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OPENSEQ.org
MRP - Protein mrp
UniProt: P0AF08 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10611
Length: 369 (346)
Sequences: 1210
Seq/Len: 3.50
MRP
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
283_C 286_C 4.629 1.00
32_N 35_T 4.081 1.00
299_E 303_E 3.904 1.00
125_A 220_V 3.405 1.00
112_V 220_V 3.05 1.00
311_G 345_L 3.025 1.00
285_N 288_H 2.836 1.00
179_A 214_P 2.784 1.00
126_V 155_L 2.695 1.00
124_T 342_Y 2.635 1.00
180_T 185_Y 2.622 1.00
247_T 298_A 2.566 1.00
281_H 290_E 2.55 1.00
125_A 141_I 2.543 1.00
137_A 218_Y 2.467 1.00
308_Q 352_Q 2.366 1.00
67_K 71_S 2.351 1.00
281_H 284_S 2.317 1.00
280_V 289_H 2.26 1.00
309_L 312_Q 2.255 1.00
135_E 347_D 2.251 1.00
152_P 184_G 2.162 1.00
135_E 343_R 2.157 1.00
51_V 70_C 2.089 1.00
286_C 290_E 2.053 1.00
155_L 180_T 2.033 1.00
44_W 49_L 2.006 1.00
285_N 290_E 1.996 1.00
154_M 252_I 1.993 1.00
200_A 230_I 1.958 1.00
283_C 290_E 1.956 1.00
299_E 312_Q 1.924 1.00
19_G 22_A 1.921 1.00
40_H 54_V 1.872 1.00
49_L 80_A 1.851 0.99
113_S 245_V 1.807 0.99
18_A 34_T 1.789 0.99
282_I 289_H 1.767 0.99
140_G 216_L 1.765 0.99
41_H 52_E 1.763 0.99
192_A 262_V 1.734 0.99
126_V 151_I 1.713 0.99
33_L 39_L 1.704 0.99
336_S 339_T 1.681 0.99
291_P 295_T 1.649 0.98
71_S 75_L 1.6 0.98
313_M 345_L 1.57 0.98
48_T 84_D 1.57 0.98
133_A 178_L 1.56 0.98
56_P 60_H 1.551 0.98
275_V 345_L 1.551 0.98
345_L 349_V 1.5 0.97
51_V 74_L 1.49 0.97
174_M 179_A 1.468 0.96
42_V 51_V 1.455 0.96
22_A 32_N 1.435 0.96
157_A 180_T 1.435 0.96
20_T 74_L 1.422 0.95
187_V 193_M 1.385 0.94
68_E 72_A 1.373 0.94
47_D 81_K 1.37 0.94
64_E 67_K 1.352 0.93
48_T 82_A 1.342 0.93
147_Y 228_G 1.341 0.93
300_K 303_E 1.337 0.93
155_L 178_L 1.337 0.93
169_H 210_E 1.332 0.93
130_L 178_L 1.331 0.93
31_H 36_L 1.329 0.93
299_E 309_L 1.318 0.92
284_S 290_E 1.298 0.91
18_A 42_V 1.292 0.91
308_Q 348_R 1.277 0.90
132_L 220_V 1.275 0.90
52_E 86_K 1.272 0.90
134_A 343_R 1.27 0.90
108_N 241_T 1.269 0.90
318_S 321_E 1.267 0.90
220_V 349_V 1.267 0.90
283_C 287_G 1.264 0.90
206_Q 210_E 1.254 0.89
17_V 44_W 1.253 0.89
313_M 341_I 1.251 0.89
113_S 260_G 1.247 0.89
165_P 171_A 1.24 0.89
126_V 154_M 1.229 0.88
17_V 42_V 1.228 0.88
29_L 36_L 1.207 0.87
192_A 345_L 1.207 0.87
255_I 259_K 1.204 0.87
181_N 211_T 1.203 0.87
64_E 68_E 1.202 0.87
15_A 19_G 1.2 0.86
157_A 185_Y 1.194 0.86
17_V 49_L 1.183 0.85
130_L 330_V 1.179 0.85
160_Q 173_I 1.171 0.85
257_A 315_L 1.171 0.85
17_V 74_L 1.17 0.84
128_L 346_A 1.167 0.84
112_V 349_V 1.166 0.84
231_Q 264_F 1.163 0.84
152_P 183_I 1.161 0.84
242_G 272_L 1.156 0.84
65_E 69_Q 1.152 0.83
292_I 315_L 1.144 0.83
256_D 264_F 1.144 0.83
335_E 340_A 1.143 0.83
124_T 313_M 1.14 0.82
201_S 237_N 1.139 0.82
73_E 76_R 1.136 0.82
340_A 344_Q 1.131 0.82
24_F 70_C 1.13 0.82
153_T 255_I 1.126 0.81
17_V 77_I 1.125 0.81
132_L 350_A 1.123 0.81
55_M 59_W 1.121 0.81
161_R 170_M 1.113 0.80
128_L 349_V 1.113 0.80
141_I 180_T 1.109 0.80
53_L 70_C 1.103 0.79
333_R 336_S 1.1 0.79
296_G 299_E 1.099 0.79
126_V 141_I 1.098 0.79
280_V 291_P 1.097 0.79
180_T 275_V 1.094 0.79
281_H 288_H 1.083 0.78
157_A 173_I 1.077 0.77
127_N 328_P 1.076 0.77
223_M 260_G 1.073 0.77
16_M 19_G 1.07 0.76
329_T 336_S 1.07 0.76
149_P 256_D 1.068 0.76
190_D 267_V 1.067 0.76
204_L 230_I 1.067 0.76
283_C 288_H 1.065 0.76
193_M 259_K 1.059 0.75
320_R 324_D 1.058 0.75
137_A 350_A 1.057 0.75
18_A 22_A 1.057 0.75
26_H 36_L 1.053 0.75
24_F 69_Q 1.053 0.75
154_M 323_L 1.051 0.75
173_I 180_T 1.05 0.74
38_A 62_A 1.049 0.74
318_S 333_R 1.046 0.74
252_I 255_I 1.044 0.74
200_A 207_M 1.041 0.74
241_T 353_L 1.037 0.73
39_L 42_V 1.033 0.73
257_A 261_I 1.031 0.73
344_Q 348_R 1.024 0.72
20_T 24_F 1.022 0.72
216_L 219_L 1.021 0.72
150_S 230_I 1.021 0.72
22_A 35_T 1.018 0.71
113_S 223_M 1.015 0.71
221_L 234_L 1.015 0.71
201_S 230_I 1.007 0.70
50_H 84_D 1.004 0.70
252_I 323_L 1.003 0.70
149_P 264_F 1.002 0.69
171_A 212_L 1 0.69
56_P 59_W 1 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pg5A40.69651000.727Contact Map0.506
2ph1A10.70191000.737Contact Map0.52
3vx3A20.67211000.743Contact Map0.71
3iqwA20.67751000.76Contact Map0.417
2wojA40.69921000.76Contact Map0.453
2wooA60.68021000.765Contact Map0.355
3io3A10.69381000.766Contact Map0.404
3zq6A40.66121000.766Contact Map0.441
3ug7A40.72091000.767Contact Map0.308
3ez9A20.92411000.768Contact Map0.436
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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