OPENSEQ.org - MOAB - ECOLI GREMLIN

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MOAB - Molybdenum cofactor biosynthesis protein B

UniProt:	P0AEZ9	Sequence MSQVSTEFIPTRIAILTVSNRRGEEDDTSGHYLRDSAQEAGHHVVDKAIVKENRYAIRAQVSAWIASDDVQVVLITGGTGLTEGDQAPEALLPLFDREVEGFGEVFRMLSFEEIGTSTLQSRAVAGVANKTLIFAMPGSTKACRTAWENIIAPQLDARTRPCNFHPHLKK	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11596
Length:	170 (153)
Sequences:	1551
Seq/Len:	10.14

MOAB
Paralog alert: 0.32 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MOAB MOG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
92_L	98_E	4.405	1.00
104_E	107_R	3.345	1.00
20_N	84_G	3.173	1.00
91_L	135_A	2.812	1.00
95_F	126_G	2.723	1.00
109_L	112_E	2.657	1.00
36_S	148_E	2.597	1.00
81_L	99_V	2.422	1.00
141_K	145_T	2.019	1.00
21_R	25_E	2.009	1.00
96_D	129_N	1.998	1.00
54_R	58_R	1.968	1.00
34_R	47_K	1.917	1.00
16_L	64_W	1.875	1.00
13_I	37_A	1.843	1.00
101_G	107_R	1.791	1.00
18_V	57_I	1.774	1.00
23_G	26_D	1.742	1.00
54_R	93_P	1.703	1.00
58_R	93_P	1.645	1.00
17_T	76_T	1.605	1.00
18_V	50_V	1.595	1.00
128_A	133_I	1.593	1.00
106_F	146_A	1.539	1.00
105_V	108_M	1.538	1.00
60_Q	63_A	1.538	1.00
48_A	63_A	1.538	1.00
53_N	56_A	1.533	1.00
113_E	145_T	1.513	1.00
95_F	124_V	1.512	1.00
103_G	107_R	1.51	1.00
35_D	39_E	1.506	1.00
48_A	60_Q	1.493	1.00
28_T	140_T	1.47	1.00
33_L	147_W	1.455	1.00
57_I	86_Q	1.442	1.00
103_G	125_A	1.418	1.00
97_R	127_V	1.414	1.00
31_H	47_K	1.397	0.99
14_A	64_W	1.374	0.99
83_E	130_K	1.355	0.99
74_L	136_M	1.354	0.99
95_F	98_E	1.344	0.99
29_S	76_T	1.34	0.99
66_A	128_A	1.339	0.99
14_A	70_V	1.326	0.99
61_V	91_L	1.326	0.99
114_I	117_S	1.305	0.99
65_I	128_A	1.277	0.99
12_R	43_H	1.273	0.99
98_E	103_G	1.269	0.99
58_R	90_A	1.244	0.98
53_N	57_I	1.229	0.98
34_R	38_Q	1.212	0.98
136_M	146_A	1.21	0.98
53_N	86_Q	1.205	0.98
33_L	143_C	1.187	0.98
54_R	86_Q	1.186	0.98
58_R	62_S	1.173	0.98
24_E	47_K	1.156	0.97
57_I	61_V	1.136	0.97
99_V	103_G	1.135	0.97
17_T	29_S	1.129	0.97
15_I	34_R	1.128	0.97
75_I	135_A	1.119	0.96
58_R	94_L	1.104	0.96
17_T	30_G	1.099	0.96
92_L	124_V	1.097	0.96
31_H	35_D	1.091	0.96
61_V	94_L	1.086	0.96
51_K	56_A	1.076	0.95
16_L	57_I	1.075	0.95
55_Y	58_R	1.071	0.95
65_I	73_V	1.071	0.95
110_S	114_I	1.062	0.95
37_A	44_V	1.041	0.94
102_F	119_L	1.041	0.94
54_R	90_A	1.034	0.94
60_Q	64_W	1.017	0.93
13_I	72_V	1.016	0.93
63_A	67_S	1	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1mkzA	2	1	100	0.399	Contact Map	0.749
1di6A	1	0.9529	100	0.405	Contact Map	0.771
2pbqA	3	0.9588	100	0.429	Contact Map	0.84
2g2cA	1	0.9176	100	0.447	Contact Map	0.676
1jljA	3	0.9529	100	0.449	Contact Map	0.882
1y5eA	3	0.9647	100	0.451	Contact Map	0.799
3rfqA	3	0.9471	100	0.454	Contact Map	0.787
2pjkA	3	0.9647	100	0.455	Contact Map	0.78
4lhbA	3	0.9412	100	0.456	Contact Map	0.812
2is8A	3	0.9353	100	0.457	Contact Map	0.804

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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