 1.00
403_E 412_K 1.472 1.00
111_A 329_D 1.463 1.00
177_A 245_D 1.461 1.00
49_N 53_P 1.458 1.00
173_A 177_A 1.452 1.00
412_K 417_A 1.44 1.00
173_A 243_K 1.406 0.99
154_A 265_A 1.402 0.99
229_E 232_K 1.402 0.99
231_V 235_A 1.4 0.99
155_F 160_L 1.398 0.99
148_L 266_M 1.397 0.99
154_A 179_L 1.383 0.99
176_A 266_M 1.381 0.99
173_A 240_M 1.379 0.99
170_Q 174_D 1.365 0.99
330_F 336_N 1.349 0.99
103_P 106_D 1.343 0.99
57_I 327_F 1.343 0.99
119_Q 350_T 1.342 0.99
420_T 424_R 1.327 0.99
413_T 417_A 1.325 0.99
48_F 52_N 1.31 0.99
374_R 377_L 1.304 0.99
96_M 137_L 1.302 0.99
239_E 242_K 1.298 0.99
403_E 421_A 1.296 0.99
84_I 324_V 1.296 0.99
101_I 311_W 1.295 0.99
47_R 335_E 1.286 0.99
170_Q 294_A 1.283 0.99
160_L 178_K 1.277 0.99
71_A 75_A 1.268 0.99
155_F 179_L 1.261 0.99
126_G 129_S 1.261 0.99
45_A 57_I 1.259 0.99
406_S 420_T 1.255 0.99
154_A 157_K 1.254 0.99
173_A 236_M 1.253 0.99
258_K 263_D 1.252 0.99
39_K 43_S 1.251 0.99
147_V 372_A 1.238 0.98
175_Y 178_K 1.233 0.98
48_F 323_G 1.226 0.98
396_I 425_G 1.224 0.98
48_F 327_F 1.214 0.98
24_V 54_D 1.21 0.98
49_N 54_D 1.209 0.98
43_S 339_E 1.199 0.98
325_A 329_D 1.194 0.98
334_P 338_A 1.184 0.98
84_I 327_F 1.18 0.98
402_E 424_R 1.179 0.98
138_S 311_W 1.179 0.98
128_Y 309_S 1.173 0.98
317_D 320_T 1.171 0.98
122_P 351_K 1.169 0.97
236_M 240_M 1.167 0.97
49_N 52_N 1.167 0.97
25_T 323_G 1.165 0.97
31_H 59_P 1.165 0.97
412_K 416_Q 1.154 0.97
163_E 167_K 1.131 0.97
234_I 407_V 1.125 0.97
327_F 330_F 1.125 0.97
54_D 326_K 1.125 0.97
158_A 179_L 1.122 0.97
276_N 279_E 1.122 0.97
130_D 133_T 1.121 0.97
235_A 238_E 1.117 0.96
151_N 283_F 1.116 0.96
371_T 374_R 1.113 0.96
102_K 314_Q 1.111 0.96
72_G 85_L 1.11 0.96
218_G 222_V 1.109 0.96
258_K 264_C 1.106 0.96
323_G 326_K 1.106 0.96
180_K 245_D 1.102 0.96
63_G 67_Q 1.101 0.96
334_P 352_A 1.097 0.96
321_Y 325_A 1.097 0.96
180_K 187_G 1.088 0.96
156_K 162_P 1.078 0.95
44_L 336_N 1.076 0.95
403_E 406_S 1.071 0.95
175_Y 266_M 1.063 0.95
83_A 318_K 1.058 0.95
147_V 287_V 1.052 0.95
402_E 406_S 1.048 0.94
49_N 57_I 1.045 0.94
400_V 421_A 1.041 0.94
43_S 343_K 1.039 0.94
231_V 418_L 1.037 0.94
223_L 422_V 1.035 0.94
424_R 427_Q 1.023 0.93
155_F 175_Y 1.021 0.93
236_M 239_E 1.015 0.93
232_K 236_M 1.01 0.93
25_T 320_T 1.008 0.93
39_K 42_D 1 0.92
128_Y 136_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4aq4A10.95431000.185Contact Map0.774
3uorA20.93381000.232Contact Map0.747
3k01A10.90641000.266Contact Map0.738
1eu8A10.8791000.271Contact Map0.751
4gqoA30.93381000.274Contact Map0.73
2w7yA20.92011000.282Contact Map0.595
4hw8A20.90411000.292Contact Map0.768
4c1uA10.89041000.293Contact Map0.664
3i3vA40.89041000.293Contact Map0.681
2z8fA20.9111000.293Contact Map0.637
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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