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OPENSEQ.org
NAGA - N-acetylglucosamine-6-phosphate deacetylase
UniProt: P0AF18 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10632
Length: 382 (380)
Sequences: 8922
Seq/Len: 23.48
NAGA
Paralog alert: 0.84 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
351_T 356_K 4.8 1.00
4_L 46_L 4.58 1.00
373_I 378_E 4.456 1.00
46_L 362_A 3.997 1.00
54_G 93_T 3.962 1.00
24_A 29_K 3.956 1.00
7_G 46_L 3.729 1.00
52_S 363_F 3.697 1.00
49_A 370_T 3.546 1.00
371_K 378_E 3.491 1.00
353_A 356_K 3.407 1.00
21_V 51_L 3.108 1.00
51_L 362_A 2.968 1.00
357_V 375_N 2.944 1.00
327_A 330_E 2.894 1.00
30_S 354_A 2.879 1.00
349_L 357_V 2.86 1.00
3_A 22_V 2.795 1.00
352_L 360_L 2.785 1.00
345_V 349_L 2.785 1.00
52_S 361_T 2.784 1.00
26_G 357_V 2.627 1.00
7_G 51_L 2.527 1.00
360_L 373_I 2.514 1.00
16_L 19_H 2.462 1.00
6_Q 45_S 2.448 1.00
23_I 360_L 2.403 1.00
364_T 370_T 2.396 1.00
27_L 357_V 2.394 1.00
5_T 43_Q 2.334 1.00
321_V 331_V 2.306 1.00
348_R 357_V 2.305 1.00
51_L 360_L 2.251 1.00
333_R 337_L 2.219 1.00
5_T 20_A 2.168 1.00
9_I 21_V 2.156 1.00
27_L 348_R 2.087 1.00
361_T 369_I 2.082 1.00
227_R 263_L 2.075 1.00
337_L 351_T 2.056 1.00
49_A 364_T 2.036 1.00
49_A 362_A 2.02 1.00
21_V 352_L 1.991 1.00
31_V 354_A 1.935 1.00
258_R 262_R 1.934 1.00
183_K 186_N 1.919 1.00
26_G 375_N 1.913 1.00
341_R 346_E 1.881 1.00
372_T 380_V 1.856 1.00
4_L 23_I 1.855 1.00
22_V 30_S 1.836 1.00
89_K 380_V 1.835 1.00
4_L 360_L 1.815 1.00
337_L 341_R 1.806 1.00
52_S 55_F 1.802 1.00
330_E 333_R 1.791 1.00
362_A 373_I 1.785 1.00
211_I 228_E 1.765 1.00
21_V 360_L 1.755 1.00
204_K 208_R 1.754 1.00
46_L 51_L 1.747 1.00
361_T 372_T 1.744 1.00
87_N 95_Y 1.716 1.00
291_T 295_R 1.711 1.00
56_I 339_P 1.697 1.00
258_R 296_N 1.679 1.00
9_I 19_H 1.678 1.00
338_Y 341_R 1.651 1.00
6_Q 18_D 1.629 1.00
2_Y 373_I 1.614 1.00
317_V 335_A 1.597 1.00
7_G 362_A 1.592 1.00
50_I 365_P 1.577 1.00
8_R 17_D 1.573 1.00
317_V 331_V 1.572 1.00
199_T 202_E 1.566 1.00
6_Q 47_N 1.557 1.00
153_A 157_D 1.553 1.00
56_I 340_A 1.536 1.00
263_L 266_D 1.532 1.00
313_M 335_A 1.527 1.00
182_S 186_N 1.511 1.00
157_D 187_A 1.508 1.00
32_C 35_A 1.507 1.00
23_I 373_I 1.502 1.00
299_C 341_R 1.5 1.00
10_F 332_L 1.482 1.00
19_H 33_P 1.48 1.00
332_L 336_T 1.479 1.00
205_A 208_R 1.474 1.00
93_T 359_N 1.474 1.00
88_E 380_V 1.454 1.00
58_V 269_C 1.448 1.00
153_A 186_N 1.447 1.00
21_V 31_V 1.444 1.00
28_I 360_L 1.435 1.00
85_K 121_H 1.432 1.00
42_E 381_T 1.427 1.00
55_F 313_M 1.418 1.00
254_Y 292_I 1.412 1.00
364_T 368_K 1.403 0.99
205_A 209_A 1.395 0.99
333_R 338_Y 1.391 0.99
201_K 205_A 1.391 0.99
183_K 187_A 1.385 0.99
56_I 349_L 1.375 0.99
341_R 351_T 1.36 0.99
3_A 20_A 1.355 0.99
29_K 354_A 1.346 0.99
374_V 379_V 1.328 0.99
293_Y 298_L 1.304 0.99
270_L 320_L 1.304 0.99
92_C 313_M 1.303 0.99
337_L 356_K 1.302 0.99
127_G 131_E 1.295 0.99
88_E 374_V 1.291 0.99
76_S 79_T 1.275 0.99
363_F 369_I 1.272 0.99
255_A 258_R 1.268 0.99
227_R 259_N 1.262 0.99
10_F 15_F 1.261 0.99
6_Q 46_L 1.261 0.99
13_H 353_A 1.259 0.99
369_I 372_T 1.249 0.99
267_K 341_R 1.246 0.98
56_I 94_N 1.229 0.98
259_N 263_L 1.227 0.98
179_E 182_S 1.224 0.98
19_H 32_C 1.223 0.98
184_L 191_V 1.218 0.98
96_L 343_I 1.215 0.98
19_H 31_V 1.215 0.98
312_T 315_E 1.212 0.98
326_I 334_M 1.208 0.98
88_E 372_T 1.207 0.98
315_E 318_R 1.2 0.98
294_Y 330_E 1.198 0.98
22_V 29_K 1.194 0.98
5_T 45_S 1.182 0.98
347_K 356_K 1.181 0.98
6_Q 48_G 1.176 0.98
52_S 332_L 1.169 0.97
318_R 322_E 1.168 0.97
314_I 318_R 1.163 0.97
4_L 362_A 1.139 0.97
20_A 35_A 1.133 0.97
28_I 352_L 1.124 0.97
335_A 339_P 1.124 0.97
8_R 50_I 1.111 0.96
2_Y 23_I 1.108 0.96
340_A 350_G 1.105 0.96
7_G 360_L 1.089 0.96
259_N 262_R 1.083 0.96
81_E 120_K 1.081 0.95
362_A 371_K 1.079 0.95
81_E 85_K 1.075 0.95
112_R 116_E 1.073 0.95
88_E 379_V 1.071 0.95
11_T 16_L 1.07 0.95
200_L 204_K 1.069 0.95
2_Y 42_E 1.066 0.95
94_N 349_L 1.066 0.95
21_V 28_I 1.063 0.95
58_V 339_P 1.061 0.95
292_I 296_N 1.059 0.95
346_E 356_K 1.059 0.95
190_V 344_G 1.058 0.95
44_R 373_I 1.058 0.95
267_K 299_C 1.054 0.95
334_M 338_Y 1.053 0.95
157_D 161_E 1.047 0.94
273_D 319_N 1.042 0.94
8_R 18_D 1.041 0.94
349_L 356_K 1.04 0.94
154_A 157_D 1.037 0.94
93_T 372_T 1.033 0.94
345_V 348_R 1.032 0.94
62_G 83_M 1.029 0.94
55_F 361_T 1.024 0.93
20_A 34_V 1.019 0.93
94_N 359_N 1.017 0.93
157_D 183_K 1.009 0.93
20_A 32_C 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1yrrA20.99741000.181Contact Map0.805
3iv8A40.98951000.209Contact Map0.825
2vhlA20.98951000.267Contact Map0.781
1o12A20.94241000.327Contact Map0.744
4dzhA10.89271000.341Contact Map0.769
3ls9A20.92671000.348Contact Map0.785
3lnpA10.89791000.354Contact Map0.787
4gbdA20.89271000.361Contact Map0.803
4f0rA10.89271000.365Contact Map0.811
3h4uA20.91881000.367Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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