May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
RELA - GTP pyrophosphokinase
UniProt: P0AG20 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10835
Length: 744 (704)
Sequences: 1646
Seq/Len: 2.34
RELA
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RELA SPOT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_R 101_K 4.364 1.00
445_G 459_D 3.836 1.00
429_Y 437_H 3.702 1.00
85_A 92_E 3.201 1.00
444_I 449_V 3.141 1.00
71_M 150_V 3.041 1.00
483_V 492_I 2.954 1.00
37_E 98_S 2.944 1.00
425_L 482_Y 2.923 1.00
285_R 288_D 2.917 1.00
726_L 738_A 2.907 1.00
239_E 242_A 2.865 1.00
161_R 197_E 2.782 1.00
248_E 341_K 2.663 1.00
505_I 544_A 2.624 1.00
35_L 76_L 2.618 1.00
671_V 729_L 2.598 1.00
676_R 682_D 2.538 1.00
512_L 546_I 2.464 1.00
284_E 341_K 2.453 1.00
282_V 341_K 2.421 1.00
236_L 296_V 2.416 1.00
246_K 284_E 2.382 1.00
168_E 171_R 2.364 1.00
435_V 465_T 2.299 1.00
455_L 461_I 2.274 1.00
74_D 102_S 2.222 1.00
34_C 77_R 2.204 1.00
268_L 273_L 2.155 1.00
85_A 95_L 2.126 1.00
228_Y 328_G 2.048 0.99
485_T 488_G 1.961 0.99
673_A 679_L 1.954 0.99
410_T 416_V 1.935 0.99
217_L 270_F 1.929 0.99
250_Y 344_H 1.924 0.99
214_I 256_I 1.879 0.99
536_F 545_A 1.875 0.99
176_K 180_N 1.865 0.99
163_V 174_A 1.847 0.99
697_V 712_M 1.814 0.98
669_V 726_L 1.811 0.98
66_L 75_T 1.808 0.98
424_P 442_A 1.795 0.98
92_E 108_H 1.787 0.98
71_M 75_T 1.785 0.98
207_H 210_E 1.742 0.98
163_V 205_Y 1.731 0.98
237_R 241_K 1.727 0.98
83_P 87_A 1.71 0.97
87_A 159_H 1.706 0.97
454_Q 484_T 1.686 0.97
668_V 713_T 1.682 0.97
94_V 97_E 1.671 0.97
626_T 632_S 1.666 0.97
453_Y 456_Q 1.664 0.97
676_R 679_L 1.648 0.96
538_D 541_E 1.647 0.96
692_V 721_V 1.64 0.96
443_K 462_E 1.636 0.96
287_Q 291_A 1.632 0.96
41_Y 90_V 1.63 0.96
218_L 256_I 1.628 0.96
159_H 162_E 1.626 0.96
231_E 330_G 1.616 0.96
63_V 76_L 1.615 0.96
59_G 159_H 1.576 0.95
34_C 74_D 1.569 0.95
283_A 292_A 1.554 0.95
83_P 159_H 1.545 0.94
433_S 437_H 1.545 0.94
444_I 453_Y 1.539 0.94
714_I 725_V 1.533 0.94
466_Q 469_P 1.531 0.94
86_D 159_H 1.527 0.94
687_L 694_V 1.521 0.94
112_D 159_H 1.498 0.93
83_P 86_D 1.498 0.93
168_E 172_V 1.484 0.93
160_L 198_L 1.482 0.93
226_E 230_E 1.474 0.92
87_A 112_D 1.462 0.92
158_A 162_E 1.459 0.92
87_A 162_E 1.446 0.91
229_I 251_G 1.445 0.91
254_K 262_K 1.444 0.91
171_R 205_Y 1.443 0.91
613_C 638_C 1.442 0.91
42_C 56_L 1.44 0.91
306_E 325_V 1.439 0.91
155_E 159_H 1.434 0.91
228_Y 329_P 1.427 0.91
46_T 49_H 1.426 0.91
509_R 543_L 1.425 0.91
46_T 159_H 1.425 0.91
215_A 256_I 1.419 0.90
501_R 541_E 1.416 0.90
46_T 83_P 1.414 0.90
105_N 144_D 1.395 0.89
220_E 332_K 1.382 0.89
87_A 111_R 1.372 0.88
424_P 444_I 1.369 0.88
106_L 151_I 1.368 0.88
86_D 162_E 1.367 0.88
422_S 729_L 1.365 0.88
58_R 82_F 1.362 0.88
354_H 357_Y 1.36 0.88
82_F 86_D 1.36 0.88
46_T 55_L 1.357 0.88
297_H 324_T 1.353 0.87
292_A 295_I 1.353 0.87
59_G 87_A 1.349 0.87
109_G 137_R 1.348 0.87
46_T 82_F 1.346 0.87
160_L 163_V 1.343 0.87
288_D 291_A 1.341 0.87
634_H 638_C 1.339 0.87
238_A 242_A 1.336 0.86
163_V 175_A 1.334 0.86
86_D 111_R 1.326 0.86
66_L 79_A 1.323 0.86
262_K 335_E 1.321 0.86
239_E 299_H 1.319 0.85
179_T 257_Y 1.316 0.85
58_R 158_A 1.316 0.85
213_R 217_L 1.311 0.85
175_A 202_C 1.31 0.85
679_L 682_D 1.308 0.85
680_L 697_V 1.305 0.85
59_G 83_P 1.305 0.85
46_T 87_A 1.305 0.85
83_P 88_N 1.297 0.84
46_T 58_R 1.297 0.84
112_D 155_E 1.291 0.84
59_G 86_D 1.291 0.84
633_V 655_A 1.291 0.84
73_I 77_R 1.291 0.84
613_C 634_H 1.291 0.84
320_Q 346_D 1.288 0.84
87_A 158_A 1.286 0.83
284_E 288_D 1.286 0.83
679_L 732_V 1.286 0.83
59_G 112_D 1.285 0.83
612_C 638_C 1.282 0.83
166_A 170_E 1.28 0.83
46_T 86_D 1.278 0.83
232_F 334_V 1.278 0.83
82_F 159_H 1.278 0.83
378_R 381_I 1.277 0.83
76_L 79_A 1.277 0.83
46_T 59_G 1.276 0.83
58_R 83_P 1.272 0.82
109_G 148_C 1.27 0.82
53_S 58_R 1.269 0.82
234_G 238_A 1.268 0.82
262_K 354_H 1.267 0.82
196_W 255_H 1.266 0.82
90_V 94_V 1.264 0.82
87_A 155_E 1.259 0.82
62_M 155_E 1.257 0.81
52_A 58_R 1.256 0.81
36_A 40_A 1.255 0.81
344_H 348_E 1.254 0.81
473_R 496_F 1.254 0.81
443_K 448_I 1.253 0.81
221_R 224_D 1.246 0.81
65_I 161_R 1.243 0.80
111_R 159_H 1.242 0.80
58_R 159_H 1.241 0.80
46_T 111_R 1.238 0.80
254_K 354_H 1.237 0.80
66_L 76_L 1.231 0.80
622_V 641_L 1.229 0.79
38_T 42_C 1.228 0.79
83_P 158_A 1.227 0.79
88_N 159_H 1.223 0.79
92_E 105_N 1.222 0.79
597_V 621_I 1.22 0.79
83_P 162_E 1.218 0.79
675_D 708_A 1.218 0.79
59_G 158_A 1.217 0.78
290_Y 297_H 1.216 0.78
82_F 158_A 1.215 0.78
377_L 406_V 1.215 0.78
34_C 37_E 1.209 0.78
82_F 87_A 1.209 0.78
439_C 451_F 1.209 0.78
196_W 222_R 1.207 0.78
352_A 358_K 1.206 0.78
624_F 651_R 1.206 0.78
92_E 96_R 1.203 0.77
678_G 693_N 1.201 0.77
40_A 43_L 1.2 0.77
433_S 491_K 1.199 0.77
59_G 82_F 1.198 0.77
83_P 111_R 1.191 0.76
86_D 155_E 1.189 0.76
430_H 487_R 1.189 0.76
676_R 708_A 1.189 0.76
83_P 112_D 1.188 0.76
132_V 401_V 1.186 0.76
615_P 638_C 1.184 0.76
505_I 540_D 1.183 0.76
687_L 714_I 1.182 0.76
46_T 162_E 1.18 0.75
55_L 159_H 1.18 0.75
55_L 83_P 1.176 0.75
55_L 82_F 1.175 0.75
222_R 253_P 1.174 0.75
82_F 162_E 1.173 0.75
167_P 170_E 1.173 0.75
237_R 248_E 1.173 0.75
44_Q 47_Q 1.172 0.75
341_K 345_E 1.172 0.75
82_F 155_E 1.171 0.75
600_E 656_V 1.171 0.75
210_E 213_R 1.17 0.75
77_R 103_V 1.166 0.74
111_R 155_E 1.158 0.73
612_C 634_H 1.157 0.73
623_G 653_V 1.156 0.73
294_G 297_H 1.155 0.73
58_R 87_A 1.155 0.73
262_K 275_D 1.151 0.73
55_L 112_D 1.15 0.73
74_D 103_V 1.149 0.73
59_G 162_E 1.148 0.73
85_A 108_H 1.144 0.72
33_E 37_E 1.142 0.72
86_D 158_A 1.142 0.72
83_P 178_C 1.136 0.71
155_E 162_E 1.133 0.71
687_L 712_M 1.133 0.71
82_F 111_R 1.13 0.71
78_A 106_L 1.13 0.71
531_L 539_V 1.128 0.71
86_D 112_D 1.127 0.71
233_V 237_R 1.126 0.70
45_Q 94_V 1.123 0.70
58_R 62_M 1.123 0.70
166_A 174_A 1.122 0.70
236_L 336_I 1.122 0.70
46_T 88_N 1.122 0.70
290_Y 293_L 1.12 0.70
240_M 292_A 1.114 0.69
34_C 103_V 1.111 0.69
55_L 87_A 1.11 0.69
227_H 231_E 1.11 0.69
46_T 158_A 1.109 0.69
683_I 687_L 1.107 0.69
336_I 483_V 1.107 0.69
160_L 178_C 1.107 0.69
41_Y 98_S 1.106 0.69
335_E 354_H 1.106 0.69
290_Y 294_G 1.104 0.68
260_W 264_Q 1.103 0.68
262_K 278_A 1.102 0.68
46_T 112_D 1.101 0.68
687_L 692_V 1.101 0.68
65_I 197_E 1.099 0.68
293_L 338_I 1.099 0.68
112_D 158_A 1.098 0.68
354_H 358_K 1.096 0.67
262_K 352_A 1.095 0.67
280_R 358_K 1.094 0.67
214_I 270_F 1.092 0.67
55_L 58_R 1.092 0.67
687_L 725_V 1.091 0.67
112_D 162_E 1.091 0.67
536_F 542_L 1.089 0.67
58_R 162_E 1.087 0.67
155_E 158_A 1.087 0.67
55_L 158_A 1.086 0.66
142_M 146_F 1.086 0.66
421_G 454_Q 1.085 0.66
626_T 640_Q 1.084 0.66
254_K 335_E 1.082 0.66
52_A 159_H 1.082 0.66
293_L 297_H 1.079 0.66
254_K 358_K 1.078 0.66
58_R 86_D 1.076 0.65
55_L 162_E 1.075 0.65
278_A 354_H 1.075 0.65
59_G 88_N 1.075 0.65
111_R 162_E 1.074 0.65
138_M 302_H 1.071 0.65
232_F 279_V 1.069 0.65
235_H 300_Y 1.069 0.65
254_K 352_A 1.068 0.65
111_R 158_A 1.064 0.64
96_R 104_V 1.064 0.64
108_H 137_R 1.064 0.64
699_S 710_I 1.064 0.64
203_F 210_E 1.062 0.64
170_E 174_A 1.061 0.64
52_A 82_F 1.06 0.64
66_L 110_V 1.059 0.64
620_E 636_A 1.057 0.63
196_W 253_P 1.057 0.63
352_A 357_Y 1.055 0.63
92_E 104_V 1.054 0.63
93_D 461_I 1.052 0.63
88_N 112_D 1.052 0.63
669_V 712_M 1.048 0.62
280_R 352_A 1.045 0.62
622_V 652_I 1.044 0.62
402_F 497_R 1.044 0.62
262_K 280_R 1.043 0.62
62_M 82_F 1.042 0.62
335_E 352_A 1.041 0.62
545_A 551_I 1.041 0.62
52_A 155_E 1.04 0.62
59_G 111_R 1.04 0.62
63_V 79_A 1.039 0.61
406_V 453_Y 1.039 0.61
51_D 59_G 1.038 0.61
134_N 409_F 1.036 0.61
329_P 680_L 1.036 0.61
537_N 541_E 1.036 0.61
55_L 59_G 1.035 0.61
677_S 693_N 1.034 0.61
212_K 215_A 1.034 0.61
58_R 111_R 1.034 0.61
453_Y 459_D 1.033 0.61
62_M 112_D 1.031 0.61
88_N 162_E 1.03 0.60
181_I 305_D 1.03 0.60
86_D 170_E 1.029 0.60
87_A 170_E 1.028 0.60
296_V 326_V 1.028 0.60
500_D 503_K 1.027 0.60
280_R 335_E 1.027 0.60
204_R 215_A 1.024 0.60
47_Q 50_P 1.024 0.60
74_D 77_R 1.023 0.60
280_R 337_Q 1.022 0.60
280_R 354_H 1.02 0.59
379_K 383_W 1.019 0.59
390_S 730_N 1.016 0.59
355_W 612_C 1.015 0.59
676_R 732_V 1.013 0.59
46_T 62_M 1.013 0.59
191_I 195_K 1.012 0.58
62_M 159_H 1.012 0.58
669_V 738_A 1.011 0.58
241_K 540_D 1.007 0.58
59_G 62_M 1.006 0.58
615_P 634_H 1.006 0.58
679_L 734_D 1.004 0.57
46_T 52_A 1.004 0.57
442_A 449_V 1.002 0.57
62_M 83_P 1 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vj7A20.52021000.524Contact Map0.561
3l9dA20.32531000.765Contact Map0.397
2be3A20.28761000.834Contact Map0.482
3nr1A20.23121000.84Contact Map0.464
3nqwA20.22851000.846Contact Map0.438
2ekiA10.112999.80.923Contact Map0.593
3hvzA60.104899.70.935Contact Map0.969
1wwtA10.116999.40.947Contact Map0.48
2kmmA10.098199.40.948Contact Map0.789
1wxqA10.322699.20.952Contact Map0.713
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.6318 seconds.