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OPENSEQ.org
SBMA - Protein SbmA
UniProt: P0AFY6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10928
Length: 406 (357)
Sequences: 503
Seq/Len: 1.41
SBMA
Paralog alert: 0.34 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_A 117_D 2.52 1.00
220_L 244_V 2.388 1.00
134_F 343_V 2.383 1.00
141_F 145_A 2.152 0.99
111_W 115_F 1.82 0.95
95_I 210_I 1.775 0.95
134_F 339_F 1.762 0.94
258_L 323_R 1.762 0.94
122_A 345_G 1.685 0.92
164_F 306_R 1.67 0.92
261_V 322_A 1.659 0.91
259_A 373_W 1.648 0.91
185_E 287_E 1.62 0.90
93_L 158_F 1.594 0.89
121_T 130_T 1.592 0.89
219_F 222_V 1.582 0.89
254_G 326_Y 1.577 0.89
141_F 328_Q 1.559 0.88
216_L 326_Y 1.557 0.88
252_L 255_T 1.556 0.88
171_N 279_Y 1.54 0.87
104_V 108_V 1.531 0.86
192_Q 272_N 1.49 0.84
50_A 68_V 1.473 0.83
228_A 341_S 1.455 0.82
309_Y 368_Y 1.444 0.82
308_N 386_L 1.437 0.81
145_A 328_Q 1.424 0.81
329_V 365_A 1.422 0.80
342_I 349_L 1.419 0.80
256_G 260_V 1.395 0.79
115_F 362_V 1.389 0.78
175_M 298_V 1.386 0.78
184_I 187_A 1.386 0.78
87_S 93_L 1.373 0.77
102_V 222_V 1.349 0.75
175_M 279_Y 1.348 0.75
72_A 76_F 1.343 0.75
170_M 199_A 1.341 0.75
186_G 230_V 1.338 0.74
171_N 302_F 1.335 0.74
193_E 273_Q 1.332 0.74
260_V 263_I 1.322 0.73
315_H 318_Y 1.32 0.73
184_I 230_V 1.309 0.72
142_L 146_L 1.302 0.72
106_V 222_V 1.299 0.71
251_S 366_F 1.297 0.71
186_G 231_P 1.295 0.71
116_Y 349_L 1.286 0.70
50_A 53_W 1.275 0.69
146_L 325_L 1.268 0.69
285_Y 294_T 1.264 0.68
95_I 213_I 1.258 0.68
50_A 67_C 1.256 0.68
270_F 274_R 1.254 0.67
256_G 305_V 1.254 0.67
65_I 69_G 1.247 0.67
186_G 287_E 1.245 0.67
219_F 340_P 1.24 0.66
141_F 332_V 1.239 0.66
164_F 199_A 1.239 0.66
154_L 158_F 1.238 0.66
112_Y 357_N 1.231 0.65
399_Q 402_T 1.224 0.65
50_A 54_S 1.224 0.65
54_S 57_F 1.213 0.64
187_A 230_V 1.212 0.64
114_P 117_D 1.211 0.63
272_N 308_N 1.207 0.63
209_F 344_A 1.205 0.63
168_T 306_R 1.205 0.63
172_E 176_A 1.2 0.62
243_L 338_L 1.199 0.62
149_V 261_V 1.192 0.62
153_V 362_V 1.19 0.61
109_N 276_E 1.186 0.61
187_A 277_A 1.183 0.61
48_S 57_F 1.182 0.61
53_W 64_Y 1.178 0.60
278_A 389_F 1.178 0.60
110_A 393_L 1.172 0.60
224_V 334_G 1.172 0.60
203_E 315_H 1.17 0.60
260_V 264_K 1.169 0.59
339_F 343_V 1.168 0.59
398_I 401_V 1.162 0.59
47_I 65_I 1.162 0.59
124_S 127_H 1.153 0.58
48_S 59_I 1.151 0.58
290_A 294_T 1.147 0.57
65_I 73_L 1.144 0.57
48_S 62_A 1.143 0.57
47_I 54_S 1.138 0.56
251_S 281_K 1.137 0.56
69_G 73_L 1.136 0.56
142_L 336_F 1.133 0.56
150_V 233_L 1.132 0.56
181_L 230_V 1.128 0.55
259_A 369_L 1.126 0.55
51_R 56_D 1.109 0.53
234_P 237_G 1.109 0.53
341_S 347_I 1.107 0.53
47_I 73_L 1.106 0.53
247_A 251_S 1.104 0.53
224_V 241_Y 1.102 0.53
185_E 230_V 1.1 0.53
248_I 325_L 1.099 0.52
115_F 312_L 1.098 0.52
305_V 309_Y 1.097 0.52
164_F 366_F 1.093 0.52
59_I 69_G 1.093 0.52
270_F 388_S 1.087 0.51
243_L 366_F 1.087 0.51
209_F 349_L 1.086 0.51
47_I 57_F 1.086 0.51
156_N 320_N 1.085 0.51
226_L 355_I 1.085 0.51
185_E 231_P 1.08 0.50
50_A 64_Y 1.078 0.50
273_Q 317_M 1.077 0.50
134_F 240_P 1.075 0.50
159_V 222_V 1.075 0.50
55_L 66_V 1.073 0.50
281_K 284_V 1.071 0.50
193_E 276_E 1.071 0.50
49_A 69_G 1.068 0.49
65_I 68_V 1.067 0.49
183_H 186_G 1.067 0.49
195_T 258_L 1.066 0.49
55_L 59_I 1.064 0.49
59_I 74_F 1.064 0.49
146_L 263_I 1.064 0.49
284_V 298_V 1.062 0.49
47_I 50_A 1.06 0.48
79_S 209_F 1.06 0.48
161_H 310_F 1.057 0.48
97_V 154_L 1.054 0.48
125_S 128_K 1.053 0.48
48_S 53_W 1.048 0.47
65_I 74_F 1.047 0.47
116_Y 389_F 1.047 0.47
154_L 317_M 1.047 0.47
117_D 348_T 1.046 0.47
63_Y 67_C 1.046 0.47
109_N 115_F 1.045 0.47
51_R 69_G 1.045 0.47
164_F 261_V 1.045 0.47
150_V 210_I 1.045 0.47
94_I 259_A 1.044 0.47
106_V 174_Y 1.043 0.47
205_M 376_L 1.042 0.47
221_P 225_T 1.042 0.47
222_V 370_I 1.04 0.46
50_A 59_I 1.039 0.46
62_A 67_C 1.038 0.46
50_A 69_G 1.035 0.46
209_F 213_I 1.033 0.46
258_L 319_F 1.03 0.45
335_L 339_F 1.029 0.45
170_M 329_V 1.028 0.45
64_Y 76_F 1.026 0.45
308_N 389_F 1.024 0.45
62_A 65_I 1.024 0.45
192_Q 309_Y 1.024 0.45
57_F 73_L 1.023 0.45
270_F 349_L 1.022 0.45
266_P 380_M 1.019 0.44
304_A 307_K 1.019 0.44
232_E 290_A 1.018 0.44
281_K 288_D 1.016 0.44
62_A 69_G 1.013 0.44
62_A 68_V 1.013 0.44
264_K 315_H 1.013 0.44
198_F 386_L 1.01 0.43
338_L 352_M 1.01 0.43
152_S 335_L 1.01 0.43
199_A 226_L 1.007 0.43
193_E 196_M 1.006 0.43
240_P 274_R 1.006 0.43
212_A 365_A 1.005 0.43
320_N 324_I 1.004 0.43
104_V 367_Q 1.003 0.43
48_S 56_D 1.003 0.43
152_S 349_L 1.003 0.43
83_W 87_S 1.002 0.43
258_L 322_A 1 0.42
162_Y 203_E 1 0.42
268_L 308_N 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a82A40.775999.30.901Contact Map0.004
3b5xA20.793199.20.906Contact Map0.028
3qf4B10.825199.20.907Contact Map0.284
3qf4A10.790699.10.909Contact Map0.266
3b60A40.793199.10.909Contact Map0.324
2yl4A10.788299.10.91Contact Map0.269
4f4cA10.86798.50.927Contact Map0.2
3g5uA20.842498.30.932Contact Map0.151
2pt7A60.293155.20.973Contact Map0.073
2xq2A10.290613.90.98Contact Map0.401
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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