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OPENSEQ.org
PUR1 - Amidophosphoribosyltransferase
UniProt: P0AG16 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10794
Length: 505 (477)
Sequences: 1641
Seq/Len: 3.44
PUR1
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
181_A 207_V 6.52 1.00
285_E 316_I 4.546 1.00
424_D 427_R 4.452 1.00
278_N 281_T 4.167 1.00
114_K 163_L 3.821 1.00
282_K 445_D 3.791 1.00
422_E 425_E 3.614 1.00
193_L 225_V 3.609 1.00
5_V 20_A 3.326 1.00
286_K 442_D 3.26 1.00
49_N 81_S 3.227 1.00
287_I 436_I 3.085 1.00
355_R 359_R 3.027 1.00
207_V 233_I 2.819 1.00
35_I 43_F 2.789 1.00
286_K 439_D 2.765 1.00
362_N 390_K 2.733 1.00
195_K 220_D 2.688 1.00
281_T 316_I 2.636 1.00
282_K 285_E 2.621 1.00
298_V 363_V 2.613 1.00
17_I 69_G 2.6 1.00
214_L 219_F 2.591 1.00
193_L 207_V 2.426 1.00
347_V 374_T 2.374 1.00
193_L 231_I 2.348 1.00
439_D 442_D 2.346 1.00
440_L 463_N 2.337 1.00
266_F 271_S 2.329 1.00
295_D 362_N 2.307 1.00
381_E 385_E 2.291 1.00
296_I 364_L 2.252 1.00
225_V 231_I 2.251 1.00
192_V 214_L 2.236 1.00
139_E 159_A 2.171 1.00
282_K 442_D 2.063 1.00
294_L 394_A 2.051 1.00
188_I 468_T 2.045 1.00
35_I 45_L 2.039 1.00
215_D 352_N 2.034 1.00
100_A 171_V 2.011 1.00
226_A 243_Q 1.991 1.00
181_A 231_I 1.985 1.00
132_L 170_C 1.977 1.00
406_Y 468_T 1.914 1.00
424_D 428_Q 1.912 1.00
31_A 86_A 1.906 1.00
394_A 436_I 1.901 1.00
254_L 457_F 1.89 1.00
208_A 213_A 1.887 1.00
412_S 415_E 1.879 1.00
417_I 426_I 1.876 1.00
459_C 463_N 1.859 0.99
193_L 233_I 1.845 0.99
404_N 458_E 1.821 0.99
426_I 437_F 1.81 0.99
31_A 49_N 1.785 0.99
254_L 447_V 1.768 0.99
277_V 315_R 1.757 0.99
168_Y 185_P 1.743 0.99
192_V 211_S 1.719 0.99
273_Y 308_D 1.719 0.99
423_V 427_R 1.715 0.99
48_A 83_A 1.693 0.99
35_I 98_T 1.685 0.99
223_R 241_T 1.668 0.99
427_R 432_A 1.661 0.99
205_Y 222_L 1.659 0.99
178_G 234_T 1.657 0.98
427_R 435_L 1.654 0.98
270_I 275_A 1.654 0.98
392_Y 434_G 1.652 0.98
223_R 229_E 1.63 0.98
404_N 460_S 1.629 0.98
393_L 430_I 1.622 0.98
211_S 221_F 1.614 0.98
113_K 117_E 1.614 0.98
376_S 393_L 1.611 0.98
275_A 279_M 1.608 0.98
234_T 237_G 1.607 0.98
180_V 232_Y 1.591 0.98
178_G 232_Y 1.583 0.98
362_N 389_K 1.569 0.98
444_I 459_C 1.538 0.97
5_V 17_I 1.536 0.97
344_R 374_T 1.518 0.97
170_C 182_F 1.503 0.97
274_S 356_A 1.502 0.97
440_L 459_C 1.5 0.97
57_E 60_H 1.498 0.97
171_V 181_A 1.48 0.96
191_L 225_V 1.474 0.96
159_A 162_R 1.473 0.96
207_V 231_I 1.472 0.96
68_M 173_M 1.466 0.96
284_G 316_I 1.463 0.96
458_E 461_V 1.448 0.96
399_E 418_A 1.446 0.96
281_T 315_R 1.445 0.96
161_N 182_F 1.444 0.96
234_T 240_F 1.431 0.95
132_L 164_I 1.421 0.95
118_E 138_S 1.406 0.95
193_L 223_R 1.402 0.95
379_I 382_M 1.4 0.95
400_I 410_M 1.396 0.94
46_R 60_H 1.388 0.94
9_G 13_V 1.375 0.94
192_V 221_F 1.363 0.93
334_T 346_S 1.358 0.93
172_A 180_V 1.352 0.93
180_V 230_A 1.352 0.93
406_Y 460_S 1.351 0.93
296_I 319_K 1.351 0.93
36_T 44_R 1.349 0.93
381_E 431_G 1.345 0.93
421_R 429_I 1.344 0.93
253_C 404_N 1.341 0.93
3_G 73_V 1.325 0.92
293_D 394_A 1.306 0.91
6_G 171_V 1.299 0.91
363_V 383_A 1.296 0.91
307_C 323_Q 1.296 0.91
427_R 434_G 1.285 0.91
423_V 435_L 1.284 0.91
205_Y 233_I 1.276 0.90
161_N 168_Y 1.274 0.90
158_A 242_R 1.267 0.90
32_A 56_F 1.266 0.90
215_D 355_R 1.25 0.89
36_T 69_G 1.249 0.89
440_L 443_L 1.248 0.89
254_L 443_L 1.247 0.89
384_R 433_D 1.242 0.88
2_C 102_N 1.232 0.88
402_F 413_A 1.23 0.88
304_E 329_R 1.229 0.88
157_I 180_V 1.222 0.87
277_V 322_R 1.222 0.87
287_I 394_A 1.222 0.87
358_F 383_A 1.213 0.87
279_M 443_L 1.21 0.87
353_A 358_F 1.209 0.87
393_L 432_A 1.199 0.86
152_N 155_A 1.196 0.86
418_A 426_I 1.195 0.86
105_L 408_I 1.188 0.85
287_I 293_D 1.188 0.85
349_R 352_N 1.174 0.84
300_I 324_G 1.169 0.84
20_A 208_A 1.169 0.84
181_A 233_I 1.157 0.83
17_I 71_G 1.155 0.83
314_A 319_K 1.154 0.83
391_V 432_A 1.152 0.83
169_A 188_I 1.145 0.82
106_T 165_R 1.143 0.82
360_D 389_K 1.138 0.82
358_F 388_A 1.137 0.82
4_I 171_V 1.134 0.81
89_F 127_S 1.133 0.81
234_T 238_Q 1.132 0.81
179_M 233_I 1.129 0.81
358_F 363_V 1.125 0.81
361_K 417_I 1.114 0.80
293_D 436_I 1.109 0.79
278_N 282_K 1.102 0.79
167_A 461_V 1.095 0.78
377_E 429_I 1.091 0.78
77_T 102_N 1.09 0.78
287_I 294_L 1.088 0.78
399_E 423_V 1.087 0.78
136_F 180_V 1.086 0.77
243_Q 247_N 1.086 0.77
252_P 268_D 1.085 0.77
270_I 278_N 1.084 0.77
389_K 428_Q 1.082 0.77
301_P 307_C 1.082 0.77
353_A 432_A 1.077 0.77
443_L 447_V 1.076 0.77
74_R 77_T 1.07 0.76
399_E 461_V 1.069 0.76
397_A 462_F 1.065 0.75
76_P 81_S 1.065 0.75
304_E 307_C 1.061 0.75
37_I 41_N 1.059 0.75
225_V 239_L 1.057 0.75
364_L 394_A 1.052 0.74
314_A 317_L 1.044 0.73
1_M 4_I 1.044 0.73
291_W 434_G 1.039 0.73
376_S 379_I 1.037 0.73
205_Y 239_L 1.035 0.72
388_A 391_V 1.033 0.72
105_L 164_I 1.032 0.72
279_M 396_A 1.024 0.71
323_Q 329_R 1.017 0.71
139_E 156_A 1.016 0.70
136_F 160_T 1.015 0.70
370_I 393_L 1.015 0.70
224_D 268_D 1.012 0.70
21_L 71_G 1.005 0.69
211_S 215_D 1.001 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ecfA20.9961000.368Contact Map0.802
1ao0A40.9031000.432Contact Map0.783
1xffA20.46931000.765Contact Map0.854
1te5A20.44951000.766Contact Map0.42
2bplA30.86731000.773Contact Map0.799
3mdnA40.46931000.779Contact Map0.54
1ct9A40.78811000.785Contact Map0.498
1ofdA20.81781000.788Contact Map0.424
1ea0A20.81981000.792Contact Map0.404
1jgtA20.69311000.795Contact Map0.503
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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